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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 307-318页

作者： Lu Xu zhi-hao xie Jun Li Shi Tao Fang-Li Ren Yin-Yin Wang zhi-Jie Chang Xin-Bao hao Department of Hematology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China State Key Laboratory of Membrane Biology School of MedicineTsinghua UniversityBeijing 100084China Heya Beijing Med-Biotech Inc. Beijing 100084China Department of Hematology Roswell Park Comprehensive Cancer CenterNY 14263USA

Objective:To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma(DLBCL)and its potential as a therapeutic ***:This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival *** vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and ***:RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor *** vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling ***:RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular *** RPRD1B may offer a novel therapeutic strategy for DLBCL,suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.

关键词： RPRD1B RNAPⅡ Diffuse large B-cell lymphoma NF-κB Apoptosis

Efficient secretory expression of phospholipase D for the high-yield production of phosphatidylserine and phospholipid derivates from soybean lecithin

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Synthetic and Systems Biotechnology 2023年第2期8卷 273-280页

作者： Peng Zhang Jin-Song Gong zhi-hao xie Chang Su Xiao-Mei Zhang zhi-Ming Rao Zheng-Hong Xu Jin-Song Shi Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of Life Sciences and Health EngineeringJiangnan UniversityWuxi214122PR China National Engineering Research Center for Cereal Fermentation and Food Biomanufacturing School of BiotechnologyJiangnan UniversityWuxi214122PR China Jiangsu Provincial Engineering Research Center for Bioactive Product Processing Jiangnan UniversityWuxi214122PR China Yixing Institute of Food and Biotechnology Co. LtdYixing214200PR China School of Chemical and Material Engineering Jiangnan UniversityWuxi214122PR China

Phospholipase D(PLD)is an essential biocatalyst for the biological production of phosphatidylserine and phospholipid ***,the efficient heterologous expression of PLD is limited by its cell *** this study,a PLD was secretory expressed efficiently in Bacillus subtilis with an activity around 100 U/mL.A secretory expression system containing the signal peptide SPEstA and the dual-promoter PHpaII-SrfA was estab-lished,and the extracellular PLD activity further reached 119.22 U/mL through scale-up fermentation,191.30-fold higher than that of the *** optimum reaction conditions,a 61.61%conversion ratio and 21.07 g/L of phosphatidylserine production were ***,the synthesis system of PL derivates was established,which could efficiently synthesis novel PL *** results highlight that the secretory expression system constructed in this study provides a promising PLD producing strain in industrial application,and laid the foundation for the biosynthesis of phosphatidylserine and other PL *** far as we know,this work re-ports the highest level of extracellular PLD expression to date and the enzymatic production of several PL der-ivates for the first time.

关键词： Phospholipase D Secretion expression Bacillus subtilis Biosynthesis Enzymatic PLs modification

Endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor:A case report

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World Journal of Clinical Oncology 2020年第12期11卷 1076-1083页

作者： zhi-Xiong Hu Min-Hua Tan Qiong-Zhen Li Jia-Li Xu Wei Chen zhi-hao xie Yong-Jian Zhou Qing Liang Jian-Hong An Hong Shen Department of Pathology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Gynaecology and Obstetrics The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina Department of Radiology The First People’s Hospital of ZhaoqingZhaoqing 526020Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Department of Pathology Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND To investigate the clinicopathological features of endometrial clear cell carcinoma that has invaded the right oviduct with a cooccurring ipsilateral oviduct adenomatoid *** SUMMARY A case of endometrial clear cell carcinoma invading the right oviduct with a cooccurring ipsilateral oviduct adenomatoid tumor was collected and analyzed using pathomorphology and *** clear cell carcinoma cells were distributed in a solid nest,papillary,shoe nail-like,and glandular tube-like *** was infiltrative growth,and tumor cells had clear cytoplasm and obvious nuclear *** cancer tissue was necrotic and *** cancer tissue invaded the right *** ipsilateral oviduct also had an adenomatoid *** adenomatoid tumor was arranged in microcapsules lined with flat or cubic cells that were surrounded by smooth muscle *** adenomatoid tumor cells were round in *** Clear cell carcinoma of the endometrium can invade the oviduct and occur simultaneously with tubal adenomatoid *** pathological diagnosis,one should pay close attention to distinguishing whether an endometrial clear cell carcinoma is invading the oviduct or whether it is accompanied by an adenomatoid tumor of the *** is helpful to differentiate these two disease *** clear cell carcinomas express Napsin-A and P16 and are negative for estrogen receptor and progesterone *** presence of endometrial clear cell carcinoma does not affect the expression of CK and calretinin in adenomatoid tumors.

关键词： Endometrium Clear cell carcinoma Oviduct Adenomatoid tumors Differential diagnosis Case report

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin xie Yuanhui Guo Yun Chen hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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ATM系统建模/仿真与评估环境研究

系统仿真学报 2008年第S2期20卷 225-228页

作者：蔡志浩谢劭辰陈峰北京航空航天大学无人机所北京100191

民航系统的快速发展对空中交通管理系统提出了更高的要求,通过建立空中交通管理系统评估体系,采用建模/仿真技术,针对现有空中交通管理系统的问题及未来新航行系统的特点,构建一个覆盖空中交通管理系统运行各阶段、接口灵活、可扩展、... 详细信息

民航系统的快速发展对空中交通管理系统提出了更高的要求,通过建立空中交通管理系统评估体系,采用建模/仿真技术,针对现有空中交通管理系统的问题及未来新航行系统的特点,构建一个覆盖空中交通管理系统运行各阶段、接口灵活、可扩展、模块化好的分布式建模/仿真支撑环境,为空管系统问题的快速建模、空管新技术在业务系统中应用的论证与验证、不同气象和人为条件下的空管系统运行情况等,提供仿真运行环境和评估手段。

关键词：空中交通管理建模/仿真评估环境可视化

真空包装结合低温处理对鲜切菠萝贮藏品质的影响

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食品工业科技 2018年第6期39卷 259-264页

作者：方宗壮段宙位窦志浩何艾谢辉海南省农业科学院农产品加工设计研究所海南省热带果蔬冷链研究重点实验室海南海口571100

以巴厘菠萝为试材,研究真空包装结合低温处理对鲜切菠萝贮藏期内可溶性固形物含量、失水率、褐变度、硬度、有机酸含量、维生素C含量以及多酚氧化酶(PPO)和过氧化物酶(POD)活性的影响。结果表明:和对照组相比,真空包装结合3℃低温贮藏... 详细信息

以巴厘菠萝为试材,研究真空包装结合低温处理对鲜切菠萝贮藏期内可溶性固形物含量、失水率、褐变度、硬度、有机酸含量、维生素C含量以及多酚氧化酶(PPO)和过氧化物酶(POD)活性的影响。结果表明:和对照组相比,真空包装结合3℃低温贮藏有效的保持了鲜切菠萝的品质,整个贮藏期间鲜切菠萝的失重率减少了4.31%~7.22%;褐变度降低了1.4~2.6;果实硬度提高了4.07~7.51 N;总可溶性固形物20 d时处理组比对照组高1.48;另外,经处理组处理后,相比对照组PPO活性降低了10.33~44.52 U·min^(-1)·g^(-1)FW;POD活性前8 d降低了19.36~27.25 U·min^(-1)·g^(-1)FW,有效的降低了酶活性,防止鲜切菠萝褐变的发生和维生素C的氧化,20 d时处理组维生素C的含量比对照组高8.44 mg/100 g,经处理后贮藏,鲜切菠萝的保质期从4 d延长到11 d。

关键词：鲜切菠萝真空贮藏品质贮藏期

Modeling of configurations and the third-order nonlinear optical properties of M@C82 （M=Sc,Y,La） and C82

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Modeling of configurations and the third-order nonlinear opt...

Relationship between martensite microstructure and ductility of H13 steel from aspect of crystallography

中国化学会第五届全国结构化学学术会议

作者： Hui Hu Wen-Dan Cheng~* Dong-Sheng Wu Juan Shen Shu-Ping Huang zhi xie hao Zhang State Key Laboratory of Structural Chemistry,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences.Fuzhou,Fujian 350002,People''s Republic of China

＜正＞M@C82（M=Sc,Y,La）is most widely experimentally and theoretically investigated as a representational monometallofullerene.[1]Until now much attention is focused mainly on the structural and electronic of them an...

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Journal of Iron and Steel Research International 2021年第10期28卷 1268-1281页

作者： Jian Zhu zhi-hao Zhang Jian-xin xie Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing100083China Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology BeijingBeijing100083China

Based on the parent austenite orientation reconstruction method,it is aimed to reveal the origination of high angle grain boundaries(HAGBs)and its relationship with ductility of H13 *** orientation relationship between martensite and parent austenite of quenched H13 samples was(123.5°,9.3°,192.5°),which agreed with the Kurdumov–Sachs *** variant distribution of quenched samples was dominated by close-packed plane group,and its high length fraction of V1/V2 inter-variant boundaries of calculated 62.6%was mainly contributed to HAGBs(>45°).When the quenched H13 samples underwent the pre-tempering treatment,their density of HAGBs(>45°)notably increased from 1.33 to 2.39μm^(−1),which improved its total elongation from 8.3%to 11.5%.Compared with the quenched H13 samples,the length fraction of V1/V2 inter-variant boundaries of H13 samples with pre-tempering for 5,10 and 60 min was reduced by 6.7%,7.0%and 7.5%,*** pre-tempering treatment,V1/V3&V5 variant pairs,etc.,merged V1/V2 variant pair by strain-induced grain boundary migration,which decreased the length fraction of V1/V2 inter-variant boundaries by 7.0%.The pre-tempering treatment significantly increased HAGBs(>45°)of H13 samples by sub-grains coarsening and strain-induced grain boundary migration mechanism.

关键词： H13 steel Pre-tempering treatment Variant selection Parent austenite orientation reconstruction High angle grain boundary

Hyper-crosslinked Conjugated Microporous Polymers with Increased Micropores Promotes Confining Polymerization for Electromagnetic Absorption Application

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Chinese Journal of Polymer Science 2023年第8期41卷 1305-1316,I0011页

作者： hao Chen Fang-Yuan Chu Hai-Yan Zhuang Lu Wang zhi-Min Ye Wei Dong zhi-Peng xie A-Ming xie School of Mechanical Engineering Nanjing University of Science&TechnologyNanjing 210094China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research Institute(LSMRI)Xiamen 361100China School of Chemistry and Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China

Conjugated microporous polymers have excellent skeleton structures but poor electrical conductivity limits their applications in microwave *** solve this problem,a strategy of molecular expansion and confining polymerization is proposed in this work to synthesize conductive hyper-crosslinked conjugated microporous *** topology of the conjugated microporous polymer is changed into a three-dimensional skeleton structure with high specific surface area by using molecular expansion technique,and the controlled growth of polypyrrole in the channel constructs a unique network *** balance of excellent composite backbone structure,proper conductivity,attenuation capability and impedance matching enable the material to exhibit electromagnetic wave absorption *** a result,with low filler loading of 10 wt%,a strongest reflection loss of-52.68 d B and a maximum effective bandwidth of 5.76 ***,CST simulations of the radar scattering cross section have been carried out to verify the excellent material *** study provides new concepts for new conductive polymers and broadens the application of hyper-crosslinked conjugated microporous polymer in the field of electromagnetic wave absorption.

关键词： Hyper-crosslinked conjugated microporous polymer Electromagnetic wave absorbing Molecular expansion Polypyrrole