检索结果-南通市图书馆

Science China Chemistry 2019年第12期62卷 1675-1685页

作者： zhi-juan li Chang-Jiang Yao Yu-Wu Zhong Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of PhotochemistryCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China

A cyclometalated diruthenium complex 2 bridged by 1,2,4,5-tetra(pyrid-2-yl)benzene with six carboxylic acid groups at two ends was *** and multilayer films FTO/TiO2/(2)n(Zr)(n=1,2)and FTO/SnO2:Sb/(2)n(Zr)(n=1-4)have been prepared via interfacial layer-by-layer coordination assembly of 2 with zirconium(IV)*** films show two consecutive redox couples in the potential range between 0 and+1.0 V ***/*** films exhibit reversible near-infrared electrochromism upon switching of redox *** response time of the films on SnO2:Sb is around a few seconds,while that on TiO2 is around a few tens of *** film deposition cycles were found to have a great impact on the electrochromic *** six films examined,the two-layered film on SnO2:Sb displays the best balanced performance with a contrast ratio of 56%at 1,150 nm and good cyclic stability(9%loss of contrast ratio after 1,000 continuous double-potential-switching cycles),which is superior to that of the previously reported electropolymerized films of a related diruthenium complex with the same bridging *** addition,the X-ray photoelectron spectroscopy,scanning electron microscopy,and electron transfer mechanism of these films have been investigated.

关键词： electrochromism diruthenium complexes multilayer films metal oxides layer-by-layer assembly

Triterpene Acids from Cynoglossum amabile

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2009年第3期25卷 404-406页

作者： XU Qing-jun ZHANG De-zhi DANG li-juan li Kun-ping College of Pharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China

Cynoglossum amabile Stapf et Drumm is widely distributed in southern China, which has been used as an anti-inflammatory, antihepatitis, anticystitis agent in Chinese folk medicine. However, only a few phytochemical researches have been performed . Therefore, a systematic chemical investigation of it was carried out. In this work, we further investigated the chemical constituents and ten compounds were obtained, three of which were triterpene acids.

关键词： Cynoglossum amabile Triterpene acid Amabilic acid

Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfα-1 pathway

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第12期11卷 905-911页

作者： Fang liU Hui ZHONG Jing-yuan liANG Ping FU zhi-juan LUO li ZHOU Rong GOU Jun HUANG Division of Nephrology West China Hospital Sichuan University Chengdu 610041 China

In this paper, we investigate the effect and the possible mechanism of high glucose levels on the calcification of human aortic smooth muscle cells （HASMCs）. HASMCs were divided into four groups： normal glucose group （NG）, osmolality control group （OC）, high glucose group （HG, HASMCs culture medium containing 30 mmol/L glucose）, and high glucose plus recombinant human Noggin protein （bone morphogenetic protein-2 （BMP-2） antagonist） group （HN）. The mRNA levels and the protein expressions of BMP-2 and core binding factor alpha-1 （Cbfa-1） were measured by real-time quantitative polymerase chain reaction （PCR） and Western blot. After induced by 10 mmol/L β-glycerol phosphoric acid, cells were had＇vested for assessments of alkaline phosphatase （ALP） activities at Days 1,2, and 3, and intracellular calcium contents at Days 7 and 14, respectively. High glucose levels increased the mRNA levels and the protein expressions of BMP-2 and Cbfa-1 （P〈0.05）. The expression of Cbfa-1 was partially blocked by Noggin protein （P〈0.05）, while BMP-2 was not （P〉0.05）. After being induced by β-glycerol phosphoric acid, high glucose levels increased the ALP activity [（48.63±1.03） vs. （41.42±2.28） U/mg protein, Day 3; P〈0.05] and the intracellular calcium content [（2.76±0.09） vs. （1.75±0.07） μmol/mg protein, Day 14; P〈0.05] in a time-dependent manner when compared with the NG group, while the ALP activity could not be blocked by Noggin protein [（48.63±1.03） vs. （47.37±0.97） U/mg protein, Day 3; P〉0.05]. These results show that high glucose levels can evoke the calcification of HASMCs by inducing osteoblastic trans-differentiation and intracellular calcium deposition via the BMP-2/Cbfa-1 pathway, which can be partially blocked by Noggin protein.

关键词： Bone morphogenetic protein (BMP) Core binding factor alpha-1 (Cbfa-1) Vascular smooth muscle cell,Noggin protein

Inhibiting water evaporation of sandy soil by the soil particles modified with Japanese wax

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2009年第1期20卷 59-62页

作者： ZHANG Zeng-zhi WANG Hong-juan li Cui-Lan Research institute of Ecological and Functional Material China University of Mining and Technology Beijing 100083

This study was conducted to resolve the problems of water conservation of sandy soil in desertification areas. The surface of soil particles was modified by molecules of natural Japanese wax through some specially screened surfactant. The modified particles were then well sprayed onto the sand, which was placed in an artificial climate box with simulating desert environment, to form a soil film with effect of suppressing water and gas-permeability. Structure of soil film was analyzed by means of X-ray diftYaction （XRD） and infrared spectrometry （IR）. And its mechanism of water inhibition was illustrated with DSC and TG curves. Its influence on grass-planting was tested through the instruments of water detector. The results show that sorbitol anhydride stearate （ Span 80） could well disperse the Japanese wax and make it combine with the clay which is also dispersed. The pores among soil particles grew smaller and turned from hydrophilic into hydrophobic, in which way resistance to water penetrating through the film was increased. Experimental grass grows normally on sandy soil with the soil film in the artificial desert climate box, indicating that the soil particles modified with Japanese wax is an effective method to inhibit water evaporation.

