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Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation

World Journal of Clinical Cases 2024年第17期12卷 2995-3003页

作者： Mei-Chen Ji zhi-Jia Li Ke Li Yun-Xiao Wang Bo Yang Lin-Lin Lv Ying Su zhi-Wei Zhang Zhong-Chao Huo Qing Qi Yong-Chang Lu zhi-qiang cui Yan-Bao Liu Oncology Center The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina General Surgery Department Handan First HospitalHandan 056002Hebei ProvinceChina Department of Breast Surgery The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina School of Clinical Medicine Hebei University of EngineeringHandan 056002Hebei ProvinceChina

BACKGROUND Radiation esophagitis(RE)is one of the most common clinical symptoms of regional lymph node radiotherapy for breast ***,there are fewer studies focusing on RE caused by hypofractionated radiotherapy(HFRT).AIM To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph *** Between January and December 2022,we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/*** Of the 64 patients in this study,24(37.5%)did not develop RE,29(45.3%)developed grade 1 RE(G1RE),11(17.2%)developed grade 2 RE(G2RE),and none developed grade 3 RE or *** univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose,mean dose,relative volume 20-40,and absolute volume(AV)*** stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE(P<0.001).The optimal threshold for AV30 was 2.39 mL[area under the curve(AUC):0.996;sensitivity:90.9%;specificity:91.1%].The optimal threshold for AV35 was 0.71 mL(AUC:0.932;sensitivity:90.9%;specificity:83.9%).CONCLUSION AV30 and AV35 were significantly associated with *** thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL,respectively.

关键词： Breast cancer Dosimetric parameters Radiation esophagitis Esophagitis Hypofractionated radiotherapy

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Phase I clinical trial of intracerebral injection of lentiviral-ABCD1 for the treatment of cerebral adrenoleukodystrophy

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Science Bulletin 2024年第16期69卷 2596-2603页

作者： Qiu-Hong Wang Jing Wanga zhi-Pei Ling zhi-qiang cui Jie Gong Rui Zhang Shi-Jun Li Yang-Yang Wang Rui Yang De-Hui Huang Wen He Jing Gao Chen Feng Pei-Li Hu Li-Ying Liu Lung-Ji Chang Li-Ping Zou Senior Department of Pediatrics Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Department of Neurosurgery Hainan Hospital of PLA General HospitalSanya 572013China Department of Neurosurgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China Chengdu Women’s and Children’s Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Meikang Biotechnology Co. LTD.Beijing 100085China Department of Radiology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pediatrics Xuanwu HospitalCapital Medical UniversityBeijing 100053China Shenzhen Geno-Immune Medical Institute Shenzhen 518057China Beijing Institute for Brain Disorders Center for Brain Disorders Research Capital Medical UniversityBeijing 100069China

This was a single-arm,multicenter,open-label phase I *** vectors(LV)carrying the ABCD1 gene(LV-ABCD1)was directly injected into the brain of patients with childhood cerebral adrenoleukodystrophy(CCALD),and multi-site injection was *** injection dose increased from 200 to 1600 lL(vector titer:1×10^(9) transduction units per mL(TU/mL)),and the average dose per kilogram body weight ranges from 8 to 63.6 lL/*** primary endpoint was safety,dose-exploration and immunogenicity and the secondary endpoint was initial evaluation of efficacy and the expression of ABCD1 protein.A total of 7 patients participated in this phase I study and were followed for 1 *** injectionrelated serious adverse event or death *** adverse events associated with the injection were irritability(71%,5/7)and fever(37.2-38.5℃,57%,4/7).Adverse events were mild and selflimited,or resolved within 3 d of symptomatic *** maximal tolerable dose is 1600 *** 5 cases(83.3%,5/6),no lentivirus associated antibodies were *** overall survival at 1-year was 100%.The ABCD1 protein expression was detected in neutrophils,monocytes and *** study suggests that the intracerebral injection of LV-ABCD1 for CCALD is safe and can achieve successful LV transduction in vivo;even the maximal dose did not increase the risk of adverse ***,the direct LV-ABCD1 injection displayed low *** addition,the effectiveness of intracerebral LV-ABCD1 injection has been preliminarily demonstrated while further investigation is *** study has been registered in the Chinese Clinical Trial Registry(https://***/,registration number:ChiCTR1900026649).

关键词： Adrenoleukodystrophy Lentiviral vectors ABCD1 Intracerebral injection

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Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation

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Neural Regeneration Research 2018年第12期13卷 2164-2172页

作者： zhi-Qi Mao Xin Wang Xin Xu zhi-qiang cui Long-Sheng Pan Xiao-Jing Ning Bai-Xuan Xu Lin Ma zhi-Pei Ling Jian-Jun Jia Xin-Guang Yu Department of Neurosurgery Chinese PLA General Hospital School of Medicine Nankai University Department of Nuclear Medicine Chinese PLA General Hospital Department of Radiology Chinese PLA General Hospital Department of Neurology Chinese PLA General Hospital

Deep brain stimulation is a therapy for Alzheimer＇s disease（AD） that has previously been used for mainly mild to moderate cases. This study provides the first evidence of early alterations in performance induced by stimulation targeted at the fornix in severe AD patients. The performance of the five cases enrolled in this study was scored with specialized assessments including the Mini-Mental State Examination and Clinical Dementia Rating, both before and at an early stage after deep brain stimulation. The burden of caregivers was also evaluated using the Zarit Caregiver Burden Interview. As a whole, the cognitive performance of patients remained stable or improved to varying degrees, and caregiver burden was decreased. Individually, an improved mental state or social performance was observed in three patients, and one of these three patients showed remarkable improvement in long-term memory. The conditions of another patient deteriorated because of inappropriate antipsychotic medications that were administered by his caregivers. Taken together, deep brain stimulation was capable of improving some cognitive aspects in patients with severe AD, and of ameliorating their emotional and social performance, at least at an early stage. However, long-term effects induced by deep brain stimulation in patients with severe AD need to be further validated. More research should focus on clarifying the mechanism of deep brain stimulation. This study was registered with ***（NCT03115814） on April 14, 2017.

关键词： Alzheimer's disease deep brain stimulation fornix cognition memory mood performance early stage functional neurosurgery dementia

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TMEM16F may be a new therapeutic target for Alzheimer's disease

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Neural Regeneration Research 2023年第3期18卷 643-651页

作者： zhi-qiang cui Xiao-Ying Hu Tuo Yang Jing-Wei Guan Ying Gu Hui-Yuan Li Hui-Yu Zhang Qing-Huan Xiao Xiao-Hong Sun Department of Neurology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Ion Channel Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoning ProvinceChina

TMEM16F is involved in many physiological processes such as blood coagulation,cell membrane fusion and bone *** of TMEM16F has been studied in various central nervous system *** TMEM16F level has been also found to participate in microglial phagocytosis and ***-mediated neuroinflammation is a key factor in promoting the progression of Alzheimer’s ***,few studies have examined the effects of TMEM16F on neuroinflammation in Alzheimer’s *** this study,we established TMEM16F-knockdown AD model in vitro and in vivo to investigate the underlying regulatory mechanism about TMEM16F-mediated neuroinflammation in *** performed a Morris water maze test to evaluate the spatial memory ability of animals and detected markers for the microglia M1/M2 phenotype and NLRP3 *** results showed that TMEM16F was elevated in 9-month-old APP/PS1 *** TMEM16F knockdown in mice,spatial memory ability was improved,microglia polarization to the M2 phenotype was promoted,NLRP3 inflammasome activation was inhibited,cell apoptosis and Aβplaque deposition in brain tissue were reduced,and brain injury was *** used amyloid-beta(Aβ_(25-35))to stimulate human microglia to construct microglia models of Alzheimer’s *** levels of TMEM16F,inducible nitric oxide synthase(iNOS),proinflammatory cytokines and NLRP3 inflammasome-associated biomarkers were higher in Aβ_(25-35) treated group compared with that in the control ***16F knockdown enhanced the expression of the M2 phenotype biomarkers Arg1 and Socs3,reduced the release of proinflammatory factors interleukin-1,interleukin-6 and tumor necrosis factor-α,and inhibited NLRP3 inflammasome activation through reducing downstream proinflammatory factors interleukin-1βand *** inhibitory effect of TMEM16F knockdown on M1 microglia was partially reversed by the NLRP3 agonist *** findings suggest that TMEM16F participates i

关键词： Alzheimer’s disease Aβplaque inflammatory cytokines M1 phenotype M2 phenotype microglia polarization neuroinflammation NLRP3 inflammasome siRNA TMEM16F

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Correlation of serum inflammatory cytokine and immunoglobulin content with post-herpetic neuralgia in patients with acute herpes zoster

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Journal of Hainan Medical University 2017年第1期23卷 97-100页

作者： Hai-Jun Shi zhi-qiang cui Pain Department the First People’s Hospital of Akesu Prefecture XinjiangAkesu 843000China

