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Chinese Journal of Polymer Science 2024年第10期42卷 1442-1448,I0008页

作者： Ya-Wen Liu Huan Liang Hong-Tu Xu En-Jian He zhi-jun yang Yi-Xuan Wang Yen Wei Zhen Li Yan Ji The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China Advanced Materials and Energy Center Academy of Aerospace Science and InnovationBeijing100088China

Realizing multiple locked shapes in pre-oriented liquid crystal elastomers(LCEs)is highly desired for diversifying deformations and enhancing ***,conventional LCEs only deform between two shapes for each actuation cycle upon liquid crystal-isotropic phase transitions induced by external ***,we propose to regulate the actuation modes and the locked shapes of a pre-orientated epoxy LCE by combining dynamic covalent bonds with cooling-rate-mediated *** actuation modes can be adjusted on demand by exchange reactions of dynamic covalent *** from the established actuation modes,such as elongation,bending,and spiraling,the epoxy LCE displays varied locked shapes at room temperature under different cooling *** mediums are utilized to control the cooling rate,including water,silicone oil,and copper *** approach provides a novel way for regulating the actuation modes and locked shapes of cuttingedge intelligent devices.

关键词： Liquid crystal elastomer Epoxy Dynamic covalent bond Vitrimer Cooling rate

Choline suppresses hepatocellular carcinoma progression by attenuating AMPK/mTOR-mediated autophagy via choline transporter SLC5A7 activation

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 393-411,I0001,I0002页

作者： Chen Wang Zhao-Yan Liu Wen-Ge Huang zhi-jun yang Qiu-Ye Lan Ai-Ping Fang Meng-jun Hou Xiao-Lin Luo Yao-jun Zhang Si Chen Hui-Lian Zhu Department of Nutrition School of Public HealthSun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouChina Center of Experimental Animals Sun Yat-sen UniversityGuangzhouChina Experimental and Teaching Center for Public Health School of Public HealthSun Yat-sen UniversityGuangzhouChina Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouChina

Background:Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-associated *** evidence suggests that autophagy plays a critical role in HCC tumorigenesis,metastasis,and *** is an essential nutrient related to prolonged survival and reduced risk of ***,it remains unclear whether this phenomenon is mediated by ***:Two HCC cell lines(HUH-7 and Hep3B)were used in the present *** growth was evaluated by cell counting kit 8(CCK-8),colony formation,and in vivo mouse xenografts *** motility was calculated by wound healing and transwell *** were measured by transmission electron microscope(TEM),and autophagy flux was detected by mRFP-GFP-labeled LC3 *** mRNA level of genes was measured by quantitative real-time polymerase chain reaction(qRT-PCR).The protein levels were detected by Western blotting(WB).Results:We found that choline inhibited the proliferation,migration,and invasion of HCC cells by downregulating autophagy in vitro and in *** expression of the solute carrier family 5 member 7(SLC5A7),a specific choline transporter,correlated with better HCC *** further discovered that choline could promote SLC5A7 expression,upregulate cytoplasm p53 expression to impair the AMPK/mTOR pathway,and attenuate ***,we found that choline acted synergistically with sorafenib to attenuate HCC development in vitro and in ***:Our findings provide novel insights into choline-mediated autophagy in HCC,providing the foothold for its future application in HCC treatment.

关键词： Hepatocellular carcinoma(HCC) autophagy choline solute carrier family 5 member 7(SLC5A7)

An exploration of the origin and flow of the development of traditional Chinese medicine orthopedic and chiropractic massage

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History & Philosophy of Medicine 2024年第4期6卷 1-6页

作者： Peng-Hui Li zhi-jun yang Lin Jiang You-Kang Dong The Second School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 650500China Department of Tuina The First Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021China

