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Application of multi-algorithm ensemble methods in high-dimensional and small-sample data of geotechnical engineering:A case study of swelling pressure of expansive soils

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1896-1917页

作者： Chao li Lei Wang jie li Yang Chen School of Urban Railway Transportation Shanghai University of Engineering ScienceShanghai201620China Discipline of Civil and Infrastructure Engineering RMIT UniversityMelbourne3001Australia School of Naval Architecture and Civil Engineering Shanghai Jiao Tong UniversityShanghai200240China

Geotechnical engineering data are usually small-sample and high-dimensional,which brings a lot of challenges in predictive *** paper uses a typical high-dimensional and small-sample swell pressure(P_(s))dataset to explore the possibility of using multi-algorithm hybrid ensemble and dimensionality reduction methods to mitigate the uncertainty of soil parameter *** on six machine learning(ML)algorithms,the base learner pool is constructed,and four ensemble methods,Stacking(SG),Blending(BG),Voting regression(VR),and Feature weight linear stacking(FWL),are used for the multi-algorithm ***,the importance of permutation is used for feature dimensionality reduction to mitigate the impact of weakly correlated variables on predictive *** results show that the proposed methods are superior to traditional prediction models and base ML models,where FWL is more suitable for modeling with small-sample datasets,and dimensionality reduction can simplify the data structure and reduce the adverse impact of the small-sample effect,which points the way to feature selection for predictive *** on the ensemble methods,the feature importance of the five primary factors affecting P_(s) is the maximum dry density(31.145%),clay fraction(15.876%),swell percent(15.289%),plasticity index(14%),and optimum moisture content(13.69%),the influence of input parameters on P_(s) is also investigated,in line with the findings of the existing literature.

关键词： Expansive soils Swelling pressure Machine learning(ML) Multi-algorithm ensemble Sensitivity analysis

High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-Ming li Ya-Ting Chen Meng-jie Deng Yan li Yue-Ming Peng Jian-Jun Gao zhi-Wei Mo Jia-Guo Zhou zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

A robust tensor watermarking algorithm for diffusion-tensor images

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 384-397页

作者： Chengmeng liU zhi li Guomei WANG Long ZHENG State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang 550025China

Watermarking algorithms that use convolution neural networks have exhibited good robustness in studies of deep learning ***,after embedding watermark signals by convolution,the feature fusion eficiency of convolution is relatively low;this can easily lead to distortion in the embedded *** distortion occurs in medical images,especially in diffusion tensor images(DTIs),the clinical value of the DTI is *** address this issue,a robust watermarking algorithm for DTIs implemented by fusing convolution with a Transformer is proposed to ensure the robustness of the watermark and the consistency of sampling distance,which enhances the quality of the reconstructed image of the watermarked DTIs after embedding the watermark *** the watermark-embedding network,Ti-weighted(Tlw)images are used as prior *** correlation between T1w images and the original DTI is proposed to calculate the most significant features from the T1w images by using the Transformer *** maximum of the correlation is used as the most significant feature weight to improve the quality of the reconstructed *** the watermark extraction network,the most significant watermark features from the watermarked DTI are adequately learned by the Transformer to robustly extract the watermark signals from the watermark *** results show that the average peak signal-to-noise ratio of the watermarked DTI reaches 50.47 dB,the diffusion characteristics such as mean diffusivity and fractional anisotropy remain unchanged,and the main axis deflection angleαAc is close to *** proposed algorithm can effectively protect the copyright of the DTI and barely affects the clinical diagnosis.

关键词： Robust watermarking algorithm Transformer Image reconstruction Diffusion tensor images Soft attention Hard attention Tl-weighted images

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： li Song Xiao-Hong Zhong Fang-lin Wang zhi-Hui Huang Zhe Hong Yun-Fang Gao Hai-Dong Wang Jian-Wei Ren Sheng-jie Peng Lei li College of Biological Chemical Sciences and EngineeringJiaxing University College of Chemical Engineering Zhejiang University of Technology College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Research and Development Department Jiangxi Ganfeng Li Energy Technology Co.Ltd. Department of Mechanical Engineering Science University of Johannesburg

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***, the carbon nanotubes（CNTs） coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH（denoted as SN-Ni Co-LDH） nanosheets array are grown on Ni Co foam（NCF） substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation costs. Benefiting from the S–N co-doping and low-crystallinity of Ni Co-LDH, the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g-1(4.94 C·cm-2) at 5 m A·cm-2. Furthermore, the fabricated asymmetry supercapacitor（ASC） achieves an extraordinary energy density of 77 Wh·kg-1(0.617 m Wh·cm-2) at a power density of 438 W·kg-1(3.5 m W·cm-2) and outstanding stability(91% capacity retention after 5000 cycles at20 m A·cm-2). Impressively, the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman spectra. Therefore,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance, and also provides guidance for the rational design of the smart electrodes.

关键词： Carbon nanotubes Convenient synthesis NiCo-LDH Sulfur and nitrogen co-doped Supercapacitor

Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： li jie CHEN Ya-feng GAO Lei li Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(EliSA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(Plity,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

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Military Medical Research 2023年第1期10卷 17-31页

作者： Piao Luo Qian Zhang Tian-Yu Zhong Jia-Yun Chen Jun-Zhe Zhang Ya Tian liu-Hai Zheng Fan Yang ling-Yun Dai Chang Zou zhi-jie li Jing-Hua liu Ji-Gang Wang Artemisinin Research Center and Institute of Chinese Materia MedicaChinese Academy of Chinese Medical SciencesBeijing 100700China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Laboratory Medicine the First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000JiangxiChina Department of Geriatric Medicine Shenzhen People’s Hospitalthe Second Clinical Medical CollegeJinan University and the First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020GuangdongChina Guangdong Provincial Key Laboratory of Proteomics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Center for Reproductive Medicine Dongguan Maternal and Child Health Care HospitalSouthern Medical UniversityDongguan 523125GuangdongChina Central People’s Hospital of Zhanjiang Zhanjiang 524037GuangdongChina

