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Effect of Moxibustion on Cardiac Remodeling and Myocardial Function in Rats with Exercise-Induced Fatigue

World Journal of Traditional Chinese Medicine 2021年第2期7卷 254-257页

作者： Zheng-Xian Shen Jie Zhu Yu-Lei Liang zhi-fang zhang Diagnostics of Traditional Chinese Medicine Research Hebei University of Chinese MedicineShijiazhuangChina Information Technology Center Hebei Province Traditional Chinese Medicine HospitalShijiazhuangChina Moxibustion Research Hebei Key Laboratory of Chinese Medicine Research on Cardio‑Cerebrovascular DiseaseShijiazhuangChina

Objective:To explore the effect of moxibustion at Shenque(CV8)on myocardial structure and function in rats with exercise-induced ***:A 12-week treadmill training program was used to establish a rat model of exercise-induced ***-six male SD rats removed six rats that did not reach the molding condition,Remaining rats were randomly divided into the following five groups:a normal group(n=10)that did not under go the exercise routine and were not treated,a control group(n=10)that did not under go the exercise routine,but received a mild dose of moxibustion at"Shenque"(CV 8)for 15 min,an untreated group(n=10)that received no treatment after exercise,a CV 8 group(n=10)that received a mild dose of moxibustion at"Shenque"(CV 8)for 15 min after exercise,a non-acupoint(tail)group(n=10)that received a mild dose of moxibustion at"non-acupoint"for 15 min after *** one hour after the end of the 12-week training program,the left ventricular diastolic volume(LVDV),left ventricular systolic volume(LVSV),peak early diastolic mitral blood flow velocity(E),and peak late diastolic mitral blood flow velocity(A)were measured,and the E/A ratio were *** serum myoglobin(Mb),creatine kinase-muscle/brain(CK-MB),and cardiac troponin-I(cTnI)levels were detected using an automatic biochemical ***:When the values obtained before and after treatment were compared within the same groups,the LVDV,LVSV,E,and A were increased(P<0.05 or P<0.01),and the E/A were decreased(P<0.01)in the untreated group and the tail *** inter-group comparisons,the LVDV,LVSV,E,and A were increased(P<0.05 or P<0.01),and the E/A were decreased(P<0.01)in the untreated group and the tail group compared to the normal group and control *** to the untreated group and the tail group,the LVDV,LVSV,E,and A were decreased(P<0.01)and the E/A were increased(P<0.01)in the CV 8 *** to the normal group and the control group,the serum Mb,CK-MB,and cTnI l

关键词： Cardiac remodeling exercise-induced fatigue moxibustion myocardial function rats Shenque(CV8)

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A rare case of acute renal infarction due to idiopathic renal arterial thrombosis

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Chinese Medical Journal 2008年第2期121卷 185-187页

作者： FU zhi-fang zhang zhi-gang LIU Xin-min Department of Geriatrics Peking University First Hospital Beijing 100034 China

Because of the lack of specific clinical signs and symptoms, acute renal infarction is apt to be missed in diagnosis and hence has a ＂low＂ incidence. In this report, a case of acute renal infarction due to idiopathi... 详细信息

关键词： signs and symptoms

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Delayed arterial symptomatic epidural hematoma on the 14th day after posterior lumbar interbody fusion:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7973-7981页

作者： Shen-Shen Hao Zhen-Fu Gao Hong-Ke Li Shuai Liu Sheng-Li Dong Hong-Lei Chen zhi-fang zhang Department of Spine and Bone Oncology General Hospital of Pingmei Shenma Medical GroupPingdingshan 467000Henan ProvinceChina

