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Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

World Journal of Gastroenterology 2024年第24期30卷 3086-3105页

作者： Miao-Miao lin Shan-Shan Yang Qiu-Yue Huang Guang-hui Cui Xiao-Fen Jia Yao Yang Zong-Ming Shi hui Ye Xue-zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100034China

BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric *** infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to *** has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in *** In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected *** vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,*** most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm *** assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm *** violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP *** effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain ***-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD *** HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the *** had str

关键词： Qingre Huashi decoction Helicobacter pylori Drug resistance Biofilm Metabolomics

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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan Ying-Shi Zou Ying-lin Yu Le-Yi Hu Ting Zhang hui Chen ling Jin Duo-Ru lin Yi-zhi Liu Hao-Tian lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu lin Shen hui-Fan Liu Xiang-hui Zou Juan Zhao Yu Huang Yu-Fan Zhu Zhao-Yu Li Chao Xu Li-Hua Luo zhi-Qiang Luo Min-Hao Wu lin Cai Xiao-Kun Li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 ***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

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Percutaneous transhepatic stenting for acute superior mesenteric vein stenosis after pancreaticoduodenectomy with portal vein reconstruction:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1195-1202页

作者： Chen lin Zi-Yan Wang Liang-Bo Dong zhi-Wei Wang Ze-hui Li Wei-Bin Wang Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery Peking Union Medical College HospitalBeijing 100730China Interventional Section Department of RadiologyPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Percutaneous transhepatic stent placement has become a common strategy for the postoperative treatment of portal vein(PV)/superior mesenteric veins(SMV)stenosis/*** has been widely used after liver transplantation surgery;however,reports on stent placement for acute PV/SMV stenosis after pancreatic surgery within postoperative 3 d are *** SUMMARY Herein,we reported a case of intestinal edema and SMV stenosis 2 d after pancreatic *** patient was successfully treated using stent *** the stenosis resolved after stent placement,complications,including bleeding,pancreatic fistula,bile leakage,and infection,made the treatment highly *** use of anticoagulants was adjusted multiple times to prevent venous thromboembolism and the risk of *** careful treatment,the patient stabilized,and stent placement effectively managed postoperative PV/SMV *** Stent placement is effective and feasible for treating acute PV/SMV stenosis after pancreatic surgery even within postoperative 3 d.

关键词： Pancreaticoduodenectomy Portal vein reconstruction Portal vein stenosis Portal vein stent Case report

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Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： Jian-Chao Liang zhi-Feng Ding Chun-lin Li Yi-Ming Hu zhi-Xin Zhou Gan-Wen Lie Xiao-Nan Niu Wen-Bin Huang hui-Jian Hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China huizhou Institute of Forestry(huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the Hu line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation Hu line Species dispersal ability Breeding birds

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Polysaccharide of Alocasia cucullata Exerts Antitumor Effect by Regulating Bcl-2, Caspase-3 and ERK1/2 Expressions during Long-Time Administration

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Chinese Journal of Integrative Medicine 2024年第1期30卷 52-61页

作者： ZHOU Qi-chun XIAO Shi-lin lin Ru-kun LI Chan CHEN zhi-jie CHEN Yi-fei LUO Chao-hua MO zhi-xian lin Ying-bo School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Clinical and Basic Research Team of TCM Prevention and Treatment of Non-Small Cell Lung Cancer the Second Clinical College of Guangzhou University of Chinese MedicineGuangzhou(510120)China Department of Chinese Medicine Zhujiang Hospital Affiliated to Southern Medical UniversityGuangzhou(510282)China Department of Pharmacy Jiangmen Central HospitalJiangmen(529000)China

Objective: To study the in vitro and in vivo antitumor effects of the polysaccharide of Alocasia cucullata(PAC) and the underlying mechanism. Methods: B16F10 and 4T1 cells were cultured with PAC of 40 μg/m L, and PAC was withdrawn after 40 days of administration. The cell viability was detected by cell counting kit-8. The expression of Bcl-2 and Caspase-3 proteins were detected by Western blot and the expressions of ERK1/2 mRNA were detected by quantitative real-time polymerase chain reaction(qRT-PCR). A mouse melanoma model was established to study the effect of PAC during long-time administration. Mice were divided into 3 treatment groups: control group treated with normal saline, positive control group(LNT group) treated with lentinan at 100 mg/(kg·d), and PAC group treated with PAC at 120 mg/(kg·d). The pathological changes of tumor tissues were observed by hematoxylin-eosin staining. The cell apoptosis of tumor tissues was detected by TUNEL staining. Bcl-2 and Caspase-3 protein expressions were detected by immunohistochemistry, and the expressions of ERK1/2, JNK1 and p38 mRNA were detected by qRT-PCR. Results: In vitro, no strong inhibitory effects of PAC were found in various tumor cells after 48 or 72 h of administration. Interestingly however, after 40 days of cultivation under PAC, an inhibitory effect on B16F10 cells was found. Correspondingly, the long-time administration of PAC led to downregulation of Bcl-2 protein(P <0.05), up-regulation of Caspase-3 protein(P<0.05) and ERK1 mRNA(P<0.05) in B16F10 cells. The above results were verified by in vivo experiments. In addition, viability of B16F10 cells under long-time administration culture in vitro decreased after drug withdrawal, and similar results were also observed in 4T1 cells. Conclusions: Long-time administration of PAC can significantly inhibit viability and promote apoptosis of tumor cells, and had obvious antitumor effect in tumor-bearing mice.