Background: Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol(Cel) is a natural anti-inflammatory compound that shows potential against systemic inflammatory diseases. This study aimed to investigate the pharmacological activity and molecular mechanism of Cel in models of endotoxemia and ***: We evaluated the anti-inflammatory efficacy of Cel against endotoxemia and sepsis in mice and macrophage cultures treated with lipopolysaccharide(LPS). We screened for potential protein targets of Cel using activity-based protein profiling(ABPP). Potential targets were validated using biophysical methods such as cellular thermal shift assays(CETSA) and surface plasmon resonance(SPR). Residues involved in Cel binding to target proteins were identified through point mutagenesis, and the functional effects of such binding were explored through gene ***: Cel protected mice from lethal endotoxemia and improved their survival with sepsis, and it significantly decreased the levels of pro-inflammatory cytokines in mice and macrophages treated with LPS(P lity group box 1(HMGB1) protein, reducing the secretion of inflammatory cytokine interleukin(IL)-1β. Cel bound to the Cys residues in lactate dehydrogenase A(LDHA).Conclusions: Cel inhibits inflammation and the Warburg effect in sepsis via targeting PKM2 and HMGB1 protein.

关键词： Celastrol Sepsis Pyruvate kinase M2 High mobility group box 1 Aerobic glycolysis

A new integrated model of deformation resistance and its application in prediction of rolling force of a thick plate

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Journal of Iron and Steel Research International 2024年第4期31卷 882-893页

作者： Shun-hu Zhang Yan li li-zhi Che Wen-hao Tian Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The prediction accuracy of existing models of the rolling force of a thick plate is always very *** address this problem,a high-precision genetic algorithm-backpropagation network(GA-BP)model of deformation resistance was built,and its integration with the traditional fitted model was further ***,a novel rolling force model was obtained by embedding the integration model of deformation resistance in the original model of rolling *** to this research idea,the industrial data are normalized at *** this basis,the interactions among the process parameters were disclosed through the variance analysis,and then described by various virtual *** factors are set as part of input ***,the optimal structure of the GA-BP model of deformation resistance was determined and an integration model of deformation resistance was ***,a novel rolling force model is obtained by substituting the traditional fitted deformation resistance into the Sims model with the integration model of the deformation *** results proves that the introduction of virtual factors can increase the hit rate of±5%from 75.8%to 78%and can reduce the root mean square error from 4.72%to 4.48%.Besides,it is found that the mean relative error of the traditional fitted deformation resistance is 0.142,while that of the modified deformation resistance is only *** addition,the mean relative error in the original rolling force model is 0.145,while that of the present model is only 0.03.

关键词： Integration model-Deformation resistance Variance analysis Virtual factor Genetic algorithm-backpropagation network model

Meibomian glands segmentation in infrared images with limited annotation

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 401-407页

作者： Jia-Wen lin ling-jie lin Feng Lu Tai-Chen Lai Jing Zou lin-ling Guo zhi-Ming lin li li College of Computer and Data Science Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou UniversityFuzhou 350108Fujian ProvinceChina Shengli Clinical Medical College of Fujian Medical University Fuzhou 350001Fujian ProvinceChina Department of Ophthalmology Fujian Provincial Hospital South BranchFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

●AIM:To investigate a pioneering framework for the segmentation of meibomian glands(MGs),using limited annotations to reduce the workload on ophthalmologists and enhance the efficiency of clinical diagnosis.●METHODS:Totally 203 infrared meibomian images from 138 patients with dry eye disease,accompanied by corresponding annotations,were gathered for the study.A rectified scribble-supervised gland segmentation(RSSGS)model,incorporating temporal ensemble prediction,uncertainty estimation,and a transformation equivariance constraint,was introduced to address constraints imposed by limited supervision information inherent in scribble *** viability and efficacy of the proposed model were assessed based on accuracy,intersection over union(IoU),and dice coefficient.●RESULTS:Using manual labels as the gold standard,RSSGS demonstrated outcomes with an accuracy of 93.54%,a dice coefficient of 78.02%,and an IoU of 64.18%.Notably,these performance metrics exceed the current weakly supervised state-of-the-art methods by 0.76%,2.06%,and 2.69%,***,despite achieving a substantial 80%reduction in annotation costs,it only lags behind fully annotated methods by 0.72%,1.51%,and 2.04%.●CONCLUSION:An innovative automatic segmentation model is developed for MGs in infrared eyelid images,using scribble annotation for *** model maintains an exceptionally high level of segmentation accuracy while substantially reducing training *** holds substantial utility for calculating clinical parameters,thereby greatly enhancing the diagnostic efficiency of ophthalmologists in evaluating meibomian gland dysfunction.

关键词： infrared meibomian glands images meibomian gland dysfunction meibomian glands segmentation weak supervision scribbled annotation

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2655-2663页

作者： zhi-Min Fan Dao-Lei Wu Neng-Wen Xu li Ye li-Ping Yan lin-jie li Jun-Yu Zhang Department of Hematology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Ophthalmology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of General Practice Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Municipal Central HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 *** is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)*** often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate *** SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase *** analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary *** chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and *** patient tolerated treatment well,and reached partial *** patient had recurrence of hepatocellular carcinoma and died of multifunctional organ *** survived for 12 months after *** Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

关键词： Marginal zone lymphoma High-grade B-cell lymphoma Terminal deoxynucleotidyl transferase Venetoclax TP53 mutation Case report