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Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study

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World Journal of Clinical Cases 2024年第15期12卷 2551-2559页

作者： Jing-Lei Liu zhi-Hui Liang Bao cui Jian-Yu Liu Li Sun Department of Interventional Treatment 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina Department of Obstetrics and Gynecology 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina

Uterine fibroids are benign tumors that originate from smooth muscle cells of the *** is the most common gynecological disorder,affecting up to 80%of women of reproductive *** fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy *** treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive *** To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other *** two groups were matched for age,body mass index,parity,and baseline characteristics of uterine *** primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and *** participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after *** The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a *** significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months ***,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two *** weights were also ***

关键词： Uterine fibroids Uterine artery embolization Ovarian function Fertility Pregnancy outcome Embolic agent

Cross-linked Electrospun Gel Polymer Electrolytes for Lithium-Ion Batteries

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Chinese Journal of Polymer Science 2024年第8期42卷 1021-1028页

作者： Xue Gong Qin Xiao Qing-Yin Li Wen-cui Liang feng Chen Long-Yu Li Shi-Jie Ren College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Lithium-ion batteries(LIBs)benefit from an effective electrolyte system design in both terms of their safety and energy storage ***,a series of precursor membranes with high porosity were produced using electrospinning technology by mixing PVDF and triblock copolymer(PS-PEO-PS),resulting in a porous structure with good interconnections,which facilitates the absorbency of a large amount of electrolyte and further increases the ionic conductivity of gel polymer electrolytes(GPEs).It has been demonstrated that post-cross-linking of the precursor membranes increa ses the rigidity of the nanofibers,which allows the polymer film to be dimensionally sta ble up to 260℃while maintaining superior electrochemical *** obtained cross-linked GPEs(CGPEs)showed high ionic conductivity up to 4.53×10^(-3)S·cm^(-1).With the CGPE-25,the assembled Li/LiFeP04 half cells exhibited good rate capability and maintained a capacity of 99.4%and a coulombic efficiency of99.3%at 0.1 *** results suggest that the combination of electrospinning technique and post-cross-linking is an effective method to construct polymer electrolytes with high thermal stability and steadily decent electrochemical performance,particularly useful for Lithium-ion battery applications that require high-temperature usage.

关键词： Electrospinning Cross-linked Gel polymer electrolytes Lithium-ion batteries

High-speed GeSn resonance cavity enhanced photodetectors for a 50 Gbps Si-based 2 μm band communication system

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Photonics Research 2024年第4期12卷 767-773页

作者： JINLAI cui JUN ZHENG YUPENG ZHU XIANGQUAN LIU YIYANG WU QINXING HUANG YAZHOU YANG zhiPENG LIU zhi LIU YUHUA ZUO BUWEN CHENG Key Laboratory of Optoelectronic Materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Expanding the optical communication band is one of the most effective methods of overcoming the nonlinear Shannon capacity limit of single *** this study,GeSn resonance cavity enhanced(RCE)photodetectors(PDs)with an active layer Sn component of 9%–10.8%were designed and fabricated on an SOI *** GeSn RCE PDs present a responsivity of 0.49 A/W at 2μm and a 3-dB bandwidth of approximately 40 GHz at 2μ***,Si-based 2μm band optical communication with a transmission rate of 50 Gbps was demonstrated by using a GeSn RCE *** work demonstrates the considerable potential of the Si-based 2μm band photonics in future high-speed and high-capacity optical communication.

关键词： resonance system approximate

Pancreatic β-cell failure,clinical implications,and therapeutic strategies in type 2 diabetes

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Chinese Medical Journal 2024年第7期137卷 791-805页

作者： Daxin cui Xingrong feng Siman Lei Hongmei Zhang Wanxin Hu Shanshan Yang Xiaoqian Yu zhiguang Su Molecular Medicine Research Center and Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Clinical Translational Innovation Center West China HospitalSichuan UniversityChengduSichuan 610041China

Pancreaticβ-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes(T2D).Reserving insulin-producingβ-cells and hence restoring insulin production are gaining attention in translational diabetes research,andβ-cell replenishment has been the main focus for diabetes *** findings inβ-cell proliferation,transdifferentiation,pluripotent stem cell differentiation,and associated small molecules have served as promising strategies to regenerateβ-*** this review,we summarize current knowledge on the mechanisms implicated inβ-cell dynamic processes under physiological and diabetic conditions,in which genetic factors,age-related alterations,metabolic stresses,and compromised identity are critical factors contributing toβ-cell failure in *** article also focuses on recent advances in therapeutic strategies for diabetes treatment by promotingβ-cell proliferation,inducing non-β-cell transdifferentiation,and reprograming stem cell *** a significant challenge remains for each of these strategies,the recognition of the mechanisms responsible forβ-cell development and mature endocrine cell plasticity and remarkable advances in the generation of exogenousβ-cells from stem cells and single-cell studies pave the way for developing potential approaches to cure diabetes.

关键词： Pancreaticβ-cell regeneration Diabetes Insulin Dedifferentiation Transdifferentiation Stem cell

Laguerre Series Expansion for Scale Functions and Its Applications in Risk Theory

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Acta Mathematicae Applicatae Sinica 2024年

作者： Jia-yi XIE Zhen-yu cui zhi-min ZHANG School of Business Stevens Institute of Technology College of Mathematics Science Chongqing Normal University College of Mathematics and Statistics Chongqing University

We propose an exact explicit closed-form Laguerre series expansion formula to compute the q-scale function of a spectrally negative L′evy process (SNLP), and other functions associated to the scale function for the first time. The proposed closed-form formula for the scale function has many applications in applied probability and in particular in the Le′vy insurance risk theory. We shall show that the new series expansion formulas can be used to express the expected discounted penalty functions, the moments of the present value of total dividend payments as well as the time value of Parisian ruin in the L′evy risk models.

