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Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats

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Neural Regeneration Research 2019年第8期14卷 1387-1393页

作者： Li-Mei Cao zhi-qiang dong qiang Li Xu Chen Department of Neurology Shanghai No.8 People’s Hospital

RehabilNation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/reperfusion, and then received treadmill training of different intens让ies, twice a day for 30 minutes for 1 week. Low-intensity training was conducted at 5 m/min, with a 10-minute running, 10-minute rest, and 10-minute running cycle. In the moderate-intensity training, the intensity gradually increased from 5 m/min to 10 m/min in 5 minutes, with the same rest cycle as above. In high-intensity training, the intensity gradually increased from 5 m/min to 25 m/min in 5 minutes, with the same rest cycle as above. The Bederson scale was used to evaluate the improvement of motor function. Infarct volume was detected using 2,3,5-triphenyltetrazolium chloride staining. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining was applied to detect the apoptosis of nerve cells in brain tissue. Western blot assay was employed to analyze the activation of cyclic adenosine monophosphate (cAMP)/protein kinase A and Akt/glycogen synthase kinase-3卩 signaling pathways in rat brain tissue. All training intensities reduced the neurological deficit score, infarct volume, and apoptosis in nerve cells in brain tissue of stroke rats. Training intensities activated the cAMP/protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This activation was more obvious with higher training intensities. These changes were reversed by intracerebroventricular injection of protein kinase A inhibitor Rp-cAMP. Our findings indicate that the neuroprotective effect of rehabilitation training is achieved via activation of the cAMP/ protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This study was approved by the Ethics Committee of Animal Experimentation in Shanghai No. 8 Peoples Hospital, China.

关键词： nerve regeneration ischemic stroke treadmill training neuronal deficit apoptosis cyclic adenosine monophosphate protein kinase A glycogen synthase kinase-3^ neuroprotective effect neural regeneration

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Y-shaped shunt for the treatment of Dandy-Walker malformation combined with giant arachnoid cysts:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2275-2280页

作者： zhi-qiang dong Yan-Fei Jia Zhen-Shan Gao Qiao Li Liang Niu qiang Yang Ya-Wen Pan qiang Li Department of Neurosurgery The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Institute of Neurology The Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Dandy-Walker malformation(DWM)was first reported in *** this case report,a pediatric case was complicated with giant and isolated arachnoid cysts in the right cerebellar hemisphere along with the typical *** SUMMARY The patient was at 20 mo old boy,with the complaint of staggering for more than 2 *** was admitted to the hospital due to high intracranial pressure and *** admission,the patient had typical manifestations of high intracranial pressure,including vomiting,poor appetite and feeding *** examination revealed increased head circumference,closed anterior fontanelle,unstable standing,staggering,leaning right while walking and *** admission,he was diagnosed with DWM accompanied by giant isolated arachnoid cysts in the posterior *** underwent Y-shaped three-way valve repair for treating differential pressure between the supratentorial hydrocephalus and the subtentorial arachnoid cysts at *** child recovered well after the *** In this case,supratentorial and subtentorial shunts were placed,which solved the problem of differential pressure between the supratentorial and subtentorial parts *** provides useful information regarding treatment exploration in this rare disease.

关键词： Arachnoid cyst Cysto-peritoneal shunt Dandy-Walker malformation Ventriculoperitoneal shunt Case report

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Geomechanical risk and mechanism analysis of CO_(2) sequestration in unconventional coal seams and shale gas reservoirs

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2023年第4期2卷 38-55页

作者： Nian-jie Kuang Jun-ping Zhou Xue-fu Xian Cheng-peng Zhang Kang Yang zhi-qiang dong State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China School of Resources and Safety Engineering Chongqing UniversityChongqing400044China

With global greenhouse gas emissions hitting record highs in 2021,CO_(2) geological sequestration(CGS)is the most realistic and feasible technology to ensure large-scale carbon reduction to achieve global carbon capping and carbon neutrality *** coalbed methane and shale gas have the characteristics of self-generation and selfstorage,which is considered to be a valuable target reservoir for geological sequestration of CO_(2).After a high volume of CO_(2) is injected into unconventional coal seams and shale gas reservoirs,many geomechanical issues may be induced,resulting in ***,it is crucial to evaluate the geomechanical risks of CO_(2) geological *** this article,global CO_(2) emissions and geological resources available for sequestration are teased *** effects of coupled CO_(2)-water-rock-driven geomechanical,geophysical,and geochemical interactions on the evolution of rock physical properties and pore characteristics,as well as caprock sealing,are *** caprock failure and its inducing mechanism are analyzed,and the criteria for predicting the occurrence of risk are summarized,which is necessary for pressure management and risk *** serve as a benchmark for CO_(2) sequestration in unconventional coal seams and shale gas reservoirs.

关键词： CO_(2)sequestration Adsorption effect Coupling effect Unconventional reservoir Caprock failure Leakage path

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Severe biliary complications after hepatic artery embolization

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World Journal of Gastroenterology 2002年第1期8卷 119-123页

作者： Xiao-qiang Huang zhi-qiang Huang Wei-dong Duan Nin-Xing Zhou Yu-Quan Feng Department of Hepatobiliary Surgery,General Hospital of PLA,Beijing 100853,China Department of Hepatobiliary Surgery General Hospital of PLA 28 Fuxing Road Beijing 100853China. huangxq@***

AIM: To study the mechanism and treatment of severebiliary complications arising from hepatic artery embolization(HAE).METHODS: Of seven cases of intra- and extrahepatic biliarydamage resulting from hepatic artery embolization reportedsince 1987, 6 suffered from hepatic haemangioma, the othercase was due to injection of TH compound into the hepaticartery during operation. The hepatic artery was injected withethanol so as to evaluate the liver damage in ***: All the cases were found to have destructivedamage of intra- and extrahepatic bile duct at the hilum withbiliary hepetocirrhosis. Experimental results revealednecrosis of the liver parenchyma, especially around theportal tract and obliteration of intrahepatic bile ***: To prevent the severe biliary comlications ofHAE, the use of HAE for hepatic haemangioma which waswidely practiced in China, should be re-evaluated. Hepaticarterial embolization of hepatic haemangioma may result insevere destructive biliary damages and its indiscriminate useshould be prohibited.

关键词：肝动脉栓塞术重症胆损伤并发症肝癌

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Relationships between microhardness, microstructure, and grain orientation in laser-welded joints with different welding speeds for Ti6Al4V titanium alloy

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Transactions of Nonferrous Metals Society of China 2020年第5期30卷 1277-1289页

作者： Zhen-zhen XU zhi-qiang dong Zhao-hui YU Wen-ke WANG Jian-xun ZHANG State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

The microhardness curve trend and its relationships with microstructure and misorientation were analyzed to enhance the comprehension of the microstructure and mechanical property of micro-areas in Ti6 Al4 V laser-welded joints with different welding speeds. The microhardness measured on the fusion line(H_m) is the highest from the weld center to the base metal. H_m increases with increasing weld width in a welded joint and increasing degree of the non-uniformity in all studied welded joints. The microhardness decreases from the weld metal to the base metal with decreasing amount of martensite α’ and increasing amount of original α phase. When the microstructure is mainly composed of martensite α’, the microhardness changes with the cooling rate, grain size of the martensite, and peak values of the fraction of misorientation angle of the martensite in a wide weld metal zone or weld center at different welding speeds, whereas the difference is small in a narrow weld metal zone.

关键词： microhardness microstructure misorientation angle non-uniformity welding speed

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复方板蓝根颗粒APCI-MS指纹图谱及化学成分的LC-APCI-MS^n研究

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质谱学报 2017年第3期38卷 320-327页

作者：闫峻刘舒李伯平刘志强郭冬发核工业北京地质研究院北京100029 中国科学院长春应用化学研究所吉林长春130022

建立了复方板蓝根颗粒提取物的大气压化学电离质谱(APCI-MS)的指纹图谱分析方法,并利用液相色谱-大气压化学电离-串联质谱(LC-APCI-MS^n)技术对主要指纹峰的归属进行确认。结果表明:质谱指纹图谱确定了10批不同来源复方板蓝根颗粒提取物... 详细信息

建立了复方板蓝根颗粒提取物的大气压化学电离质谱(APCI-MS)的指纹图谱分析方法,并利用液相色谱-大气压化学电离-串联质谱(LC-APCI-MS^n)技术对主要指纹峰的归属进行确认。结果表明:质谱指纹图谱确定了10批不同来源复方板蓝根颗粒提取物的10个共有峰,各提取物的指纹图谱相似度均在97%以上。化学成分的LC-APCI-MS^n分析鉴别了复方板蓝根颗粒提取物中吲哚类、奎唑酮类、有机酸类和卟啉类等12个化合物,并确定了5个质谱指纹峰的归属。采用体外实验研究对复方板蓝根颗粒提取物的抗病毒活性进行评价,结果表明,其具有一定的抗病毒活性。该指纹图谱的精密度、稳定性和重现性良好,化学成分分析快捷、灵敏,结合化学成分分析和药效学研究,可为复方板蓝根颗粒质量控制标准的制订奠定基础,同时也为深入研究其药效物质基础和谱效关系提供理论依据。

