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RHEOLOGIC STUDIES ON CHEMICAL CROSS-LINKING KINETICS FOR LDPE

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Chinese Journal of Polymer Science 2012年第3期30卷 378-386页

作者：杨红梅 zhi-gang liu Yong-zhu Yang Qiang Zheng Zhejiang Univ Dept Polymer Sci&EngnHangzhou 310027ZhejiangPeoples R China Minist Educ Key Lab Macromol Synth&FunctionalizatHangzhou 310027ZhejiangPeoples R China

Crosslinking reaction of LDPE resin in the presence of dicumyl peroxide （DCP） was studied by isothermal rheological measurements at different temperatures and non-isothermal differential scanning calorimetry （DSC） technique with different heating rates. The kinetic parameters of crosslinking reaction were calculated by both rheological and DSC measurements. The results reveal that with the increase of DCP contents, the apparent activation energy, Ea, ranges from about 140 kJ/mol to 170 kJ/mol and the order of crosslinking reaction, n, approaches unity. The influence of measurement frequency, on crosslinking reaction was also investigated. It can be found that n does not change with the increase of ωand Ea decreases slightly with the increase of ω

关键词： Crosslinking kinetic LDPE Rheological measurement DSC measurement.

Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury

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Neural Regeneration Research 2018年第7期13卷 1263-1268页

作者： Heng-Tao Xie Zhong-Yuan Xia Xia Pan Bo Zhao zhi-gang liu Department of Anesthesiology Renmin Hospital of Wuhan University

Puerarin is a major active ingredient of the traditional Chinese plant medicine,Radix Puerariae,and commonly used in the treatment of myocardial and cerebral ***,the effects of puerarin on neuropathic pain are still *** this study,a neuropathic pain animal model was created by partial sciatic nerve ***（30 or 60 mg/kg） was intraperitoneally injected once a day for 7 *** allodynia and thermal hyperalgesia were examined at 1 day after model *** threshold and paw withdrawal latency markedly increased in a dose-dependent manner in puerarin-treated rats,especially at 7 days after model *** 7 days after model establishment,quantitative real-time reverse transcriptase-polymerase chain reaction results showed that puerarin administration reversed m RNA expression of transient receptor potential vanilloid 1（Trpv1） and transient receptor potential ankyrin 1（Trpa1） in a dose-dependent manner in dorsal root ganglion neurons after peripheral nerve *** results suggest that puerarin dose-dependently ameliorates neuropathic pain by suppressing Trpv1 and Trpa1 up-regulation in dorsal root ganglion of neuropathic pain rats.

关键词： nerve regeneration puerarin Radix Puerariae traditional Chinese medicine Trpv1 Trpa1 dorsal root ganglion peripheral nerve injury neuropathic pain mechanical allodynia thermal hyperalgesia neural regeneration

MicroRNA regulatory pattern in spinal cord ischemia-reperfusion injury

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Neural Regeneration Research 2020年第11期15卷 2123-2130页

作者： zhi-gang liu Yin Li Jian-Hang Jiao Hao Long Zhuo-Yuan Xin Xiao-Yu Yang Department of Orthopedics The Second Hospital of Jilin UniversityChangchunJilin ProvinceChina School of Public Health Jilin UniversityChangchunJilin ProvinceChina Pain Clinic The Sixth Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang Uygur Autonomous RegionChina The Key Laboratory of Zoonosis Search Chinese Ministry of EducationCollege of Basic MedicineJilin UniversityChangchunJilin ProvinceChina

After spinal cord injury, dysregulated miRNAs appear and can participate in inflammatory responses, as well as the inhibition of apoptosis and axon regeneration through multiple pathways. However, the functions of miRNAs in spinal cord ischemia-reperfusion injury progression remain unclear. miRCURY LNATM Arrays were used to analyze miRNA expression profiles of rats after 90 minutes of ischemia followed by reperfusion for 24 and 48 hours. Furthermore, subsequent construction of aberrantly expressed miRNA regulatory patterns involved cell survival, proliferation, and apoptosis. Remarkably, the mitogen-activated protein kinase(MAPK) signaling pathway was the most significantly enriched pathway among 24-and 48-hour groups. Bioinformatics analysis and quantitative reverse transcription polymerase chain reaction confirmed the persistent overexpression of miR-22-3 p in both groups. These results suggest that the aberrant miRNA regulatory network is possibly regulated MAPK signaling and continuously affects the physiological and biochemical status of cells, thus participating in the regulation of spinal cord ischemia-reperfusion injury. As such, miR-22-3 p may play sustained regulatory roles in spinal cord ischemia-reperfusion injury. All experimental procedures were approved by the Animal Ethics Committee of Jilin University, China [approval No. 2020(Research) 01].

