检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

全球变化与人类健康的内在关系

上海财经大学学报（哲学社会科学版） 2017年第3期19卷 4-12页

作者：杨志秦臻中国人民大学经济学院北京100872

全球变化的实质是地球生态系统发生的新变化,不仅包括地球自然生态系统运动规律呈现出的新特征,而且包括世界人文生态系统运行中出现的新问题,这两方面彼此融合并不断发生交互作用。当前,这种复杂的变化呈加速趋势,并危及人类自身。文... 详细信息

全球变化的实质是地球生态系统发生的新变化,不仅包括地球自然生态系统运动规律呈现出的新特征,而且包括世界人文生态系统运行中出现的新问题,这两方面彼此融合并不断发生交互作用。当前,这种复杂的变化呈加速趋势,并危及人类自身。文章以唯物史观为理论指导,以当代马克思主义人类命运共同体理论为分析框架,探索全球变化的内在依据及机制、机理,揭示人类本身、人类活动与人类健康的准确内涵和它们之间的内在联系,指出在全球变化背景下实现人类健康的科学路径,分析"健康中国"与"美丽中国"之间的内在逻辑。

关键词：全球变化人类本身人类活动人类健康

Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang Jian-qin Liu Jie Chen zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

糙叶败酱挥发油镇静作用的研究

天然产物研究与开发 1989年第1期1卷 82-84页

作者：齐治田珍秦玉香楼之岑北京医科大学药学院生药教研室

本文观察了败酱科植物糙叶败酱(Patrinia scabra Bunge)根和根茎中制得的挥发油的镇静作用,井与黄花败酱挥发油做了比较。结果表明,此油灌胃给予数组小鼠,剂量0.45ml/kg,显示如下的作用:[1]能显著延长由于腹腔注射戊巴比妥钠(50mg/kg)... 详细信息

本文观察了败酱科植物糙叶败酱(Patrinia scabra Bunge)根和根茎中制得的挥发油的镇静作用,井与黄花败酱挥发油做了比较。结果表明,此油灌胃给予数组小鼠,剂量0.45ml/kg,显示如下的作用:[1]能显著延长由于腹腔注射戊巴比妥钠(50mg/kg)引起的小鼠睡眠时间,但其作用强度弱于黄花败酱挥发油。(2)一次灌胃给予小鼠大剂量10.46g/kg的糙叶败酱挥发油,连续观察10天,动物外观正常,无一死亡,体重增加与对照组相似。

关键词：糙叶败酱挥发油镇静作用

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

药品生产企业在《药品定期安全性更新报告》的作用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药物警戒 2014年第9期11卷 547-549页

作者：魏树民甄志芹李科南邢台市药品不良反应和药物滥用监测中心河北邢台054000

药品定期安全性更新报告(PSUR)作为药物警戒的重要工具,是完善我国药品不良反应报告制度和加强药品上市后安全监管的有效手段,药品生产企业负责撰写PSUR。通过对我国药品生产企业在执行《药品定期安全性更新报告》中的责任和现状分析,... 详细信息

药品定期安全性更新报告(PSUR)作为药物警戒的重要工具,是完善我国药品不良反应报告制度和加强药品上市后安全监管的有效手段,药品生产企业负责撰写PSUR。通过对我国药品生产企业在执行《药品定期安全性更新报告》中的责任和现状分析,探讨生产企业在执行PSUR面临的问题和挑战,对药品生产企业上报PSUR提出了建议。

关键词：药品定期安全性更新报告药物警戒生产企业建议

A facile synthesis of magnetite single-crystal particles by employing GO sheets as template for promising application in magnetic fluid

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2019年第8期38卷 764-769页

作者： zhen qin zhen-Hui Ma Jian-Kang zhi Yong-Ling Fu School of Mechanical Engineering and Automation Beihang University Beijing 100083China College of Materials Science and Engineering Beijing University of Technology Beijing 100124China

It was reported a facile strategy to fabricate magnetite(Fe3O4)single-crystal particles with critical single-domain size by employing graphene oxide(GO)sheets as *** this method,the small-sized Fe2 O3 nanoparticles were first synthesized,and then low-temperature annealing under H2 would convert them into large-sized Fe3 O4 single-crystal *** synthetic particles with an average size of 100 nm exhibit high saturation magnetization(Ms)of 0.085 A·m^2·g^-1,which is very close to theoretical value,being among the highest values in ever reported for Fe3O4 made from chemical *** this basis,the small-sized Fe3 O4 particles(average size of 30 nm)were also fabricated by coating with Na2 CO3 shell.

关键词： Fe3O4 Critical single-domain size Saturation magnetization Chemical synthesis

Random Group Recommendation Model Based on Fuzzy Clustering

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2020年第2期18卷 169-178页

作者： Zhe Ding zhen qin Qi-Xu Wang zhi-Guang qin School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu 610054

The group recommendation system is a viral requirement for the Internet service provider to provide recommendation services for all the users in a group. Due to the shared or different interests among users in the group, it is difficult for traditional personal recommendation algorithms to predict items that can meet the requirements of all the users in the group. In this paper, a random group recommendation model is proposed to recommend the top K most appealing items for all the users in a random group. By analyzing item ratings of all the users in the group, the recommendation model can abstract the group as a virtual user. Then a personal recommendation algorithm is applied to suggest the top K most appealing items for the virtual user. And the preference score and fuzzy clustering algorithm based on multiclass are applied to optimize the recommendation result of the group recommendation model. Finally, the Movie Lens-100 K dataset is applied to verify the efficiency of the recommendation model. The experimental results show that the items recommended by the proposed group recommendation model are more popular for all the users in the group than the items recommended by traditional group recommendation algorithms.

关键词： services app service

在线全文

学校读者我要写书评

暂无评论

掺杂对单层石墨烯纳米梁振动频率的影响

原子与分子物理学报 2025年第3期42卷 67-71页

作者：王志钦王静新疆大学物理科学与技术学院乌鲁木齐830017

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、... 详细信息

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、硼-硼(B-B)掺杂、铍(Be)掺杂和铍-铍(Be-Be)掺杂均会导致单层石墨烯纳米梁的振动频率降低.此外,随着硼(B)/铍(Be)掺杂浓度的增加,单层石墨烯纳米梁的振动频率逐渐降低.且随着掺杂浓度的增加,硼(B)掺杂石墨烯纳米梁的振动频率和铍(Be)掺杂石墨烯纳米梁的振动频率的差异逐渐增大.这对石墨烯纳米机械谐振器、振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：石墨烯振动频率分子动力学

维普期刊数据库博看期刊

Molecular Phylogeny of the “True Citrus Fruit Trees” Group (Aurantioideae, Rutaceae) as Inferred from Chloroplast DNA Sequence

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2011年第1期10卷 49-57页

作者： LU zhen-hua ZHOU zhi-qin XIE Rang-jin College of Horticulture and Landscape Architecture Southwest University Chongqing 400716 P.R.China Citrus Research Institute Chinese Academy of Agricultural Sciences/Southwest University Chongqing 400712 P.R.China zhengzhou Fruit Research Institute Chinese Academy of Agricultural Sciences Zhengzhou 450009 P.R. China

The genus Citrus L. has a long controversial taxonomy history, and a well-resolved molecular phylogeny of the ＂true citrus fruit trees＂ group in the future will provide new information for advancing breeding techniques and developing better conservation strategies. In the present study, three cpDNA fragments （TrnL-TrnF, PsbH-PetB, and TrnS-TrnG） of 30 genotypes chosen from the six genera of the ＂true citrus fruit trees＂ group were analyzed. A molecular phylogenetic tree of the ＂true citrus fruit trees＂ group ＂~as reconstructed based on plastid DNA sequences. The results confirmed that the ＂true citrus fruit trees＂ group was monophyletic, and thereby the group was divided into genera as previously suggested based on morphological characters. The cpDNA data also suggested that Poncirus might be the first genus separated from the other five genera in the group. The genus Fortunella were of hybrid origin and Citrus might be as its putative paternal parent. The genera Microcitrus, Eremocitrus, and Clymenia were possibly monophyletic and their common ancestor might branch out from Citrus. Furthermore, the phylogenetic relationships within the Citrus genus were discussed.

关键词： Rutaceae Aurantioideae true citrus fruit trees group molecular phylogenetics cpDNA sequence