关键词：复方板蓝根颗粒指纹图谱液相色谱-大气压化学电离-串联质谱法(LC-APCI-MSn) 抗病毒活性

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三种氨基酸在尿素-水混合溶剂中的体积性质

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化学学报 2008年第1期66卷 129-137页

作者：马林许莉林瑞森魏志强刘东群广西大学化学化工学院南宁530004 浙江大学化学系杭州310027

用精密密度法详细测定甘氨酸、L-丙氨酸、L-丝氨酸在尿素-水混合溶剂中的表观摩尔体积.计算了三种氨基酸从水到尿素-水混合溶剂的迁移偏摩尔体积,结合前期的氨基酸从水到尿素-水混合溶剂的迁移焓,探讨尿素-水混合溶剂的结构特点及其对... 详细信息

用精密密度法详细测定甘氨酸、L-丙氨酸、L-丝氨酸在尿素-水混合溶剂中的表观摩尔体积.计算了三种氨基酸从水到尿素-水混合溶剂的迁移偏摩尔体积,结合前期的氨基酸从水到尿素-水混合溶剂的迁移焓,探讨尿素-水混合溶剂的结构特点及其对氨基酸与尿素相互作用的影响.结果表明,尿素分子在水中自缔合,引起溶剂结构的变化并削弱其与氨基酸分子的结构相互作用,造成氨基酸从水到尿素-水混合溶剂的迁移偏摩尔体积和迁移焓随尿素浓度的增加而出现多个变化点,这一效应随着氨基酸疏水性的增强而增大,表明氨基酸的疏水性越强,其与尿素相互作用引起的去水化作用越明显.

关键词：氨基酸尿素偏摩尔体积相互作用

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均质圆形巷道蝶型冲击地压发生机理及其判定准则

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煤炭学报 2016年第11期41卷 2679-2688页

作者：马念杰郭晓菲赵志强赵希栋刘洪涛中国矿业大学(北京)资源与安全工程学院北京100083

从均质圆形巷道围岩塑性破坏区的产生、发展和爆炸式破坏的力学机制入手,揭示了巷道蝶型冲击地压的发生机理:在一定的应力和围岩环境中,由于触发事件的诱导作用,使巷道区域应力场突然发生某种改变,导致围岩蝶形塑性区瞬间出现急剧、跳... 详细信息

从均质圆形巷道围岩塑性破坏区的产生、发展和爆炸式破坏的力学机制入手,揭示了巷道蝶型冲击地压的发生机理:在一定的应力和围岩环境中,由于触发事件的诱导作用,使巷道区域应力场突然发生某种改变,导致围岩蝶形塑性区瞬间出现急剧、跳跃式扩展,并以震动、声响和煤岩体抛出的形式释放存储于体内和围岩系统中的大量弹性能,出现爆炸式破坏的动力现象。巷道蝶型冲击地压理论阐明了冲击地压的发生条件,给出了"蝶型冲击三准则",为巷道冲击地压的预测、预报及其防治提供了新的思路。

关键词：巷道冲击地压蝶形塑性区

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论钟馗形象的演变

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山西大学学报(哲学社会科学版) 2001年第6期24卷 57-61页

作者：郭志强董国炎山西大学文学院山西大学文学院山西太原030006

钟馗形象是横跨正统文化和民间文化、连接古代和近代社会文化心理的重要的文学形象，它的最终形成经历了从神化的人到人化的神两大阶段。钟馗形象的演变过程具有极其丰富的文化意蕴和文学价值，对于中国古代文学中的神魔形象的发展形成... 详细信息

钟馗形象是横跨正统文化和民间文化、连接古代和近代社会文化心理的重要的文学形象，它的最终形成经历了从神化的人到人化的神两大阶段。钟馗形象的演变过程具有极其丰富的文化意蕴和文学价值，对于中国古代文学中的神魔形象的发展形成过程和中华文化中的社会文化心理、文化内涵、文艺审美的演变过程的研究有着重要的意义。

关键词：钟馗文学形象文化意义

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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