关键词： gene regulatory networks microarray analysis microRNA miR-22-3p mitogen-activated protein kinase signaling pathway nerve regeneration neural regeneration spinal cord ischemia-reperfusion injury transcriptome

Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

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Congenital Heart Disease 2023年第1期18卷 7-21页

作者： Ji-Yang Zuo Huan-Xin Chen zhi-gang liu Qin Yang Guo-Wei He Clinical School of Cardiovascular Disease Department of Cardiovascular SurgeryTEDA International Cardiovascular HospitalTianjin Medical UniversityTianjin300457China The Institute of Cardiovascular Diseases&Department of Cardiovascular Surgery TEDA International Cardiovascular HospitalTianjin University&Chinese Academy of Medical SciencesTianjin300457China

Background:Atrial septal defect(ASD)is one of the common congenital heart *** MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been ***:In 613 subjects including 320 ASD patients,we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics ***:Eleven variants were identified in the MYH6 gene promoter,of which four variants were found only in ASD patients,and two variants(g.3434G>C and g.4524C>T)were identified for the first *** functional experiments indicated that all four variants reduced the transcriptional activity of the MYH6 gene promoter(p<0.05).Subsequent analysis through the JASPAR(A database of transcription factor binding profiles)suggests that these variants may alter transcription factor binding sites,which may in turn lead to changes in myocardin subunit expression and ASD ***:Our study for the first time focuses on variants in the promoter region of the MYH6 gene in Chinese patients with ASD and the discovered variants have functional *** study provides new insights in the role of the MYH6 gene promoter region to better understand the genetic basis of ASD formation and facilitates clinical diagnosis.

关键词： Atrial septal defect MYH6 genetic variants congenital heart disease

Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

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Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang zhi-gang liu Yan-Qi Yang zhi-gang Zhang Xiao-Li Wang Yu-Long Li Rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of Pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the Comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the Comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

Polydatin attenuated food allergy via store-operated calcium channels in mast cell

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World Journal of Gastroenterology 2013年第25期19卷 3980-3989页

作者： Bo Yang Jian-Jie Li Ji-Juan Cao Cheng-Bin Yang Jie liu Qiong-Mei Ji zhi-gang liu Allergy Branch of the State Key Laboratory of Respiratory Disease School of Medicine Shenzhen University Liaoning Entry-Exit Inspection and Quarantine Bureau Department of Pathophysiology School of Medicine Shenzhen University

AIM: To investigate the effect of polydatin (PD), a resveratrol glucoside, on mast cell degranulation and antiallergic activity. METHODS: After the rats were orally sensitized with ovalbumin (OVA) for 48 d and underwent PD treatment for 4 d, all the rats were stimulated by 100 mg/mL OVA for24 h and then sacrificed for the following experiments. The small intestines from all the groups were prepared for morphology examination by hematoxylin and eosin staining. We also used a smooth muscle organ bath to evaluate the motility of the small intestines. The OVA-specific immunoglobulin E (IgE) production and interleu-kin-4 (IL-4) levels in serum or supernatant of intestinal mucosa homogenates were analyzed by enzyme-linked immunosorbent assay (ELISA). Using toluidine blue stain, the activation and degranulation of isolated rat peritoneal mast cells (RPMCs) were analyzed. Release of histamine from RPMCs was measured by ELISA, and regulation of PD on intracellular Ca 2+ mobilization was investigated by probing intracellular Ca 2+ with fluo-4 fluo-rescent dye, with the signal recorded and analyzed. RESULTS: We found that intragastric treatment with PD significantly reduced loss of mucosal barrier integrity in the small intestine. However, OVA-sensitization caused significant hyperactivity in the small intestine of allergic rats, which was attenuated by PD administration by 42% (1.26 ± 0.13 g vs OVA 2.18 ± 0.21 g, P < 0.01). PD therapy also inhibited IgE production (3.95 ± 0.53 ng/mL vs OVA 4.53 ± 0.52 ng/mL, P < 0.05) by suppressing the secretion of Th2-type cytokine, IL-4, by 34% (38.58 ± 4.41 pg/mLvs OVA 58.15 ± 6.24 pg/mL, P < 0.01). The ratio of degranulated mast cells, as indicated by vehicles (at least five) around the cells, dramatically increased in the OVA group by 5.5 fold (63.50% ± 15.51% vs phosphate-buffered saline 11.15% ± 8.26%, P < 0.001) and fell by 65% after PD treatment (21.95% ± 4.37% vs OVA 63.50% ± 15.51%, P < 0.001). PD mediated attenuation of mast cell

