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农机化研究 2005年第5期27卷 265-266页

作者：吴勤南京师范大学电气与电子工程学院南京210097

从教育学的角度看,体验一种融课程和教学为一体的教育模式,体验回归教育,使情感、价值、技巧、信念等隐性知识及其认识方法进入了课程与教学领域,有利于培养情感、实践技能、创新能力。为此,论述了体验在新的内涵上重新回归教育所具有... 详细信息

从教育学的角度看,体验一种融课程和教学为一体的教育模式,体验回归教育,使情感、价值、技巧、信念等隐性知识及其认识方法进入了课程与教学领域,有利于培养情感、实践技能、创新能力。为此,论述了体验在新的内涵上重新回归教育所具有的价值。

关键词：教育学教育价值体验回归

Significance of HER2 protein expression and HER2 gene amplification in colorectal adenocarcinomas

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 335-347页

作者： Xin-Yu Wang zhi-Xue Zheng Yu Sun Yan-Hua Bai Yun-Fei Shi Li-Xin Zhou Yun-Feng Yao Ai-Wen wu Deng-Feng Cao Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of PathologyPeking University Cancer Hospital and Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Gastrointestinal Cancer Center Peking University Cancer Hospital and Institute Department of General Surgery Beijing Jishuitan Hospital Department of Pathology and Immunology Washington University School of Medicine

BACKGROUND Human epidermal growth factor receptor 2(HER2) is an oncogenic driver, and a well-established therapeutic target in breast and gastric cancers. While the role of HER2 as a prognostic biomarker in colorectal adenocarcinomas(CRCs) remains uncertain, its relevance as a therapeutic target has been established. We undertook the present study to evaluate the frequency of HER2 expression in CRC and to correlate it with various clinicopathological *** To correlate HER2 protein expression and HER2 gene amplification with clinicopathological features and survival in surgically resected *** About 1195 consecutive surgically resected CRCs were analyzed by immunohistochemical staining(IHC) to assess HER2 protein expression, and 141 selected tumors were further evaluated by fluorescence in situ hybridization(FISH) to assess HER2 gene amplification. Follow-up information was availablefor 1058 patients, and using this information we investigated the prevalence of HER2 protein overexpression and gene amplification in a large series of surgically resected CRCs, and evaluated the relationship between overexpression and clinicopathological parameters and *** HER2 IHC scores of 3+, 2+, 1+, and 0 were seen in 31(2.6%), 105(8.8%), 475(39.7%), and 584(48.9%) tumors, respectively. HER2 gene amplification was seen in 24/29 tumors with an IHC score of 3+(82.8%; unreadable in 2/31), 12/102 tumors with an IHC score of 2+(11.8%; unreadable in 2/104), and 0 tumors with IHC score of 1+(0/10). HER2 gene amplification was seen in 36/1191 tumors(3.0%; unreadable in 4/1195). Among the tumors with HER2 IHC scores of 3+and 2+, the mean percentage of tumor cells with positive IHC staining was 90%(median 100%, range 40%-100%) and 67%(median 75%, range 5%-95%),respectively(P < 0.05). Among tumors with IHC scores of 2+, those with HER2 gene amplification had a higher number of tumors cells with positive IHC staining(n = 12, mean 93%, median 95%, range 90%-95%) than

关键词： Human epidermal growth factor receptor 2 Immunohistochemical staining Fluorescent in situ hybridization Prognosis Colorectal cancers

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肿瘤干细胞耐药机制研究进展

中国药理学通报 2012年第12期28卷 1637-1642页

作者：赵小琴符立梧华南肿瘤学国家重点实验室中山大学肿瘤防治中心广东广州510060

肿瘤是一种干细胞疾病,治疗肿瘤面临的主要挑战之一是肿瘤对传统治疗产生了耐药性,研究证明耐药性的产生与肿瘤干细胞(cancer stem cells,CSCs)的生物学特性密切相关。鉴定各种肿瘤中的CSCs以及维持其特性所必需的微环境和生物学进程对... 详细信息

肿瘤是一种干细胞疾病,治疗肿瘤面临的主要挑战之一是肿瘤对传统治疗产生了耐药性,研究证明耐药性的产生与肿瘤干细胞(cancer stem cells,CSCs)的生物学特性密切相关。鉴定各种肿瘤中的CSCs以及维持其特性所必需的微环境和生物学进程对治疗肿瘤复发至关重要。CSCs周围局部微环境(niche)的改变能影响其生物学行为,而多种与发育相关的信号通路的激活,DNA修复能力的增强以及ABC转运蛋白介导的药物外排等是导致临床耐药的主要原因。该文就近年来CSCs与耐药的相关研究进展作一综述。

