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新型农村集体经济现代化的发展要求与路径

中南民族大学学报(人文社会科学版) 2025年第1期45卷 140-148,187页

作者：陈全功徐念中南民族大学经济学院湖北武汉430074

新型农村集体经济是一种有明确的经营主体、能够行使产权并能创造收入,以合作和股份经营为主、按“股”分配集体收益的农村经济形态。我国新型农村集体经济市场主体初步建立,资产负债比有所下降,经营性收入占比有所上升,收支略有结余,... 详细信息

新型农村集体经济是一种有明确的经营主体、能够行使产权并能创造收入,以合作和股份经营为主、按“股”分配集体收益的农村经济形态。我国新型农村集体经济市场主体初步建立,资产负债比有所下降,经营性收入占比有所上升,收支略有结余,成员获得一定收益。新时代新征程,新型农村集体经济现代化发展的要求是产权明晰、治理科学、经营稳健、分配合理和功能丰富。地方政府应把新型农村集体经济发展作为重要工作职责和任务,加大政策和资金支持力度,以推进其健康发展,并逐步实现现代化。

关键词：新型农村集体经济发展现状现代化

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高聚物对土壤结构改良的研究 Ⅲ.聚丙烯酰胺对赤红壤的改良研究

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土壤通报 2002年第1期33卷 9-13页

作者：龙明杰张宏伟陈志泉陈港曾繁森华南理工大学材料学院高分子系广东广州510640 华南理工大学制浆造纸国家重点实验室广东广州510640

研究了不同离子类型 (中性、阴离子和两性 )聚丙烯酰胺对赤红壤的改良作用。实验结果显示 ,聚丙烯酰胺能够提高赤红壤 >0 .2 5mm水稳性团粒结构数量 ,降低土壤容重 ,增大土壤的毛管持水量和渗透系数 ,提高土壤的含水量 ;在施用量为 0 .0... 详细信息

研究了不同离子类型 (中性、阴离子和两性 )聚丙烯酰胺对赤红壤的改良作用。实验结果显示 ,聚丙烯酰胺能够提高赤红壤 >0 .2 5mm水稳性团粒结构数量 ,降低土壤容重 ,增大土壤的毛管持水量和渗透系数 ,提高土壤的含水量 ;在施用量为 0 .0 0 5 %— 0 .2 0 0 %的范围内 ,改良剂对赤红壤的改良效果随其施用量的增大而增强 ;

关键词：聚丙烯酰胺土壤改良剂赤红壤水稳性团粒结构高聚物

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新加坡的语言政策与国家安全

外语学刊 2025年第1期 113-118页

作者：陈志杰南京信息工程大学新加坡研究中心南京210044

新加坡的语言政策与国家身份建构息息相关,因而一直受到学界的关注。然而,国家安全是新加坡国家身份建构的前提。因此,本文从国家安全的视角出发,分析了语言政策在新加坡的国际政治安全、国内社会安全、经济安全和文化安全等方面所起的... 详细信息

新加坡的语言政策与国家身份建构息息相关,因而一直受到学界的关注。然而,国家安全是新加坡国家身份建构的前提。因此,本文从国家安全的视角出发,分析了语言政策在新加坡的国际政治安全、国内社会安全、经济安全和文化安全等方面所起的作用,指出新加坡的双语制制造了新加坡语言身份与文化身份的割裂,在一定程度上阻碍了新加坡文化安全的实现,可能最终威胁到新加坡的国家安全。

关键词：新加坡语言政策国家安全文化身份语言身份

Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway

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World Journal of Gastroenterology 2025年第7期31卷 88-97页

作者： Qian chen Ya-Li Zhang Yong-quan Shi Lie Zheng Institute of Digestive Disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Xijing Hospital affiliated to Air Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Gastroenterology Traditional Chinese Medicine Hospital of Shaanxi ProvinceXi’an 710003Shaanxi ProvinceChina

BACKGROUND Excessive endoplasmic reticulum(ER)stress in intestinal epithelial cells can lead to damage to the intestinal mucosal barrier,activate the signal transducer and activator of transcription 3(STAT3)/nuclear factor kappa B(NF-κB)signaling pathway,and exacerbate the inflammatory response,thus participating in the pathogenesis of ulcerative colitis(UC).Mesalazine is a commonly used drug in the clinical treatment of ***,further studies are needed to determine whether mesalazine regulates the ER stress of intestinal epithelial cells,downregulates the STAT3/NF-κB pathway to play a role in the treatment of *** To study the therapeutic effects of mesalazine on spontaneous colitis in interleukin-10(IL-10)-/-*** The 24-week-old IL-10-/-mice with spontaneous colitis were divided into the model group and the 5-amino salicylic acid *** of wild-type mice of the same age group served as the *** were eight mice in each group,four males and four *** severity of symptoms of spontaneous colitis in IL-10-/-mice was assessed using disease activity index *** day 15,the mice were *** colon length was measured,and the histopathological changes and ultrastructure of colonic epithelial cells were *** protein expressions of STAT3,p-STAT3,NF-κB,IκB,p-IκB,and glucoseregulated protein 78 were identified using Western *** STAT3 and NF-κB mRNA expressions were identified using real-time polymerase chain *** glucose-regulated protein 78 and C/EBP homologous protein expressions in colon sections were detected using *** Mesalazine reduced the symptoms of spontaneous colitis in IL-10 knockout mice and the histopathological damage of colonic tissues,and alleviated the ER stress in epithelial cells of colitis *** blotting and quantitative real-time polymerase chain reaction results showed that the STAT3/NF-κB pathway in the colon tissue of model mice was activated,sugge

关键词： Mesalazine Ulcerative colitis Interleukin-10-/-mice Signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway Endoplasmic reticulum stress Inflammatory bowel disease

辽阳市大气污染物浓度变化特征及PM_(10)与气象因子的关系

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成都信息工程大学学报 2016年第5期31卷 537-543页

作者：张志恒陈权亮赵梓淇马晓晨吴振东张国成都信息工程大学大气科学学院四川成都610225 辽宁省气象局辽宁沈阳110000 中国气象局沈阳大气环境研究所辽宁沈阳110000 辽宁省防雷技术服务中心辽宁沈阳110000 辽阳市环境监测站辽宁辽阳110000

为研究辽阳市大气污染物浓度变化特征及污染状况,采用Pearson相关系数法等方法并建立预报方程对辽阳地市污染物浓度变化特征及PM10与气象因子的关系进行分析。结果表明:交通区为辽阳市平均程度上受污染最严重的地区,2月为辽阳市污染最... 详细信息

为研究辽阳市大气污染物浓度变化特征及污染状况,采用Pearson相关系数法等方法并建立预报方程对辽阳地市污染物浓度变化特征及PM10与气象因子的关系进行分析。结果表明:交通区为辽阳市平均程度上受污染最严重的地区,2月为辽阳市污染最严重的月份;辽阳市的主要污染物为可吸入颗粒物(PM10);PM10质量浓度月变化与气象因子有较高相关性;建立PM10质量浓度预报方程,预报值与实际值变化趋势基本一致。

关键词：气象学大气污染辽阳市质量浓度 PM10 气象因子

Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 202-220页

作者： Ling Wu Hong-Yao chen Jing-Ting Zhang Ren-Yi Yang zhi-Bin Wang Pei-Sen Xue Wei Peng Ke-Xiong Li Wen-Hui Gao Pu-Hua Zeng College of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Oncology Hunan Provincial Hospital of Integrated Traditional Chinese and Western ChineseChangsha 410006Hunan ProvinceChina Cancer Research Institute of Hunan Academy of Traditional Chinese Medicine Hunan Provincial Hospital of Integrated Traditional Chinese and Western ChineseChangsha 410006Hunan ProvinceChina

BACKGROUND Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid *** is associated with the inactivation of glutathione peroxidase(GPX)and the accumulation of lipid peroxides within *** is closely related to the occurrence and development of hepatocellular carcinoma(HCC).Chlorogenic acid(CGA),an important bioactive component found in 61 traditional Chinese medicines such as Eucommia ulmoides,has been extensively studied for its effects on various malignant ***,the specific role and potential mechanism of CGA in HCC remain *** To elucidate the anti-tumor characteristics and potential mechanisms of CGA in inducing ferroptosis in HCC *** The effects of CGA on the proliferation,migration,and invasion of HCC cells were evaluated through in vitro *** analysis combined with network pharmacology was used to study the potential targets and molecular mechanisms of CGA intervention in HCC *** vitro experiments were conducted to verify and explore the anti-HCC effects and mechanisms of CGA through the ferroptosis *** In vitro experiments showed that CGA dose-dependently inhibited the proliferation,invasion,and migration of HCC *** analysis combined with network pharmacology revealed that the pathway of CGA intervention in HCC cell ferroptosis was mainly enriched in the prostaglandin endoperoxide synthase 2(PTGS2)/aldoketo reductase family 1 member C3(AKR1C3)/GPX4 signaling pathway,which was associated with arachidonic *** vitro experiments further confirmed that CGA-induced ferroptosis in HCC cells was related to mitochondrial damage through the reprogramming of arachidonic acid metabolism by regulating the PTGS2/AKR1C3/GPX4 signaling *** This study demonstrates that CGA inhibits HCC cell proliferation,migration,and invasion by inducing ferroptosis through the PTGS2/A

关键词： Chlorogenic acid Hepatocellular carcinoma Ferroptosis Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis Bioinformatics In vitro experiment

论党的自我革命制度规范:内容特征、表现形态与体系架构

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思想教育研究 2025年第1期 3-11页

作者：陈思羽裴植北京大学马克思主义学院北京100871

研究规范体系首先需要从规范入手,党的自我革命制度规范是党的自我革命制度规范体系的基本构成要素。党的自我革命制度规范在内容上呈现出两方面特征:第一,以保持党的先进性和纯洁性为目的;第二,调整“四个自我”所涵盖的不同党务关系... 详细信息

研究规范体系首先需要从规范入手,党的自我革命制度规范是党的自我革命制度规范体系的基本构成要素。党的自我革命制度规范在内容上呈现出两方面特征:第一,以保持党的先进性和纯洁性为目的;第二,调整“四个自我”所涵盖的不同党务关系。在表现形态上,党的自我革命制度规范由党的主张类文件、党内法规和党内规范性文件这三类构成。这些文件根据“四个自我”所涉及的不同调整对象,形成了党的自我革命制度规范体系中的各个子体系,从而在静态层面上整合为党的自我革命制度规范体系的基本架构。同时,依据各自的效力原则,不同表现形态的规范也在动态层面上构建起层层递进、协调统一的位阶体系。

关键词：党的自我革命制度规范体系规范表现形态体系架构

Primary duodenal T/histiocyte-rich large B-cell lymphoma complicated with obstructive jaundice:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2025年第1期17卷 282-289页

作者： Xing-Yu chen Jia-Yi Yang Yi-Hua chen A-Niu Liu Shan-Shan Wu Se-Niu Ji zhi Shu-Mei Zheng Department of Gastroenterology and Hepatology North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Gastroenterology and Hepatology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Radiology Wuxi People’s HospitalNanjing Medical UniversityNanjing 214023Jiangsu ProvinceChina Department of Pathology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

BACKGROUND T/histiocyte-rich large B-cell lymphoma(T/HRBCL)is a highly aggressive subtype of diffuse large B-cell lymphoma characterized histologically by the presence of a few neoplastic large B cells amidst an abundant background of reactive T lymphocytes and/or histiocytes.T/HRBCL commonly affects the lymph nodes,followed by extranodal sites,such as the spleen,liver,and bone marrow,with rare occurrences in the gastrointestinal *** gastrointestinal T/HRBCL lacks specific clinical and endoscopic manifestations,and it is difficult to differentiate from inflammatory diseases,nodular lymphocyte predominant Hodgkin lymphoma,and other diseases on a histological basis,thereby hindering early *** SUMMARY A 63-year-old man was hospitalized with a one-month history of jaundice and weight loss of approximately 3 *** tests revealed increased hepatic parameters in a cholestatic pattern and elevated carbohydrate antigen 19-9 *** abdominal computed tomography scan revealed a low-density mass within the descending duodenum and dilation of the bile and pancreatic *** was clinically diagnosed with a duodenal *** surgery,a 7.0 cm×8.0 cm mass was identified within the descending duodenum,so pancreaticoduodenectomy and cholecystectomy were *** operative biopsy,the tumor was diagnosed as primary duodenal T/*** patient refused postoperative chemotherapy and died four months after *** Primary duodenal T/HRBCL is an extremely rare and highly aggressive *** initial treatment strategies should be based on the original site of the tumor,the disease stage,and the patient's physical ***-based comprehensive treatment is still the main treatment method for primary gastrointestinal T/HRBCL.

关键词： T/Histiocyte-rich B cell lymphoma Primary duodenal lymphoma Jaundice Immunohistochemistry Case report

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-cheng Tang Ding-Kang chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids