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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang zhi-Lai Zhan Guang-Lu Chang Yan Gao xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of modern Chinese medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(m.igui).methods:in this study,40 batches of samples including m.igui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that m.igui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,m.inly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： Di Ke XiE meng xia Huarong CHENG Anyu LiU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

in this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-dom.in（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PiT） effect at terahertz frequency, thereby converting from a single PiT to a double-PiT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PiT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PiT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. in addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RiU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

Prospects on mangrove knowledge services in the smart era: From plant atlas to knowledge graphs

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Science China Earth Sciences 2025年第1期 111-127页

作者： zhi-Wei HOU Wenlong JiNG Cheng-zhi QiN Ji YANG Qing xia xiaoling YiN Key Laboratory of Guangdong for Utilization of Remote Sensing and Geographical information System Guangdong Open Laboratory of Geospatial Information Technology and Application Guangzhou Institute of Geography Guangdong Academy of Sciences Southern marine Science and Engineering Guangdong Laboratory (Guangzhou) State Key Laboratory of Resources and Environmental information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Traffic & Transportation Engineering Changsha University of Science and Technology

mangroves are crucial to the ecological security of the Earth and human well-being. Their management, conservation, and restoration are of great importance and necessitate the support of spatio-temporal information and multidisciplinary knowledge such as biology and ecology. Traditional knowledge services such as plant atlas provide illustrated textual knowledge of mangroves. However, this kind of service is oriented to information retrieval and is incapable of effectively mining and utilizing fragmented knowledge from multi-source heterogeneous data, facing the problem of “massive data, rare knowledge”. Knowledge graphs are capable of extracting, organizing, and fusing the knowledge contained in massive data into semantic networks that can be understood and computed by computers. They provide a solution for the realization of intelligent knowledge services. Focusing on the urgent need for mangrove knowledge acquisition, formal representation, and intelligent services, this paper proposes a research prospect on mangrove knowledge graphs and knowledge services. We first analyze the similarities and differences between various dom.in-specific concepts of Tupu. On this basis, we define the mangrove knowledge graph as a large-scale knowledge base that integrates multi-disciplinary knowledge and spatio-temporal information with mangrove ecosystems as the core. Then, we propose a research framework for mangrove knowledge services that can realize the transformation from multi-modal data to intelligent knowledge services, including multiple research levels such as ubiquitous data sensing and aggregation, knowledge organization and graph construction, and intelligent mangrove knowledge services. Subsequently, the methods and workflow for constructing mangrove knowledge graphs are introduced. Finally, we discuss the challenges and possible future directions of mangrove knowledge services in the smart era, including the construction of a mangrove knowledge system that integra

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Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf muhammad Bilal Hanif Zuhra Tayyab matej Veis mAKYousaf Shah Naveed mushtaq Dmitry medvedev Yibin Tian Chen xia martin motola Bin Zhu College of mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism.in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) ionic conductivity Heterostructure electrolyte

Recom.inant chitinase-3-like protein 1 alleviates learning and memory impairments via m2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou minhui Xu Jiyan Xu Zhengliang ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of molecular medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Om.ibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recom.inant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),m2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NmDA receptor subunit NR2B)were measured in hippocampus by western *** with recom.inant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory m2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recom.inant CHi3L1

Parameter feature extraction for hyperspectral detection of the shallow underwater target

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Science China(Technological Sciences) 2021年第5期64卷 1092-1100页

作者： xia zhi GU YanFeng Acoustic Science and Technology Laboratory Harbin Engineering UniversityHarbin 150001China College of Underwater Acoustic Engineering Harbin Engineering UniversityHarbin 150001China School of Electronics and information Engineering Harbin Institute of TechnologyHarbin 150001China

For the detection of shallow underwater targets by the hyperspectrum, the information of the target is carried in the water-leaving radiation. However, the differences between the water-leaving radiation of the underwater target and the ocean background radiation are not significant, and the spectrum of the water-leaving radiation is sensitive to the changes of the marine environment. Therefore, taking the spectrum as the feature is not stable for hyperspectral detection of the underwater target. in this paper, we propose a parameter feature extraction method for hyperspectral detection of the shallow underwater target. The presence of an underwater target would change the optical properties of seawater in a local place. Based on that, a quasianalytical model of the water-leaving radiation is adopted to inverse the properties of the marine environment from the radiated spectrum. Then the inversed water depth and bottom reference reflectance are taken as the features. Simulation results show that the samples which belong to the water-leaving radiation of underwater target have higher inversed depth and reference reflectance than that belong to the ocean background radiation. Furthermore, these two kinds of samples can be separated significantly and stably in a 2-dimension feature space.

关键词： hyperspectral imaging underwater technology feature extraction

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing xia Department of Biochemistry and molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic medical institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Weighted Pseudo Asymptotically Periodic mild Solutions of Evolution Equations

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Acta mathematica Sinica,English Series 2015年第8期31卷 1215-1232页

作者： zhi Nan xia Department of Applied mathematics Zhejiang University of Technology

in this paper, we propose a new class of functions called weighted pseudo S-asymptotically periodic function in the Stepanov sense and explore its properties in Banach space including composition theorems. Furthermore, the existence, uniqueness of the weighted pseudo S-asymptotically periodic mild solutions to partial evolution equations and nonautonomous semilinear evolution equations are investigated. Some interesting examples are presented to illustrate the m.in findings.

关键词： Sp-weighted pseudo S-asymptotic periodicity weighted pseudo S-asymptotic periodicity evolution equations mild solutions

multi-harmonic forced vibration and resonance of simple beams to moving vehicles

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Frontiers of Structural and Civil Engineering 2023年第7期17卷 981-993页

作者： zhi SUN Limin SUN Ye xia State Key Laboratory for Disaster Reduction in Civil Engineering Shanghai 200092China Department of Bridge Engineering Tongji UniversityShanghai 200092China

This study modeled the moving-vehicle-induced forcing excitation on a single-span prismatic bridge as a multiple frequency-multiplication harmonic load on the modal coordinates of a linear elastic simple Euler–Bernoulli beam,and investigated the forced modal oscillation and resonance behavior of this type of dynamic *** forced modal responses consist of multiple frequency-multiplication steady-state harmonics and one damped mono-frequency complementary *** analysis revealed that a moving load induces high-harmonic forced resonance amplification when the moving speed is *** verify the occurrence of high-harmonic forced resonance,numerical tests were conducted on single-span simple beams based on structural modeling using the finite element method(FEm)and a moving sprung-mass oscillator vehicle *** forced resonance amplification characteristics of the fundamental mode for beam response estimation are presented with consideration to different end restraint *** results reveal that the high-harmonic forced resonance may be significant for the investigated beams subjected to vehicle loads moving at specific low *** the investigated single-span simple beams,the moving vehicle carriage heaving oscillation modulates the beam modal frequency,but does not induce notable variation of the modal oscillation harmonic structure for the cases that vehicle of small mass moves in low speed.

关键词： forced vibration linear Euler beam moving load harmonic structure frequency modulation end restraints