Traditional Chinese medicine(TCM)chiropractic massage is a kind of orthopedic therapy that corrects the abnormal anatomical position of bone or joint and corrects the dislocation of joint by manipulation so that the bone is soft and the Qi and blood are reconciled(Qi:The intangible,high-mobility nutritive substance that maintains vital activities).Manipulation treatment is the first of the four major orthopedic *** the same time,TCM chiropractic massage is also an essential part of *** orthopedic chiropractic practice originated from the struggle between humanity and nature,sprouted from the Warring States period to the two Han Dynasty,formed in the Sui,Tang,and Song Dynasties,matured in the Ming and Qing Dynasties,and flourished in the modern *** more than 2,000 years of development,many practical techniques have been produced,which have profoundly influenced the inheritance and development of modern techniques,making the TCM orthopedic chiropractic massage in the contemporary era form the characteristics of“tendon and bone”and“point-line-face combination”.At present,the development of TCM chiropractic massage is facing the great challenges of modern medicine and modern advanced science and technology such as American chiropractic and the limitations of its ***,in the future,the development direction of Chinese medicine orthopedic chiropractic massage should be“hybrid to treat”.In the face of modern medicine,we should take its essence to its dross,eclectic,organically integrate its advantages into itself,enrich its theoretical framework,and strengthen the construction of disciplines and departments to enhance its *** is believed that Chinese medicine orthopedic chiropractic massage can have better development in the future and can make more contributions to the health of the world’s people.

关键词： traditional Chinese medicine osteopathy manipulation traditional Chinese medicine chiropractic manipulation source and flow examination development and prospects

LPC parameters substitution for speech information hiding

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 103-112页

作者： WU zhi-jun GAO Wei yang Wei School of Electronics and Information Engineering Civil Aviation University of China Tianjin 300300 China

Information hiding techniques adopted in secret communication should meet the requirements of high hiding capacity,real-time and high *** the purpose of real-time speech secure communication,an information hiding algorithm based on the analysis-by-synthesis（ABS） speech coding scheme is presented in this *** algorithm substitutes secret speech data bits for linear predictive coefficients（LPCs） in linear predictive coding（LPC）.Statistics show that the change of voiced signal track is slow and the codebook for LPCs vector is large in ABS coding ***,a new concept,filter similarity,is proposed to determine the LPC parameters for substituting with secret speech information,and to generate multi-codebook for saving storage space to store secret speech *** achieve the best effects of information hiding,a dynamic threshold is built to make an optimal trade-off among hiding-capacity,security,robustness,transparence and real *** show that the proposed approach meets the requirements of information hiding and secret communication speech *** test results indicate that this approach reaches high hiding capacity with an excellent speech quality and complicating speakers＇ recognition.

关键词： ABS LPC LPCs information hiding filter similarity

Spectral Characteristics of LiSrBO_3:Tb^(3+) Green Phosphor

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Chemical Research in Chinese Universities 2009年第5期25卷 610-613页

作者： LI Pan-lai WANG zhi-jun yang zhi-ping GUO Qing-lin College of Physics Science ＆ Technology Hebei University Baoding 071002 P. R. China

LiSrBO3：Tb^3＋ green phosphor was synthesized by means of a solid state reaction and its spectral characteristics were studied. The emission spectrum of LiSrBO3：Tb^3＋ consists of four major bands at 486, 544, 595 and 620 nm under the excitation of near ultraviolet irradiation, which are originated from the ^5Da→^7F6, ^5D4→^7F5, ^5D4→^7F4 and ^5D4→^7F3 characteristic transitions of Tb^3＋, respectively. Monitored at 544 nm, the excitation spectrum of the phosphor extends from 220 nm to 390 nm, with the excitation peaks centered at 242, 277, 368 and 381 nm, respectively. The effect of Tb^3＋ concentration on the emission intensity of LiSrBO3：Tb^3＋ was also investigated. The results show that firstly the intensity increases with increasing Tb^3＋ concentration, reaches a maximum value at 3%（molar fraction） Tb^3＋ and then decreases, showing a concentration self-quenching, whose mechanism is proposed as a d-d interaction based on Dexter theory. The emission intensity of LiSrBO3：Tb^3＋ was enhanced by co-doping Li^＋, Na^＋ and K^＋.

关键词： LiSrBO3:Tb^3+ Green phosphor Spectral characteristics

Comparison of amplicon-sequencing, pyrosequencing and real-time PCR for detection of YMDD mutants in patients with chronic hepatitis B

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World Journal of Gastroenterology 2006年第44期12卷 7192-7196页

作者： zhi-jun yang Mei-Zeng Tu Jian Liu Xiao-Ling Wang Hong-zhi Jin Management School Shanghai Jiaotong University Shanghai 200052 China Laboratory Center First Hospital of Yangzhou Yangzhou 225001 Jiangsu Province China Laboratory Center Subei People's Hospital Yangzhou 225001 Jiangsu Province China School of Life Science Shanghai Jiaotong University Shanghai 200240 China

AIM: To compare the sequencing of PCR products, pyro- sequencing, and real-time PCR for detection of Tyrosine- methionine-aspartate-aspartate (YMDD) mutants in patients with chronic hepatitis B. METHODS: Mixtures of plasmids and serum samples from 69 chronic hepatitis B patients treated with lamivu- dine were tested for YMDD mutations by sequencing of PCR products, pyrosequencing, and real-time PCR, re- spectively. Time required and reagent costs of the three assays were evaluated. RESULTS: Real-time PCR detected 100%, 50%, 10%, 1% and 0.1% of YVDD plasmid in mixtures with 106 copies/mL of YMDD plasmid, whereas sequencing and pyrosequencing only detected 100% and 50% of YVDD plasmid in aliquots of the corresponding mixtures. Com- pletely concordant results were obtained from 60 (87%) out of the 69 clinical serum samples by the three assays. Mutants were detected by real-time PCR in less than 20% of the total virus population, but no mutant was de- tected by sequencing and pyrosequencing. In addition, real-time PCR required less time and was more cost-ef- fective than the other two assays. However, throughput of pyrosequencing was the highest. CONCLUSION: Among the three assays compared, real-time PCR is the most sensitive, cost-effective, and time saving for monitoring YMDD mutants in patients with chronic hepatitis B on lamivudine therapy.

关键词： Tyrosine-methionine-aspartate-aspartate mutant Hepatitis B virusi Real-time PCR Sequencing Pyrosequencing

Detection of *** using universal template real-time PCR

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World Journal of Gastroenterology 2006年第8期12卷 1308-1311页

作者： Rong-Sheng Wang Hua Zhang Yu-Fen Zhu Bei Han zhi-jun yang Jiangsu Oil Field Hospital Shaobo Jiangdu 225261 JiangsuProvince China Fosun Diagnositcs Shanghai 200233 China

AIM： To establish a rapid and accurate method for the detection of lamivudine-resistant mutations in hepatitis B virus and monitor of lamivudine resistance during lamivudine treatment in patients with chronic hepatitis B virus infection. METHODS： We established a real-time PCR method using a universal template and TaqMan probe to detect YMDD mutants. Variants of YVDD and YIDD were tested by individual reactions （reaction Ⅴ and reaction Ⅰ） and total hepatitis B viruses were detected in another reaction for control （reaction C）. Results were determined by △Ct〈3.5 （△Ct = Ct of reaction Ⅴ or Ⅰ - Ct of reaction C）. Clones of the HBV polymerase gene containing different YMDD mutations were tested. Serum samples from 163 lamivudine-treated patients with chronic hepatitis B virus infection were detected using this method and the results were confirmed by DNA sequencing. RESULTS： As many as 1000 copies per milliliter of widetype plasmid were detected and nonspecific priming was excluded. In the 163 samples from patients treated with lamivudine, lamivudine-resistant mutations were detected in 51 samples. CONCLUSION： This universal real-time PCR is a rapid and accurate method for quantification of YMDD mutants of HBV virus in lamivudine-treated patients and can be used to monitor lamivudine-resistant mutations before and during lamivudine therapy.

关键词： HBV, YMDD Mutation UT-PCR

Combined Detection of Serum Matrix Metalloproteinase 9,Acetyl Heparinase and Cathepsin L in Diagnosis of Ovarian Cancer

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Chinese Journal of Cancer Research 2012年第1期24卷 67-71页

作者： Wei Zhang Xiao-xia Hu Xing-zhi yang Qi Wang Hong Cheng Shu-mei Wang Yan-ling Hu zhi-jun yang Li Li Department of Gynecologic Oncology Cancer Institute and HospitalGuangxi Medical UniversityNanning 530021China Department of Gynecology and Obstetrics the People's Hospital of Guangxi ProvinceNanning 530022China

Objective： To investigate the clinic values of combining test of serum matrix metalloproteinase 9 （MMP-9）, acetyl heparinase （Hpa） and Cathepsin L （CL） in diagnosis of ovarian cancer. Methods： Serum levels of MMP-9, Hpa and CL were detected in a total of 418 cases, including 217 cases with ovarian malignant tumor, 100 cases with ovarian benign tumor and 101 healthy controls, by using enzyme-linked immunosorbent assay （ELISA）. Their correlation with clinicopathologic feature of ovarian malignant tumor was analyzed and their diagnosis performance was evaluated by receiver operating characteristic （ROC）. The combined diagnosis model was established by logistic regression analysis. Results： The serum levels of MMP-9, Hpa and CL were significantly higher in patients with ovarian malignant tumor than in benign tumor and healthy control, the serum levels of CL and Hpa were higher in epithelial cancer than in non-epithelial tumor, and MMP-9, Hpa and CL were elevated in low grade and advanced stage compared to high grade and early stage. The sensitivity for diagnosis of ovarian malignant tumor from high to low was CL, Hpa and MMP-9, and the specificity was MMP-9, CL and Hpa. The united diagnosis model was established and showed the sensitivity and specificity of combined detection were 84.6% and 82.1%, respectively, which were significantly higher than a single tumor marker. Conclusion： Serum MMP-9, Hpa and CL were correlated with ovarian malignant tumor and the combined detection of which may be valuable for clinical diagnosis of ovarian malignant tumor.

关键词： Ovarian cancer Matrix metalloproteinase 9 Acetyl heparinase Cathepsin Diagnosis

Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li Chen zhi-Xin Rao zhi Chen Zhao-Hui Wu Shuai yang zhi-jun Feng Hui-Yong yang Fan-Yan Zeng Xi-Bao Li Jin-yang Hu jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

Luminescence and Site Occupancy of Eu2＋ in Ba2 Ca（BO3）2

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Chinese Physics Letters 2011年第1期28卷 190-192页

作者： LI Pan-Lai WANG zhi-jun yang zhi-Ping GUO Qing-Lin Colleg-e of Physics Science and Technology Hebei University Baoding 071002

A green phosphor Ba2Ca（BOa）2：Eu2＋ was syntheMzed by a high temperature solid-state reaction method under a reductive amosphere,, The luminescence and site occupancy of Eu2＋ in Ba2Ca（BOa）2 are investigated. Ba2Ca（BO3）2：Eu2＋ shows one green band （537nzn） under 400nln near ultraviolet excitation which is suitable for UV LED. Ca2＋ and Ba2＋ ions in Ba2Ca（BO3）2 are replaced by Eu2＋ ions, the Ba2Ca（BO3）2：Eu2＋ shows a dissymmetrical emission band. The influence of Eu2＋ doping concentrations on the emission intensity of Ba2Ca（BOa）2：Eu2＋ is studied. It is found that the emission intensity is influenced by the Eu2＋ concentration and reaches the maxinmm value at 2% Eu2＋, According to the Dexter theory, the concentration quenching mechanisms of Eu2＋ in Ba2 Ca（B03）2 are the d - d interaction,

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