关键词：肿瘤干细胞耐药 niche 机制研究进展

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A型喷油泵柱塞弹簧的可靠性计算

拖拉机与农用运输车 2005年第1期32卷 32-33,36页

作者：吴勤南京师范大学电气与电子学院南京210024

分析了A型喷油泵柱塞弹簧的工作特点和材料性能,闸述了柱塞弹簧的可靠性计算过程,并通过计算分析验证了该弹簧的可靠性。

关键词：内燃机 A型喷油泵柱塞弹簧可靠性计算工作特点材料性能

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国际货币体系与汇率理论发展

河南师范大学学报（哲学社会科学版） 2006年第1期33卷 79-81页

作者：吴芹复旦大学经济学院上海200433

国际货币体系是一个非常重要和复杂的现实问题,自从布雷顿森林体系崩溃以后,国际金融市场一直动荡不定,而汇率制度是国际货币体系的中心内容之一,汇率决定理论又在国际金融发展进程中始终占据着举足轻重的地位。本文试从国际货币体系的... 详细信息

国际货币体系是一个非常重要和复杂的现实问题,自从布雷顿森林体系崩溃以后,国际金融市场一直动荡不定,而汇率制度是国际货币体系的中心内容之一,汇率决定理论又在国际金融发展进程中始终占据着举足轻重的地位。本文试从国际货币体系的演变和汇率理论的发展的角度,剖析两者的内在关系。

关键词：国际货币体系汇率理论汇率理论发展

Oxaliplatin-containing adjuvant chemotherapy improves the survival of locally advanced rectal cancer patients with pathological complete response after pre-operative chemoradiotherapy

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Gastroenterology Report 2018年第3期6卷 195-201,I0002页

作者： Jian-Hong Peng Jun-Zhong Lin Yu-Ming Rong Ying Zhu Yu-Xiang Deng Yu-Jie Zhao Zhen-Hai Lu Xiao-Jun wu zhi-Zhong Pan Department of Colorectal Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China VIP Region Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China

Background:The necessity for adjuvant chemotherapy(ACT)in locally advanced rectal cancer(LARC)patients who achieve pathological complete response(pCR)after pre-operative chemoradiotherapy(CRT)is still not *** aimed to investigate the therapeutic value of ACT in these ***:Clinical data were retrospectively collected from 105 consecutive LARC patients who achieved pCR after pre-operative CRT and underwent radical tumor resection between December 2008 and April 2014 in a comprehensive cancer *** chemotherapy(CT)was administered by combining oxaliplatin with capecitabine(XELOX regimen).Disease-free survival(DFS)and overall survival(OS)rates of patients with or without ACT were ***:Eighty-three(79.0%)patients received ACT and 22(21.0%)did *** a median follow-up of 49 months,the ACT group had a significantly higher 3-year DFS rate(92.8 vs 86.4%,p=0.029)and 3-year OS rate(95.1 vs 86.1%,p=0.026)than the non-ACT *** multivariable analyses,the presence of ACT was an independent prognostic factor for DFS(hazard ratio[HR]:0.271;95%confidence interval(CI):0.080–0.916;p=0.036)but not for *** benefit was more obvious in patients younger than 60 years via subgroup analysis(adjusted HR:0.106;95%CI:0.019–0.606;p=0.012).Conclusions:Oxaliplatin-containing ACT may confer survival benefits to patients with pCR,particularly younger ***,the routine use of ACT in patients with pCR needs further validation.

关键词： Adjuvant chemotherapy rectal cancer pre-operative chemoradiotherapy pathological complete response survival

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喷油泵凸轮型线的拟合

拖拉机与农用运输车 2001年第3期28卷 22-23页

作者：吴勤南京师范大学电气与电子工程学院 420042

在喷油泵样泵的凸轮测绘中 ,常常只能通过实测得到一张离散数据的凸轮升程表 ,而无法知道其凸轮型线。为此 ,本文讨论了如何运用最小二乘法原理。

关键词：最小二乘法凸轮型线拟合从动件

Prevalence and clinical characteristics of COVID-19 in inpatients with schizophrenia in wuhan,China

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World Journal of Psychiatry 2022年第1期12卷 140-150页

作者： Hong-Wei Sheng Hong-Gang Wang Chun-zhi Wang Jiang wu Li-Jian Huo Ruo-Xi Wang Yong-Jie Zhou Xiang-Yang Zhang Department of Psychiatry Wuhan Youfu HospitalWuhan 430070Hubei ProvinceChina qingdao Mental Health Center Qingdao UniversityQingdao 266000Shandong ProvinceChina CAS Key Laboratory of Mental Health Chinese Academy of SciencesBeijing 10000China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430070Hubei ProvinceChina Department of Psychiatric Rehabilitation Shenzhen Kangning HospitalShenzhen 510810Guangdong ProvinceChina

BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric *** prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are *** To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a wuhan psychiatric *** We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at wuhan’s Youfu *** Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison *** overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were *** most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for *** patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between *** Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.

