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Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

Zoological Research 2024年第4期45卷 791-804页

作者： Wen-Hao li zhi-qiang li Meng-Di Bu Jia-Zhen li liang-Biao Chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress Ovarian failure Metabolome Zebrafish

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Riemann-Hilbert Approach to the Fifth-order Nonlinear Schr?dinger Equation with Non-vanishing Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2024年

作者： Jin-jie YANG Shou-fu TIAN zhi-qiang li School of Mathematics China University of Mining and Technology

The Cauchy problem of the fifth-order nonlinear Schr?dinger (foNLS) equation is investigated with nonzero boundary conditions in detailed. Firstly, the spectral analysis of the scattering problem is carried out.A Riemann surface and affine parameters are introduced to transform the original spectral parameter to a new spectral parameter in order to avoid the multi-valued problem. Based on Lax pair of the foNLS equation, the Jost functions are obtained, and their analytical, asymptotic, symmetric properties, as well as the corresponding properties of the scattering matrix are established systematically. For the inverse scattering problem, we discuss the cases that the scattering coefficients have simple zeros and double zeros, respectively, and we further derive their corresponding exact solutions via solving a suitable Riemann-Hilbert problem. Moreover, some interesting phenomena are found when we choose some appropriate parameters for these exact solutions, which are helpful to study the propagation behavior of these solutions.

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Sub-additive Unstable Topological Pressure of Diffeomorphisms

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Acta Mathematica Sinica,English Series 2022年第12期38卷 2285-2298页

作者： Wen Da ZHANG zhi qiang li Yun Hua ZHOU College of Mathematics and Statistics Chongqing Jiaotong UniversityChongqing 400074P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

In this paper,we study unstable topological pressure for C^(1)-smooth partially hyperbolic diffeomorphisms with sub-additive ***,without any additional assumption,we have established the expected variational principle which connects this unstable topological pressure and the unstable measure theoretic entropy,as well as the corresponding Lyapunov exponent.

关键词： Partially hyperbolic systems unstable topological pressure sub-additive potentials

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Co single atoms and nanoparticles dispersed on N-doped carbon nanotube as high-performance catalysts for Zn-air batteries

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Rare Metals 2022年第6期41卷 2055-2062页

作者： Jing-Jing Chen Shuai Gu Rui Hao Zhen-Yu Wang Mu-Qing li zhi-qiang li Kun liu Ke-Meng liao zhi-qiang Wang He Huang Ying-zhi li Kai-li Zhang Zhou-Guang Lu Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Energy Materials for Electric PowerShenzhen Key Laboratory of Interfacial Science and Engineering of MaterialsSouthern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China

Diminishing the size of active sites in catalysts is promis-ing to improve the kinetics of oxygen reduction reaction(ORR)and reduce the cost of metal-air ***,the facile preparation of high-performance catalysts with nanoscale active sites still suffers from great ***,we report a facile template-free strategy to fabri-cate Co single atoms and nanoparticles dispersed on porous N-doped carbon nanotube(Co-NCNT)by the pyrolysis of the composites of metal-organic complexes and porous carbon *** from the conventional strategy,the precursor metal-organic complexes in this work were prepared under mild conditions and used without complex purification *** with the pristine carbon nanotube,N-doped carbon nanotube with abundant meso-pores contribute to the formation of nanoscale Co sites.

关键词： nanoparticles composites carbon

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Deep-detection of formation boundary using transient multicomponent electromagnetic logging measurements

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Petroleum Science 2022年第3期19卷 1085-1098页

作者： Xi-Yong Yuan Shao-Gui Deng zhi-qiang li Xiao-Mei Han Xu-Fei Hu Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China Sinopec Matrix Corporation QingdaoShandong266000China China Research Institute of Radiowave Propagation XinxiangHenan453000China China University of Petroleum—Beijing at Karamay KaramayXinjiang834000China

