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Combined treatment of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer

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World Journal of Gastroenterology 2009年第7期15卷 871-876页

作者： tian-Jie Qin Gai-Li An Xin-han Zhao Fang tian Xiao-Hua Li Juan-Wen Lian Bo-Rong Pan Shan-zhi Gu Department of Medical Oncology First Affiliated Hospital of Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Department of Oncology Cancer Institute Fourth Military Medical University Xi'an 710032 Shaanxi Province China Key Laboratory of Environment and Genes Related to Diseases Ministry of Education School of Medicine of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer(ESCC) and the survival of the ***:Sixty-four patients(median age of 63 years) with histological or cytological confirmation of ESCC received oxaliplatin 120 mg/m2 intravenously on day 1 and capecitabine 1000 mg/m2 orally twice daily on days 1 to 14 in a 21-d treatment cycle as palliative *** patient received at least two cycles of *** efficacy,side effects and patient survival were ***:The partial response(PR) rate was 43.8%(28/64).Stable disease(SD) rate was 47.9%(26/64),and disease progression rate was 15.6%(10/64).The clinical benefit rate(PR + SD) was 84.4%.The main toxicities were leukopenia(50.0%),nausea and vomiting(51.6%),diarrhea(50.0%),stomatitis(39.1%),polyneuropathy(37.5%) and hand-foot syndrome(37.5%).No grade 4 event in the entire cohort was *** median progression-free survival was 4 mo,median overall survival was 10 mo(95% CI:8.3-11.7 mo),and the 1-and 2-year survival rates were 38.1% and 8.2%,*** Karnofsky index,single metastatic lesion and response to the regimen indicated respectively good ***:Oxaliplatin plus capecitabine regimen is effective and tolerable in metastatic ESCC *** regimen has improved the survival moderately and merits further studies.

关键词： Oxaliplatin Capecitabine Metastaticesophageal squamous cell cancer Survival analysis

A survey of neural network accelerators

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Frontiers of Computer Science 2017年第5期11卷 746-761页

作者： Zhen LI Yuqing WANG tian zhi tianshi CHEN State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China School of Computer Science and Technology University of Science and Technology of China Hefei 230026 China

Machine-learning techniques have recently been proved to be successful in various domains, especially in emerging commercial applications. As a set of machine- learning techniques, artificial neural networks （ANNs）, requiring considerable amount of computation and memory, are one of the most popular algorithms and have been applied in a broad range of applications such as speech recognition, face identification, natural language processing, ect. Conventionally, as a straightforward way, conventional CPUs and GPUs are energy-inefficient due to their excessive effort for flexibility. According to the aforementioned situation, in recent years, many researchers have proposed a number of neural network accelerators to achieve high performance and low power consumption. Thus, the main purpose of this literature is to briefly review recent related works, as well as the DianNao-family accelerators. In summary, this review can serve as a reference for hardware researchers in the area of neural networks.

关键词： neural networks accelerators FPGAs ASICs,DianNao series

Experimental investigation of surface roughness effects on flow behavior and heat transfer characteristics for circular microchannels

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Chinese Journal of Aeronautics 2016年第6期29卷 1575-1581页

作者： Yuan Xing Tao zhi Li Haiwang tian Yitu National Key Laboratory of Science and Technology on Aero-Engine Beihang University Collaborative Innovation Center for Advanced Aero-Engine of China of Aerodynamics Beihang University

This paper experimentally investigates the effect of surface roughness on flow and heat transfer characteristics in circular microchannels. All test pieces include 44 identical, parallel circular microchannels with diameters of 0.4 mm and 10 mm in length. The surface roughness of the microchannels is R= 0.86, 0.92, 1.02 lm, and the Reynolds number ranges from 150 to *** show that the surface roughness of the circular microchannels has remarkable effects on the performance of flow behavior and heat transfer. It is found that the Poiseuille and Nusselt numbers are higher when the relative surface roughness is larger. For flow behavior, the friction factor increases consistently with the increasing Reynolds number, and it is larger than the constant theoretical value for macrochannels. The Reynolds number for the transition from laminar to turbulent flow is about 1500, which is lower than the value for macrochannels. For the heat transfer property, Nusselt number also increases with increasing Reynolds number, and larger roughness contributes to higher Nusselt number.

关键词： Circular Flow behavior Heat transfer Microchannels Roughness

Tracking control of the linear differential inclusion

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第6期12卷 464-469页

作者： Jun HUANG Zheng-zhi han School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 China

The tracking control of linear differential inclusion is discussed. First, the definition of uniformly ultimate boundedness for linear differential inclusion is given. Then, a feedback law is constructed by using the convex hull Lyapunov function. The sufficient condition is given to guarantee the tracking error system uniformly ultimately bounded. Finally, a numerical example is simulated to illustrate the effectiveness of this control design.