关键词： Polydatin Food allergy Mast cells Store-operated calcium channels Ca2+

A rare case of acute renal infarction due to idiopathic renal arterial thrombosis

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Chinese Medical Journal 2008年第2期121卷 185-187页

作者： FU zhi-fang ZHANG zhi-gang liu Xin-min Department of Geriatrics Peking University First Hospital Beijing 100034 China

Because of the lack of specific clinical signs and symptoms, acute renal infarction is apt to be missed in diagnosis and hence has a ＂low＂ incidence. In this report, a case of acute renal infarction due to idiopathi... 详细信息

关键词：肾动脉梗阻/先天性肾动脉梗阻/诊断人类

High-temperature polymer-based nanocomposites for high energy storage performance with robust cycling stability

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Rare Metals 2023年第11期42卷 3682-3691页

作者： Yi-Fan Chen Yan-Tao Zheng Feng-Yuan Zhang zhi-gang liu Ling-Yu Zhang Lu Yang Xin-Di Sun Yuan Deng Yao Wang School of Materials Science and Engineering Beihang UniversityBeijing100191China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China Hangzhou Innovation Institute Beihang UniversityHangzhou310052China

High-power capacitors are highly demanded in advanced electronics and power systems,where rising concerns on the operating temperatures have evoked the attention on developing highly reliable high-temperature dielectric ***,polyetherimide(PEI)filled with highly insulating Al_(2)O_(3)(AO)nanoparticles dielectric composite films have been fabricated aiming for high thermal stability and reliability operated under high cycling electric field and elevated *** room temperature,incorporating a small fraction of 0.5 vol%AO nanoparticles gives rise to a highest discharged energy density(U_(e))of 5.57 J·cm^(-3)and efficiency(η)of 90.9%at650 MV·m^(-1),and a robust cycling stability up to 10^(7) cycles at 400 MV·m^(-1).Due to the substantially reduced dielectric loss,2.0 vol%AO/PEI nanocomposite film exhibits excellent high-temperature capacitive performances,delivering U_(e)~7.33 J·cm^(-3)withη~88.8%under 700 MV·m^(-1),and cycling stability up to 10^(6) cycles under 400 MV·m^(-1)at 100℃,and U_(e)~5.57 J·cm^(-3)withη~84.7%under 620 MV·m^(-1)at 150℃.Molecular dynamic simulations are performed to understand the microscopic mechanism via revealing the polymer relaxation process in the AO/PEI composite at elevated *** results are therefore very encouraging for high-temperature high-power capacitor application.

关键词： Polymer-based nanocomposites Dielectric Energy storage Temperature stability

Excellent energy storage properties realized in novel BaTiO_(3)-based lead-free ceramics by regulating relaxation behavior

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Journal of Materiomics 2023年第5期9卷 910-919页

作者： Peng-Zu Ge zhi-gang liu Xian-Xiong Huang Xin-Gui Tang Zhen-Hua Tang Shui-Feng Li Qiu-Xiang liu Yan-Ping Jiang Xiao-Bin Guo School of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China Guangzhou Panyu Polytechnic Guangzhou511483China

BaTiO_(3)(BT)has attracted extensive attention among advanced lead-free ferroelectric materials due to its unique dielectric and ferroelectric ***,the enormous remanent polarization and coercive field severely impede the improvement of its energy storage ***,the BaTiO_(3)e-Bi(Zn_(0.5)Hf_(0.5))O_(3)(BT-BZH)ceramics with high breakdown field strength and remarkable relaxation characteristics can be obtained by introducing the composite component BZH in BT to regulate the phase structure and grain size of the *** findings demonstrate that the improvement of energy storage performance is related to the increase of relaxation behavior.A large energy storage density(Wrec~3.62 J/cm^(3))along with superior energy storage efficiency(h~88.5%)is achieved in 0.88BT-0.12BZH relaxor ceramics only at 240 kV/*** addition,the sample suggests superior thermal stability and frequency stability within 25e115℃and 1e500 Hz,***,the outstanding chargedischarge properties with an ultrafast discharge time(100 ns),large discharged energy density(1.2 J/cm^(3)),impressive current density(519.4 A/cm^(2))and power density(31.1 MW/cm^(3))under the electric field of 120 kV/cm are achieved in studied *** excellent energy storage performance of BT-BZH ceramics provides a promising platform for the application of lead-free energy-storage materials.

关键词： BT-based ceramics Relaxor Energy storage Charge-discharge