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Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish

Zoological Research 2024年第4期45卷 791-804页

作者： Wen-Hao li zhi-qiang li Meng-Di Bu Jia-Zhen li liang-Biao Chen Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266237China International Research Center for Marine Biosciences Ministry of Science and TechnologyCollege of Fisheries and Life SciencesShanghai Ocean UniversityShanghai 201306China

As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish(Danio rerio) ovaries exposed to a temperature gradient ranging from the thermopreferendum temperature of the species,27℃, to lower temperatures of 22℃, 20℃, and 13℃ over a period of two weeks. Comparative metabolomic(six biological replicates for each temperature) and transcriptomic(four biological replicates for each temperature) analyses were conducted under the four temperature conditions. Results indicated that lower temperatures inhibited oocyte development and differential metabolites were involved in steroid hormone production,antioxidant function, and lipid and protein *** reproductive hormones, increased proteolysis,and lipid degradation significantly impeded oocyte development and egg maturation. Notably, a significant increase in bile acid content was noted in the ovaries of the cold-treated fish, indicating that bile acids play a critical role in ovarian failure. Overall, these findings provide valuable insights into the mechanisms governing the reproductive response of fish to cold stress.

关键词： old stress Ovarian failure Metabolome Zebrafish

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Riemann-Hilbert Approach to the Fifth-order Nonlinear Schr?dinger Equation with Non-vanishing Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2024年

作者： Jin-jie YANG Shou-fu TIAN zhi-qiang li School of Mathematics China University of Mining and Technology

The Cauchy problem of the fifth-order nonlinear Schr?dinger (foNLS) equation is investigated with nonzero boundary conditions in detailed. Firstly, the spectral analysis of the scattering problem is carried out.A Riemann surface and affine parameters are introduced to transform the original spectral parameter to a new spectral parameter in order to avoid the multi-valued problem. Based on Lax pair of the foNLS equation, the Jost functions are obtained, and their analytical, asymptotic, symmetric properties, as well as the corresponding properties of the scattering matrix are established systematically. For the inverse scattering problem, we discuss the cases that the scattering coefficients have simple zeros and double zeros, respectively, and we further derive their corresponding exact solutions via solving a suitable Riemann-Hilbert problem. Moreover, some interesting phenomena are found when we choose some appropriate parameters for these exact solutions, which are helpful to study the propagation behavior of these solutions.

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Research trends of clinical studies on acupuncture protocols over the past 20 years:a bibliometric analysis

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Integrative Medicine Discovery 2024年第28期8卷 1-14页

作者： zhi-qiang li Xue-Feng Wang Heng Yin Feng Cao Yu-Tong Fei Jian-Ping liu Centre for Evidence-based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China The National Research Center in Complementary and Alternative Medicine Department of Community MedicineFaculty of Health ScienceUiT the Arctic University of NorwayTromsøN-9037Norway.

Background:Acupuncture protocols are essential as they guide study design and improve the quality of clinical trial,thus preventing avoid research *** the increasing number of publications on acupuncture protocols,this study aimed to assess the publications trends of acupuncture protocols over the past two decades and provided an overview for future research ***:Publications focusing on acupuncture protocols in clinical settings were retrieved and compiled from the Web of Science Core Collection spanning the period from 2004 to *** and Microsoft Excel software were used to analyze the relationship of publication with countries,institutions,authors,co-cited author,journals,references,keywords and other literature ***:This study analyzed 721 articles encompassing acupuncture protocols.A continuous yet fluctuating growth in publications volume were observed from 2004 to ***,China stands at the forefront in contributing to acupuncture protocols,publishing 513 papers and demonstrating a high centrality score of 1.07 in cooperative ***,China has fostered close collaborations with the USA and South *** University of Chinese Medicine(89),zhishun liu(36)and Trials(306)emerged as the top contributors in terms of institution,author,and journal,***,inter-institutional and author collaboration was relatively *** H was the most frequently cited ***-frequency keywords included“randomized controlled trials”,“acupuncture”,“management”,“study protocol”,“quality of life”.Analysis of timeline diagram of keywords indicated that“functional dyspepsia”,“stroke”,“electroacupuncture”,and“colorectal cancer”were the research development trends and ***:Clinical acupuncture protocols have experienced robust development over the past two decades,with current research hotspots focusing on disease management and quality of life,which remain key research ***

关键词： acupuncture protocol bibliometric hotspots CiteSpace

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Mixtures of Semiparametric Varying Coefficient Models for Longitudinal Data with Nonignorable Dropout

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Acta Mathematicae Applicatae Sinica 2010年第1期26卷 125-132页

作者： zhi-qiang li liu-gen Xue College of Sciences Beijing University of Chemical Technology Beijing 100029 China College of Applied Sciences Beijing University of Technology Beijing 100022 China

Informative dropout often arise in longitudinal data. In this paper we propose a mixture model in which the responses follow a semiparametric varying coefficient random effects model and some of the regression coefficients depend on the dropout time in a non-parametric way. The local linear version of the profile-kernel method is used to estimate the parameters of the model. The proposed estimators are shown to be consistent and asymptotically normal, and the finite performance of the estimators is evaluated by numerical simulation.

关键词： Nonignorable dropout, Estimating equation, Profile-kernel, Local linear estimation, Longitudinal data Semiparametric varying coefficient

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Glioma-conditioned Medium Blocks Endothelial Cells' Apoptosis Induced by Hypoxia and Promotes Its Angiogenesis via Up-regulation of u-PA/u-PAR

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Chinese Journal of Cancer Research 2010年第2期22卷 119-125页

作者： Xi-zhen Xu zhi-qiang li zhi-hua Wen Department of Neurosurgery Zhongnan Hospital Wuhan University Wuhan 430071 China Laboratory of Neuro-oncology Zhongnan Hospital Wuhan University Wuhan 430071 China

Objective： To investigate the role of urokinase-type plasminogen activator/urokinase-type plasminogen receptor（u-PA/u-PAR） system in glioma angiogenesis under hypoxic conditions, we studied the effect of glioma-conditioned medium on the hypoxia induced changes in human endothelial-like ECV304 cells proliferation, apoptosis, cord formation in vitro and u-PA/u-PAR expression. Methods： MTT assay was used to examine the changes in cell proliferation. Cell apoptosis was analyzed by Hoechst 33258 staining. Matrigel cord-like formation assay was used to evaluate the angiogenesis ability of ECV304 cells in vitro. Expressions of u-PA/u-PAR mRNA were detected by quantitative real-time RT-PCR. Results： Hypoxia inhibited ECV304 cells proliferation and induced cell apoptosis. Hypoxic conditioned medium（H-CM） while not normoxic conditioned medium（N-CM） of U251 glioma ceils partially blocked the effect of hypoxia on ECV304 cells proliferation and apoptosis. H-CM of U251 glioma ceils also promoted the cord formation of ECV304 cells seeded on matrigel. When u-PA or u-PAR monoclonal antibodies were added into ECV304 cells culturing medium, cord formation ability was partially inhibited. H-CM of U251 glioma cells induced uPA and uPAR expression in ECV304 cells. Conclusion： These suggest that u-PA/u-PAR system is involved in glioma angiogenesis trigged by hypoxic microenviroment.

关键词： Endothelia Glioma Hypoxia u-PA u-PAR

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Sub-additive Unstable Topological Pressure of Diffeomorphisms

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Acta Mathematica Sinica,English Series 2022年第12期38卷 2285-2298页

作者： Wen Da ZHANG zhi qiang li Yun Hua ZHOU College of Mathematics and Statistics Chongqing Jiaotong UniversityChongqing 400074P.R.China College of Mathematics and Statistics Chongqing UniversityChongqing 401331P.R.China

In this paper,we study unstable topological pressure for C^(1)-smooth partially hyperbolic diffeomorphisms with sub-additive ***,without any additional assumption,we have established the expected variational principle which connects this unstable topological pressure and the unstable measure theoretic entropy,as well as the corresponding Lyapunov exponent.

关键词： Partially hyperbolic systems unstable topological pressure sub-additive potentials

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Co single atoms and nanoparticles dispersed on N-doped carbon nanotube as high-performance catalysts for Zn-air batteries

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Rare Metals 2022年第6期41卷 2055-2062页

作者： Jing-Jing Chen Shuai Gu Rui Hao Zhen-Yu Wang Mu-Qing li zhi-qiang li Kun liu Ke-Meng liao zhi-qiang Wang He Huang Ying-zhi li Kai-li Zhang Zhou-Guang Lu Department of Materials Science and Engineering Guangdong Provincial Key Laboratory of Energy Materials for Electric PowerShenzhen Key Laboratory of Interfacial Science and Engineering of MaterialsSouthern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China

Diminishing the size of active sites in catalysts is promis-ing to improve the kinetics of oxygen reduction reaction(ORR)and reduce the cost of metal-air ***,the facile preparation of high-performance catalysts with nanoscale active sites still suffers from great ***,we report a facile template-free strategy to fabri-cate Co single atoms and nanoparticles dispersed on porous N-doped carbon nanotube(Co-NCNT)by the pyrolysis of the composites of metal-organic complexes and porous carbon *** from the conventional strategy,the precursor metal-organic complexes in this work were prepared under mild conditions and used without complex purification *** with the pristine carbon nanotube,N-doped carbon nanotube with abundant meso-pores contribute to the formation of nanoscale Co sites.

关键词： nanoparticles composites carbon

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Performance evaluation of the backprojection filtered (BPF) algorithm in circular fan-beam and cone-beam CT

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Nuclear Science and Techniques 2006年第2期17卷 113-117页

作者： li liang CHEN zhi-qiang ZHANG li KANG Ke-Jun Department of Engineering Physics Tsinghua University Beijing 100084 China

In this article we introduce an exact backprojection filtered (BPF) type reconstruction algorithm for cone-beam scans based on Zou and Pan’s work. The algorithm can reconstruct images using only the projection data passing through the parallel PI-line segments in reduced scans. Computer simulations and practical experiments are carried out to evaluate this algorithm. The BPF algorithm has a higher computational efficiency than the famous FDK algorithm. The BPF algorithm is evaluated using the practical CT projection data on a 450 keV X-ray CT system with a flat-panel detector (FPD). From the practical experiments, we get the spatial resolution of this CT system. The algo- rithm could achieve the spatial resolution of 2.4 lp/mm and satisfies the practical applications in industrial CT inspec- tion.

关键词：反向发射滤波器算法 BPF Hilbert转换算法理论

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liver resection for benign hepatic lesions:A retrospective analysis of 827 consecutive cases

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World Journal of Gastroenterology 2008年第47期14卷 7247-7251页

作者： zhi-qiang Feng zhi-qiang Huang li-Ning Xu Rong liu Ai-Qun Zhang xiao-qiang Huang Wen-zhi Zhang Jia-Hong Dong Department of Hepatobiliary Surgery GeneralHospital ofPLA Beijing 100853 China

AIM:To analyze the operative and perioperative factors associated with hepatectomy of benign hepatic ***:A total of 827 condecutive cases of benign hepatic lesion undergoing hepatectomy from January 1986 to December 2005 in the Chinese PLA General Hospital were investigated retrospectively according to their medical ***:The effect of operative and perioperative factors on the outcome of patients were *** the 827 cases undergoing hepatectomy for more than 3 liver segments accounted for 22.1%,316(38.21%) required transfusion of blood products during *** average operating time was 220.59 ± 109.13 min,the average hospital stay after operation was 13.55 ± 9.38 ***-Pugh A accounted for 98.13%.The postoperative complication rate was 13.54% and the in-hospital mortality rate was 0.24%.Multivariate analysis showed that operating time(P = 0.004,OR = 1.003) and albumin value(P = 0.040,OR = 0.938) were the independent predictors of morbidity and indicated that operating time,blood transfusion,complication rate,and LOS had a trend to ***:Hepatectomy for benign hepatic lesions can be performed safely with a low morbidity and mortality,provided that it is carried out with optimized perioperative management and an innovative surgical technique.

关键词： Hepatectomy Benign hepatic lesion Perioperative

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Numerical simulation of high-resolution azimuthal resistivity laterolog response in fractured reservoirs

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Petroleum Science 2015年第2期12卷 252-263页

作者： Shao-Gui Deng li li zhi-qiang li Xu-Quan He Yi-Ren Fan School of Geosciences China University of Petroleum China Research Institute of Radiowave Propagation China Petroleum Southwest Oil and Gas Field Branch

The high-resolution azimuthal resistivity laterolog response in a fractured formation was numerically simulated using a three-dimensional finite element method. Simulation results show that the azimuthal resistivity is determined by fracture dipping as well as dipping direction, while the amplitude differences between deep and shallow laterolog resistivities are mainly controlled by the former. A linear relationship exists between the corrected apparent conductivities and fracture aperture. With the same fracture aperture, the deep and shallow laterolog resistivities present small values with negative separations for low-angle fractures, while azimuthal resistivities have large variations with positive separations for high-angle fractures that intersect the borehole. For dipping fractures, the variation of the azimuthal resistivity becomes larger when the fracture aperture increases. In addition, for high-angle fractures far from the borehole, a negative separation between the deep and shallow resistivities exists when fracture aperture is large as well as high resistivity contrast exists between bedrock and fracture fluid. The decreasing amplitude of dual laterolog resistivity can indicate the aperture of low-angle fractures, and the variation of the deep azimuthal resistivity can give information of the aperture of high-angle fractures and their position relative to the borehole.

关键词： High-resolution azimuthal resistivitylaterolog Fractured reservoir Fracture dipping angleFracture aperture. Fracture dipping direction

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