Objective:To study the correlation of serum inflammatory cytokine and immunoglobulin content with post-herpetic neuralgia in patients with acute herpes ***:Patients diagnosed with herpes zoster in our hospital between May 2012 and October 2015 were selected and divided into herpes zoster-post-herpetic neuralgia group (VZV-PHN group) and herpes zoster-control group (VZV-Con group) according to the incidence of post-herpetic neuralgia (PHN);healthy volunteers receiving physical examination in our hospital during the same period were selected as normal control group (Con group).Results: Serumβ-EP, NT, IFN-γ and IL-2 levels of VZV-PHN group and VZV-Con group were significantly lower than those of Con group (P<0.05), while SP, VGF, CGRP, IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10, TGF-β1, IgG, IgM and IgA levels were significantly higher than those of Con group (P<0.05);serumβ-EP, NT, IFN-γ, IL-2, IgG, IgM and IgA levels of VZV-PHN group were significantly lower than those of VZV-Con group (P<0.05) while SP, VGF, CGRP, IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β1 levels were significantly higher than those of VZV-Con group (P<0.05);β-EP and NT were positively correlated with IFN-γ, IL-2, IgG, IgM and IgA, and negatively correlated with IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β1;SP, VGF and CGRP were negatively correlated with IFN-γ, IL-2, IgG, IgM and IgA, and positively correlated with IL-4, IL-6, IL-17, IL-21, TNF-α, IL-10 and TGF-β***:Abnormal secretion of inflammatory cytokines and immunoglobulin caused by humoral immune and cellular immune response disorder is associated with the occurrence of post-herpetic neuralgia in patients with acute herpes zoster.

关键词： Varicella-zoster virus Post-herpetic neuralgia Humoral immunity Cellular immunity

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Control Method for Power Quality Compensation Based on Levenberg-Marquardt Optimized BP Neural Networks

Control Method for Power Quality Compensation Based on Leven...

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CES/IEEE 5th International Power Electronics and Motion Control Conference

作者： ZHOU MING WAN JIAN-RU WEI zhi-qiang AND cui JIAN Tianjin University/Electrical Engineering & Automation Tianjin China Electrical Engineering & Automation Tianjin University TJU Tianjin China

ISBN: (纸本)1424404487;9781424404483

＜正＞Unified Power Quality Conditioner （UPQC） has the function of improving voltage supply, compensating load reactive power, suppressing harmonic current and increasing power factor;however, tradition control method has a certain extent limitation for such multiple input, multiple output, close coupling nonlinear issue. Artificial Neural Networks （ANN） can deal with data for multiple objective learning in parallel continuous way, the control of complex object is achieved through interactions between nerve cells. Levenberg-Marquardt algorithm optimized back propagation neural network has the characteristic of efficient learning and faster convergence;ANN outputs control signals for voltage and current compensation to UPQC through weights training. Simulation model is built in Matlab, load which is three phase unbalanced and has badly distorted current is simulated under the case of voltage sag. Simulation experiment indicates its compensation effectiveness is much more satisfying than traditional control method.

关键词： UPQC neural network harmonics compensation voltage sag

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Reduction of dinitrogen to ammonia on doped three-atom clusters Nb_(2)M(M=Sc to Cu & Y to Ag)

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Rare Metals 2024年第8期43卷 3810-3818页

作者： Ran Cheng Chao-Nan cui zhi-Xun Luo Beijing National Laboratory for Molecular Science(BNLMS) State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China

Catalytic reduction of dinitrogen to ammonia under mild conditions remains an attractive topic for the purpose of lowering energy ***-atom metal clusters have been proved an ideal model to explore highly efficient catalysts taking advantage of unique geometric/electronic structures and cooperative active *** a study of N2 activation and reduction on seventeen bimetallic Nb_2M(M=Sc to Cu,and Y to Ag) clusters was *** key processes for ammonia fixation(namely nitrogen activation,hydrogenation,and ammonia desorption) are fully studied,and three preferred systems(Nb_2Ni,Nb_2Rh and Nb_2Pd) are highlighted with outstanding catalytic *** d-σ and d-π~* orbital hybridizations between these metal clusters and N_(2) were demonstrated and the internal association with the N≡N bond activation was *** examining the ammonia synthesis on four chosen Nb_(2)M clusters(M=Fe,Ni,Rh and Pd),it can be elucidated that the distal pathway is more favorable than the alternative pathway in these *** work not only clarifies the N_(2) reduction on the bimetallic Nb_(2)M clusters,but also guides efficient bimetallic catalyst design.

