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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-ming Xu Wei wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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重型肝炎患者血清肝纤维化指标及甲胎蛋白水平的动态变化及其与预后的关系

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世界华人消化杂志 2008年第21期16卷 2408-2411页

作者：时红波陈煜韩大康赵军武志明段钟平北京市卫生局肝炎研究所北京市100069 首都医科大学附属北京佑安医院人工肝中心北京市100069

目的:初步探讨重型肝炎患者血清肝纤维化指标及甲胎蛋白(AFP)水平的动态变化及其与预后的关系.方法:在比较89例病毒性肝炎患者血清肝纤维化指标及AFP水平的基础上,着重研究其中39例重型肝炎患者血清肝纤维化指标及AFP水平在不同时期的... 详细信息

目的:初步探讨重型肝炎患者血清肝纤维化指标及甲胎蛋白(AFP)水平的动态变化及其与预后的关系.方法:在比较89例病毒性肝炎患者血清肝纤维化指标及AFP水平的基础上,着重研究其中39例重型肝炎患者血清肝纤维化指标及AFP水平在不同时期的动态变化规律.结果:重型肝炎患者血清透明质酸(HA)、Ⅲ型胶原氨基末端肽(PⅢP)和AFP水平高于慢性肝炎患者及正常人(3273.19±2060.83vs127.63±110.63,35.50±18.59;2.13±1.20vs1.18±0.43,0.80±0.18;130.98±244.51vs20.40±12.68,7.50±1.23,均P<0.05),重型肝炎患者血清LN水平仅高于正常人(148.95±54.47vs120.70±18.35,P<0.05);HA、PⅢP和LN在生存组总体呈现下降趋势,死亡组呈现上升趋势,AFP水平在生存组呈现先升后降趋势,在死亡组急剧下降;血清HA、PⅢP、LN和AFP水平在亚急性组低于慢性组;重型肝炎患者HA与PTA、ALB、TBIL有较好的相关性(r=-0.372,-0.395,0.344,均P<0.05).结论:动态监测血清HA、PⅢP、LN和AFP水平对重型肝炎患者的预后判断有一定意义.

关键词：重型肝炎肝纤维化指标甲胎蛋白动态变化

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing wu Wei wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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建昌帮和中国药典法炮制的山药中多糖含量比较

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安徽农业科学 2018年第22期46卷 159-161页

作者：郑燕枝谢明吴火生福建生物工程职业技术学院福建福州350002

[目的]比较建昌帮和中国药典法炮制的山药中多糖含量。[方法]采用超声法提取山药多糖,以料液比、提取时间、提取温度为因素,通过正交试验,得出提取山药多糖的最优条件,采用苯酚-硫酸法测定山药水提液中多糖含量。[结果]山药多糖提取的... 详细信息

[目的]比较建昌帮和中国药典法炮制的山药中多糖含量。[方法]采用超声法提取山药多糖,以料液比、提取时间、提取温度为因素,通过正交试验,得出提取山药多糖的最优条件,采用苯酚-硫酸法测定山药水提液中多糖含量。[结果]山药多糖提取的最佳工艺为料液比1∶30、提取时间1 h、提取温度60℃。多糖含量从大到小依次为建昌帮法、中国药典法、生品。[结论]建昌帮法炮制的山药多糖高于中国药典法,为建昌帮炮制法提供试验依据。

关键词：山药多糖含量建昌帮法中国药典法

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Optimal distributed resource allocation in a wireless sensor network for control systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 106-112页

作者： MAO Jian-lin wu zhi-ming Department of Automation Shanghai Jiao Tong University Shanghai 200240 China School of Information Engineering and Automation Kunming University of Science and Technology Kunming 650093 China

Wireless technology is applied increasingly in networked control systems. A new form of wireless network called wireless sensor network can bring control systems some advantages, such as flexibility and feasibility of network deployment at low costs, while it also raises some new challenges. First, the communication resources shared by all the control loops are limited. Second, the wireless and multi-hop character of sensor network makes the resources scheduling more difficult. Thus, how to effectively allocate the limited communication resources for those control loops is an important problem. In this paper, this problem is formulated as an optimal sampling frequency assignment problem, where the objective function is to maximize the utility of control systems, subject to channel capacity constraints. Then an iterative distributed algorithm based on local buffer information is proposed. Finally, the simulation results show that the proposed algorithm can effectively allocate the limited communication resource in a distributed way. It can achieve the optimal quality of the control system and adapt to the network load changes.

关键词： Wireless sensor networks (WSN) Distributed resource allocation Control systems Optimization.

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Effect of Stokes number on energy modulation of the fluid in turbulent particle-laden channel flows

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Journal of Hydrodynamics 2022年第3期34卷 510-521页

作者： zhi-feng wu Jian-zhao wu Bo-fu Wang zhi-ming Lu Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai200072China

The effect of Stokes number on the kinetic energy(KE)budget in particle-laden turbulent channel flows is examined by conducting two-way coupled direct numerical simulations using the Eulerian-Lagrangian *** friction Reynolds number of the single phase channel flow is Re_(τ)=180,the particle mass loading and volume fraction areφ_(m)=0.2,φ_(v)≈10−4,and the Stokes numbers range from St^(+)=14–*** statistics show that due to the presence of solid particles,the mean velocity is reduced in the vicinity of the wall but enhanced in the outer region,and the off-streamwise intensity of fluctuated velocity and the Reynolds stress are reduced in the whole *** analysis on the budgets of turbulent kinetic energy(TKE)finds that the presence of particles induces a significant reduction on both the production and dissipation *** increasing Stokes number St^(+),both the production and dissipation rates exhibit non-monotonical trends,i.e.,both initially decrease for St^(+)*** suggests that the particle-induced suppression on TKE production and dissipation is the strongest nearly at St^(+)=*** is also found that particles act as an additional sink/source term in the budgets of both mean-flow kinetic energy(MKE)and *** addition,we investigate the influence of St^(+)on the“zero point”which indicates the balance of exchanging energy between the particle and fluid *** is shown that with increasing St^(+),the“zero point”moves toward the wall,suggesting that the position of perfect following between particle and fluid is closer to the wall with larger St^(+).The present results reveal the Stokes number effects on the spatial transport mechanisms of MKE,TKE in turbulent channel flows laden with inertial particles.

关键词： Particle-laden flows two-way coupling Stokes numbers kinetic energy budgets

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新型维甲酸对乳腺癌细胞周期蛋白D1、E表达的影响

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复旦学报（医学版） 2001年第4期28卷 284-286页

作者：陆劲松邵志敏吴炅沈坤炜韩企夏沈镇宙 JA Fontana 复旦大学附属肿瘤医院乳腺外科上海200032 美国韦恩州立大学医学院底特律48201

目的　研究新型维甲酸AHPN对乳腺癌细胞的生长抑制的可能机制。方法　应用细胞生长抑制试验及Western印迹法 ,研究新型维甲酸对乳腺癌细胞株MDA MB 435细胞的生长抑制现象、不同时间点细胞内周期蛋白D1、周期蛋白E蛋白表达情况。结果　A... 详细信息

目的　研究新型维甲酸AHPN对乳腺癌细胞的生长抑制的可能机制。方法　应用细胞生长抑制试验及Western印迹法 ,研究新型维甲酸对乳腺癌细胞株MDA MB 435细胞的生长抑制现象、不同时间点细胞内周期蛋白D1、周期蛋白E蛋白表达情况。结果　AHPN可有效地抑制MDA MB 435细胞的生长 ,周期蛋白D1的蛋白表达随药物的作用时间的延长而逐渐降低 ,但周期蛋白E的蛋白表达却无明显的改变。结论　AHPN可有效地抑制人乳腺癌细胞株MDA MB 435细胞的生长 ,这种抑制作用可能通过降低周期蛋白D1的蛋白表达实现。

关键词：维甲酸乳腺癌周期蛋白 AHPN

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-zhi wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Tight association of hepatocellular carcinoma with HBV infection in North China

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 46-49页

作者： Ji-Dong Gao, Yong-Fu Shao, Yang Xu, Li-Hua ming, zhi-Yuan wu, Guo-Ting Liu, Xiao-Hong Wang, Wen-Hong Gao, Yun-Tian Sun, Xiao-Li Feng, Li-ming Liang, Yun-Hui Zhang and Zong-Tang Sun Beijing, China Department of General Surgery, Cancer Hospital National Laboratory of Molecular On- cology, Cancer Institute Department of Pathology, Cancer Hospital and Central Laboratory, Cancer Institute , Chinese Academy of Medical Sciences, Peking Union Medical College, Bei- jing 100021 , China Department of General Surgery Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China.

BACKGROUND: Hepatocellular carcinoma (HCC) is the second most common cancer in China. Hepatitis B and C viruses (HBV and HCV) and aflatoxins are known risk fac- tors for HCC, but the etiological status of these factors in HCC development is not clear. This study was undertaken to define the absolute importance of HBV in hepatocarci- nogenesis of North China. METHODS: A consecutive series of 119 patients with patho- logically proven HCC were collected from North China during January 1998 to December 2000 by the Cancer Hos- pital of the Chinese Academy of Medical Sciences, Beijing. Serum HBsAg, anti-HBc and anti-HCV were negative HBV sero-markers. The HBV X gene was analyzed for its expression by PCR, DNA sequencing, and immunohisto- chemistry. RESULTS; In the 119 HCC patients, 82.4% (98/119) were HBsAg seropositive. When a comprehensive set of HBV markers were detected, the HBV infection rate in these HCC patients was 99.2% (118/119). Of the patients, 11.8% (14/119) were found to be anti-HCV positive. But all the anti-HCV positive HCC patients were co-infected with HBV. CONCLUSIONS: HBV infection is virtually ubiquitous in HCC patients in North China. The tight association of HBV with HCC strongly suggests the dominant role of HBV infection in causing hepatocellular carcinoma. About 11.8% of HCC patients being HCV-related are co-infected with HBV.

关键词： liver neoplasms hepatitis B virus hepatitis C virus chronic hepatitis

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