关键词： polysaccharide of Alocasia cucullata tumor cells Bcl-2 Caspase-3 ERK1/2 Chinese medicine

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Stable stripe and vortex solitons in two-dimensional spin-orbit coupled Bose-Einstein condensates

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Communications in Theoretical Physics 2024年第6期76卷 26-33页

作者： Yuan Guo Muhammad Idrees Ji lin hui-jun Li Institute of Nonlinear Physics and Department of Physics Zhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics and Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua 321004China

We present a flexible manipulation and control of solitons via Bose-Einstein *** the presence of Rashba spin-orbit coupling and repulsive interactions within a harmonic potential,our investigation reveals the numerical local solutions within the *** manipulating the strength of repulsive interactions and adjusting spin-orbit coupling while maintaining a zero-frequency rotation,diverse soliton structures emerge within the *** include plane-wave solitons,two distinct types of stripe solitons,and odd petal solitons with both single and double *** stability of these solitons is intricately dependent on the varying strength of spin-orbit ***,stripe solitons can maintain a stable existence within regions characterized by enhanced spin-orbit coupling while petal solitons are unable to sustain a stable existence under similar *** rotational frequency is introduced to the system,solitons undergo a transition from stripe solitons to a vortex array characterized by a sustained *** rotational directions of clockwise and counterclockwise are non-equivalent owing to spin-orbit *** a result,the properties of vortex solitons exhibit significant variation and are capable of maintaining a stable existence in the presence of repulsive interactions.

关键词： Bose-Einstein condensate spin-orbit coupling rotation frequency stripe solitons vortex array

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Digitalizing river aquatic ecosystems

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Journal of Environmental Sciences 2024年第3期137卷 677-680页

作者： Yaohui Bai hui lin Chenchen Wang Qiaojuan Wang Jiuhui Qu Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China School of Environmental and Municipal Engineering Tianjin Chengjian UniversityTianjin 300384China Center for Water and Ecology Tsinghua UniversityBeijing 100084China

Traditional river health assessment relies on limited water quality indices and representative organism activity,but does not comprehensively obtain biotic and abiotic information of the ***,we propose a new approach to evaluate the ecological and health risks of river aquatic ***,detailed physicochemical and biological characterization of a river ecosystem can be obtained through pollutant determination(especially emerging pollutants)and DNA/RNA ***,supervised machine learning can be applied to perform classification analysis of characterization data and ascertain river ecosystem ecology and *** proposed methodology transforms river ecosystem health assessment and can be applied in river management.

关键词： Digitalizing River ecosystem health Emerging pollutants High throughput sequencing Machine learning

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Research on intelligent search-and-secure technology in accelerator hazardous areas based on machine vision

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Nuclear Science and Techniques 2024年第4期35卷 96-107页

作者： Ying-lin Ma Yao Wang Hong-Mei Shi hui-Jie Zhang School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Prompt radiation emitted during accelerator operation poses a significant health risk,necessitating a thorough search and securing of hazardous areas prior to ***,manual sweep methods are ***,the limitations of manual sweeps have become increasingly evident with the implementation of large-scale *** leveraging advancements in machine vision technology,the automatic identification of stranded personnel in controlled areas through camera imagery presents a viable solution for efficient search and *** the criticality of personal safety for stranded individuals,search and security processes must be sufficiently *** ensure comprehensive coverage,180°camera groups were strategically positioned on both sides of the accelerator tunnel to eliminate blind spots within the monitoring *** YOLOV8 network model was modified to enable the detection of small targets,such as hands and feet,as well as larger targets formed by individuals near the ***,the system incorporates a pedestrian recognition model that detects human body parts,and an information fusion strategy is used to integrate the detected head,hands,and feet with the identified pedestrians as a cohesive *** strategy enhanced the capability of the model to identify pedestrians obstructed by equipment,resulting in a notable improvement in the recall ***,recall rates of 0.915 and 0.82were obtained for Datasets 1 and 2,*** there was a slight decrease in accuracy,it aligned with the intended purpose of the search-and-secure software *** tests conducted within an accelerator tunnel demonstrated the effectiveness of this approach in achieving reliable recognition outcomes.

关键词： Search and secure Machine vision Camera Human body parts recognition Particle accelerator Hazardous area

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Thickness dependence of superconductivity in layered GeP_(5)

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Rare Metals 2024年第3期43卷 1323-1328页

作者： lin Wu Ke-Meng Yang Wei Gan Rui-Chun Xiao Ya-Jie Dai Xi Tang Hong lin hui Han hui Li Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei230601China

Understanding the relationship between dimensionality and superconductivity has attracted substantial research *** this work,we report the effective modulation of superconductivity in GeP_(5)through *** superconducting phase transition temperature improves by~10%as the thickness of GeP_(5)decreases from bulk to~96 nm,behaving as a unique negative relationship between the superconducting phase transition temperatureand thickness.

关键词： superconductivity dimensionality

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