关键词： Japanese wax surfactant desert soil hydrophobic soil film

The preparation and moisture-holding capacity of soil-based hydrophobic film with Japanese wax

在线全文

学校读者我要写书评

暂无评论

材料科学与工程（中英文版） 2008年第12期2卷 1-6页

作者： ZHANG Zeng-zhi WANG Hong-juan li Cui-lan Research Institute of Ecological and Functional Material China University of Mining and Technology. Beijing 100083 China

Near-infrared and Two-Wavelength Electrochromism Based on Nanocrystalline TiO2 Films Functionalized with Ruthenium-Amine Conjugated Complexes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Near-infrared and Two-Wavelength Electrochromism Based on Na...

liver Cirrhosis and Intestinal Bacterial Translocation

中国化学会第八届全国配位化学会议

作者： zhi-juan li Jiang-Yang Shao Yu-Wu Zhong Institute of Chemistry Chinese Academy of Science

Two cyclometalated ruthenium complexes 2[1] and 4 containing a redox-active amine substituent and three carboxylic acid groups were synthesized,where the ruthenium ion and the amine site was separated by a phenyl or biphenyl bridge for 2 and 4,*** TiO films on FTO/glass substrates anchored with 2 or 4 were *** films display two consecutive anodic waves in the potential region between +0.1 and +1.0 V vs Ag/*** four organic solvents examined,the FTO/TiO/2 film displays the best cyclic electrochemical stability in ClCH CH *** films exhibit promising two-step electrochromism in the NIR region.A contrast ratio(T%) of 42%at 1000 nm and 40%at 680 nm was achieved for the FTO/TiO/2 film in the single-and doubleoxidation process,*** contrast,the FTO/TiO/4 film shows electrochromism at 1300 nm(□ T%= 58%)and 780 nm(T%= 59%) in the single-and double-oxidation process,*** coloration efficiency of these processes varies in a range of 150-270 cm/*** conduction mechanism of these films is believed to be dominated by lateral hopping processes,with partial involvement of the valence band of TiO in the doubleoxidation *** films are potentially useful as variable optical attenuators for telecommunications.

关键词： ruthenium electochromism near-infrared titanium dioxide electrochemistry

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

国际感染病学（电子版） 2014年第3期3卷 133-138页

作者： Tao Lan Bao-chun Chen li-ping Fu zhi-juan li Xiang-jun Wu Nai-qiang Cui Graduate School of Tianjin University of Traditional Chinese Medicine Cangzhou People's Hospital Affiliated to Southern Medical University

Intestinal barrier dysfunction, facilitating translocation of bacteria and bacterial products, plays an important role in the pathophysiology of liver cirrhosis and its complications. Intestinal defense system including microbial barrier, immunologic barrier, mechanical barrier, chemical barrier, plays an important role in the maintenance of intestinal function. Under normal circumstances, the intestinal barrier can prevent intestinal bacteria through the intestinal wall from spreading to the body. Severe infection, trauma, shock, cirrhosis, malnutrition, immune suppression conditions, intestinal bacteria and endotoxin translocation, can lead to multiple organ dysfunction. The intestinal microflora is not only involved in the digestion of nutrients, but also in local immunity, forming a barrier against pathogenic microorganisms. The derangement of the gut microflora may lead to microbial translocation, defined as the passage of viable microorganisms or bacterial products from the intestinal lumen to the mesenteric lymph nodes and other extraintestinal sites. In patients with cirrhosis, primary and intestinal flora imbalance, intestinal bacterial overgrowth, intestinal mucosal barrier dysfunction, endotoxemia is associated with weakened immunity.

关键词： Cirrhosis Intestinal barrier Bacterial translocation Endotoxemia

在线全文

学校读者我要写书评

暂无评论

猕猴活体形态指标相关性分析

安徽农业科学 2008年第12期36卷 4958-4958,4972页

作者：职丽娟新乡学院河南新乡453002

对63例成年太行山猕猴的21项活体测量指标进行了相关性分析。结果表明:头高除了与体重、肩宽、尾长、手长、大腿长、头长的相关程度较小外,与大部分变量间的相关性都达显著或极显著。

关键词：猕猴活体形态比较相关分析太行山

在线全文

学校读者我要写书评

暂无评论

公平感对供应链成员定价决策影响的研究

管理科学学报 2017年第7期20卷 115-126页

作者：刘威志李娟张迪陈炜南京大学工程管理学院南京210093

本文研究公平感对由一个供应商和一个零售商组成的二级供应链中的定价决策的影响,其中供应商决定批发价格,零售商在接受供应商批发价格合同之后决定零售价格,市场需求受到零售价格的线性影响.采用管理实验方法得出,首先,供应商的批发价... 详细信息

本文研究公平感对由一个供应商和一个零售商组成的二级供应链中的定价决策的影响,其中供应商决定批发价格,零售商在接受供应商批发价格合同之后决定零售价格,市场需求受到零售价格的线性影响.采用管理实验方法得出,首先,供应商的批发价格和零售商的零售价格均分别低于完全理性假设下的均衡解;供应商是利他性的,即,乐于看到零售商收益的增加,并且,供应商认为零售商是完全理性的,即零售商的决策目标是最大化自身收益;然而,零售商却是刻毒性的,即乐于看到供应商收益的减少.其次,批发价格的变异度大于零售价格的,即供应商决策的难度大于零售商的.给管理者的启示是:供应商应考虑零售商的刻毒性的特征,降低批发价格,以提高零售商接受供应商所提批发价格的概率;此外,还应该为供应商提供辅助决策手段,以降低批发价格的变异度。

关键词：公平感变异度管理实验

Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2