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Differentiation of pyogenic hepatic abscesses from malignant mimickers using multislice-based texture acquired from contrast-enhanced computed tomography

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 391-398页

作者： Shi-Teng Suo zhi-guo zhuang Meng-Qiu Cao Li-Jun Qian Xin Wang Run-Lin Gao Yu Fan Jian-Rong Xu Department of Radiology Renji-Hospitall School of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Hepatic Surgery Renji-Hospitall School of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Pathology Renji-Hospitall School of MedicineShanghai Jiaotong UniversityShanghai 200127China

BACKGROUND： Pyogenic hepatic abscess may mimic primary or secondary carcinoma of the liver on contrast-enhanced computed tomography（CECT）. The present study was to explore the usefulness of the analysis of multislice-based texture acquired from CECT in the differentiation between pyogenic hepatic abscesses and malignant ***： This retrospective study included 25 abscesses in 20 patients and 33 tumors in 26 subjects who underwent CECT. To make comparison, we also enrolled 19 patients with hepatic single simple cyst. The images from CECT were analyzed using a Laplacian of Gaussian band-pass filter（5 filter levels with sigma weighting ranging from 1.0 to 2.5）. We also quantified the uniformity, entropy, kurtosis and skewness of the multislice-based texture at different sigma weightings. Statistical significance for these parameters was tested with oneway ANOVA followed by Tukey honestly significant difference（HSD） test. Diagnostic performance was evaluated using the receiver operating characteristic（ROC） curve ***： There were significant differences in entropy and uniformity at all sigma weightings（P〈0.001） among hepatic abscesses, malignant mimickers and simple cysts. The significant difference in kurtosis and skewness was shown at sigma 1.8 and 2.0 weightings（P=0.002-0.006）. Tukey HSD testshowed that the abscesses had a significantly higher entropy and lower uniformity compared with malignant mimickers（P=0.000-0.004）. Entropy（at a sigma 2.0 weighting） had the largest area under the ROC curve（0.888） in differentiating abscesses from malignant mimickers, with a sensitivity of 81.8% and a specificity of 88.0% when the cutoff value was set to ***： Multislice-based texture analysis may be useful for differentiating pyogenic hepatic abscesses from malignant mimickers.

关键词： texture analysis contrast-enhanced computed tomography liver pyogenic hepatic abscess malignant mimicker

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Computed tomography perfusion study of hemodynamic changes and portal hyperperfusion in a rabbit model of small-for-size liver

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 74-80页

作者： zhi-guo zhuang,Jian-Rong Xu,Li-Jun Qian,Qiang Xia and Jia-Chang Chi Department of Radiology,and Center of Transplantation,Renji Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200127,China [a] Department of Radiology Shanghai Jiaotong University School of Medicine Shanghai 200127 Shanghai China [b] Center of Transplantation Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai 200127 Shanghai China

BACKGROUND:Portal hyperperfusion in the small-for-size (SFS) liver can threaten survival of ***,it is important to understand the hemodynamic changes in the SFS ***:Twenty rabbits were divided into two groups:a control group and a modulation *** control group underwent an extended *** modulation group underwent the same procedure plus splenectomy to reduce portal blood *** perfusion examinations were performed on all rabbits before and after *** parameter values,especially portal vein perfusion (PVP),were ***:PVP in the modulation group was lower than in the control group after operation (P=0.002).In the control group,postoperative PVP increased by 193.7±55.1% compared with preoperative PVP.A weak correlation was found between the increased percentage of PVP and resected liver-to-body weight ratio (RLBWR) (r=0.465,P=0.033).In the modulation group,postoperative PVP increased by 101.4±32.5%.No correlation was found between the increased percentage of PVP and RLBWR (r=0.167,P=0.644).Correlations were found between PVP and serum alanine aminotransferase,aspartate aminotransferase,and total bilirubin after surgery (P<0.05).CONCLUSION:We successfully evaluated the characteristics of hemodynamic changes as well as the effects of splenectomy in the SFS liver in rabbits by the CT technique.