BACKGROUND Delayed arterial symptomatic epidural hematoma(SEH)on the 14th day after posterior lumbar interbody fusion(PLIF)is rare but it may lead to severe complications if not identified and treated in a timely *** diagnosis of the current case,early surgical removal of the hematoma and strict hemostasis treatment was *** case report highlights the importance of swift diagnosis and treatment in SEH *** SUMMARY A 41-year-old male patient with a single-segment lumbar disc herniation underwent left-side *** the 14th post-operative day,the patient complained of lumbar incision pain with sudden onset accompanied by left limb radiation pain and aggravated cauda equina *** resonance imaging examination and a puncture blood draw at the incision site confirmed a delayed arterial *** surgical removal of the hematoma and hemostasis was *** 70 mL of hematoma was found in the left *** bleeding was found in the anterior branch of the transverse process of the 4th lumbar artery in the muscle area about 2 cm below the transverse process of the 4th lumbar vertebra.A blood jet of about 10 cm in height was observed and bipolar electrocoagulation was used to stop the ***-operative lumbar incision pain and left lower limb pain were relieved immediately and gradually *** was no recurrence during the 12-mo *** For delayed arterial SEH on the 14th day after PLIF,preventive measures including pre-,intra-and post-operative prevention should be implemented.

关键词： Delayed arterial symptomatic epidural hematoma Treatment methods Preventive measures Posterior lumbar interbody fusion Case report

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Loss of heterozygosity on long arm of chromosome 22 in sporadic colorectal carcinoma

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World Journal of Gastroenterology 2002年第4期8卷 668-673页

作者： Chong-zhi Zhou zhi-Hai Peng fang zhang Guo-Qiang Qiu Department of General Surgery,Shanghai First People Hospital,Shanghai 200080,China Lin He Shanghai Institutes for Biological Science,Chinese Academy of Science,Shanghai 200031,China Department of General Surgery Shanghai First People Hospital 85 Wujin Road Shanghai 200080 China.

AIM: The loss of heterozygosity (LOH) on tumorsuppressor genes is believed to play a key role incarcinogenesis of colorectal cancer, In this study, weanalyzed the LOH at 5 loci on the long arm ofchromosome 22 in sporadic colorectal cancer to identifyadditional loci involved in colorectal ***: Five polymorphic microsatellite markerswere analyzed in 83 cases of colorectal and normal DNAby PCR. PCR products were eletrophoresed on an ABI377 DNA sequencer; Genescan 3.1 and Genotype 2.1software were used for LOH scanning and analysisComparison between LOH frequency andclinicopathological data were performed by x2 test. P＜0.05 was considered as statistically ***: The average LOH frequency on chromosome22q was 28.38 %. The region between markersD22S280 and D22S274 (22q12.2-q13.33) exhibitedrelatively high LOH frequency. The two highest LOH lociwith frequencies of 35.09 % and 34.04 % wasidentified on D22S280 (22q12.2-12.3) and D22S274(22q13.32-13.33). 8 cases showed LOH at allinformative loci, suggesting that one chromosome 22qhad been completely lost. On D22S274 locus, LOHfrequency of rectal cancer was 50 % (9/18), which washigher than that of proximal colon cancer (12 %, 2/17) (P=0.018). The frequency of distal colon cancer was42 % (5/12), also higher than that of proximal coloncancer. But there was no statistical significance. Puttingboth the tumors in distal colon and rectum togetherinto consideration, the frequency, 47 % (14/30), washigher than that of proximal colon cancer (P=0.015),suggesting the mechanism of carcinogenisis wasdifferent in both ***: This study provided evidence for theinvolvement of putative tumor suppressor genes relatedto the sporadic colorectal carcinoma on chromosome22q. The tumor-suppressor-gene(s) might locate on the22q12.2-12.3 and/or 22q13.32-13.33.