关键词： Three-atom cluster catalysis Three-criteria strategy Nitrogen fixation Ammonia synthesis Theoretical calculations

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Optical system for extremely large spectroscopic survey telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 158-174页

作者： Ding-qiang Su Hua Bai Xiangyan Yuan Xiangqun cui Key Laboratory of the Ministry of Education School of Astronomy and Space ScienceNanjing UniversityNanjing 210023China Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Nanjing 211135China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

This article presents research work on a spectroscopic survey *** idea is as follows:for such a telescope,a pure reflecting optical system is designed,which should have an aperture and a field of view(FOV)both as large as possible and excellent image quality,and then a strip lensm(lens-prism)atmospheric dispersion corrector(S-ADC)is added,only for correcting the atmospheric *** the fund limitation and the simplicity of scaling up,some 12-m telescopes are designed as ***,Korsch,and Meinel put forward the four-mirror Nasmyth systems I and II,which are used in this *** of 1.5°,2°,and 2.5°are *** all systems,the image qualities are *** the S-ADC relaxes the optical glass size restriction,this 12-m telescope with a FOV of 2.5°can be magnified in proportion to a 16-m *** etendue(from Frenchétendue)and focal surface will now be the largest in the *** such a telescope,a pure reflecting optical system can also be obtained.A subsequent coudésystem is designed with excellent image quality.

关键词： telescopes spectroscopic survey

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Treatment of Epilepsy with Bipolar Electro-coagulation： An Analysis of Cortical Blood Flow and Histological Change in Temporal Lobe

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Chinese Medical Journal 2015年第2期128卷 210-215页

作者： zhi-qiang cui Guo-Ming Luan Jian Zhou Feng Zhai Yu-Guang Guan Min Bao Department of Neurosurgery Sanbo Brain Hospital Capital Medical University Beijing 100093 China Department of Neurosurgery Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Postgraduate Medical School Beijing 100853 China

Background：Bipolar electro-coagulation has a reported efficacy in treating epilepsy involving functional cortex by pure electro-coagulation or combination with ***,the mechanisms of bipolar electro-coagulation are not completely *** studied the acute cortical blood flow and histological changes after bipolar electro-coagulation in 24 patients with intractable temporal lobe ***：Twenty-four patients were consecutively enrolled,and divided into three groups according to the date of *** regional cortical blood flow （rCBF）,electrocorticography,the depth of cortex damage,and acute histological changes （H and E staining,neuronal staining and neurofilament （NF） staining） were analyzed before and after the *** t-test analysis was used to compare the rCBF before and after the ***：The rCBF after coagulation was significantly reduced （P 〈 0.05）.The spikes were significantly reduced after *** the temporal cortex,the depth of cortical damage with output power of 2-9 W after electro-coagulation was 0.34 ± 0.03,0.48 ± 0.06,0.69 ± 0.06,0.84 ± 0.09,0.98 ± 0.08,1.10 ± 0.1 l,1.11 ± 0.09,and 1.22 ± 0.11 mm,*** with output power of 4-5 W completely damaged the neurons and NF protein in the molecular layer,external granular layer,and external pyramidal ***：The electro-coagulation not only destroyed the neurons and NF protein,but also reduced the *** concluded that the injuries caused by electro-coagulation would prevent horizontal synchronization and spread of epileptic discharges,and partially destroy the epileptic focus.

关键词： Acute Histological Change Bipolar Electro-coagulation Electrocorticography Regional Cortical Blood Flow Temporal Lobe Epilepsy

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A comprehensive review on microchannel heat sinks for electronics cooling

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International Journal of Extreme Manufacturing 2024年第2期6卷 133-162页

作者： zhi-qiang Yu Mo-Tong Li Bing-Yang Cao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

The heat generation of electronic devices is increasing dramatically,which causes a serious bottleneck in the thermal management of electronics,and overheating will result in performance deterioration and even device *** the development of micro-machining technologies,the microchannel heat sink(MCHS)has become one of the best ways to remove the considerable amount of heat generated by high-power *** has the advantages of large specific surface area,small size,coolant saving and high heat transfer *** paper comprehensively takes an overview of the research progress in MCHSs and generalizes the hotspots and bottlenecks of this *** heat transfer mechanisms and performances of different channel structures,coolants,channel materials and some other influencing factors are ***,this paper classifies the heat transfer enhancement technology and reviews the related studies on both the single-phase and phase-change flow and heat *** comprehensive review is expected to provide a theoretical reference and technical guidance for further research and application of MCHSs in the future.

关键词： microchannel heat sink thermal management of electronics microscale heat transfer heat transfer enhancement

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