关键词： computed tomography perfusion portal vein perfusion hemodynamics hepatectomy small-for-size liver

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Vascular complications following prophylactic balloon occlusion of the internal iliac arteries resolved by successful interventional thrombolysis in a patient with morbidly adherent placenta

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第3期18卷 272-276页

作者： Ning ZHANG Wei-hua LOU Xue-bin ZHANG Jia-ning FU Yun-yan CHEN zhi-guo zhuang Jian-hua LIN Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China Department of lnterventional Oncolog Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China Columbia Center for Translational Immunology Columbia University Medical Center New York NY 10032 USA Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200126 China

The increasing incidence of morbidly adherent placenta （MAP） is placing women at a higher risk of life-threatening massive hemorrhage. The involvement of interventional radiology to manage this complex condition by performing prophylactic lilac artery balloon occlusion has been reported recently. However, the effectiveness and safety of this technique have not been fully determined. Here we report the case of a 25-year-old woman with placenta increta with preemptive bilateral internal lilac artery balloons who had external lilac artery thrombosis detected by computed tomography angiography （CTA） 72 h post cesarean section. A digital subtraction angiogram （DSA） and intra-arterial thrombolysis were instantly performed followed by supplementary conservative treatments, leading to a desirable resolution, of thrombus without sequela. This is the first report of vascular complications with successful interventional thrombolysis in this setting. Our experience suggests that prophylactic lilac artery balloon occlusion should be used cautiously in cases of MAP and consideration given to minimizing vascular complications given the hypercoagulable state of pregnancy.

关键词： Balloon catheter Internal iliac artery Placenta accrete Vascular complication Interventional thrombolysis

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丹东地区地震海啸的危险性分析

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防灾减灾学报 2018年第3期34卷 97-100页

作者：郭志壮邓志岩丹东地震台辽宁丹东118000

针对丹东地区(主要东港市近海)近海地震对本地及周边地区可能引起的海啸进行科学的论证和分析;参考国内外及丹东本地的大量历史数据分析海啸可能造成的危害,针对可能性提出了合理的解决方案。

关键词：丹东地区近海地震海啸危险性分析

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Non-Darcy flows in layered porous media(LPMs)with contrasting pore space structures

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Petroleum Science 2022年第5期19卷 2004-2013页

作者： Xue-Yi Zhang zhi Dou Jin-guo Wang zhi-Fang Zhou Chao zhuang School of Earth Sciences and Engineering Hohai UniversityNanjing 210098JiangsuChina

Compared to single layer porous media,fluid flow through layered porous media(LPMs)with contrasting pore space structures is more *** study constructed three-dimensional(3-D)pore-scale LPMs with different grain size ratios of 1.20,1.47,and *** flow behavior in the constructed LPMs and single layer porous media was numerically investigated.A total of 178 numerical experimental data were collected in LPMs and single layer porous *** all cases,two different flow regimes(i.e.,Darcy and Non-Darcy)were *** influence of the interface of layers on Non-Darcy flow behavior in LPMs was analyzed based pore-scale flow *** was found that the available correlations based on single layer porous media fail to predict the flow behavior in LPMs,especially for LPM with large grain size *** effective permeability,which incorporated the influence of the interface is more accurate than the Kozeny-Carman equation for estimating the Darcy permeability of *** inertial pressure loss in LPMs,which determines the onset of the Non-Darcy flow,was underestimated when using a power law expression of mean grain *** constant B,an empirical value in the classical Ergun equation,typically equals *** inertial pressure loss in LPMs can be significantly different from it in single lager porous *** Non-Darcy flow in LPMs,it is necessary to consider a modified larger constant B to improve the accuracy of the Ergun empirical equation.

关键词： Non-Darcy flow Layered porous media Heterogeneity Forchheimer equation Simulations

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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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结直肠癌进展与抑制的十字路口:间充质干细胞治疗干预效果及难题

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中国组织工程研究 2025年第23期29卷 5022-5030页

作者：郭昭庄浩岩史学文山东中医药大学第一临床医学院山东省济南市250000 山东中医药大学附属医院肛肠科山东省济南市250000

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用... 详细信息

背景:结直肠癌早期的治疗方法包括内镜和手术切除,但是术后并发症多,晚期多采用化疗方法,然而化疗会引起胃肠功能紊乱、骨髓抑制、肝肾功能损伤等不良反应,导致大多数患者不主动、不配合治疗。目的:综述间充质干细胞治疗结直肠癌的作用机制、最新治疗进展及目前存在的问题,为将来临床应用提供依据。方法:计算机检索Pub Med数据库、中国知网、万方数据库收录的相关文献。英文检索词为“mesenchymal stem cells,colorectal cancer,cancer stem cell,tumor microenvironment”,中文检索词为“间充质干细胞,结直肠癌,癌症干细胞,肿瘤微环境”,最终纳入119篇文献进行分析。结果与结论:(1)间充质干细胞对于结直肠癌具有促进和抑制的双面作用;(2)间充质干细胞的肿瘤归巢特性使其能够准确迁移到肿瘤位置并释放药物,基于这一特性,增加了治疗结直肠癌的安全性和有效性;(3)间充质干细胞衍生的外泌体作为良好的药物载体,在结直肠癌靶向治疗中显示出良好的应用前景;(4)使用病毒载体、非病毒载体或其他转染工具将具有成熟抗肿瘤作用的药物加载到间充质干细胞中,共同治疗结直肠癌;(5)间充质干细胞与化疗药物联合使用可以提高化疗药物疗效并降低化疗药物不良反应;(6)间充质干细胞促进结直肠癌的发展机制主要与结直肠癌细胞中的信号转导、趋化因子的表达状态及间充质干细胞向癌症相关成纤维细胞转化有关;(7)间充质干细胞可能具有驱动癌症干细胞的特性,促进肿瘤起始并提高肿瘤侵袭性;(8)间充质干细胞治疗结直肠癌还存在着不可避免的问题:缺乏标准化治疗方案及疗效评价方法、治疗成本高昂、间充质干细胞的保存与运输问题、间充质干细胞与化疗药物共同使用的比例等。

关键词：结直肠癌间充质干细胞癌症干细胞肿瘤微环境化疗外泌体

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Theoretical estimation of sonochemical yield in bubble cluster in acoustic field

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Chinese Physics B 2020年第1期29卷 357-365页

作者： zhuang-zhi Shen School of Physics&Information Technology Shaanxi Normal UniversityShaanxi Key Laboratory of UltrasonicsXi'an 710119China

In order to learn more about the physical phenomena occurring in cloud cavitation,the nonlinear dynamics of a spherical cluster of cavitation bubbles and cavitation bubbles in cluster in an acoustic field excited by a square pressure wave are numerically investigated by considering viscosity,surface tension,and the weak compressibility of the *** theoretical prediction of the yield of oxidants produced inside bubbles during the strong collapse stage of cavitation bubbles is also *** effects of acoustic frequency,acoustic pressure amplitude,and the number of bubbles in cluster on bubble temperature and the quantity of oxidants produced inside bubbles are *** results show that the change of acoustic frequency,acoustic pressure amplitude,and the number of bubbles in cluster have an effect not only on temperature and the quantity of oxidants inside the bubble,but also on the degradation types of pollutants,which provides a guidance in improving the sonochemical degradation of organic pollutants.

关键词： bubble cluster models bubble cluster dynamics chemical kinetics bubble temperature strong oxidants acoustic cavitation

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Multi-Exposure Motion Estimation Based on Deep Convolutional Networks

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Journal of Computer Science & Technology 2018年第3期33卷 487-501页

作者： zhi-Feng Xie Yu-Chen guo Shu-Han Zhang Wen-Jun Zhang Li-zhuang Ma Department of Film and Television Engineering Shanghai University Shanghai 200072 China Shanghai Engineering Research Center of Motion Picture Special Effects Shanghai 200072 China Department of Software Science and Technology East China Normal University Shanghai 200062 China

In motion estimation, illumination change is always a troublesome obstacle, which often causes severely per- formance reduction of optical flow computation. The essential reason is that most of estimation methods fail to formalize a unified definition in color or gradient domain for diverse environmental changes. In this paper, we propose a new solution based on deep convolutional networks to solve the key issue. Our idea is to train deep convolutional networks to represent the complex motion features under illumination change, and further predict the final optical flow fields. To this end, we construct a training dataset of multi-exposure image pairs by performing a series of non-linear adjustments in the traditional datasets of *** estimation. Our multi-exposure flow networks （MEFNet） model consists of three main components： low-level feature network, fusion feature network, and motion estimation network. The former two components belong to the contracting part of our model in order to extract and represent the multi-exposure motion features; the third component is the expanding part of our model in order to learn and predict the high-quality optical flow. Compared with many state- of-the-art methods, our motion estimation method can eliminate the obstacle of illumination change and yield optical flow results with competitive accuracy and time efficiency. Moreover, the good performance of our model is also demonstrated in some multi-exposure video applications, like HDR （high dynamic range） composition and flicker removal.

关键词： motion estimation optical flow convolutional neural network multi-exposure

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