关键词： Mental health Schizophrenia Inpatient Epidemiology

微小RNA-30a调控丝裂原活化蛋白激酶通路对主动脉夹层大鼠的影响

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解剖学报 2024年第2期55卷 222-228页

作者：吴跃武胡斌过小冬付琴邹志佳江西省抚州市第一人民医院心胸外科江西抚州344000 江西省抚州市第一人民医院检验科江西抚州344000

目的探讨微小RNA(miR)-30a调控MAPK通路对主动脉夹层大鼠模型夹层形成、炎性因子及血管收缩的影响。方法选取SD大鼠50只,建立主动脉夹层大鼠模型,将其随机分为对照组、模型组、miR-NC组、miR-30a组、miR-30a抑制剂组,各组10只。组织病... 详细信息

目的探讨微小RNA(miR)-30a调控MAPK通路对主动脉夹层大鼠模型夹层形成、炎性因子及血管收缩的影响。方法选取SD大鼠50只,建立主动脉夹层大鼠模型,将其随机分为对照组、模型组、miR-NC组、miR-30a组、miR-30a抑制剂组,各组10只。组织病理学染色观察大鼠主动脉组织变化、主动脉中膜弹力纤维与胶原纤维变化;采用PCR、尾动脉压力计、ELISA法对各组miR-30a表达、干预前后收缩压情况、血清炎性因子表达进行检测;采用Western blotting检测各组大鼠基质金属蛋白酶(MMP)-6、MMP-2蛋白表达以及MAPK通路相关蛋白表达。结果MiR-30a抑制剂组血管壁撕裂程度和内动脉壁排列紊乱有所改善;miR-30a抑制剂组改善血管重构;与对照组相比,模型组miR-30a表达较高,与miR-NC组相比,miR-30a组、miR-30a抑制剂组表达较低,P0.05;与对照组相比,模型组收缩压较高,与miR-NC组相比,miR-30a组表达较高,miR-30a抑制剂组表达较低,P<0.05;与对照组相比,模型组肿瘤坏死因子(TNF)、白细胞介素(IL)-6、IL-1β表达较高,与miR-NC组相比,miR-30a组表达较高,miR-30a抑制剂组表达较低,P<0.05;与对照组相比,模型组、MMP-6、MMP-2、Ras、Raf、P38 MAPK及ERK1/2蛋白表达较高,与miR-NC组相比,miR-30a组表达较高,miR-30a抑制剂组表达较低,P<0.05。结论MiR-30a参与主动脉夹层的形成、炎症反应、调控主动脉夹层血管重构,可能是通过调控MAPK信号通路实现的。

关键词：微小RNA-30a 丝裂原活化蛋白激酶通路主动脉夹层免疫印迹法大鼠

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运行流量对库区污染物下泄影响研究

水利学报 2005年第10期36卷 1183-1187页

作者：李嘉李志勤李然四川大学水力学与山区河流开发保护国家重点实验室四川成都610065 西南科技大学土木学院四川绵阳621000

本文通过直接求解水体三维污染物运动方程,模拟了概化水库中污染物运动,系统分析了运行流量对污染物下泄的影响。研究表明,不同污染物来流条件下,增大运行流量有利于污染物下泄,减小污染物在库区滞留时间和水库下泄水流水质超标时间。... 详细信息

本文通过直接求解水体三维污染物运动方程,模拟了概化水库中污染物运动,系统分析了运行流量对污染物下泄的影响。研究表明,不同污染物来流条件下,增大运行流量有利于污染物下泄,减小污染物在库区滞留时间和水库下泄水流水质超标时间。作者将分析结果应用到紫坪铺水库突发性污染事故预警系统中,针对不同污染物来流条件提出了相应应急目标和应急运行措施,为相关管理部门和人员决策提供技术支持。

关键词：运行流量库区污染物下泄影响研究