关键词： Linear differential inclusions Tracking control Convex hull Lyapunov functions Uniformly ultimate boundedness

Ant colony optimization for assembly sequence planning based on parameters optimization

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Frontiers of Mechanical Engineering 2021年第2期16卷 393-409页

作者： Zunpu han Yong WANG De tian Renewable Energy School North China Electric Power UniversityBeijing 102206China College of Mechanical and Electronic Engineering Tarim UniversityAlar 843300China

As an important part of product design and manufacturing, assembly sequence planning (ASP) has a considerable impact on product quality and manufacturing costs. ASP is a typical NP-complete problem that requires effective methods to find the optimal or near-optimal assembly sequence. First, multiple assembly constraints and rules are incorporated into an assembly model. The assembly constraints and rules guarantee to obtain a reasonable assembly sequence. Second, an algorithm called SOS-ACO that combines symbiotic organisms search (SOS) and ant colony optimization (ACO) is proposed to calculate the optimal or near-optimal assembly sequence. Several of the ACO parameter values are given, and the remaining ones are adaptively optimized by SOS. Thus, the complexity of ACO parameter assignment is greatly reduced. Compared with the ACO algorithm, the hybrid SOS-ACO algorithm finds optimal or near-optimal assembly sequences in fewer iterations. SOS-ACO is also robust in identifying the best assembly sequence in nearly every experiment. Lastly, the performance of SOS-ACO when the given ACO parameters are changed is analyzed through experiments. Experimental results reveal that SOS-ACO has good adaptive capability to various values of given parameters and can achieve competitive solutions.

关键词： assembly sequence planning ant colony optimization symbiotic organisms search parameter optimization

Nanocrystallization-locked Network of Poly(styrene-6-isobutylene-6-styrene)-g-Polytetrahydrofuran Block Graft Copolymer

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Chinese Journal of Polymer Science 2021年第7期39卷 874-886页

作者： hang-tian Zhang zhi-Tao Wei Fang Zhang tian Yang Yi-Xian Wu State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Sciences and EngineeringBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China

Poly(styrene-6-isobutylene-6-styrene)triblock copolymer(SIBS),a kind of thermoplastic elastomer with biocompatibility and biostability containing fully saturated soft segments,could be synthesized via living cationic copolymerization.A novel poly[(styrene-co-methylstyrene)-b-isobutylene-b-(styrene-co-methylstyrene)]-g-polytetrahydrofuran(M-SIBS-g-PTHF)block graft copolymer was prepared to increase the polarity and service temperature of SIBS by grafting polar PTHF segments onto SIBS.A series of the above block graft copolymers with average grafting numbers from 2 to 6 and molecular weights of PTHF branches ranging from 200 g·mol^(-1)to 4200 g·mol^(-1)were successfully synthesized via living cationic ring-opening polymerization of tetrahydrofuran(THF)coinitiated by *** introduction of PTHF branches led to an obvious microphase separation due to thermodynamic incompatibility among the three kinds of segments of polyisobutylene(PIB),polystyrene(PS)and ***,the microphase separation promotes the rearrangement of PTHF branches to form the nanocrystallization-locked physically cross-linked network after storage at room temperature for 2 months,leading to insolubility of the copolymers even in good *** melting temperature and enthalpy of PTHF nanocrystallization locked in hard domains of M-SIBS-g5-PTHF-1.1k block graft copolymer increased remarkably up to 153℃and 117.0 J·g^(-1)by 23℃and 11.6 J·g^-1(respectively after storage for long *** modulus(G′)is higher than loss modulus(G″)of M-SIBS-g-PTHF block graft copolymer at temperatures ranging from 100℃to 180℃,which is much higher than those of the SIBS triblock *** the best of our knowledge,this is the first example of high performance M-SIBS-g-PTHF block graft copolymers containing segments of PIB,PS and PTHF with nanocrystallization-locked architecture.

