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Synthesis of (±)-Demethylnitidanin, Herpetol and Salvinal as well as Their Glycosyl Derivatives

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Chemical Research in Chinese Universities 2011年第6期27卷 949-954页

作者： WU Zheng liang zhi-ying LI Wei REN ying-mei WANG Qiu-an State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China

Three neolignans, （±）-demethylnitidanin（1）, herpetol（2） and salvinal（3） were synthesized from methyl 4,5-dihydroxy-3-methoxy cinnamate or methyl 4-hydroxy-3-methoxy cinnamate with Ag2O-catalyzed biomimetic oxidative coupling as the key step of the synthetic route. Five novel benzofuran neolignan-4＇-O-β-D-glycosides（4―8） were achieved by the glycosylation reactions of benzofuran neolignans 2, 3 and 15. The structures of all the compounds synthesized were determined by MS, 1H NMR and IR spectra. （±）-Demethylnitidanin（1） and herpetol（2） were the first synthesized and the synthesis of salvinal（3） was efficiently improved by the new synthetic routes.

关键词： Neolignan (±)-Demethylnitidanin Herpetol Salvinal Glycosylation

Synthesis of Dihydrobenzofuran Neoligans Licarin A and Dihydrocarinatin as Well as Related Triazolylglycosides

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Chemical Research in Chinese Universities 2013年第6期29卷 1119-1124页

作者： LIU Shuang-yan WANG Gang-qiang liang zhi-ying WANG Qiu-an State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Changsha 410082 P.R.China

Two natural dihydrobenzofuran neolignans licarin A（1） and dihydrocarinatin（2） were systhesized from isoeugenol with Ag20-catalyzed biomimetic oxidative coupling as the key step. Four novel dihydrobenzofuran triazolylglycoside（3--6） were achieved in good yields via Cu（I）-catalyzed azide-alkyne cycloadditions of licarin A terminal alkynes with different azide acetylated sugar and deacetylation with sodium methoxide in anhydrous methanol. The structures of all the compounds synthesized were determined by elemental analysis, MS, 1H NMR and ~3C NMR. And the inhibition activity of synthesized compounds on a-glucosidase was determined by in vitro experiments. The results show that triazolyglycosides 3, 4, 5 and 6 show moderate inhibitory activity on a-glucosidase.

关键词： Dihydrobenzofuran Licarin A Dihydrocarinatin Triazolylglycoside

IMPROVING THE PROPERTIES OF HDPE BASED SEPARATORS FOR LITHIUM ION BATTERIES BY BLENDING BLOCK WITH COPOLYMER PE-b-PEG

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Chinese Journal of Polymer Science 2013年第2期31卷 309-317页

作者： Jun-li Shi Hao Li Li-feng Fang zhi-ying liang 朱宝库 Department of Polymer Science and Engineering ERC of Membrane and Water Treatment Technology Key Laboratory of Macromolecular Synthesis and Functionalization MOE Zhejiang University

To improve the performances of HDPE-based separators, polyether chains were incorporated into HDPE membranes by blending with poly（ethylene-block-ethylene glycol）（PE-b-PEG） via thermally induced phase separation （TIPS） process. By measuring the composition, morphology, crystallinity, ion conductivity, etc, the influence of PE-b-PEG on structures and properties of the blend separator were investigated. It was found that the incorporated PEG chains yielded higher surface energy for HDPE separator and improved affinity to liquid electrolyte. Thus, the stability of liquid electrolyte trapped in separator was increased while the interfacial resistance between separator and electrode was reduced effectively. The ionic conductivity of liquid electrolyte soaked separator could reach 1.28 ×10^-3 ***^-1 at 25℃, and the electrochemical stability window was up to 4.5 V （versus Li^＋/Li）. These results revealed that blending PE-b-PEG into porous HDPE membranes could efficiently improve the performances of PE separators for lithium batteries.

关键词： Polyethylene Poly(ethylene-block-ethylene glycol) copolymer Blend porous separator Thermally inducedphase separation Lithium ion battery separator.

Convergence Rate of the L-N Estimator in Poisson-Gamma Models

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Acta Mathematicae Applicatae Sinica 2006年第4期22卷 639-654页

作者： Na Xia Zhong-zhan Zhang zhi-liang ying College of Applied Sciences Beijing University of Technology Beijing 100022 China Department of Statistics Columbia University New York NY10027 USA

We focus on in this paper the convergence rate of the L-N estimators for the fixed effect β in Poisson-Gamma models which are typical hierarchical generalised linear models（HGLMs）. Under the proper assumptions on response variables and some smoothing conditions, we obtain the strong consistency and the convergence rate of the L-N estimator based on the combination of L-N and quasi-likelihood.

关键词： H-likelihood L-N estimators Poisson-Gamma models strong consistency random effect

Analysis of the Lignin Contents and Related Enzymes Activities in Seed Coat Between Black-Seeded and Yellow-Seeded Rapes (Brassica napus L.)

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Agricultural Sciences in China 2005年第12期4卷 890-897页

作者： RAN Xiu-zhi liang ying LI Jia-na College of Agronomy and Life Science Southwest Agricultural University Chongqing 400716 P.R.China

One pair of near isonegic yellow/black seeded rape （Brassica napus L） were used as experimental materials to study the changes of lignin contents and enzymes activities of 4-coumarate： CoA ligase （4CL）, Cinnamyl alcohol dehydrogenase （CAD） and ferulate 5-hydroxylase （F5H） in seedcoats during the stage of seed development. The variation analysis showed that the changes of lignin contents and enzyme activities of 4CL, CAD and F5H in seed coat had significant differences between black- and yellow-seeded rapes, and also between different development stages. The correlation analysis demonstrated that the lignin contents were positively correlative to the activities of all three enzymes investigated in the study, and the interactions between them in the seed coat of the two lines. For yellow-seeded rape, the correlation coefficient （0.7262018） of lignin content and the interaction between 4CL and F5H was significant, the lignin contents were highly positively correlative to the activities of CAD and F5H, the interaction between 4CL and CAD, and the interaction between CAD and F5H. For the black-seeded rape, only the lignin content was highly positively correlative to the activity of F5H （the correlation coefficient was 0.772949）, the other correlation coefficients, i. e. lignin contents to 4CL, CAD activities, the interactions between the three enzymes were not significant although all the correlation coefficients were above 0.5000. The results suggested that 4CL, CAD and F5H regulated the biosynthesis of lignin in seedcoat of rapes, leading to the lignin contents in the seedcoats of the yellow-seeded rape much lower than that of the black-seeded line, and affecting the thickness of the developing seedcoats in rapes. Therefore, it was likely to change the seedcoat ratio by overexpressing or suppressing the activities of one of the enzymes, both of them or all of them.

关键词： Brassica napus L.0 Lignin contents0 4CL CAD F5H

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Chinese patients with adult onset leukodystrophy caused by CST3 variants

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Journal of Genetics and Genomics 2024年第7期51卷 778-780页

作者： Yi Zhang zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical TranslationSecond Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Nanhu Brain-computer Interface Institute HangzhouZhejiang 314050China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310012China

Leukodystrophies represent a group of cerebral white matter disorders that mainly affect axon-glia *** disorders are clinically diverse and display significant genetic *** is challenging to differentiate hereditary leukodystrophies,particularly those that present in adulthood,from acquired leukodystrophies and other genetic disorders,such as multiple sclerosis(MS)or hereditary spastic paraplegia(HSP)(Wei et al.,2021).Over the past few decades,a series of causative genes associated with leukodystrophies have been identified(Kohler et al.,2018).Nevertheless,a significant proportion of patients still lack a precise molecular diagnosis.

关键词： al. patients Kohler

Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences

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Science China(Life Sciences) 2024年第9期67卷 2045-2047页

作者： Bing-zhi Li ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a significant role in disease,evolution,and tumorigenesis(Mani and Chinnaiyan,2010).While single nucleotide polymorphisms(SNPs)and small insertions/deletions contribute substantially to gen... 详细信息

关键词： insertion sequences

Microstructure and mechanical properties of Ti/Al/Ti clad plates prepared via powder-in-tube method

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Journal of Iron and Steel Research International 2024年第3期31卷 670-687页

作者： Xian-lei Hu Qin-cheng Xie Yi Yuan ying zhi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Suzhou Dongbao Haixing Metal Material Technology Co. Ltd.Suzhou 215600JiangsuChina School of Material Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina

The Ti/Al/Ti clad plates exhibit a broad spectrum of potential ***,the conventional techniques of hot-pressing composite and explosive composite are intricate and environmentally hazardous.A novel method was introduced for preparing clad plates,namely,the powder-in-tube *** method involves a combination of cold rolling,annealing at a temperature of 550℃,and double *** morphology of the intermetallic compound layer was analyzed through the utilization of interface stripping test,tensile test,and microscopic *** interface morphology,interface bonding properties,tensile fracture structures,and properties of plates under the first and second rolling were compared,along with the effects of intermetallic compounds on the interface *** results indicate that the powder-in-tube method,when annealed at 550℃,can produce a composite plate featuring a complete and uniform Ti/Al *** obtained plate exhibits a peeling strength of 21.5 N/mm,tensile strength of 424 MPa,and elongation of 11.5%.Furthermore,a systematic analysis was conducted to determine the causes of performance degra-dation observed during annealing at temperatures of 600 and 650℃.

关键词： Powder-in-tube method-Ti/Al/Ti clad plate Annealing Cold rolling-Mechanical property