The maximum distance at which an electromagnetic(EM)logging while drilling(LWD)tool detects an approaching boundary is defined as the depth of detection(DOD).Ultra-deep detection capability of the transient multicomponent EM logging measurement is investigated ***,we adopt sine and cosine transform to calculate the transient multicomponent *** to the cosine transform,sine transform is more accurate in solving late-time ***,a time-domain geosignal is introduced to sense the *** show that DOD of this transient EM measurement can be up to tens of meters,including directionally ***,by studying the decay characteristics of different components with time,cross component is confirmed to decay much faster than the coaxial/coplanar components in the formation coordinate system.A pseudo-inversion is thereby proposed to determine the dip angle of anisotropic stratified *** simulation results indicate that this algebraic method can determine the true dip at some particular *** is still stable and valid even when considering random measurement ***,we establish the linear relationship between the time at which the half-point of geosignal curve appears and the distance to boundary(DTB),which would assist in the quick determination of DTB.

关键词： Time-domain Logging while drilling Formation boundary Dip angle Distance to boundary

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A comprehensive review on microchannel heat sinks for electronics cooling

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International Journal of Extreme Manufacturing 2024年第2期6卷 133-162页

作者： zhi-qiang Yu Mo-Tong li Bing-Yang Cao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

The heat generation of electronic devices is increasing dramatically,which causes a serious bottleneck in the thermal management of electronics,and overheating will result in performance deterioration and even device *** the development of micro-machining technologies,the microchannel heat sink(MCHS)has become one of the best ways to remove the considerable amount of heat generated by high-power *** has the advantages of large specific surface area,small size,coolant saving and high heat transfer *** paper comprehensively takes an overview of the research progress in MCHSs and generalizes the hotspots and bottlenecks of this *** heat transfer mechanisms and performances of different channel structures,coolants,channel materials and some other influencing factors are ***,this paper classifies the heat transfer enhancement technology and reviews the related studies on both the single-phase and phase-change flow and heat *** comprehensive review is expected to provide a theoretical reference and technical guidance for further research and application of MCHSs in the future.

关键词： microchannel heat sink thermal management of electronics microscale heat transfer heat transfer enhancement

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Uncertainty and sensitivity analysis of in-vessel phenomena under severe accident mitigation strategy based on ISAA-SAUP program

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Nuclear Science and Techniques 2024年第1期35卷 108-123页

作者： Hao Yang Ji-Shen li zhi-Ran Zhang Bin Zhang Jian-qiang Shan School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

The phenomenology involved in severe accidents in nuclear reactors is highly ***,integrated analysis programs used for severe accident analysis heavily rely on custom empirical parameters,which introduce considerable ***,in recent years,the field of severe accidents has shifted its focus toward applying uncertainty analysis methods to quantify uncertainty in safety assessment programs,known as“best estimate plus uncertainty(BEPU).”This approach aids in enhancing our comprehension of these programs and their further development and *** study concentrates on a third-generation pressurized water reactor equipped with advanced active and passive mitigation *** an Integrated Severe Accident Analysis Program(ISAA),numerical modeling and uncertainty analysis were conducted on severe accidents resulting from large break loss of coolant *** uncertainty parameters of the ISAA program were meticulously *** Wilks'formula,the developed uncertainty program code,SAUP,was employed to carry out Latin hypercube sampling,while ISAA was employed to execute batch *** analysis was then conducted on two figures of merit,namely hydrogen generation and the release of fission products within the pressure *** calculations revealed that hydrogen production and the fraction of fission product released exhibited a normal distribution,ranging from 182.784 to 330.664 kg and from 15.6 to 84.3%,*** ratio of hydrogen production to reactor thermal power fell within the range of 0.0578–0.105.A sensitivity analysis was performed for uncertain input parameters,revealing significant correlations between the failure temperature of the cladding oxide layer,maximum melt flow rate,size of the particulate debris,and porosity of the debris with both hydrogen generation and the release of fission products.

关键词： Gen-III PWR Severe accident mitigation Wilks’formula Hydrogen Fission products Uncertainty and sensitivity analysis

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Research on a TOPSIS energy efficiency evaluation system for crude oil gathering and transportation systems based on a GA-BP neural network

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Petroleum Science 2024年第1期21卷 621-640页

作者： Xue-qiang Zhang Qing-lin Cheng Wei Sun Yi Zhao zhi-Min li Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing163318HeilongjiangChina China Petroleum Pipeline Material and Equipment Co. LtdLangfang065000HebeiChina Research Institute of Petroleum Engineering and Technology Sinopec Northwest Oilfield CompanyUrumqi830011XinjiangChina

As the main link of ground engineering,crude oil gathering and transportation systems require huge energy consumption and complex *** is necessary to establish an energy efficiency evaluation system for crude oil gathering and transportation systems and identify the energy efficiency *** this paper,the energy efficiency evaluation system of the crude oil gathering and transportation system in an oilfield in western China is *** with the big data analysis method,the GA-BP neural network is used to establish the energy efficiency index prediction model for crude oil gathering and transportation *** comprehensive energy consumption,gas consumption,power consumption,energy utilization rate,heat utilization rate,and power utilization rate of crude oil gathering and transportation systems are *** the efficiency and unit consumption index of the crude oil gathering and transportation system,the energy efficiency evaluation system of the crude oil gathering and transportation system is established based on a game theory combined weighting method and TOPSIS evaluation method,and the subjective weight is determined by the triangular fuzzy analytic hierarchy *** entropy weight method determines the objective weight,and the combined weight of game theory combines subjectivity with objectivity to comprehensively evaluate the comprehensive energy efficiency of crude oil gathering and transportation systems and their ***,the weak links in energy utilization are identified,and energy conservation and consumption reduction are *** above research provides technical support for the green,efficient and intelligent development of crude oil gathering and transportation systems.

关键词： Crude oil gathering and transportation system GA-BP neural network Energy efficiency evaluation TOPSIS evaluation method Energy saving and consumption reduction

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Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK/NF-κB signaling pathway

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World Journal of Psychiatry 2023年第6期13卷 340-350页

作者： Ming-Ming Zhang Jing-Wei Zhao zhi-qiang li Jing Shao Xi-Yan Gao Department of Pain Treatment Luoyang Orthopedic Traumatological Hospital of Henan ProvinceZhengzhou 471002Henan ProvinceChina Department of Geriatric Medicine The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Acupuncture and Moxibustion The Third Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina

BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall *** medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse *** has a good curative effect and unique advantages in the treatment of *** To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of *** We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive *** treatment,the sleep time and general behavior of the rats were *** Morris water maze test was used to assess the learning ability and spatial memory ability of the *** expression levels of inflammatory cytokines in serum and the hippocampus were detected by *** was used to detect the mRNA expression changes in the ERK/NF-κB signaling *** blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κ*** Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial *** addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling *** These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.

关键词： ERK/NF-κB signaling pathway Acupuncture Insomnia Inflammation Acupuncture at Back-Shu point Traditional Chinese medicine

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Heel pain caused by os subcalcis:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5373-5379页

作者： Saijilafu Suo-Yuan li Xiao Yu zhi-qiang li Guang Yang Jing-Huan Lv Guang-Xiang Chen Ren-Jie Xu Department of Orthopaedics Soochow UniversitySuzhou 215007Jiangsu ProvinceChina Department of Orthopaedics the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalSuzhou 215000Jiangsu ProvinceChina Department of pathology the Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalSuzhou 215000Jiangsu ProvinceChina

BACKGROUND The accessory bones are common bone variations around the feet and ankles,which usually originate from nonunion of the secondary ossification center adjacent to the main bone mass,and most of them remain *** subcalcis is an accessory bone at the plantar aspect of the calcaneus,which is located just posterior to the insertion of the plantar *** bone formation at the calcaneal plantar pole with heel pain has rarely been *** SUMMARY A 55-year-old man presented to our clinic with left plantar heel pain and a progressive swelling for 8 years.X-ray,computer tomography and magnetic resonance imaging showed a large os subcalcison the plantar side of the calcaneus,located at the insertion of the plantar *** underwent surgical excision of the *** the bony trabeculae were intermingled with fat and covered with *** This is a rare case with accessory os subcalcis leading to heel *** highlights the awareness of os subcalcis and helps avoid future misdiagnosis of heel pain.

关键词： Heel pain Accessory ossicle Calcaneus Os subcalcis Case report

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