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国际设计艺术院校联盟主席克里斯蒂安·格勒林访谈

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装饰 2009年第8期 60-61页

作者：周志朱亮

克里斯蒂安·格勒林(Christian Guellerin),法国南特高等设计学院院长,国际艺术、设计与媒体院校联盟(CUMULUS)主席。2009年7月11日—13日,由中国建筑装饰协会、中国国际经济合作发展局、清华大学美术学院、中国工业设计协会联合主办的... 详细信息

克里斯蒂安·格勒林(Christian Guellerin),法国南特高等设计学院院长,国际艺术、设计与媒体院校联盟(CUMULUS)主席。2009年7月11日—13日,由中国建筑装饰协会、中国国际经济合作发展局、清华大学美术学院、中国工业设计协会联合主办的第四届中国北京(国际)设计艺术博览会在北京展览馆举办,格勒林教授应组委会之邀来到中国,并专程访问了清华大学美术学院,本刊编辑借此良机走访了这位国际著名的设计教育家,以下为访谈录音整理内容。

关键词：国际经济合作设计学院艺术院校中国建筑装饰协会清华大学美术学院北京展览馆盟主设计艺术

发展设计水平,提升国家形象——郑曙旸教授访谈

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装饰 2009年第9期 44-47页

作者：周志朱亮

郑曙旸教授是清华大学美术学院常务副院长,也是我国环境艺术设计方面的著名专家。他从20世纪80年代起就参与了许多国家重点工程项目的建设工作,包括驻德使馆、中南海紫光阁、国务院接待楼、中央军委办公楼以及北京第11届亚运会的环境设... 详细信息

郑曙旸教授是清华大学美术学院常务副院长,也是我国环境艺术设计方面的著名专家。他从20世纪80年代起就参与了许多国家重点工程项目的建设工作,包括驻德使馆、中南海紫光阁、国务院接待楼、中央军委办公楼以及北京第11届亚运会的环境设计等等。从2005年起,主持制定了2008北京奥运会城市环境景观规划纲要。通过多年来参与国家重点项目实践工作的积累,郑曙旸教授对国家形象与设计的关系有着自己深刻的见解。本刊编辑近日就国家形象问题对郑教授进行了访谈,以下为访谈内容整理。

关键词：设计水平形象清华大学美术学院第11届亚运会北京奥运会环境艺术设计环境景观规划工程项目

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan zhi-Yuan Liu Zi-zhu Liu zhi-Cong Xiao Jing-Hui Li Cheng-zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

IVF-ET治疗后发生生化妊娠的相关因素分析

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中国优生与遗传杂志 2016年第12期24卷 137-140页

作者：王智超朱亮安徽医科大学合肥230032 解放军第306医院生殖医学中心北京100101

目的探讨经体外受精-胚胎移植(IVF-ET)治疗后发生生化妊娠的相关因素。对象选择2011年4月至2015年4月在我中心行IVF-ET治疗后发生生化妊娠的49例患者作为病例组(生化组);对照组为IVF-ET治疗后有活产的100例患者(活产组)。方法回顾性分... 详细信息

目的探讨经体外受精-胚胎移植(IVF-ET)治疗后发生生化妊娠的相关因素。对象选择2011年4月至2015年4月在我中心行IVF-ET治疗后发生生化妊娠的49例患者作为病例组(生化组);对照组为IVF-ET治疗后有活产的100例患者(活产组)。方法回顾性分析两组患者的临床资料,比较两组间各暴露因素的发生情况。结果女方年龄、取卵日内膜类型与生化妊娠发生的相关回归系数均>0(P<0.05);优胚率、移植胚胎数、移植后第4天E2值与生化妊娠发生的相关回归系数均<0(P<0.05)。结论 IVF-ET治疗周期,女方年龄,取卵日内膜类型是生化妊娠发生的危险因素;优胚率、移植胚胎数、移植后第4天E2值是生化妊娠发生的保护因素。

关键词：体外受精-胚胎移植生化妊娠 Logistic回归危险因素保护因素

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie zhu zhile liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第01期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong liang Weipeng Li Chengjian zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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无信号区输电线路智能监测系统的应用研究

通信电源技术 2019年第2期36卷 152-153页

作者：潘宏伟梁芝柱宁波供电公司浙江宁波315033

针对无信号覆盖区输电线路杆塔普遍具有日常巡视维护难度大且事故率高的特点,以输电线路智能监测系统为研究对象,采用实例研究的方式,准确掌握现场的覆冰程度、线路走廊周围环境状况、气象状况和导线是否有舞动等运行工况信息。通过分... 详细信息

针对无信号覆盖区输电线路杆塔普遍具有日常巡视维护难度大且事故率高的特点,以输电线路智能监测系统为研究对象,采用实例研究的方式,准确掌握现场的覆冰程度、线路走廊周围环境状况、气象状况和导线是否有舞动等运行工况信息。通过分析现场实施情况,阐述降低覆冰灾情发生倒塔/断线的事故率、降低线路维护人员特巡的工作量、提高输电部门智能化管理效率的优势,这对提升无信号区输电线路智能监测具有重要的现实意义。

关键词：无信号区案例分析线路智能监测事故

“Slope-adsorption & plateau-pore filling” mechanism unlocking the potential of hard carbon anodes for “fast-charging & large-sized”batteries

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Science China Materials 2025年第01期 309-311页

作者： Tian liang Xiaoming zhu Hubei Key Laboratory of Radiation Chemistry and Functional Materials School of Nuclear Technology and Chemistry & Biology Hubei University of Science and Technology

To date, there has been no report on fast-charging and Ahlevel sodium-ion batteries (SIBs) by utilizing thick hard carbon anodes that demonstrate prolonged cycling life and high areal capacity at high rates. Further, the relationship among the complex structure of hard carbon, storage mechanism, and fastcharging performance in alkali-metal ion batteries has been a subject of ongoing debate [1,2].

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Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells