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Toward wiping out osteoarthritis in China:research highlights

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Chinese Medical Journal 2020年第8期133卷 883-885页

作者： zhi-zhong ye zhi-Yi Zhang Zhan-Guo Li Ci-Bo Huang Yue Zhang Shenzhen Futian Hospital for Rheumatic Diseases ShenzhenGuangdong 518000China Department of Rheumatology and Immunology The First Clinical College of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Rheumatology and Immunology Peking University People’s HospitalBeijing 100044China Department of Rheumatology and Immunology National Center of GerontologyBeijing HospitalBeijing 100730China

Osteoarthritis(OA)is currently considered as more than a degenerative disorder of weight-bearing joints,instead one organ disease of“all-joint”due to cause(s)of aging,injury,inflammation,metabolic disorders,*** prevalence is high:9.6%in men and 18.0%in women aged over 60 *** health professionals say that OA is incurable and focus exclusively on palliative treatment,as we lack effective disease modifying osteoarthritis drugs(DMOADs).[1]But should we hope that treating OA precisely in China is possible through intensive research and drug development?

关键词： osteoarthritis drugs inflammation

Progress in the pathogenesis and treatment of rheumatoid arthritis with sleep apnea hypopnea syndrome

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Journal of Hainan Medical University 2019年第2期25卷 83-86页

作者： Jian-Wei Xiao Xu Cai Fen-Lian Guo Yi-Wei Hong zhi-Hua Yin Xin-Peng Chen Li-Ping Dai zhi-zhong ye Department of Rheumatology Shenzhen Futian Hospital for Rheumatic DiseasesShenzhenGuangdong Province518000China

Objective:Sleep apnea hypopnea syndrome (SAHS) is a common sleep disorder, which is manifested as a reduction in tidal volume or apnea during sleep, which results in intermittent hypoxia and tissue hypoxia and induces oxidative stress and inflammatory responses. Rheumatoid arthritis (RA) is a systemic disease contributing to hyperplasia of synovial membrane, cartilage erosion and joint damage. Fibroblast like synoviocytes (FLS), which make up the lining of the synovial membrane, are believed to play a role in the pathogenesis of RA. RA is a series of inflammation-like responses that induce joint damage and dysfunction and impair patients' life quality. This article first introduced the basic features of RA and analyzes the pathogenesis of RA with SAHS. Then the relationship between RA and SAHS was investigated. Finally, the progress in the treatment for RA with SAHS was reviewed emphatically.

关键词： Sleep apnea hypopnea syndrome Rheumatoid arthritis Pathogenesis Progress in treatment

基于参照因子的连续时间均值方差最优投资策略

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山西大学学报(自然科学版) 2008年第3期31卷 414-417页

作者：卫淑芝叶中行上海交通大学数学系

推广了连续时间均值-方差投资策略模型,其中风险资产价格受参照因子的影响,而且投资策略终止时间也由参照因子确定.模型化为一个具随机周期的随机最优控制问题,该问题可通过一个辅助的随机LQ模型求解.解决随机LQ模型的关键是导出了两个... 详细信息

推广了连续时间均值-方差投资策略模型,其中风险资产价格受参照因子的影响,而且投资策略终止时间也由参照因子确定.模型化为一个具随机周期的随机最优控制问题,该问题可通过一个辅助的随机LQ模型求解.解决随机LQ模型的关键是导出了两个偏微分的初边值问题,利用Feynman-Kac表示定理得出了这两个偏微分方程问题的解,进而求出了模型的最优投资策略.

关键词：参照因子随机LQ Feynman-Kac表示定理最优投资策略

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充内压端封闭异厚度薄圆柱壳的塑性分析

清华大学学报(自然科学版) 1982年第1期 71-82页

作者：费志中徐秉业工程力学系

本文研究充内压端封闭异厚度薄圆柱壳的极限分析问题。在多数壳体问题中，弯矩和薄膜力并不是同时重要的，因此在屈服条件中，可以不考虑力矩和薄膜力之间的相互影响。本文根据两矩弱作用的屈服条件以及相关联的流动法则，找到了上述问... 详细信息

本文研究充内压端封闭异厚度薄圆柱壳的极限分析问题。在多数壳体问题中，弯矩和薄膜力并不是同时重要的，因此在屈服条件中，可以不考虑力矩和薄膜力之间的相互影响。本文根据两矩弱作用的屈服条件以及相关联的流动法则，找到了上述问题的完全解。

关键词：圆柱壳应力场极限分析薄壳结构圆板内压塑性分析结构分析

Polyethylene glycol-polyethylenimine nanoparticles for effective plasmid delivery of rat bone marrow stem cells via N/P charge ratio optimization

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Polyethylene glycol-polyethylenimine nanoparticles for effec...

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Xiao-ai Chen~1,zhi-zhong ye~2,Wei-wei Wang~3,Qian zhong~1,Bo Xu~1,Xin-tao Shuai~3,Yu-bin Deng~(1*) Department of Pathophysiology,zhongshan School of Medicine,SUN Yat-sen University,Guang zhou, 51008,China

Background:Bone marrow stem cells(BMSCs) are broadly applied in gene augmentation. Modified BMSCs posseses strengthened ability of specific tissue differentiation,resisting apoptosis and ***,viral vectors showed the disadvantages of potential immunogenicity,carcinogenicity and complicated synthetic *** to easy preparation,potentially targeting modification and low cytotoxicity and immunogenicity,polyethylene glycol grafted polyethylenimine(PEG-PEI) holds promise in packing plasmid into nanoparticle and gene delivery. Methods:2 kDa polyethylene glycol(PEG) was conjugated to 25 kDa polyethylenimine(PEI) to form PEG-PEI graft copolymer;MTT assay,Wound and Healing Assay and MSC Differentiation Assay were used to test the states of rBMSCs treated with PEG-PEI;Agarose Gel Retardation Assay and Dynamic Light Scattering were applied to determine the nanoparticles formation;Fluorescence Microscope and Flow Cytometry were employed to determine the transfection efficiency at the optimal N/P charge ratio. Results:PEG8k-PEI25k graft copolymer was successfully *** with the copolymer, rBMSCs still maintained high viability,could migrate and resettle the wound area,and differentiate into adipocyte and ***-PEI completely packed plasmid at N/P charge ratio of 3,and condensed plasmid to form the stable nanoparticles of 100-200nm diameters until N/P charge ratio ***-PEI deliveryed plasmid into rBMSCs at N/P from 10 to 50,but obtained optimum transfection efficiency of 8% which is similar to cationic liposome's. Conclusions:The bionomics of rBMSCs had no significant change with PEG-PEI ***-PEI sufficiently condensed EGFP-C1 plasmid into *** optimizating the N/P charge ratio, PEG-PEI could efficiently deliver EGFP-C1 plasmid into rBMSCs with transfection efficiency similar to cationic liposome's.

关键词： Polyethylene glycol

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru ye Liyan zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Onboard real time modeling of aircraft engines with Hammerstein-Wiener representation

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航空动力学报 2014年第10期29卷 2499-2506页

作者： WANG Ji-qiang ye zhi-feng HU zhong-zhi Jiangsu Province Key Laboratory of Aerospace Power System College of Energy and Power EngineeringNanjing University of Aeronautics and Astronautics

An identification-based approach for aircraft engine modeling using the nonlinear HammersteinWiener representation was ***-Wiener modeling for both limited flight envelope and extended flight envelope was *** shows that the resulting model can be valid over 10%variation of rotational speed of the engine,compared with those linear models that are only valid over 3%—5%change of rotational *** is further demonstrated that the proposed method can be utilized over large envelope up to 20% variation of rotational speed of the *** fundamental idea is to use nonlinear models to extend the feasible/valid region rather than those linear *** may consequently simplify the switching logic in the onboard digital control *** is often overlooked in aircraft engine control community,but has been emphasized in the research.

关键词： aircraft engines engine modeling onboard real time modeling system identification Hammerstein-Wiener representation

强直性脊柱炎伴发前葡萄膜炎患者眼前段病变严重程度的相关因素

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国际眼科杂志 2014年第7期14卷 1310-1312页

作者：宋国祥黄进贤邓亚玲尹志华梁张翼叶志中中国广东省深圳市第三人民医院眼科 518000 广东医学院附属福田医院香蜜湖风湿病分院广东医学院风湿病研究所中国广东省深圳市518000

目的：分析强直性脊柱炎（ AS）伴发前葡萄膜炎患者眼前段病变严重程度和炎性指标以及骶髂关节的影像学表现等相关因素的相互关系。方法：回顾性分析55例AS伴前葡萄膜炎患者裂隙灯下眼前段病变情况与红细胞沉降率（ ESR ）、C 反应蛋... 详细信息

目的：分析强直性脊柱炎（ AS）伴发前葡萄膜炎患者眼前段病变严重程度和炎性指标以及骶髂关节的影像学表现等相关因素的相互关系。方法：回顾性分析55例AS伴前葡萄膜炎患者裂隙灯下眼前段病变情况与红细胞沉降率（ ESR ）、C 反应蛋白（ CRP）以及骶髂关节的核磁共振表现。前葡萄膜炎严重程度根据EIU的临床标准改良,骶髂关节骨髓水肿的程度根据SPARCC的骶髂关节（ SIJ）评分,分析二者之间的相互关系。结果：AS患者55例中,EIU评分为2~10分,SPARCC评分为0~22分。进一步分析表明,葡萄膜炎评分与ESR （r=0.869,P〈0.001）和CRP（r=0.485,P〈0.001）均密切相关。强直性脊柱炎患者前葡萄膜炎严重程度与骶髂关节炎症程度不相关（r=0.237,P=0.081）。结论：强直性脊柱炎患者前葡萄膜炎局部自身免疫炎症和骶髂关节的炎症及后续的骨化可能是各自独立的两个进程。

关键词：强直性脊柱炎前葡萄膜炎骶髂关节核磁共振

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture