检索结果-南通市图书馆

Controllable Synthesis of Silicon-Based Nanohybrids for Reliable Surface-Enhanced Raman Scattering Sensing

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第6期40卷 734-745页

作者： Xing Lu Houyu Wang Yao he Suzhou Key Laboratory of Nanotechnology and Biomedicine Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhouJiangsu 215123China

Interface between metallic nanoparticles and dielectric silicon substrate can strongly confine electromagnetic field(EM-field)through its localized surface plasmons,together contributing great surface-enhanced Raman scattering(SERS)***,silicon-based nanohybrids(metallic nanoparticles in situ grown on silicon substrate)have been widely employed as SERS-active substrates in sensing platforms for the detection of chemical and biological ***-based nanohybrids with surface plasmons allow amplifying Raman signals that associate molecular binding events by several orders of *** with interfacial architectures for the specific binding of target analyte on the silicon-based nanohy-brid surface,silicon-based nanohybrid-enhanced Raman scattering represents a promising method for increasing reliability and *** re-view affords a presentation to the basics of SERS enhancement of silicon-based nanohybrid,illustrates current advances in controllable synthesis of silicon-based nanohybrid substrates,and outlines current implementations to sensors for reliable detection of ultralow amounts of analytes.

关键词： Raman spectroscopy Nanostructures Silicon Galvanic displacement Microfluidics

Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第4期33卷 365-372页

作者： he-Ren Gao Qian-Xing Zhuang Yong-Xiao Zhang Zhang-Peng Chen Bin Li Xiao-Yang Zhang Yi-Ting Zhong Jian-jun Wang Jing-Ning Zhu State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology School ofLife SciencesNanjing UniversityNanjing 210023China

Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion,and cognition. However, the role of orexin in somatic motor control is still little known. here, using whole-cell patch clamp recording and immunostaining, we investigated the effect and the underlying receptor mechanism of orexin-A on neurons in the globus pallidus internus（GPi）,a critical structure in the basal ganglia and an effective target for deep brain stimulation therapy. Our results showed that orexin-A induced direct postsynaptic excitation of GPi neurons in a concentration-dependent *** orexin-A-induced excitation was mediated via co-activation of both OX1 and OX2 receptors. Furthermore, the immunostaining results showed that OX1 and OX2 receptors were co-localized in the same GPi neurons. These results suggest that the central orexinergic system actively modulates the motor functions of the basal ganglia via direct innervation on GPi neurons and presumably participates in somatic-non-somatic integration.

关键词： Orexin OX1 receptor OX2 receptor Globus pallidus internus Basal ganglia

Guizhi-Shaoyao-zhimu decoction attenuates rheumatoid arthritis by inhibiting mast cell degranulation

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2023年第6期8卷 39-48页

作者： Lin Li Xiang-Yu Kong Wu Chen Mei-Jiao Wang zhi-Xing he Yun Zhang Cheng-Ping Wen Qiao Wang Lin Huang Institute of Basic Research in Clinical Medicine College of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Hangzhou 310053China

Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast ***:Collagen-induced arthritis was used to evaluate the effect of GSZ in preventing arthritis and joint *** staining revealed the accumulation of histamine H4 receptor and tryptase alpha/beta-1 in the ankle joint of the ***,we explored the effect of GSZ serum on fibroblast-like synoviocytes using standard transwell invasion and migration ***-time quantitative polymerase chain reaction and western blot were used to detect the expression of toll-like receptor 4(TLR4)/myeloid differentiationfactor 88(MyD88)/nuclear factor-κB p65(NF-κB p65).Results:The results showed that pre-rheumatoid arthritis treatment with GSZ could reduce inflammation and maintain cartilage structure in the collagen-induced arthritis ***,GSZ significantly blocked mast cell degranulation and inhibited the TLR4/MyD88/NF-κB p65 *** the combined activation of mast cells via TLR4 and immune complexes enhances inflammation in synovial tissue,we concluded that GSZ may block mast cell degranulation by inhibiting the TLR4/MyD88/NF-κB p65 pathway and thus influence rheumatoid arthritis ***:Taken together,our data suggested that GSZ may be a promising therapeutic decoction for the prophylactic treatment of rheumatoid arthritis.

关键词： rheumatoid arthritis mast cells degranulation TLR4

Responses of Alpine Wetlands to Climate Changes on the Qinghai-Tibetan Plateau Based on Remote Sensing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2020年第2期30卷 189-201页

作者： WANG Rui he Min NIU Zhenguo State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

The alpine wetlands in QTP(Qinghai-Tibetan Plateau)have been profoundly impacted along with global climate *** employ satellite datasets and climate data to explore the relationships between alpine wetlands and climate changes based on remote sensing *** show that:1)the wetland NDVI(Normalized Difference Vegetation Index)and GPP(Gross Primary Production)were more sensitive to air temperature than to precipitation *** wetland ET(evapotranspiration)across alpine wetlands was greatly correlated with precipitation rate.2)Alpine wetlands responses to climate changes varied spatially and temporally due to different geographic environments,variety of wetland formation and human disturbances.3)The vegetation responses of the Zoige wetland was the most noticeable and related to the temperature,while the GPP and NDVI of the Qiangtang Plateau and Gyaring-Ngoring Lake were significantly correlated with both temperature and precipitation.4)ET in the Zoige wetland showed a significantly positive trend,while ET in Maidika wetland and the Qiangtang plateau showed a negative trend,implying wetland degradation in those two wetland *** complexities of the impacts of climate changes on alpine wetlands indicate the necessity of further study to understand and conserve alpine wetland ecosystems.

关键词： Qinghai-Tibetan Plateau(QTP) alpine wetlands climate change Moderate-resolution Imaging Spectroradiometer(MODIS) remote sensing

钢套管再生混凝土加固柱抗震性能及影响参数研究

在线全文

学校读者我要写书评

暂无评论

工程力学 2019年第12期36卷 206-217,256页

作者：陈庆军梁竣杰蔡健黎哲何岸左志亮华南理工大学土木与交通学院广东广州510641 华南理工大学亚热带建筑科学国家重点试验室广东广州510641 代尔夫特理工大学土木工程与地球科学学院荷兰代尔夫特市

通过1个未加固的钢筋混凝土柱和9个钢套管加固钢筋混凝土柱的低周反复加载试验,研究了钢套管加固柱的抗震性能。随后在ABAQUS中,利用经试验校验的纤维梁模型,进行钢套管再生混凝土柱的数值模拟,并对相关影响因素进行参数化分析。结果表... 详细信息

通过1个未加固的钢筋混凝土柱和9个钢套管加固钢筋混凝土柱的低周反复加载试验,研究了钢套管加固柱的抗震性能。随后在ABAQUS中,利用经试验校验的纤维梁模型,进行钢套管再生混凝土柱的数值模拟,并对相关影响因素进行参数化分析。结果表明:经钢套管再生混凝土加固后,钢筋混凝土柱的抗震性能显著提升;在所研究的参数范围内,轴压比小于0.58时,加固柱抗侧承载力随轴压比的增大而提高,但轴压比大于0.58时,加固柱抗侧承载力随轴压比的增大显著下降,且损伤发展速度加快;钢套管厚度能提升加固柱的抗震性能,但提升幅度随厚度的增加而减缓;原柱轴压比对加固柱的力学性能和破坏模式有较大影响,且初始压弯组合应力显著降低高轴压比加固柱的压弯承载力;在钢套管的有效约束下,再生混凝土对构件整体承载力的影响不明显,但使得构件的抗震性能有所下降。

关键词：钢套管再生混凝土低周反复加载试验纤维梁模型参数化分析

考虑太阳帆板指向的编队卫星相对姿态跟踪控制

在线全文

学校读者我要写书评

暂无评论

宇航学报 2008年第1期29卷 202-207页

作者：张治国李俊峰宝音贺西清华大学航天航空学院北京10084

编队飞行一种应用是受控卫星对目标卫星跟飞或者绕飞,有效载荷指向目标卫星以执行各种任务。研究了太阳帆板固定的卫星姿态控制,在保证有效载荷始终指向目标卫星的前提下,使得太阳帆板尽可能朝向太阳。给出了太阳帆板法线与太阳光夹角... 详细信息

编队飞行一种应用是受控卫星对目标卫星跟飞或者绕飞,有效载荷指向目标卫星以执行各种任务。研究了太阳帆板固定的卫星姿态控制,在保证有效载荷始终指向目标卫星的前提下,使得太阳帆板尽可能朝向太阳。给出了太阳帆板法线与太阳光夹角最小的几何条件。采用四元数状态反馈的控制律实现了姿态跟踪,仿真结果检验了控制律有效性及太阳帆板朝向太阳的效果。

关键词：卫星编队飞行姿态跟踪控制太阳帆板指向

Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder

在线全文

学校读者我要写书评

暂无评论

National Science Review 2023年第11期10卷 34-44页

作者： Rongwei Zhai Geya Tong Zheqin Li Weichen Song Yang Hu Sha Xu Qiqi Wei Xiaocheng Zhang Yi Li Bingbing Liao Chenyu Yuan Yinqing Fan Ge Song Yinyin Ouyang Wenxuan Zhang Yaqiu Tang Minghui Jin Yuxian Zhang he Li zhi Yang Guan Ning Lin Dan J.Stein zhi-Qi Xiong Zhen Wang Shanghai Mental health Center Shanghai Jiao Tong University School of Medicine Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of Sciences Lingang Laboratory 4. Shanghai Center for Brain Science and Brain-Inspired Technology Translational Neuropsychiatry Unit(TNU) Department of Clinical MedicineAarhus University Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of Medicine

Obsessive-compulsive disorder(OCD) is a chronic and debilitating psychiatric disorder that affects ～2%–3% of the population globally. Studying spontaneous OCD-like behaviors in non-human primates may improve our understanding of the disorder. In large rhesus monkey colonies, we found 10 monkeys spontaneously exhibiting persistent sequential motor behaviors(SMBs) in individual-specific sequences that were repetitive, time-consuming and stable over prolonged periods. Genetic analysis revealed severely damaging mutations in genes associated with OCD risk in humans. Brain imaging showed that monkeys with SMBs had larger gray matter(GM) volumes in the left caudate nucleus and lower fractional anisotropy of the corpus callosum. The GM volume of the left caudate nucleus correlated positively with the daily duration of SMBs. Notably, exposure to a stressor(human presence) significantly increased SMBs. In addition, fluoxetine, a serotonergic medication commonly used for OCD, decreased SMBs in these monkeys. These findings provide a novel foundation for developing better understanding and treatment of OCD.

关键词： obsessive-compulsive disorder (OCD) primate ritualistic behavior model OCD risk genes caudate nucleus fluoxetine

Achieving high efficiency and low voltage loss simultaneously for non-fullerene organic solar cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第4期62卷 405-406页

作者： Liwei Yang Yanyan Jia he Yan School of Civil Engineering Chang'an University Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay

Conventional organic solar cells are based on fullerene acceptors,which caused several drawbacks including poor absorption in visible and near IR regions,limited tunability of energy levels,and most importantly,large voltage loss from the optical bandgap of the cell to the open circuit voltage of the solar cell[1].During the past few years,nonfullerene OSCs have emerged as a promising alternative to fullerene devices,as their optical and electronic properties can be readily ***,it has been demonstrated in numerous cases that non-fullerene OSCs[2]can achieve small voltage loss of about 0.55 V,which is much improved compared to that of conventional *** such a small voltage loss is of paramount importance to OSCs,as it indicates the maximum achievable efficiency of OSCs can be increased to nearly 20%.

关键词： high efficiency low voltage loss solar cells

Study of Pickering emulsions stabilized by mixed particles of silica and calcite

在线全文

学校读者我要写书评

暂无评论

Particuology 2010年第4期8卷 390-393页

作者： Sha Wang Yongjun he Yong Zou Department of Applied Chemistry Xi'an University of Science and Technology Xi'an 710054 China

Picketing emulsions were prepared using mixed particles of silica and calcite as emulsifiers. The effects of the silica content in the mixed particles on the stability and the drop size of the Picketing emulsions were investigated. The results showed that the Picketing emulsions were of the oil-in-water type. With increasing silica content in the mixed partides, the stability and the drop size of the Pickering emulsions decreased. Larger silica particles had more influence on the stability of the emulsions, while smaller ones had more influence on the drop size of the emulsions. The effect of the silica particles on the emulsions was attributed to their adsorptive behavior at the oil-water interfaces of the Picketing emulsions.

关键词： Calcite Silica Mixed panicles Pickering emulsions Stability