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Circular RNA hsacirc0000745 may serve as a diagnostic marker for gastric cancer

World Journal of Gastroenterology 2017年第34期23卷 6330-6338页

作者： Mei Huang Yi-Ren He Li-Chuan liang Qiang Huang zhi-Qiang zhu Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery Department of General SurgeryAnhui Provincial Hospital Affiliated to Anhui Medical University Department of General Surgery Anhui Provincial Hospital Affiliated to Anhui Medical University

AIM To determine whether circular RNAs(circ RNAs) are involved in pathological processes of gastric cancer(GC).METHODS Three circ RNAs with differential expression in GC and colorectal cancer were randomly selected for validation by quantitative reverse transcription-polymerase chain reaction(q RT-PCR), using 20 pairs of gastric tissues and normal tissues. Based on the predicted circ RNAmi RNA network, we then focused on hsa_circ_0000745, which was found to be down-regulated in 20 GC tissues compared with normal tissues. The hsa_circ_0000745 levels were further analyzed by q RT-PCR in 60 GC tissues and paired adjacent non-tumor tissues, as well as 60 plasma samples from GC patients and 60 plasma samples from healthy controls. The associations between the levels of hsa_circ_0000745 and the clinicopathological features of GC patients were statistically assessed. A receiver operating characteristic(ROC) curve was used to evaluate the diagnostic value of hsa_circ_0000745 in *** Hsa_circ_0000745 was down-regulated in GC tissues vs non-tumorous tissues(P < 0.001) and in plasma samples from patients with GC vs healthy controls(P < 0.001). The expression level of hsa_circ_0000745 in GC tissues correlated with tumor differentiation, while the expression level in plasma correlated with tumor-nodemetastasis stage. The area under the ROC curve(AUC) of hsa_circ_0000745 in plasma was 0.683, suggesting good diagnostic value. Plasma hsa_circ_0000745 level combined with carcinoembryogenic antigen(CEA) level increased the AUC to *** Hsa_circ_0000745 plays an important role in GC and its expression level in plasma in combination with CEA level is a promising diagnostic marker for this malignancy.

关键词： Circular RNA circ_0000745 Gastric cancer Diagnosis Noncoding RNA

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Modifying optical properties of ZnO nanowires via strain-gradient

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Frontiers of physics 2013年第5期8卷 509-515页

作者： Xue-Wen Fu Qiang Fu liang-zhi Kou Xin-Li zhu Rui zhu Jun Xu zhi-Min Liao Qing Zhao Wan-Lin Guo Da-Peng Yu State Key Laboratory for Mesoscopic Physics and Electron Microscopy Laboratory Department of Physics Peking University Beijing 100871 China State Key Laboratory for Mechanics and Control of Mechanical Structures and MOE Key Laboratory of IntelligentNano Materials and Devices Institute of Nano Science Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

We conduct systematical cathodolumiuescence study on red-shift of near-band-edge emission energy in elastic bent ZnO nanowires with diameters within the exciton diffusion length （- 200 nm） in liquid nitrogen temperature （81 K）. By charactering the emission spectra of the nanowires with different; local curvatures, we find a linear relationship between strain-gradient and the red-shift of near-band-edge emission photon energy, an elastic strain-gradient effect in semiconductor similar to the famous flexoelectric effect in liquid crystals. Our results provide a new route to understand the inhomogeneous strain effect on the energy bands and optical properties of semiconductors and should be useful for designing advanced nano-optoelectronic devices.