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Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang Yuan-dong Huang Chong Xu Xiao-yi Shao Lei Li Li-ye feng Hui-ran Gao Yu-long cui Shuai Wu zhi-qiang Yang Kai Ma National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China No.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.24 km^(2)(36°N-40°N,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LND),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 20°to 30°,maximum slope angle above 80°,along with orientations towards the north(N),northeast(NE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 20-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

Lunar In Situ Large-Scale Construction:Quantitative Evaluation of Regolith Solidification Techniques

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Engineering 2024年第8期39卷 204-221页

作者： Charun Bao Daobo Zhang Qinyu Wang Yifei cui Peng feng MOE Key Laboratory of Civil Engineering Safety and Durability Department of Civil EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China

Lunar habitat construction is crucial for successful lunar exploration *** to the limitations of transportation conditions,extensive global research has been conducted on lunar in situ material processing techniques in recent *** aim of this paper is to provide a comprehensive review,precise classification,and quantitative evaluation of these approaches,focusing specifically on four main approaches:reaction solidification(RS),sintering/melting(SM),bonding solidification(BS),and confinement formation(CF).Eight key indicators have been identified for the construction of low-cost and highperformance systems to assess the feasibility of these methods:in situ material ratio,curing temperature,curing time,implementation conditions,compressive strength,tensile strength,curing dimensions,and environmental *** scoring thresholds are determined by comparing the construction requirements with the actual *** the evaluated methods,regolith bagging has emerged as a promising option due to its high in situ material ratio,low time requirement,lack of hightemperature requirements,and minimal shortcomings,with only the compressive strength falling below the neutral *** compressive strength still maintains a value of 2–3 *** proposed construction scheme utilizing regolith bags offers numerous advantages,including rapid and large-scale construction,ensured tensile strength,and reduced reliance on equipment and *** this study,guidelines for evaluating regolith solidification techniques are provided,and directions for improvement are *** proposed lunar habitat design based on regolith bags is a practical reference for future research.

关键词： Lunar habitats Lunar in situ construction Regolith bag Solidification and formation In situ materials Evaluation method

Metal-organic frameworks and their composites for advanced lithium-ion batteries:Synthesis,progress and prospects

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Journal of Energy Chemistry 2024年第2期89卷 449-470,I0011页

作者： Chengcai Liu Borong Wu Tao Liu Yuanxing Zhang Jingwen cui Lingjun Huang Guoqiang Tan Ling Zhang Yuefeng Su feng Wu School of Material Science and Engineering Beijing Institute of TechnologyBeijing 100081China Chonging Innovation Center Beijing Institute of TechnologyChongqing 401120China Collaborative Innovation Center of Electric Vehicles in Beijing Beijing 100081China

Metal-organic frameworks(MOFs)are among the most promising materials for lithium-ion batteries(LIBs)owing to their high surface area,periodic porosity,adjustable pore size,and controllable chemical *** instance,their unique porous structures promote electrolyte penetration,ions transport,and make them ideal for battery *** the chemical composition of MOF can introduce more active sites for electrochemical ***,MOFs and their related composites have been extensively and thoroughly explored for ***,the reported reviews solely include the applications of MOFs in the electrode materials of LIBs and rarely involve other aspects.A systematic review of the application of MOFs in LIBs is essential for understanding the mechanism of MOFs and better designing related MOFs battery *** review systematically evaluates the latest developments in pristine MOFs and MOF composites for LIB applications,including MOFs as the main materials(anode,cathode,separators,and electrolytes)to auxiliary materials(coating layers and additives for electrodes).Furthermore,the synthesis,modification methods,challenges,and prospects for the application of MOFs in LIBs are discussed.

关键词： Metal-organic frameworks Electrodes Electrolytes Separators Lithium-ion batteries

Biocatalytic stereoselective synthesis of methyl mandelates by engineering a cytochrome P450 hydroxylase

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 88-93页

作者： Lingzhi Xie Yun Zhang Ruyue Zhang Haibo cui Baodong cui Wenyong Han Nanwei Wan zhi Li Yongzheng Chen Key Laboratory of Biocatalysis&Chiral Drug Synthesis of Guizhou Province Generic Drug Research Center of Guizhou ProvinceGreen Pharmaceuticals Engineering Research Center of Guizhou ProvinceSchool of PharmacyZunyi Medical UniversityZunyi 563000China Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563000China Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4Singapore 117585Singapore

Chiral methyl mandelates are useful synthons in organic transformation and pharmaceutical *** synthesis of these valuable compounds by direct C–H activating oxidative hydroxylation has attracted keen *** herein is achieving the stereoselective and efficient bio-hydroxylation of methyl 2-phenylacetates to the chiral methyl mandelates by directed evolution of the cytochrome P450DA *** the present study,a new colorimetric high-throughput screening assay was successfully developed based on a dualenzyme cascade for the engineering of the P450DA's hydroxylation *** beneficial variants with enhanced bio-hydroxylation activity were created by combining random mutagenesis and site-saturated/directed mutagenesis ***-cell bio-hydroxylation of various methyl 2-phenylacetates using the best septupletmutant P450DA-11 yielded the corresponding chiral methyl mandelates in up to 92%isolated yields and>99%ee.

关键词： Bio-hydroxylation Directed evolution Cytochrome P450 High-throughput screening Methyl mandelates