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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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THE UPWIND FINITE ELEMENT SCHEME AND MAXIMUM PRINCIPLE FOR NONLINEAR CONVECTION-DIFFUSION PROBLEM

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Journal of Computational Mathematics 2004年第5期22卷 699-718页

作者： zhi-yongZhao jian-weiHu LPMCandISC SchoolofMathematicalSciencesNankaiUniverstyLiuHuiCenterforAppliedMathematicsNankaiUniversityTianjin300071China

In this paper, a kind of partial upwind finite element scheme is studied for twodimensional nonlinear convection-diffusion problem. Nonlinear convection term approximated by partial upwind finite element method considered over a mesh dual to the triangular grid, whereas the nonlinear diffusion term approximated by Galerkin method. A linearized partial upwind finite element scheme and a higher order accuracy scheme are constructed respectively. It is shown that the numerical solutions of these schemes preserve discrete maximum principle. The convergence and error estimate are also given for both schemes under some assumptions. The numerical results show that these partial upwind finite element scheme are feasible and accurate.

关键词： Convection-diffusion problem Partial upwind finite element Maximum principle

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A Parallel Genetic Algorithm Based on Spark for Pairwise Test Suite Generation

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Journal of Computer Science & Technology 2016年第2期31卷 417-427页

作者： Rong-zhi Qi zhi-jian Wang Shui-Yan Li College of Computer and Information Hohai University Nanjing 211106 China CoUege of Science Hohai University Nanjing 211106 China

Pairwise testing is an effective test generation technique that requires all pairs of parameter values to be by at least one test case. It has been proven that generating minimum test suite is an NP-complete problem covered Genetic algorithms have been used for pairwise test suite generation by researchers. However, it is always a time-consuming process, which leads to significant limitations and obstacles for practical use of genetic algorithms towards large-scale test problems. Parallelism will be an effective way to not only enhance the computation performance but also improve the quality of the solutions. In this paper, we use Spark, a fast and general parallel computing platform, to parallelize the genetic algorithm to tackle the problem. We propose a two-phase parallelization algorithm including fitness evaluation parallelization and genetic operation parallelization. Experimental results show that our algorithm outperforms the sequential genetic algorithm and competes with other approaches in both test suite size and computational performance. As a result, our algorithm is a promising improvement of the genetic algorithm for pairwise test suite generation.

关键词： pairwise testing parallel genetic algorithm Spark test generation

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Illuminating Neural Circuits in Alzheimer’s Disease

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Neuroscience Bulletin 2021年第8期37卷 1203-1217页

作者： Yang Ying jian-zhi Wang Department of Pathophysiology School of Basic MedicineMinistry of Education Key Laboratory for Neurological DisordersHubei Key Laboratory for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Alzheimer’s disease(AD)is the most common neurodegenerative disorder and there is currently no *** circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with ***,it is important to understand the structural features and mechanisms underlying the deregulated circuits during AD progression,by which new tools for intervention can be ***,we briefly summarize the most recently established cutting-edge experimental approaches and key techniques that enable neural circuit tracing and manipulation of their *** also discuss the advantages and limitations of these ***,we review the applications of these techniques in the discovery of circuit mechanisms underlyingβ-amyloid and tau pathologies during AD progression,and as well as the strategies for targeted AD treatments.

关键词： Neural circuit Alzheimer’s disease Single cell RNA sequencing Neural circuit tracing Optogenetics Chemogenetics

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Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease

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Neuroscience Bulletin 2014年第2期30卷 359-366页

作者： jian-zhi Wang zhi-Hao Wang Qing Tian Department of Pathology and Pathophysiology Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical College Huazhong University of Science and Technology

Since abnormal post-translational modifications or gene mutations of tau have been detected in over twenty neurodegenerative disorders, tau has attracted widespread interest as a target protein. Among its various post-translational modifications, phosphorylation is the most extensively studied. It is recognized that tau hyperphosphorylation is the root cause of neurodegeneration in Alzheimer＇s disease （AD）; however, it is not clear how it causes neurodegeneration. Based on the findings that tau hyperphosphorylation leads to the escape of neurons from acute apoptosis and simultaneously impairs the function of neurons, we have proposed that the nature of AD neurodegeneration is the consequence of aborted apoptosis induced by tau phosphorylation. Therefore, proper manipulation of tau hyperphosphorylation could be promising for arresting AD neurodegeneration. In this review, the neuroprotective and neurodegenerative effects of tau hyperphosphorylation and our thoughts regarding their relationship are presented.

关键词： Alzheimer's disease microtubule-associated protein tau hyperphosphorylaUon apoptosis neurodegeneration

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Ultrasound enhancement of the reduction of the Basic Green dye in wastewater by cast iron

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Journal of Environmental Sciences 2006年第1期18卷 1-3页

作者： SHEN Zhuang-zhi SHEN jian-zhong Institute of Acoustics Chinese Academy of Sciences Beijing 100080 China

Dyes in wastewater are of particular environmental concern since they give an undesirable color to the waters, dye and their derivatives are harmful to human health and the environment （ Annadurai et al., 2002）. Due to their biological persistency, conventional biological treat-ment processes such as activated sludge process are ineffective for their removal（Shaul et al., 1991）. There is a need to develop effective methods for the degradation of such persistent organic pollutants, either to less harmful compounds or, more desirable, to their complete mineralization.

关键词： cast iron ultrasound Basic Green combined effect

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Alzheimer's disease: from molecule to clinic

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Neuroscience Bulletin 2014年第2期30卷 169-171页

作者： jian-zhi Wang Department of Pathophysiology Key Laboratory of Neurological Diseases of The Ministry of Education Tongji Medical College Huazhong University of Science and Technology

AIzheimer＇s disease （AD） is the most common neurodegenerative disorder and is characterized pathologically by the progressive intracellular accumulation of neurofibrillary tangles and extracellular deposition of plaques in the brain. Since hyperphosphorylated tau and ^-amyloid （A/3） are respectively the major components of the tangles and the plaques, recent studies have mainly focused on the alterations associated with these two molecules. Clinically, AD features memory deterioration. More than 6 million patients in China alone are suffering from this devastating disease, and this figure is increasing with the acceleration of population ageing. Although many specific aspects of AD have been documented, the disease is hard to diagnose in the early stage and the efficacy of current treatments is very limited. Therefore, AD is attracting worldwide attention.

关键词： from molecule to clinic Alzheimer’s disease AD

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High-fidelity quantum memory realized via Wigner crystals of polar molecules

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Chinese Physics B 2012年第1期21卷 91-100页

作者： Xue Peng Wu jian-zhi Department of Physics Southeast UniversityNanjing 211189China

The collective excitations of spin states of an ensemble of polar molecules are studied as a candidate for high- fidelity quantum memory. To avoid the collisional properties of the molecules, they are arranged in dipolar crystals under one or two dimensional trapping conditions. We calculate the lifetime of the quantum memory by identifying the dominant decoherence mechanisms and estimating their effects on gate operations when a molecular ensemble qubit is transferred to a microwave cavity.

关键词： polar molecules quantum memory molecular dipolar crystals

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Mechanism of Mg2+ dissolution from olivine and serpentine: Implication for bioleaching of high-magnesium nickel sulfide ore at elevated pH

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International Journal of Minerals,Metallurgy and Materials 2019年第9期26卷 1069-1079页

作者： jian-zhi Sun jian-kang Wen Bo-wei Chen Biao Wu National Engineering Laboratory of Biohydrometallurgy GRINM Group Corporation Limited

To inhibit the dissolution of Mg^2+ during the bioleaching process of high-magnesium nickel sulfide ore, the effect of major bioleaching factors on the dissolution of Mg^2+ from olivine and serpentine was investigated and kinetics studies were carried out. The results indicated that the dissolution rate-controlling steps are chemical reaction for olivine and internal diffusion for serpentine. The most influential factor on the dissolution of Mg^2+ from olivine and serpentine was temperature, followed by p H and particle size. A novel method of bioleaching at elevated pH was used in the bioleaching of Jinchuan ore. The results showed that elevated pH could significantly reduce the dissolution of Mg^2+ and acid consumption along with slightly influencing the leaching efficiencies of nickel and cobalt. A model was used to explain the leaching behaviors of high-magnesium nickel sulfide ore in different bioleaching systems. The model suggested that olivine will be depleted eventually, whereas serpentine will remain because of the difference in the rate-controlling steps. Bioleaching at elevated pH is a suitable method for treating high-magnesium nickel sulfide ores.

关键词： olivine serpentine high-magnesium nickel sulfide ore bioleaching shrinking core model elevated pH

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THE PRECISE AND NEW ANALYSIS FOR A MODE Ⅲ GROWING CRACK IN AN ELASTIC-PERFECTLY PLASTIC SOLID

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Applied Mathematics and Mechanics(English Edition) 1993年第4期14卷 345-352页

作者： Yi zhi-jian Bridge and Structural Engineering Department Chongqing Jiaotong InstituteChongqing

The near crack line field analysis method has been used to investigate into Mode III quasistatically propagating crack in an elastic-perfectly plastic *** significance of this paper is that the usual small scale yielding theory has been broken *** obtaining the general solutions of the stresses and the displacement rate of the near crack line plastic region,and by matching the general solutions with the precise elastic fields(not the usual elastic K-dominant fields)at the elastic-plastic boundary,the precise and new solutions of the stress and deformation fields,the size of the plastic region and the unit normal vector of the elastic-plastic boundary have been obtained near the crack *** solutions of this paper are sufficiently precise near the crack line region because the roughly qualitative assumptions of the small scale yielding theory have not been used and no other roughly qualitative assumptions have been taken,*** analysis of this paper shows that the assumingly'steady-state case'for stable crack growth,which has been discussed attentively in previous works,do not exist,and the plastic strains near the crack line do not have singularities,Two most important cases for stable crack growth have been discussed.

关键词： quasistatically propagating crack crack line elastic-plastic boundary precise solutions

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