关键词：散发性直肠癌 22染色体等位基因杂合性丢失

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Difference in the anti-fatigue effect of moxibustion at different acupoints in one-off exhausted rats

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World Journal of Acupuncture-Moxibustion 2019年第4期29卷 279-284页

作者： Xin Wang Ya-hui zhang zhi-fang zhang Shi-ling Lǚ Yu-lei Liang Dong-yun Sun Tian-yuan Lǚ School of Acupuncture Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200China

Objective:To explore the difference in the anti-fatigue effect of moxibustion at different acupoints through observing the impacts of moxibustion at"Shènshù(肾俞BL23)","Zúsānlǐ(足三里ST36)","Guānyuán(关元CV4)"and"Shénquè(神阙CV8)"on energy metabolic indexes in the one-off exhausted ***:A total of 56 SPF male rats were randomized into 7 groups,named a blank group,a model group,a non-acupoint group,a"BL23"group,a"ST36"group,a"CV4"group and a"CV8"group,8 rats in each *** one-off exhaustion model was established by weight-bearing swimming *** after the exhaustive swimming of rats in each intervention group,the mild moxibustion was applied at the corresponding acupoints for 15 min immediately.4 h after the exhaustive swimming,the blood was collected from the femoral artery and the quadriceps femoris of the left hindlimb was *** levels of blood lactate(BLD),lactate dehydrogenase(LDH),creatine kinase(CK)and blood urea nitrogen(BUN),the expressions of adenosine triphosphatease(ATP),fructose-6-phosphofructokinase(PFK)and malomdialdehyde(MDA)in the quadriceps femoris and the activity of superoxide dismutase(SOD)and catalase(CAT)were ***:Compared with the model group and the non-acupoint group,the levels of serum BLD,LDH,CK and BUN were all lower those in the"BL23"group,the"ST36"group,the"CV4"group and the"CV8"group,indicating a statistical significance(all P<0.05).Compared with the model group and the nonacupoint group,PFK was higher in the"BL23"group,indicating a statistical significance(both P<0.05).Compared with the model group and the non-acupoint group,PFK was higher in the"ST36"group and the"CV4"group,indicating a statistical significance(all P<0.05).Conclusion:It was found in the research that moxibustion at"BL23""ST36""CV4"and"CV8"regulated the energy metabolism in the one-off exhausted rats so as to bring the anti-fatigue effect into play and the effect was different among the *** at"CV8"may work on the preve

关键词： Anti-fatigue Exhaustive exercise Guānyuán(关元CV4) Mild moxibustion Shénquè(神阙CV8) Shènshù(肾俞BL23) Zúsānlǐ(足三里ST36)

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Percutaneous Nucleoplasty Using Coblation Technique for the Treatment of Chronic Nonspecific Low Back Pain： 5-year Follow-up Results

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Chinese Medical Journal 2015年第14期128卷 1893-1897页

作者： Da-Jiang Ren Xiu-Mei Liu Sui-Yong Du Tian-Sheng Sun zhi-Cheng zhang fang Li Department of Orthopedic Surgery Beijing Army General Hospital Dongcheng District Beijing 100700 China

Background： This study evaluated the efficacy of percutaneous nucleoplasty using coblation technique for the treatment of chronic nonspecific low back pain （LBP）, after 5 years of follow-up. Methods： From September 2004 to November 2006, 172 patients underwent percutaneous nucleoplasty for chronic LBP in our department. Forty-one of these patients were followed up for a mean period of 67 months. Nucleoplasty was performed at L3/4 in 1 patient; L4/5 in 25 patients; L5/$1 in 2 patients; L3/4 and L4/5 in 2 patients; L4/5 and L5/$1 in 7 patients; and L3/4, L4/5, and L5/$1 in 4 patients. Patients were assessed preoperatively and at 1 week, 1 year, 3 years, and 5 years postoperatively. Pain was graded using a 10-cm Visual Analogue Scale （VAS） and the percentage reduction in pain score was calculated at each postoperative time point. The Oswestry Disability Index （ODI） was used to assess disability-related to lumbar spine degeneration, and patient satisfaction was assessed using the modified MacNab criteria. Results： There were significant differences among the preoperative, 1-week postoperative, and 3-year postoperative VAS and ODI scores, but not between the 3- and 5-year postoperative scores. There were no significant differences in age, sex, or preoperative symptoms between patients with effective and ineffective treatment, but there were significant differences in the number of levels treated, Pfirrmann grade of intervertebral disc degeneration, and provocative discography findings between these two groups. Excellent or good patient satisfaction was achieved in 87.9% of patients after 1 week, 72.4% after 1 year, 67.7% after 3 years, and 63.4% at the last follow-up. Conclusions： Although previously published short- and medium-term outcomes after percutaneous nucleoplasty appeared to be satisfactory, our long-term follow-up results show a significant decline in patient satisfaction over time. Percutaneous nucleoplasty is a safe and simple technique, with therapeut

关键词： Discogenic Low Back Pain Follow-up Nonspecific Low Back Pain Nucleoplasty Surgical Treatment

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Observability for the Schr?dinger equation in a uniform magnetic field

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Acta Mathematica Sinica,English Series 2025年

作者： zhang fang Department of Mathematics Beijing Institute of Technology

We prove the observability inequalities at two time points for the Schr?dinger equation in a uniform magnetic field in dimensions 2 and 3. The proofs mainly rely on Nazarov’s uncertainty principle. In particular, the observability inequality in three dimensions can also be derived from the approach used to establish the Amerin-Berthier uncertainty principle.

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Isobaric enzymatic assays reveal depth-dependent variation in microbial ectoenzyme activities in the deepest ocean on Earth

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Science China Earth Sciences 2025年第1期68卷 185-194页

作者： Junwei CAO Jiahua WANG Hongge zhang Junhao DENG Binbin PAN Jiawang CHEN Li zhang Jiasong fang College of Oceanography and Ecological Science Shanghai Ocean University Ocean College Zhejiang University Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Microbial ectoenzymes play essential roles in the transformation and mineralization of organic matter in the ***, conventional methods for measuring microbial ectoenzyme activities(MEAs) in the deep ocean under atmospheric conditions can misrepresent the metabolic activities of indigenous microbial communities. To overcome this limitation, we measured the activities of three microbial ectoenzymes(aminopeptidase, α-glucosidase, and β-glucosidase) under both atmospheric and in situ pressure conditions in seawater collected using pressure-retaining and non-pressure-retaining samplers in the Challenger Deep, Mariana Trench. In the case of aminopeptidase and α-glucosidase, the highest isobaric MEAs were observed in the surface layer(50 m), followed by those at abyssopelagic depths(4,000–6,000 m) for aminopeptidase, hadal realm(10,903 m)for α-glucosidase, while β-glucosidase activity exhibited the highest value at 10,903 m. Furthermore, the isobaric MEAs in hadal waters were commonly found to be higher than the decompressed counterparts, highlighting the importance of pressure-retaining sampling and isobaric enzymatic assays. The half-saturation constant(Km) showed a general decreasing trend with depth,suggesting that the deep ocean microbes might have adapted to the high-pressure and oligotrophic environment by increasing their ectoenzyme's affinity to substrate. Furthermore, particle-free MEAs contribute more to the total MEAs in the deep ocean than particle-associated MEAs, suggesting the significance of cell-associated and dissolved ectoenzymes in ocean *** study provides a foundation for future investigations of MEAs in the ocean and has important implications for understanding the dynamics of microbially mediated biogeochemical cycling in marine ecosystems.

关键词： Pressure-retaining sampling Microbial ectoenzyme activity Deep-sea microbes High pressure Mariana Trench

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Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China Life Sciences 2025年第1期68卷 176-188页

作者： zhiyi Wang Mengxue Gong Yuanyuan fang Huijuan Yuan Chenhong zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

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The Establishment of Embryonic Cardiac Stem Cell Lines

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生物医学工程学杂志 2005年第S1期22卷 49-50页

作者： Xi zhang Chuan-Sen zhang Yan-Chun LIU Xiang-Qun YANG Shao-Hu XIONGEr-Peng JIANG Rui LI zhi-Ying zhang fang LIU Yong YE(Institute of Biomedical Engineering, Research Center of Developmental Biology, Department of Anatomy, The Second Military Medical University, Shanghai 200433,China)

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