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Petroleum Science 2022年第1期19卷 329-338页

作者： zhi-dong li Qing-lin Cheng You-Wang Chen Jiang-dong Wei li-li Lv Hao Wu Yang liu Key Lab of Ministry of Education for Enhancing the Oil and Gas Recovery Ratio Northeast Petroleum UniversityDaqing 163318China PetroChina Planning&Engineering Institute(CPPEI) Beijing 100000China

Based on the“three box”exergy analysis model,a black box-gray box hierarchical exergy analysis and evaluation method is put forward in this paper,which is applied to evaluate the power generation technology of differential pressure produced by natural gas *** using the exergy analysis theory,the black box-gray box hierarchical exergy analysis models of three differential pressure power generation technologies are established ***,the“black box”analysis models of main energy consuming equipment are established,and then the“gray box”analysis model of the total system is *** on the calculation results of exergy analysis indexes,the weak energy consumption equipment in the whole power generation process is accurately *** a gas field in southwest China as an example,the comprehensive energy consumption evaluation of the three power generation technologies is carried out,and the technology with the best energy consumption condition among the three technologies is ***,the rationalization improvement measures are put forward from improving the air tightness,replacing the deflector and reducing the flow loss.

关键词： Expansion differential pressure power generation Black box-gray box hierarchy Exergy analysis method Weak link of energy consumption

Identification of the 2-tridecanone cis-acting element in the promoter of cytochrome P450 CYP6B7 in Helicoverpa armigera

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Insect Science 2018年第6期25卷 959-968页

作者： li Xu dong-zhi li Yuan-Yuan Luo Jian-Ying Qin li-Hong Qiu College of Science China Agricultural UniversityBeijingChina

The expression level of cytochrome P450 genes in insects can be induced by plant allelochemicals,which is important for insects to adapt to host *** P450CYP6B 7has been reported to be involved in pyethroid insecticide resistance in Heli- coverpa armigera,and its transcription level was induced by some ***,the regulatory mechanism of the induced expression of CYP6B7remains unknown,although it is very important for understanding the detoxification mechanism to allelochemicals in host *** objective of the present study was to investigate the eis-acting ele- ment in the promoter of CYP6B7 mediating the inducible up-regulation of CYP6B7in *** by *** promoter region of CYP6B7was cloned by genome walking technique and analyzed by transient transfeetion *** 5'deletion of the promoter region of CYP6B7revealed that the relative luciferase activity of construct -320/+232could be significantly induced by *** stepwise deletion between -320 and -238 bp found that construct -292/+232 could also be significantly induced by 2-tridecanone,but the adjacent construct -256/+232could not,suggesting the essential role of the sequence between -292 and --257 bp for 2-tridecanone induction. Nucleotide mutations between -292 and -281 bp had no influence on the induction ef- fect by 2-tridecanone,but nucleotide mutations between -280 and -257 bp significantly decreased the induction *** results demonstrated that the cis-acting element for 2-trideeanone induction was between -280 and -257 bp in the promoter of CYP6B7.

关键词： cis-acting element cytochrome P450 CYP6B7 Helicoverpa armigera induction 2-tridecanone

PEG-grafted PVA Membrane and Its Blood Compatibility

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Chemical Research in Chinese Universities 2011年第6期27卷 1078-1082页

作者： JIN Gu YAO Qi-zhi dong li-quan MA Feng Department of Chemistry University of Science and Technology of China Hefei 230026 P. R. China

Preparation and blood compatibility of different shape polyvinyl alcohol（PVA） membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene（PTFE） capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol（mPEG） was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.

关键词： Polyvinyl alcohol(PVA) Polyethylene glycol(PEG) Membrane Platelet Adhesion

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连续函数式曲线光滑法（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第4期19卷 304-314页

作者： Yu-fei WU liang HE zhi-dong li School of Engineering RMIT University Carlton Victoria 3053 Australia Guangzhou Metro Design and Research Institute Co. Ltd. Guangzhou 510010 China Department of Architecture and Civil Engineering City University of Hong Kong Kowloon Hong Kong China

目的:用连续函数实现无限接近原始非连续曲线的光滑。创新点:首次提出用一个连续函数替代原来由任意多非连续区域函数构成的函数。该方法可视为一种新的函数光滑算法。方法:1.通过引入特殊的区域变量,并用该区域变量替代原函数自变量的... 详细信息

目的:用连续函数实现无限接近原始非连续曲线的光滑。创新点:首次提出用一个连续函数替代原来由任意多非连续区域函数构成的函数。该方法可视为一种新的函数光滑算法。方法:1.通过引入特殊的区域变量,并用该区域变量替代原函数自变量的方法,将区域函数改造成在该区域无限接近原函数而在区域外取值常数的函数。2.把所有的区域函数相乘得到一个连续函数的方程。结论:1.由任意多非连续区域函数构成的函数可以改造成一个连续函数。2.该连续函数在原非连续边界的光滑程度可以由各个边界上独立的参数按需调整。3.该方法产生的连续函数没有摆动现象,其形状与原始区域函数无限接近。该方程在数学上是连续的,同时无限接近原始非连续函数,包括原来在边界上函数值的非连续。

关键词：曲线光滑区域变量区域函数连续函数

Graft-versus-leukemia effects of Wilms＇ tumor 1 protein-specific cytotoxic T lymphocytes in patients with chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation

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Chinese Medical Journal 2010年第7期123卷 912-916页

作者： WANG zhi-dong li Dan HUANG Xiao-jun Institute of Hematology Peking University People's HospitalBeijing 100044 China

Background The role of Wilms＇ tumor 1 protein （WT1）-specific cytotoxic T cells （CTL） in eradicating chronic myeloid leukemia （CML） cells is to be established. The aim of this study was to determine whether WT1 contributed to the graft-versus-leukemia effects （GVLE） for CML following allogeneic hematopoietic stem cell transplantation （HSCT）. Methods High-resolution human leukocyte antigen （HLA） class I genotyping was performed by sequence-specific polymerase chain reaction （PCR）. Fifteen HLA-A~＊2402 patients with CML who underwent allogeneic HSCT were enrolled in this study. We monitored the frequency of WT1-specific CTL by pentamer assay and the molecular minimal residual disease by real-time quantitative *** A CD8＋ T-cell response to WT1 was observed in 14 of 15 patients after HSCT. The median frequencies of WT1-CTL were 0.54%, 0.62%, 0.81% and 1.28% （%CD8） on days 30, 60, 90 and 180, respectively. The median frequency of WT1-CTL （1.38%） in patients with molecular remission （MoR） was significantly higher than that in those without MoR （0.38%） on day 30, while no significant differences between them were detected on days 60, 90 and 180. The increase of WT1-CTL was associated with a decrease in bcr-abl expression and MoR; and the decrease of WT1-CTL was associated with an increase in bcr-abl expression, suggesting a WT1 -driven GVL effect. WT1-CTL had a predominant effector-memory phenotype （CD45RO＋CD27-CD57＋）.Conclusions The emergence of WT1-CTL with an effector-memory phenotype is associated with GVLE in CML patients after HSCT. This will pave the way for the WT1 vaccines to enhance GVLE after HSCT in CML.

关键词： cytotoxic T cells Wilms' tumor 1 protein graft-versus-leukemia effects chronic myeloid leukemia allogeneic hematopoietic stem cell transplantation

Bile tract adenomyoma:A case report

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World Journal of Gastroenterology 2008年第4期14卷 647-650页

作者： Gui-Ming Shu Yi-Jun Wang zhi Du dong-Yan li Chang-li liu Tianjin Third Central Hospital Tianjin Medical UniversityTianjin 300170 China

This paper described a rare case of adenomyoma of common bile duct. The case is a 51-year-old man who was hospitalized for yellow color skin and sclera and itching for 2 mo without abdominal pain. Nothing special was found in physical examination except yellowish skin and sclera. The clinical presentation and Computerized Tomography (CT),Magnetic resonance cholangiopancreatography (MRCP),and ultrasonography suspected a tumor of the distal bile duct. The patient was treated successfully by pancreaticoduodenectomy. Histologically,the lesion consisted of adenoid and myofibrous tissue and moderate atypia. The immunophenotype of the epithelial component was cytokeratin 7+/cytokeratin 20-. The patient has been well without any evidence of recurrence for 12 mo since his operation.

关键词： Common bile duct Adenomyoma Diagnosis Pancreaticoduodenectomy

K-H Instability of Dust Plasma

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紫金山天文台台刊 1996年第2期15卷 84-88页

作者： Shi zhi-dong and li Zhong-yuanUniversity of Science and Technology of China,Hefei,230026,PRC Advanced Centre for Earth Science and Astronomy,Third World Academy of Science

Areview about K-H instability related to comet tail is *** effect of dust graing on KHI is theoretically analysed and relations of critical shear to excit KHI with the properties of dust grains both for sheared ion fl... 详细信息

关键词： K-H instability comet tail dust plasma.

Peripheral Pulmonary Emboli Detected by Radial Probe Endobronchial Ultrasound

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Chinese Medical Journal 2015年第22期128卷 3116-3117页

作者： Xi-Qian Xing Jiao Yang zhi-dong li Yan-Hong liu Yi Xiao Yan-li li li-Qiong liu li-Hui Zhang Xu-Wei Wu First Department of Respiratory Medicine Yah'an Hospital Affiliated to Kunming Medical University Kunming Yunnan 650051 China First Department of Respiratory Medicine First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China

To the Editor： Endobronchial ultrasound （EBUS） has been utilized as a useful noninvasive diagnostic tool for mediastinal lymph nodes or masses. Recently, convex probe EBUS （CP-EBUS） has recently come to be used to diagnose central pulmonary embolism.I However, CP-EBUS cannot detect peripheral pulnaonary embolism. It is here believed that the potential use of EBUS is still underestimated.

关键词：肺栓塞淋巴结栓塞血浆铜蓝蛋白血气分析胰岛素铍

CHARGING OF DUST GRAINS IN COMETARY PLASMA ENVIRONMENTS

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紫金山天文台台刊 1998年第2期 92-96页

作者： Shi zhi-dong li Zhong-yuan( University of science and Technology of China, Hefei, 230026, P. R , C . ) (Advanced center for Earht Science and Astronomy, Third World Academy of Science)

The equilibrium potential of fluffy dust grains in plasma environments is modeled numerically for comet P/Halley. It is found that the dust grain acquires its largest negative potential and probability of disruption a... 详细信息

关键词： comets - plasma - dust - charging

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches