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纳米TiO_2颗粒在制冷工质中的分散

过程工程学报 2007年第3期7卷 541-545页

作者：毕胜山史琳王磊清华大学热科学与动力工程教育部重点实验室热能工程系北京100084

纳米TiO2颗粒在制备和应用过程中极易团聚,解决其分散问题是纳米TiO2颗粒在制冷系统中应用的基础和前提.本工作利用目测沉降观察、分光光度计吸收测量法和激光粒度分析法,实验研究了纳米TiO2颗粒在制冷工质中的分散特性.结果表明,纳米T... 详细信息

纳米TiO2颗粒在制备和应用过程中极易团聚,解决其分散问题是纳米TiO2颗粒在制冷系统中应用的基础和前提.本工作利用目测沉降观察、分光光度计吸收测量法和激光粒度分析法,实验研究了纳米TiO2颗粒在制冷工质中的分散特性.结果表明,纳米TiO2颗粒在制冷剂中分散较稳定,制冷剂介电常数和极性是主要的影响因素;Span-80可以作为纳米TiO2颗粒在制冷剂中的分散剂;温度对纳米TiO2颗粒在制冷剂中的分散稳定性影响明显.研究结果可为纳米TiO2颗粒在制冷系统中的应用研究提供基础数据.

关键词：纳米颗粒制冷剂颗粒粒度表面活性剂温度

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湍流强化传热反馈控制机理

天津大学学报 2011年第7期44卷 655-658页

作者：潘利生史维秀汪健生天津大学机械工程学院天津300072

对流换热与湍流结构密切相关,运用大涡模拟方法,在湍流流场中进行强化传热反馈控制,分别采用3种反馈控制速度,研究反馈控制对传热的影响机理和效果,并建立目标函数,研究平均强化传热效果.结果表明:在湍流流场中输入适当反馈控制,强化传... 详细信息

对流换热与湍流结构密切相关,运用大涡模拟方法,在湍流流场中进行强化传热反馈控制,分别采用3种反馈控制速度,研究反馈控制对传热的影响机理和效果,并建立目标函数,研究平均强化传热效果.结果表明:在湍流流场中输入适当反馈控制,强化传热效果明显;当α为5.0、10.0和15.0时,努塞尔数最大增幅分别为8.78%、11.17%和14.08%,平均增幅分别为4.80%、6.88%和9.09%;当α为15.0时,y+=5处流场温度比未输入反馈控制的流场高10,℃左右.

关键词：反馈控制强化传热大涡模拟湍流拟序结构

The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4＋CD25＋ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment

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Cellular & Molecular Immunology 2016年第5期13卷 678-687页

作者： Jiezuan Yang Guoping sheng Dangsheng Xiao Haiyan shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province PR China

The frequency and T-cell receptor beta-chain variable （TCRBV） patterns of peripheral CD4＋CD25＋ regulatory T-cells （Tregs） are ambiguously altered in chronic hepatitis B （CHB） patients following tenofovir disoproxil fumarate （TDF） treatment. Moreover, the clinical significance of these parameters in relation to hepatitis B e antigen （HBeAg） seroconversion （SC） is largely unknown. In this study, the circulation of Tregs in HBeAg-positive CHB patients was determined by flow cytometry, and the molecular profiles of frequent TCRBV patterns of Tregs were analyzed using a gene melting spectral pattern. The parameters, such as Treg frequency, the number of skewed TCRBV patterns, hepatitis B virus （HBV） DNA levels, and alanine aminotransferase （ALT） levels, were analyzed by comparing their associations in seroconverting and non-seroconverting patients following TDF treatment. The Treg frequency was significantly correlated with the ALT level in seroconverting but not in non-seroconverting patients. Similarly, skewed TCRBV patterns were remarkably associated with HBV DNA levels in the SC group. Six TCRBV families （BV3, BV11, BV12, BV14, BV20, and BV24） were more prevalent than other TCRBV members in seroconverting patients pretreated with TDF, while BV12, BV15, and BV22 were predominant in non-seroconverting patients during TDF treatment. Taken together, the preferential TCRBV patterns may be associated with immune responses related to SC. The dynamic frequency and skewed TCRBV patterns of peripheral Tregs could contribute to predicting SC in CHB patients. Moreover, the conserved TCRBV complementarity-determining region （CDR3） motif may be targeted to develop personalized immunotherapy for CHB patients.

关键词： chronic hepatitis B individual treatment gene melting spectral pattern regulatory T-cells T-cell receptorbeta-chain variable

Preparation of ion-activated in situ gel systems of scopolamine hydrobromide and evaluation of its antimotion sickness efficacy

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Acta Pharmacologica Sinica 2007年第4期28卷 584-590页

作者： shi-lei CAO Qi-zhi ZHANG Xin-guo JIANG Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 200032,China DepartmentofPharmaceutics SchoolofPharmacyFudanUniversityShanghai200032China

Aim:To develop a novel,in situ gel system for nasal delivery of scopolaminehydrobromide (SCOP) and study its efficacy on motion ***:SCOPin situ gels at 0.2%,0.5%,and 1.0% gellan gum concentration (w/v) were prepared,respectively,and characterized in terms of viscosity,in vitro release,and *** photon emission computing tomography technique was usedto evaluate the nasal residence time of gel containing ~99mTc *** antimotionsickness efficacy produced by the in situ gel formulation was investigated in ratsand compared with those achieved after subcutaneous and oral ***:The viscosity of the gellan gum formulations either in solution or in gelincreased with increasing concentrations of gellan *** release in vitro wasmoderate in artificial nasal *** micrographic results showed that in situ gelswere safe,without nasal *** comparison with phosphate buffer saline,a prolonged radioactivity of99mTc in the rabbit nasal cavity was observed afteradministration of the gellan gum *** SCOP in situ gel at a doseof 100 pg/kg decreased symptoms of motion sickness significantly in comparisonwith subcutaneous and oral administration (P<0.01).Conclusion:SCOP nasal insitu gel is a safe and promising therapeutic alternative to existing medications formotion sickness.

关键词： scopolamine gellan gum nasal delivery motion sickness residence time nasal ciliotoxicity

Establishment and reliability evaluation of the design space for HPLC analysis of six alkaloids in Coptis chinensis(Huanglian) using Bayesian approach

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Chinese Journal of Natural Medicines 2016年第9期14卷 697-708页

作者： DAI sheng-Yun XU Bing ZHANG Yi LI Jian-Yu SUN Fei shi Xin-Yuan QIAO Yan-Jiang Research Center of Traditional Chinese Medicine Information Engineering Beijing University of Chinese Medicine Engineering Research Center of Key Technologies for Chinese Medicine Production and New Drug Development Ministry of Education

Coptis chinensis(Huanglian) is a commonly used traditional Chinese medicine(TCM) herb and alkaloids are the most important chemical constituents in it. In the present study, an isocratic reverse phase high performance liquid chromatography(RP-HPLC) method allowing the separation of six alkaloids in Huanglian was for the first time developed under the quality by design(Qb D) principles. First, five chromatographic parameters were identified to construct a Plackett-Burman experimental design. The critical resolution, analysis time, and peak width were responses modeled by multivariate linear regression. The results showed that the percentage of acetonitrile, concentration of sodium dodecyl sulfate, and concentration of potassium phosphate monobasic were statistically significant parameters(P < 0.05). Then, the Box-Behnken experimental design was applied to further evaluate the interactions between the three parameters on selected responses. Full quadratic models were built and used to establish the analytical design space. Moreover, the reliability of design space was estimated by the Bayesian posterior predictive distribution. The optimal separation was predicted at 40% acetonitrile, 1.7 g·m L-1of sodium dodecyl sulfate and 0.03 mol·m L-1 of potassium phosphate monobasic. Finally, the accuracy profile methodology was used to validate the established HPLC method. The results demonstrated that the Qb D concept could be efficiently used to develop a robust RP-HPLC analytical method for Huanglian.

关键词： Coptis chinensis Quality by Design(Qb D) Bayesian approach Analytical design space Accuracy profile

Immunopurification and Mass Spectrometry Identifies Protein Phosphatase 2A （PP2A） and BIN2/GSK3 as Regulators of AKS Transcription Factors in Arabidopsis

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Molecular Plant 2017年第2期10卷 345-348页

作者： Bu, Shuo-Lei Liu, Chao Liu, Ning Zhao, Ji-Long Ai, Lian-Feng Chi, Hao Li, Kathy L. Chien, Chih-Wei Burlingame, Alma L. Zhang, sheng-Wei Wang, zhi-Yong Hebei Normal Univ Hebei Collaborat Innovat Ctr Cell Signaling Hebei Key Lab Mol & Cellular Biol Coll Life Sci Shijiazhuang 050024 Hebei Peoples R China Carnegie Inst Sci Dept Plant Biol 290 Panama St Stanford CA 94305 USA Chinese Acad Sci Key Lab Intelligent Informat Proc Inst Comp Technol Beijing 100190 Peoples R China Univ Calif San Francisco Dept Pharmaceut Chem San Francisco CA 94158 USA

Dear Editor ABA induces the phosphorylation of three basic helix-loop-helix （bHLH） transcription factors, called AKSs （ABA-responsive ki- nase substrates; AKS1, AKS2, and AKS3）. The unphosphorylated AKSs facilitate stomatal opening through promoting the tran- scription of genes encoding inwardly rectifying K＋ channels （Takahashi et al., 2013）. AKS1 and AKS3 are also regulators of flowering （Ito et al., 2012）. However, the kinases and phosphatases that directly control the phosphorylation status of AKSs in vivo have not been fully characterized. Here,

关键词： quantitative proteomics mass spectrometry brassinosteroids protein phosphatase 2A affinity enrichment phosphorylation/dephosphorylation

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肠道在多器官功能障碍综合征中的作用

世界华人消化杂志 2005年第16期13卷 2029-2032页

作者：盛新华石汉平南方医科大学南方医院普通外科广东省广州市510515

多器官功能障碍综合征(multipleorgandysfunctionsyndrome,MODS)是创伤及感染后最严重的并发症.越来越多的证据表明,肠道在MODS的形成中具有重要作用,被认为是MODS的启动器官.肠道缺血/再灌注损伤引起肠道黏膜屏障功能障碍,使肠腔中的... 详细信息

多器官功能障碍综合征(multipleorgandysfunctionsyndrome,MODS)是创伤及感染后最严重的并发症.越来越多的证据表明,肠道在MODS的形成中具有重要作用,被认为是MODS的启动器官.肠道缺血/再灌注损伤引起肠道黏膜屏障功能障碍,使肠腔中的细菌、内毒素移位,各种炎症递质的共同作用触发全身性炎症反应,最终导致MODS.文中对近年肠道在MODS中的作用研究进展情况进行了综述.

关键词：多器官功能障碍综合征肠道黏膜屏障 syndrome 缺血/再灌注损伤全身性炎症反应 MODS 内毒素移位炎症递质并发症

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非线性再生散度模型的Bayes估计

数理统计与管理 2007年第6期26卷 999-1006页

作者：唐年胜邱世芳云南大学统计系昆明650091

非线性再生散度模型是指数族非线性模型、广义线性模型和正态非线性回归模型的推广和发展,唐年胜等人研究了该模型参数的极大似然估计及其统计诊断。本文基于Gibbs抽样和MH抽样算法讨论非线性再生散度模型参数的Bayes估计。模拟研究和... 详细信息

非线性再生散度模型是指数族非线性模型、广义线性模型和正态非线性回归模型的推广和发展,唐年胜等人研究了该模型参数的极大似然估计及其统计诊断。本文基于Gibbs抽样和MH抽样算法讨论非线性再生散度模型参数的Bayes估计。模拟研究和实例分析被用来说明该方法的有效性。

关键词： Cibbs抽样 MH算法非线性再生散度模型

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再论环境正义

自然辩证法研究 2017年第9期33卷 44-49页

作者：虞新胜陈世润南昌大学马克思主义学院江西南昌330031 东华理工大学马克思主义学院江西南昌330013

环境正义被认为是环境权利与环境义务的相一致,由此,环境非正义体现为不同群体、不同地区及不同代际之间在资源占有与责任分担方面的不一致。这种从权利与义务相一致角度分析环境正义问题具有一定合理性,但它忽视了生态系统本身的承载... 详细信息

环境正义被认为是环境权利与环境义务的相一致,由此,环境非正义体现为不同群体、不同地区及不同代际之间在资源占有与责任分担方面的不一致。这种从权利与义务相一致角度分析环境正义问题具有一定合理性,但它忽视了生态系统本身的承载力前提与其本身的有机性、整体性等特征,从而导致对环境正义理解的不完整。只有在环境可承载力前提下,遵循环境本身系统性、有机性、整体性特征基础上探讨权责一致,才能完整地理解环境正义,可以说环境正义是基于生态理性下的权利与义务的统一。

关键词：环境正义生态理性经济理性