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Bioactive phytochemicals and associated multifunctional health-promoting effects of Polygonati Rhizoma

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Food Science and Human Wellness 2024年

作者： Shuzhen Wang Feng He Yunli Xiao Fu Xiang Lan Lu Wei wu Chi-Tang Ho Shiming Li College of Biology and Agricultural Resources， Huanggang Normal University School of Computer and Information Technology， Beijing Jiaotong University Department of Food Science， Rutgers University New Brunswick

Polygonati Rhizoma， a functional food and a traditional Chinese medicine broadly used in China and several Southeast Asia countries， possesses effective health-promoting activities. Prepared from three plants in Polygonatum family (P. kingianum， P. sibiricum， and P. cyrtonema)， Polygonati Rhizoma has drawn increasing attention due to its remarkable immune-enhancing and metabolic regulatory activities in recent years. In this review， we summarized the updated research of chemical constituents and biological activities of Polygonati Rhizoma， especially the metabolic regulation， immunomodulatory effects， and anti-fatigue activities， aiming to provide a comprehensive understanding， broaden the usage and promote more in-depth exploration of Polygonati Rhizoma as a functional food.

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Composite penalty method of a low order anisotropic nonconforming finite element for the Stokes problem

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Applied Mathematics(A Journal of Chinese Universities) 2013年第1期28卷 49-56页

作者： wu Jing-zhu XING Xiu-zhi SHI Dong-yang Department of Mathematics Zhoukou Normal University Department of Mathematics Zhengzhou University

Composite penalty method of a low order anisotropic nonconforming quadrilateral finite element for the Stokes problem is presented. This method with a large penalty parameter can achieve the same accuracy as the stand method with a small penalty parameter and the convergence rate of this method is two times as that of the standard method under the condition of the same order penalty parameter. The superconvergence for velocity is established as well. The results of this paper are also valid to the most of the known nonconforming finite element methods.

关键词： Stokes problem composite penalty method anisotropic mesh.

Modifying temperature-related cardiovascular mortality through green-blue space exposure

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Environmental Science and Ecotechnology 2024年第4期20卷 269-277页

作者： Kejia Hu Shiyi Wang Fangrong Fei Jinglu Song Feng Chen Qi Zhao Yujie Shen Jingqiao Fu Yunquan Zhang Jian Cheng Jieming Zhong Xuchao Yang Jiayu wu School of Public Health Zhejiang UniversityHangzhou310058China Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province Hangzhou310058China College of Agriculture and Biotechnology Zhejiang UniversityHangzhou310058China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310051China Department of Urban Planning and Design Xi'an Jiaotong-Liverpool UniversitySuzhou215123China Zhejiang Institute of Meteorological Sciences Hangzhou310008China School of Public Health Shandong UniversityJinan250012China Ocean College Zhejiang UniversityZhoushan316021China School of Public Health Wuhan University of Science and TechnologyWuhan430065China School of Public Health Anhui Medical UniversityHefei230032China

Green-blue spaces(GBS)are pivotal in mitigating thermal ***,their management lacks guidelines rooted in epidemiological evidence for specific planning and *** we show how various GBS types modify the link between non-optimal temperatures and cardiovascular mortality across different thermal *** merged fine-scale population density and GBS data to create novel GBS exposure index.A case time series approach was employed to analyse temperature-cardiovascular mortality association and the effect modifications of type-specific GBSs across 1085 subdistricts in south-eastern *** findings indicate that both green and blue spaces may significantly reduce high-temperature-related cardiovascular mortality risks(e.g.,for low(5%)***(95%)level of overall green spaces at 99th *** mortality temperature(MMT),Ratio of relative risk(RRR)=1.14(95%CI:1.07,1.21);for overall blue spaces,RRR=1.20(95%CI:1.12,1.29)),while specific blue space types offer protection against cold temperatures(e.g.,for the rivers at 1st vs MMT,RRR=1.17(95%CI:1.07,1.28)).Notably,forests,parks,nature reserves,street greenery,and lakes are linked with lower heat-related cardiovascular mortality,whereas rivers and coasts mitigate cold-related cardiovascular *** spaces provide greater benefits than green *** severity of temperature extremes further amplifies GBS's protective *** study enhances our understanding of how type-specific GBS influences health risks associated with non-optimal temperatures,offering valuable insights for integrating GBS into climate adaptation strategies for maximal health benefits.

关键词： Green space Blue space Temperature Mortality China

CO_(2)腐蚀-应力耦合下固井水泥环密封完整性

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钻井液与完井液 2024年第2期41卷 220-230页

作者：武治强武广瑷幸雪松中海油研究总院有限责任公司北京100028

CO_(2)地质封存过程中,与地层围岩中的水反应后腐蚀着固井水泥环,腐蚀损伤和套管内压(应力)耦合作用极大地影响着水泥环的密封完整性。基于CO_(2)腐蚀实验,获得不同腐蚀程度水泥石材料力学性能参数,采用混凝土损伤塑性(CDP)本构模型和Mo... 详细信息

CO_(2)地质封存过程中,与地层围岩中的水反应后腐蚀着固井水泥环,腐蚀损伤和套管内压(应力)耦合作用极大地影响着水泥环的密封完整性。基于CO_(2)腐蚀实验,获得不同腐蚀程度水泥石材料力学性能参数,采用混凝土损伤塑性(CDP)本构模型和Mohor-Coulomb准则描述腐蚀前后水泥环的应力-应变行为,利用ABAQUS软件建立考虑CO_(2)腐蚀与应力耦合作用的井筒组合体(套管-水泥环-地层围岩)有限元分析模型,分析和探讨了套管内压和腐蚀时间对水泥环完整性的影响。结果表明,较高套管内压下,井筒水泥环发生弹塑性变形,出现结构损伤,套管与水泥环界面易形成微间隙;受腐蚀和套管内压的耦合作用,水泥环更易于出现完整性失效问题,相比较于未腐蚀水泥环,腐蚀水泥环受压后径向应力、等效塑性应变、微间隙以及拉伸和压缩损伤均较大,与之相反,塑性半径是减小的;微间隙与拉伸和压缩损伤受腐蚀时间的影响不明显。

关键词：水泥环 CO_(2)腐蚀密封完整性塑性变形微间隙

Interfacial phase competition induced Kondo-like effect inmanganite-insulator composites

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Frontiers of physics 2016年第6期11卷 129-133页

作者： Ling-Fang Lin Ling-zhi wu Shuai Dong Department of Physics Southeast University Nanjing 211189 China School of Geography and Biological Information Nanjing University of Posts and Telecommunications Nanjing 210046 China

A Kondo-like effect, namely, the upturn of resistivity at low temperatures, is observed in perovskite manganite when nonmagnetic insulators are doped as secondary phase. In this paper, the low-temperature resistivity upturn effect has been argued to originate from interfacial magnetic phase reconstruction. Heisenberg spin lattices have been simulated using the Monte Carlo method to reveal phase competition around secondary phase boundary, namely, manganite-insulator boundary that behaves with a weak antiferromagnetic tendency. Moreover, the resistor network model based on double-exchange conductive mechanism reproduces the low-temperature resistivity upturn effect. Our work provides a reasonable physical mechanism to understand the novel transport behaviors in microstructures of correlated electron systems.

关键词： manganite Kondo-like effect manganite-insulator composites phase competition 75.47.Lx 75.47.Gk 73.63.-b

Frequency-dependent Electrical Capacitance and Resistance of Ultra-high Performance Concrete and Their Responses to Compressive Strain

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Journal of wuhan University of Technology(Materials Science) 2024年第4期39卷 968-978页

作者：吴瑜孙明清 ZHU Lutao SONG Qiulei CHEN Jianzhong Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics School of ScienceWuhan University of TechnologyWuhan 430070China School of Civil Engineering and Architecture Hubei University of Arts and ScienceXiangyang 441053China Suzhou Concrete and Cement Products Research Institude Co. LtdSuzhou 215026China

The frequency-dependent electrical properties and strain self-sensing behaviour of ultra-high performance concrete(UHPC)as cement-based stress/strain self-sensing(CBSS)smart materials were investigated in the frequency range from 100 Hz to 300 *** using the electrical parameters of the equivalent electric circuit model,the quantitative relations of capacitance and conductance of CBSS with the measurement frequency were *** capacitance and the conductance exhibit power-law type dependence on the measurement *** calculated capacitance values at frequencies beyond 2 kHz and conductance values are consistent with the experimental *** sweep-frequency test and the fixed-frequency test were performed to examine effects of the excitation frequencies on strain self-sensing properties of *** fractional change in capacitance(FCC)and resistance(FCR)of CBSS are frequency-dependent in the frequency range from 100 Hz to the f_(B),but frequency-independent in the frequency range from the f_(B)to 300 *** f_(A)and the f_(B)are 1.7-4.0 kHz and 11-78 kHz depending on the fiber dosages,*** and FCR reach their maximum at the f_(A)and 100 Hz,*** responses of capacitance and resistance of CBSS to strain show good repeatability during cyclic *** the fiber dosage increases,capacitance-based sensitivity to strain increases initially and then decreases at the f_(A),and resistance-based sensitivity to strain of CBSS increases with increasing fiber contents.

关键词： UHPC strain self-sensing capacitance-based frequency-dependent

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

High-throughput experimentation and machine learning-promoted synthesis of α-phosphoryloxy ketones via Ru-catalyzed P(O)O–H insertion reactions of sulfoxonium ylides

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Science China Chemistry 2024年

作者： An Lin Jingyuan Liu Yougen Xu Haiting wu Yating Chen Yan Zhang Lebin Su Xiaodan Zhao Kuangbiao Liao Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-sen University Guangzhou National Laboratory Bioland Laboratory

Herein, we report a novel and highly efficient method for the synthesis of α-phosphoryloxy carbonyl compounds via Rucatalyzed P(O)O–H insertion reactions of sulfoxonium ylides and phosphinic acids, with the assistance of high-throughput experimentation(HTE) and machine learning(ML). A variety of P(O)O-H derivatives, including diarylphosphates, alkyl phosphates, and alkoxyphosphates, are competent candidates to react with sulfoxonium ylides in this transformation, and variousα-phosphoryloxy carbonyls and propylene phosphates are directly constructed. This approach utilizes readily available sulfoxonium ylide as a carbene precursor, and features mild conditions, operational simplicity, and broad functional groups tolerance, and could be used for late-stage functionalization of structurally complex bioactive molecules. Moreover, a conducive exploration of the reaction space is also conducted(756 reactions) and a machine learning model for reaction yield prediction has been developed and applied, showcasing the practical application of this newly workflow(HTE-ML) in the field of synthetic chemistry.

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Dietary regulation in health and disease

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2945-2973页

作者： Qi wu zhi-Jie Gao Xin Yu Ping Wang Tongji University Cancer Center Shanghai Tenth People’s Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghai 200092China Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhanHubeiP.R.China

Nutriments have been deemed to impact all physiopathologic *** evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast,drosophila,rodent,primate and *** emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse ***,the nutritive advantages frequently diversify among individuals as well as organs and tissues,which brings challenges in this *** this review,we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or *** discuss the nutrient-mediated mechanisms including metabolic regulators,nutritive metabolism pathways,epigenetic mechanisms and circadian ***,we describe diet-responsive effectors by which dietary interventions influence the endocrinic,immunological,microbial and neural states responsible for improving health and preventing multiple diseases in ***,we expatiate diverse patterns of dietotheroapies,including different fasting,calorie-restricted diet,ketogenic diet,high-fibre diet,plants-based diet,protein restriction diet or diet with specific reduction in amino acids or microelements,potentially affecting the health and morbid ***,we emphasize the profound nutritional therapy,and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

关键词： metabolism organs prescribed