关键词： Poly(styrene-b-isobutylene-b-styrene) Polytetrahydrofuran Living cationic polymerization Block graft copolymers Nanocrystallization-locked network

Reference genes for quantitative real-time PCR analysis and quantitative expression of P5CS in Agropyron mongolicum under drought stress

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Journal of Integrative Agriculture 2016年第9期15卷 2097-2104页

作者： tian Qing-song WANG Shu-yan DU Jian-cai WU zhi-juan LI Xiao-quan han Bing Institute of Grassland Research Chinese Academy of Agricultural Sciences Hohhot 010010 P.R. China gronomy College Inner Mongolia Agricultural University Hohhot 010010 P.R. China College of Life Science Inner Mongolia Agricultural University Hohhot 010010 P.R. China

Reference genes, stably expressing in different tissues and cells, are commonly used as the references in expression analysis. Selecting the optimum reference gene is crucial to the success of experiments. In this study, the expression stabilities of nine common reference genes, including ACT2, 18 S r RNA, APRT, EF-1α, RNA POL II, TUBα, TUBβ, GAPDH and TLF of Agropyron mongolicum, were studied under drought condition. Among them, 18 S r RNA was found to be the most optimum reference gene under drought stress by the analyzing of ge Norm and Norm Finder software. Quantitative expression levels of P5 CS using 18 S r RNA as the reference gene, and proline contents under drought stress in A. mongolicum were further operated, and we found the expression level of P5 CS gene and proline content had a significantly positive relationship（R^2=0.7763, P〈0.05）. This study established and validated 18 S r RNA as the reference genes in A. mongolicum under drought stress, providing a powerful tool for the quantitative expression analysis of drought genes in A. mongolicum.

关键词： reference genes quantitative real-time PCR drought stress proline pyrroline-5-carboxylic acid synthetase Agropyron mongolicum

The effects of cool materials,façade orientation,and morphological parameters on energy consumption at the residential neighborhood scale

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Building Simulation 2024年第4期17卷 525-542页

作者： Fusuo Xu Dongdong tian zhi Gao Jianshun Jensen Zhang Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseNY13210USA School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjingJiangsu Province210093China

Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy *** study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,*** neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving *** and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are *** results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,*** cool materials on the south façade of buildings is not recommended due to significant heat loss in *** savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.

关键词： cool materials building energy saving neighborhood morphology façade orientation

Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma

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World Journal of Gastroenterology 2008年第33期14卷 5210-5216页

作者： tian-Jie Qin Xin-han Zhao Jun Yun Ling-Xiao Zhang zhi-Ping Ruan Bo-Rong Pan Department of Medical Oncology First Affiliated Hospital of Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Outpatient Department of Oncology Cancer Institute Fourth Military Medical University Xi'an 710032 Shaanxi Province China Department of the Third General Surgery Xijing Hospital Fourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM: To evaluate the efficacy and safety of gemcitabine-oxaliplatin (GEMOX) combined with huachansu (cinobufagin) injection treatment in patients with locally advanced or metastatic gallbladder carcinoma (GBC), and to assess the quality of life (QOL) of such patients. METHODS: Twenty-fi ve patients with locally advanced or metastatic GBC were treated with intravenous gemcitabine (1000 mg/m2) over 30 min on days 1 and 8, 2 h infusion of oxaliplatin (120 mg/m2) on day 1, and 2-3 h infusion of huachansu (20 mL/m2) on days -3-11, every 3-4 wk. Treatment was continued until occurrence of unacceptable toxicity or disease progression. QOL of patients was assessed by the EORTC QLQ-C30 at baseline, at the end of the fi rst, third and sixth chemotherapy cycles, and 1 mo after the treatment. RESULTS: Among the 25 patients with a median age of 64 years (range 42-78 years), 23 were evaluable in the study. A total of 137 cycles of therapy were performed and the median cycle was 5 (range 1-8) per patient. Out of the 23 patients whose response couldbe evaluated, 8 partial responses (PR) were observed (34.8%), while 7 patients (30.4%) demonstrated a stable disease (SD). The disease control rate was 65.2%. Progression of cancer was observed in 8 (34.8%) patients. The median progression-free and overall survival time was 5.8 mo (95% CI: 4.5-7.1 mo) and 10.5 mo, respectively. The therapy was well tolerated, with moderate myelosuppression as the main toxicity. Anemia grade 2 was seen in 16.0%, neutropenia grade 3 in 8.0% and thrombocytopenia grade 3 in 24.0% of patients, respectively. Non-hematologic toxicity ranged from mild to moderate. No death occurred due to toxicity. The QOL of patients was improved after chemotherapy, and the scores of QOL were increased by 10 to 20 points. CONCLUSION: GEMOX combined with huachansu (cinobufagin) injection is well tolerated, effective, thus improving the QOL of patients with advanced GBC.

关键词： Gallbladder carcinoma Gemcitabine Oxaliplatin Huachansu injection Quality of life