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The large-scale modular BGO detection array(LAMBDA)design and test

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Nuclear Science and Techniques 2024年第11期35卷 228-236页

作者： Yao-De sheng Lu-Yang Song Jun Su Shi-Lun Jin Fei Lu Yang-Ping shen Jun-Feng Chen Li-Yong Zhang Jian-Jun He Xin-Yue Li Hong-Na Liu Feng-Shou Zhang Meng-lin Qiu shen lin Hao Zhang Luo-Huan Wang Zi-Ming Li Yin-Ji Chen Xin-zhi Jiang Xin Chen zhi-lin shen Feng-Cheng Liu zhi-Wei Qin lin Wang Yi-Tong Huang Xiang Li Si-Ze Chen You-Bao Wang zhi-Hong Li Bing Guo Wei-Ping Liu Key Laboratory of Beam Technology of Ministry of Education School of Physics and AstronomyBeijing Normal UniversityBeijing 100875China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MoE) Institute of Modern PhysicsFudan University200433 ShanghaiChina School of Mathematics and Physics Handan UniversityHandan 056005China Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Total absorption gamma-ray spectroscopy(TAGS)is a powerful tool for measuring complexγ transitions,which has been effectively applied to the study of reactor decay *** paper presents the design of a new TAGS detector,the large-scale modular BGO detection array(LAMBDA),tailored for measuringβ-decay intensity distributions of fission *** modular design allows the LAMBDA detectors to be assembled in various *** final version of LAMBDA consists of 102 identical 60 mm×60 mm×120 mm BGO crystals and exhibits a high full-energy peak efficiency exceeding 80%at 0.5∼8 MeV based on a Monte Carlo ***,approximately half of the LAMBDA modules have been *** usingγ-ray sources and nuclear reactions demonstrated favorable energy resolution,energy linearity,and efficiency uniformity across the ***-eight modules have been integrated into the prototype *** capability of LAMBDA-I inβ-delayedγ-decay experiments was evaluated by commissioning measurements using the ^(152)Eu source.

关键词： Total absorption gamma-ray spectroscopy Reactor decay heat Beta-decay BGO detector array LAMBDA

Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cordderived mesenchymal stem cells by increasing PD-L1 expression

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World Journal of Stem Cells 2023年第8期15卷 787-806页

作者： Zhuo Chen Meng-Wei Yao zhi-lin shen Shi-Dan Li Wei Xing Wei Guo Zhan Li Xiao-Feng Wu Luo-Quan Ao Wen-Yong Lu Qi-Zhou Lian Xiang Xu Xiang Ao Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China College of Basic Medical Sciences Army Medical UniversityChongqing 400038China Department of Orthopedics Daping HospitalArmy Medical UniversityChongqing 400042China Department of Hepatobiliary Surgery The First Affiliated Hospital of Wenzhou Medical UniversityThe South of Shangcai VillageWenzhou 325005Zhejiang ProvinceChina Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Orthopedics 953 Hospital of PLA ArmyShigatse Branch of Xinqiao HospitalArmy Medical UniversityShigatse 857000Tibet Autonomous RegionChina

BACKGROUND The immunosuppressive capacity of mesenchymal stem cells(MSCs)is dependent on the“license”of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1 ligand 1(PD-L1),which determines the clinical therapeutic efficacy of MSCs for inflammatory or immune *** MSCs,interferon-gamma(IFN-γ)is a key inducer of PD-L1 expression,which is synergistically enhanced by tumor necrosis factor-alpha(TNF-α);however,the underlying mechanism is *** To reveal the mechanism of pretreated MSCs express high PD-L1 and explore the application of pretreated MSCs in ulcerative *** We assessed PD-L1 expression in human umbilical-cord-derived MSCs(hUC-MSCs)induced by IFN-γand TNF-α,alone or in ***,we performed signal pathway inhibitor experiments as well as RNA interference experiments to elucidate the molecular mechanism by which IFN-γalone or in combination with TNF-αinduces PD-L1 ***,we used luciferase reporter gene experiments to verify the binding sites of the transcription factors of each signal transduction pathway to the targeted gene ***,we evaluated the immunosuppressive capacity of hUC-MSCs treated with IFN-γand TNF-αin both an in vitro mixed lymphocyte culture assay,and in vivo in mice with dextran sulfate sodium-induced acute *** Our results suggest that IFN-γinduction alone upregulates PD-L1 expression in hUC-MSCs while TNF-αalone does not,and that the co-induction of IFN-γand TNF-αpromotes higher expression of ***-γinduces hUCMSCs to express PD-L1,in which IFN-γactivates the JAK/STAT1 signaling pathway,up-regulates the expression of the interferon regulatory factor 1(IRF1)transcription factor,promotes the binding of IRF1 and the PD-L1 gene promoter,and finally promotes PD-L1 *** TNF-αalone did not induce PD-L1 expression in hUCMSCs,the addition of TNF-αsignificantly enhanced IFN-γ-induced JAK/STAT1/IRF1 ***-αup

关键词： Human umbilical-cord-derived mesenchymal stem cells Programmed cell death 1 ligand 1 Immunomodulation Interferon-gamma Tumor necrosis factor-alpha Ulcerative colitis

EXPERIMENTAL AND THEORETICAL STUDY ON IMPACT TOUGHNESS AND THE COMPLETE STRESS-STRAIN CURVE OF PLAIN CONCRETE AND STEEL FIBER CONCRETE IN AXIAL TENSION

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EXPERIMENTAL AND THEORETICAL STUDY ON IMPACT TOUGHNESS AND T...

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

Third International Colloquium on Concrete in Developing Countries

作者： zhi-lin shen Shanghai Railway Design Institute Shanghai China

＜正＞This paper presents the comparison test results and theoretical analysis on impact toughness and complete stress-strain curve of plain concrete and steel fiber concrete in axial *** comparison test is done on the basis of orthogonal optimization method,the result of the test shows that steel fiber concrete possesses much more advantages over plain concrete in mechanical properties.A method for measuring impact resistance of plain concrete and steel fiber concrete is given,and the results of the test are analysed by means of Fracture Hechanics and Damage *** this paper,a hey calculating method is proposed.

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing shen Qiu-Wan Wei Yi-Ren Tian Yun-zhi ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(Plinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-zhi Yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Effects of the types of overlap on the mechanical properties of FSSW welded AZ series magnesium alloy joints

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International Journal of Minerals,Metallurgy and Materials 2012年第3期19卷 231-235页

作者： Dan Wang Jun shen lin-zhi Wang School of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effects of the types of overlap on the mechanical properties of the friction stir spot welding （FSSW） welded AZ series magnesium alloy joints were investigated by microstructural observations, microhardness tests, and tensile tests. The results show that the microstructure of the stir zone adjacent to the periphery of the rotating pin is mainly composed of the upper sheet. The average distance D between the longitudinal segment of the curved interface and the keyhole periphery, the tensile shear force, and the microhardness of the stir zone of the FSSW welded AZ61 alloy joint are the highest in all samples. During FSSW of AZ31 and AZ61 dissimilar magnesium alloys, the irregular deformation of the longitudinal segment of the curved interface appears, while the microhardness of the stir zone is higher when AZ61 alloy is the upper sheet. Moreover, the microhardness of the stir zone increases initially and then decreases sharply in the longitudinal test position.

关键词： magnesium alloys friction stir welding microstructure microhardness tensile properties

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甘蔗线条花叶病毒研究进展

生物技术通报 2017年第7期33卷 22-28页

作者：冯小艳王文治沈林波冯翠莲张树珍中国热带农业科学院热带生物技术研究所海口571101

甘蔗线条花叶病毒(Sugarcane streak mosaic virus,SCSMV)是引起甘蔗花叶病的主要病原之一,在世界各大蔗区普遍发生,严重威胁甘蔗产业的发展。综述了SCSMV的生物学特性、发生与危害、鉴定与检测、基因组结构与功能、防治策略等方面的研... 详细信息

甘蔗线条花叶病毒(Sugarcane streak mosaic virus,SCSMV)是引起甘蔗花叶病的主要病原之一,在世界各大蔗区普遍发生,严重威胁甘蔗产业的发展。综述了SCSMV的生物学特性、发生与危害、鉴定与检测、基因组结构与功能、防治策略等方面的研究进展,以期为深入研究SCSMV及其所致病害提供参考。

关键词：甘蔗线条花叶病毒甘蔗花叶病防治策略

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简单遗传算法的一种改进算法

上海大学学报（自然科学版） 2000年第2期6卷 108-110页

作者：吴志坚林瑞燊上海大学机械电子工程与自动化学院上海200072

针对简单遗传算法收敛速度慢的问题 ,结合复合形法 ,提出了一种改进算法并将其应用于系统辨识中 .仿真结果表明 ,改进后的算法具有收敛快。

关键词：遗传算法复合形法系统辩识优化算法改进算法

Advances in MET tyrosine kinase inhibitors in gastric cancer

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Cancer Biology & Medicine 2024年第6期21卷 484-498页

作者： Yifan Zhang lin shen zhi Peng Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China

Gastric cancer is among the most frequently occurring cancers and a leading cause of cancer-related deaths *** gastric cancer is highly heterogenous and comprised of different subtypes with distinct molecular and clinical characteristics,the management of gastric cancer calls for better-defined,biomarker-guided,molecular-based treatment *** is a receptor tyrosine kinase mediating important physiologic processes,such as embryogenesis,tissue regeneration,and wound ***,mounting evidence suggests that aberrant MET pathway activation contributes to tumour proliferation and metastasis in multiple cancer types,including gastric cancer,and is associated with poor patient *** such,MET-targeting therapies are being actively developed and promising progress has been demonstrated,especially with MET tyrosine kinase *** review aims to briefly introduce the role of MET alterations in gastric cancer and summarize in detail the current progress of MET tyrosine kinase inhibitors in this disease area with a focus on savolitinib,tepotinib,capmatinib,and *** on current knowledge,this review further discusses existing challenges in MET alterations testing,possible resistance mechanisms to MET inhibitors,and future directions of MET-targeting therapies.

关键词： Gastric cancer MET alterations MET tyrosine kinase inhibitors savolitinib MET testing