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Design and Imaging Application of Room-Temperature Terahertz Detector with Micro-Bolometer Focal Plane Array

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Journal of Electronic Science and Technology 2016年第2期14卷 98-102页

作者： Jun Wang Jun Gou zhi-ming wu Ya-Dong Jiang School of Optoelectronic Information University of Electronic Science and Technology of China

Room-temperature terahertz （THz） detectors indicate a great potential in the imaging application because of their real-time, compact bulk, and wide spectral band responding characteristics. THz detectors with different dimensions based on a micro-bridge structure have been designed and fabricated to get optimized micro-bolometer parameters from the test results of membrane deformation. A nanostructured titanium （Ti） thin film absorber is integrated in the micro-bridge structure of the VOx micro-bolometer by a combined process of magnetron sputtering and reactive ion etching （RIE）, and its improvement of THz absorption is verified by an optical characteristics mesurement. Continuous-wave THz detection and imaging are demonstrated by using a 2.52 THz far infrared CO2 laser and a 320x240 vanadium oxide micro-bolometer focal plane array with an optimized cell structure. With this detecting system, THz imaging of metal concealed in a wiping cloth and an envelope is demonstrated, respectively.

关键词： Index Terms---Focal plane array micro-bolometer structure real-time imaging room temperatureterahertz detector

Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with In-stent Restenosis after Drug-coated Balloon Angioplasty

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Current Medical Science 2024年第3期44卷 561-567页

作者： Xiang-qi wu Long-bo LI Wei YOU zhi-ming wu Lei ZHAO zhi-hui WANG Pei-na MENG Bin LIU Fei YE Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Cardiology The Second Hospital of Jilin UniversityJilin130000China

Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(ISR)by using drug-coated balloon(DCB)treatment after a long-term *** This was a retrospective study.A total of 186 patients who underwent DCB angioplasty for ISR in two hospitals from March 2014 to September 2019 were *** QFR of the entire target vessel was measured *** primary endpoint was TVF,including target vessel-cardiac death(TV-CD),target vessel-myocardial infarction(TV-MI),and clinically driven-target vessel revascularization(CD-TVR).Results The follow-up time was 3.09±1.53 years,and 50 patients had *** QFR immediately after percutaneous coronary intervention(PCI)was significantly lower in the TVF group than in the no-TVF *** Cox regression analysis indicated that the QFR immediately after PCI was an excellent predictor for TVF after the long-term follow-up[hazard ratio(HR):5.15×10−5(6.13×10−8−0.043);P<0.01].Receiver-operating characteristic(ROC)curve analysis demonstrated that the optimal cut-off value of the QFR immediately after PCI for predicting the long-term TVF was 0.925(area under the curve:0.886,95%confidence interval:0.834–0.938;sensitivity:83.40%,specificity:88.00;P<0.01).In addition,QFR≤0.925 post-PCI was strongly correlated with the TVF,including TV-MI and CD-TVR(P<0.01).Conclusion The QFR immediately after PCI showed a high predictive value of TVF after a long-term follow-up in ISR patients who underwent DCB angioplasty.A lower QFR immediately after PCI was associated with a worse TVF outcome.

关键词： percutaneous coronary intervention in-stent restenosis target vessel failure quantitative flow ratio

Danggui Sini decoction treatment of refractory allergic cutaneous vasculitis:A case report

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World Journal of Clinical Cases 2022年第33期10卷 12422-12429页

作者： Xi-Ya Chen zhi-ming wu Rui Wang Yu-Hong Cao Yong-Lian Tao The Second Clinical Medical College Yunnan University of Chinese Traditional MedicineKunming 650000Yunnan ProvinceChina School of Basic Medicine Yunnan University of Chinese Traditional MedicineKunming 650000Yunnan ProvinceChina First Affiliated Hospital Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Allergic cutaneous vasculitis(ACV)is a difficult disease to *** present,there is no effective treatment for this ***,immunosuppressants and hormones have been primarily used in its management,but the treatment effect is suboptimal,and it has several side *** SUMMARY We present the case of a 19-year-old woman who presented at our hospital with a four-year history of symmetric skin lesions mainly affecting her lower *** had previously undergone treatment with prednisolone acetate,cetirizine hydrochloride,and loratadine tablets but had not experienced any relief in her ***,she was treated with oral traditional Chinese *** skin damage gradually improved within two months of treatment *** six months,the skin ulcers had completely *** evidence of skin ulcer recurrence was observed during the subsequent *** report presents the first case of a female patient who received oral Danggui Sini decoction for the treatment of *** Danggui Sini decoction may be a promising oral treatment for ACV patients.

关键词： Allergic cutaneous vasculitis Danggui Sini decoction Traditional Chinese Medicine Ulcer Rash Case report

Treatment Efficiencies of Constructed Wetlands for Eutrophic Landscape River Water

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Pedosphere 2007年第4期17卷 522-528页

作者： HE Sheng-Bing YAN Li KONG Hai-Nan LIU zhi-ming wu De-Yi HU Zhan-Bo School of Environmental Science and Engineering Shanghai Jiaotong University Shanghai 200240 （China）.

The efficiencies of two types of constructed wetlands for the treatment of low-concentration polluted eutrophic land- scape river water were studied in the western section of the Qingyuan River at the Minhang campus of Shanghai Jiaotong *** first wetland was a single-stage system using gravel as a filtration medium,and the second was a three- stage system filled with combinations of gravel,zeolite,and fly *** from parallel operations of the wetlands showed that the three-stage constructed wetland could remove organics,nitrogen, and phosphorus *** the same time,it could also decrease ammoniacal odour in the *** to the single-stage constructed wetland,it had better nutrient removal efficiencies with a higher removal of 19.37%-65.27% for total phosphorus (TP) and 21.56%- 62.94% for total nitrogen (TN),respectively,during the operation period of 14 *** terms of removal of chemical oxygen demand (COD), turbidity,and blue-green algae,these two wetland systems had equivalent *** was also found that in the western section of the test river,in which the two constructed wetlands were located, the water quality was much better than that in the eastern and middle sections without constructed wetland because COD,TN, and TP were all in a relatively lower level and the eutrophication could be prevented completely in the western section.

关键词： constructed wetland eutrophic landscape river water treatment

Safety and immunogenicity of a recombinant COVID-19 vaccine(Sf9 cells)in healthy population aged 18 years or older:two single-center,randomised,double-blind,placebo-controlled,phase 1 and phase 2 trials

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2550-2560页

作者： Fan-Yue Meng Fan Gao Si-Yue Jia Xiang-Hong wu Jing-Xin Li Xi-Ling Guo Jia-Lu Zhang Bo-Pei Cui zhi-ming wu ming-Wei Wei zhi-Long Ma Hai-Lin Peng Hong-Xing Pan Lin Fan Jing Zhang Jiu-Qin Wan Zhong-Kui Zhu Xue-Wen Wang Feng-Cai Zhu NHC Key Laboratory of Enteric Pathogenic Microbiology Jiangsu Provincial Center for Disease Control and PreventionNanjingChina China National Institute for Food and Drug Control BeijingChina Sheyang County Center for Disease Control and Prevention YanchengChina Jiangdu District Center for Disease Control and Prevention YangzhouChina Taizhou Center for Disease Control and Prevention TaizhouChina Jiangsu Taizhou Peopled Hospital TaizhouChina Shanghai Canming Medical Technology Co. LtdShanghaiChina

COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient *** did two singlecenter,randomised,double-blind,placebo-controlled phase 1 and phase 2 trials to assess the safety,tolerability and immunogenicity of a recombinant COVID-19 vaccine(Sf9 cells)in healthy population aged 18 years or older in *** participants were enrolled,the ratio of candidate vaccine and placebo within each dose group was 3:1(phase 1)or 5:1(phase 2).From August 28,2020,168 participants were sequentially enrolled and randomly assigned to receive the low dose vaccine,high dose vaccine or placebo with the schedule of 0,28 days or 0,14,28 days in phase 1 *** November 18,2020,960 participants were randomly assigned to receive the low dose vaccine,high dose vaccine or placebo with the schedule of 0,21 days or 0;14,28 days in phase 2 *** most common solicited injection site adverse reaction within 7 days in both trials was *** most common solicited systematic adverse reactions within 7 days were fatigue,cough,sore throat,fever and *** antibodies and neutralising antibodies increased at 14 days,and peaked at 28 days(phase 1)or 30 days(phase 2)after the last dose *** GMTs of neutralising antibody against live SARS-CoV-2 at 28 days or 30 days after the last dose vaccination were highest in the adult high dose group(0,14,28 days),with 102.9(95%Cl 61.9-171.2)and 102.6(95%Cl 75.2-140.1)in phase 1 and phase 2 trials,*** T-cell response peaked at 14 days after the last dose vaccination in phase 1 *** vaccine is safe,and induced significant immune responses after three doses of vaccination.

关键词： fatigue phase double

Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO zhi-Jing GAO Yi-Fei WANG Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi wu zhi-ming wu Mei-En ZHAN Yan-Qing WANG De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

Intensive statin versus low-dose statin + ezetimibe treatment for fibrous cap thickness of coronary vulnerable plaques

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Chinese Medical Journal 2020年第20期133卷 2415-2421页

作者： Pei-Na Meng De-Lu Yin Wen-Qi Lu Tian Xu Wei You zhi-ming wu Xiang-Qi wu Fei Ye Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Cardiology The First People's Hospital of LianyungangLianyungangJiangsu 222000China

Background:Acute coronary syndromes mainly result from abrupt thrombotic occlusion caused by atherosclerotic vulnerable plaques (VPs) that suddenly rupture or erosion. Fibrous cap thickness (FCT) is a major determinant of the propensity of a VP to rupture and is recognized as a key factor. The intensive use of statins is known to have the ability to increase FCT;however, there is a risk of additional adverse effects. However, lower dose statin with ezetimibe is known to be tolerable by patients. The present study aimed to investigate the effect of intensive statin vs. low-dose stain + ezetimibe therapy on FCT, as evaluated using optical coherence tomography. Method:Patients who had VPs (minimum FCT 90°) and deferred from intervention in our single center from January 2014 to December 2018 were included in the trial. They were divided into the following two groups: intensive statin group (rosuvastatin 15-20 mg or atorvastatin 30-40 mg) and combination therapy group (rosuvastatin 5-10 mg or atorvastatin 10-20 mg + ezetimibe 10 mg). At the 12-month follow-up, we compared the change in the FCT (ΔFCT%) between the two groups and analyzed the association of ΔFCT% with risk factors. Fisher exact test was used for all categorical variables. Student’s t test or Mann-Whitney U-test was used for analyzing the continuous data. The relationship between ΔFCT% and risk factors was analyzed using linear regression analysis. Result:Total 53 patients were finally enrolled, including 26 patients who were in the intensive statin group and 27 who were in the combination therapy group. At the 12-month follow-up, the serum levels of total cholesterol (TC), total triglyceride, low-density lipoprotein (LDL-C), hypersensitive C-reactive protein (hs-CRP), and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels were reduced in both the groups. The ΔTC%, ΔLDL-C%, and ΔLp-PLA2% were decreased further in the combination therapy group. FCT was increased in both the grou

关键词： Statins Ezetimibe Fibrous cap thickness Coronary vulnerable plaques Optical coherence tomography

Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in Young Female Population： A Single-center Study

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Chinese Medical Journal 2017年第13期130卷 1534-1539页

作者： Pei-Na Meng Chen Xu Wei You zhi-ming wu Du-Jiang Xie Hang Zhang Chang Pan Fei Ye Department of Cardiology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu 210006 China

Background： Spontaneous coronary artery dissection （SCAD） is a nonatherosclerotic but a rare and extremely dangerous clinical entity, it has a high prevalence in young female population with acute myocardial infarction （AMI）. The previous reports were restricted to other countries＇ population, but rare in China. Hence, this study aimed to focus on the characteristics of SCAD as a cause of young female AMI population in Jiangsu, China. Methods： This study enrolled young female AMI patients aged ≤50 years who underwent coronary angiography （CAG） and intracoronary imaging in our center between January 2013 and December 2016. Their clinical presentations, risk factors, and CAG characteristics were analyzed. Results： A total of 60 young l＇emale AMI （〈7 days） patients were enrolled. From their CAG and intracoronary imaging results, the prevalence of SCAD in young female AMI population was 35% （21/60）, the prevalence of coronary atherosclerostic heart disease was 65% （39/60）. In the SCAD group, 43% （9/21） presented with non-ST-elevation myocardial infarction （NSTEM1） and the remainder presenting as STEMI. SCAD usually occurred in a single vessel （20/21, 95%）, especially in left anterior descending artery （14/21, 67%）. Eighteen patients （18/21, 86%） underwent conservative treatment, whereas the remaining three patients （3/21, 14%） underwent percutaneous coronary intervention. Regarding the angiographic results of SCAD lesions, intramural hematoma was discriminated in 95% （20/21）, and Type I imaging was observed in 5% （1/21）, Type l I was observed in 67% （14/21）, and Type Ⅲ was 29% （6/21）. The average stenosis in the group was 76.9% - 20.6%, and the mean lesion length was 36.6 ± 8.6 ±m. Conclusions： SCAD has a high prevalence in young female AMI population in Jiangsu, China. Discriminating the cause of AMI in young female population is very important.

关键词： Acute Myocardial lnl arction Spontaneous Coronary Artery Dissection Young Female

Cut-off values of lesion and vessel quantitative flow ratio in de novo coronary lesion post-drug-coated balloon therapy predicting vessel restenosis at mid-term follow-up

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Chinese Medical Journal 2021年第12期134卷 1450-1456页

作者： Pei-Na Meng Bin Liu Long-Bo Li De-Lu Yin Heng Zhang De-Feng Pan Wei You zhi-ming wu Xiang-Qi wu Lei Zhao zhi-Bo Li Jin-Peng Wang zhi-Hui Wang Tian Xu Xiao-Yu Huang Ruo-Nan Gao Fei Ye Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China Department of Cardiology The Second Hospital of Jilin UniversityChangchunJilin 130000China Department of Cardiology The First People's Hospital of LianyungangLianyungangJiangsu 222000China Department of Cardiovascular Medicine The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233000China Department of Cardiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China

Background:Drug-coated balloons(DCBs)have emerged as potential alternatives to drug-eluting stents in specific lesion subsets for de novo coronary *** flow ratio(QFR)is a method based on the three-dimensional quantitative coronary angiography and contrast flow velocity during coronary angiography(CAG),obviating the need for an invasive fractional flow reserve *** study aimed to assess the serial angiographic changes of de novo lesions post-DCB therapy and further explore the cut-off values of lesion and vessel QFR,which predict vessel restenosis(diameter stenosis[DS]≥50%)at mid-term ***:The data of patients who underwent DCB therapy between January 2014 and December 2019 from the multicenter hospital were retrospectively collected for QFR *** their QFR performances,which were analyzed by CAG images at follow-up,we divided them into two groups:group A,showing target vessel DS≥50%,and group B,showing target vessel DS<50%.The median follow-up time was 287 days in group A and 227 days in group *** compared the clinical characteristics,parameters during DCB therapy,and QFR performances,which were analyzed by CAG images between the two groups,in need to explore the cut-off value of lesion/vessel QFR which can predict vessel ***'s t test was used for the comparison of normally distributed continuous data,Mann-Whitney U test for the comparison of non-normally distributed continuous data,and receiver operating characteristic(ROC)curves for the evaluation of QFR performance which can predict vessel restenosis(DS≥50%)at mid-term follow-up using the area under the curve(AUC).Results:A total of 112 patients with 112 target vessels were enrolled in this *** A had 41 patients,while group B had *** QFR and lesion QFR were lower in group A than in group B post-DCB therapy,and the cut-off values of lesion QFR and vessel QFR in the ROC analysis to predict target vessel DS≥50%post-DCB therapy were 0.905(

关键词： Quantitative flow ratio Drug-coated balloons De novo coronary lesions Cut-off value Receiver operating characteristic curves