关键词： strain-gradient ZnO nanowire cathodoluminescene exciton energy energy bands

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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei zhu Lingfeng Zeng Zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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Defining A Global Map of Functional Group-based 3D Ligand-binding Motifs

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 765-779页

作者： Liu Yang Wei He Yuehui Yun Yongxiang Gao Zhongliang zhu Maikun Teng zhi liang Liwen Niu School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Division of Molecular and Cellular Biophysics Hefei National Laboratory for Physical Sciences at the MicroscaleHefei 230026China

Uncovering conserved 3D protein–ligand binding patterns on the basis of functional groups(FGs)shared by a variety of small molecules can greatly expand our knowledge of protein–ligand *** that conserved binding patterns for a few commonly used FGs have been reported in the literature,large-scale identification and evaluation of FG-based 3D binding motifs are still ***,we propose a computational method,Automatic FG-based Three-dimensional Motif Extractor(AFTME),for automatic mapping of 3D motifs to different FGs of a specific *** our method to 233 naturally-occurring ligands,we define 481 FG-binding motifs that are highly conserved across different ligand-binding *** analysis further reveals four main classes of binding motifs corresponding to distinct sets of *** of FG-binding motifs facilitate the binding of proteins to a wide spectrum of ligands with various binding ***,we show that our FG–motif map can be used to nominate FGs that potentially bind to specific drug targets,thus providing useful insights and guidance for rational design of small-molecule drugs.

关键词： Protein–ligand interaction Functional group Binding motif Computational method Drug design

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Adhesive and cohesive force matters in deformable batteries

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npj Flexible Electronics 2021年第1期5卷 229-232页

作者： Guojin liang Jiaxiong zhu Ao Chen Qi Yang Chunyi zhi Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloonChina Hong Kong Center for Cerebro-Cardiovascular Health Engineering(COCHE) ShatinNTHKSARChina

Mechanical stability of flexible batteries is the guarantee for delivering stable *** interacting external and inner forces determine it.

关键词： guarantee forces stability

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Fast determination of tobramycin by reversed-phase ion-pair high performance liquid chromatography with a refractive index detector

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Frontiers of Chemical Science and Engineering 2013年第3期7卷 322-328页

作者： liang zhu Jingkang WANG Tianjin Key Laboratory of Marine Resources and Chemistry College of Marine Science and Engineering Yianjin University of Sciencc & Technology Tianjin 300457 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

A simple and direct method without a deriva- tion step for routine analysis of tobramycin has been developed. This method used reversed-phase ion-pair high performance liquid chromatography （HPLC） with a refractive index （RI） detector and a C18 column which is stable at pH above 1.00. The presence of *** ] trifluoroacetic acid （TFA） in the mobile phase improved the protonation of tobramycin and the formation of ionpairs, and thus reduced its hydrophility. This unique separation-detection combination showed good linearity with correlation coefficients 0.9996 in the concentration range of *** 1. The quantitation limit and detection limit were determined to be 0.23 *** ~ and 0.071 mg. mL ~, respectively. Tobramycin was recovered in 98.00%, 98.84% and 99.64% for tobramycin solutions at concentrations of 2.25 ***^-1, *** 1 and 0.75 *** ＇, respectively. The relative standard deviations for six spiked samples ranged from 0.20% to 2.40%, indicating a good reproducibility of this method.

关键词： tobramycin aminoglycoside refractive index detector high-performance liquid chromatography ionpairing

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Game-theoretic spectrum sharing for cognitive radio based on the expectation of primary users

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The Journal of China Universities of Posts and Telecommunications 2010年第3期17卷 6-12页

作者： MA liang zhu Qi Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing 210003 China National Mobile Communications Research Laboratory Southeast University Nanjing 210003 China

Cognitive radio is a new intelligent wireless communication technique for remedying the shortage of spectrum resource in recent years. Secondary users have to pay when they share available spectrum with primary users while price is an important factor in the spectrum allocation. Based on the game theory, an improved pricing function is proposed by considering the expectation of primary users. In this article, expectation represents the positivity of sharing spectrum with primary users. By introducing the positivity, price not only becomes different for different secondary users, but also can be adjusted according to the positivity. It is proved that the Nash Equilibrium of the new utility function exists. The simulation results show that spectrum sharing can not only be determined by the channel quality of secondary users, but also can be adapted according to the expectation of primary users. Besides, the proposed algorithm improves the fairness of sharing.

关键词： cognitive radio game theory spectrum allocation pricing function

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NUMERICAL　MODELING　AND　OPTIMAL　ESTIMATION　OF　THE　TRANSPORT　OF　GROUNDWATER　POLLUTION

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Journal of Hydrodynamics 1996年第4期8卷 18-24页

作者： Duan, Xiangbao zhu, liang Nanjing Hydraulic Research Inst Nanjing China

A numerical method for coupled solution of the equations of groundwater flow and pollution transportation is presented on the basis of operator-splitting algorithm, and the application of Kalman filtering technique into the study of groundwater pollution are explored also in the present paper. Computative examples indicate that the numerical method and application of Kalman theory can avoid the unhealthy tendencies in numerical modeling and hence attain the computative accuracy considerably.

关键词： operator-splitting method seepage groundwater pollution FEM Kalman filtering

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Energy efficient joint power and subcarrier assignment scheme in OFDM relay system

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The Journal of China Universities of Posts and Telecommunications 2015年第5期22卷 56-62页

作者： liang Xuanwei zhu Qi College of Telecommunications & Information Engineering Nanjing University of Posts and Telecommunications

A power and subcarrier assignment algorithm is proposed in this paper for maximizing the energy efficiency in the single-relay multi-users orthogonal-frequency-division-multiplexing(OFDM) systems. Under the constraints of maximum total power and minimum transmission rate, we formulate a joint optimization scheme for subcarrier pairing and power allocation to maximize the energy efficiency. The Dinkelbach’s method is used to depress the complexity and to transform the problem to a linear programming, then we use the dual decomposition approach solve the problem. In the premise of the system transmission rate, this algorithm uses the improved decode-and-forward(IDF) relay to maximize the system energy efficiency. Simulation results illustrate that,compared with the spectral-efficient maximization(SEM) algorithm, the energy-efficient maximization(EEM) algorithm proposed in this paper makes the energy efficiency not decline when the signal-to-noise radio(SNR) is at a high level. At the point where SNR is 10 d B and the number of subcarriers is 16, system energy efficiency is increased by 6.2% and 11.9% with the subcarrier pairing strategy and power allocation strategy respectively.

关键词： energy efficiency green communications multi-user

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Ohmic contact properties of p-type surface conductive layer on H-terminated diamond films prepared by DC arc jet CVD

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International Journal of Minerals,Metallurgy and Materials 2013年第8期20卷 802-807页

作者： Jin-long Liu Cheng-ming Li Rui-hua zhu liang-xian Chen Jing-jing Wang zhi-hong Feng School of Materials Science and Engineering University of Science and Technology Beijing Science and Technology on ASIC Laboratory Hebei Semiconductor Research Institute

With the advantages of high deposition rate and large deposition area, polycrystalline diamond films prepared by direct current （DC） arc jet chemical vapor deposition （CVD） are considered to be one of the most promising materials for high-frequency and high-power electronic devices. In this paper, high-quality self-standing polycrystalline diamond films with the diameter of 100 mm were prepared by DC arc jet CVD, and then, the p-type surface conductive layer with the sheet carrier density of 10^11-10^13 cm-2 on the H-terminated diamond film was obtained by micro-wave hydrogen plasma treatment for 40 min. Ti/Au and Au films were deposited on the H-terminated diamond surface as the ohmic contact electrode, respectively, afterwards, they were treated by rapid vacuum annealing at different temperatures. The properties of these two types of ohmic contacts were investigated by measuring the specific contact resistance using the transmission line method （TLM）. Due to the formation of Ti-related carbide at high temperature, the specific contact resistance of Ti/Au contact gradually decreases to 9.95 × 10^-5 Ω-cm2 as the temperature increases to 820℃. However, when the annealing temperature reaches 850℃, the ohmic contact for Ti/Au is degraded significantly due to the strong diffusion and reaction between Ti and Au. As for the as-deposited Au contact, it shows an ohmic contact. After annealing treatment at 550℃, low specific contact resistance was detected for Au contact, which is derived from the enhancement of interdiffusion between Au and diamond films.

关键词： polycrystalline materials diamond films chemical vapor deposition ohmic contacts contact resistance

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