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肝动脉介入术联合香贝散治疗难治性乳腺癌肝转移1例报告及文献复习

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中国肿瘤生物治疗杂志 2024年第1期31卷 101-104页

作者：贾智刘传波周琴李依聪陈涛安超北京中医药大学东方医院肿瘤科北京100078 北京中医药大学东方医院放射科北京100078

乳腺癌肝转移发生率较高,一旦发生将严重影响患者预后,肝转移患者可无明显阳性体征,其化疗效果差,缺乏有效的治疗手段。患者女性,70岁,经左乳腺癌改良根治术辅助放化疗结合内分泌治疗后3年发现肝转移,继采用多种化疗及内分泌治疗方案,... 详细信息

乳腺癌肝转移发生率较高,一旦发生将严重影响患者预后,肝转移患者可无明显阳性体征,其化疗效果差,缺乏有效的治疗手段。患者女性,70岁,经左乳腺癌改良根治术辅助放化疗结合内分泌治疗后3年发现肝转移,继采用多种化疗及内分泌治疗方案,期间出现Ⅱ度神经毒性和Ⅲ度骨髓抑制,患者无法耐受,且肝转移灶不断增大。2023年3月入本院行肝动脉介入化疗术联合内分泌治疗,同时予以中药汤剂香贝散加减口服治疗,治疗4周期后,复查CT提示肝转移灶缩小近75%,疗效评价为部分缓解,患者的生活质量明显提高。该例中西医结合的治疗模式为难治性乳腺癌肝转移及其他难治性恶性肿瘤患者的治疗提供了新思路和新方法。

关键词：乳腺癌肝转移中医药绿色治疗肝动脉介入影像学

Efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder:a randomized,double-blind,controlled trial

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Journal of Traditional Chinese Medicine 2015年第4期35卷 381-388页

作者： Ye Qing zhou Jie yuan Xiaolei yuan Canxing Yang Xuming Neurology Department of Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine College of Acumox and Tuina Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and ***: We conducted a double-blind,randomized,controlled trial involving 100 patients with insomnia of Qi-deficiency of heart and *** were randomly divided into the treatment group(n = 50) and the control group(n = 50) according to a random number table. The treatment group was given Zhenjingdingzhi decoction,while the control group was treated with Suanzaoren decoction. the pharmacological treatment lasted for 8weeks. The clinical efficacy was assessed by using Spiegel scale,Pittsburgh sleep quality index(PSQI)and Traditional Chinese Medicine(TCM) syndrome ***: Comparing Spiegel scores between the two groups at 4 and 8 weeks,the differences in curative effect between the two groups were both significant(both P zhi decoction is effective and safe for the treatment of insomnia with Qi-deficiency of heart and gallbladder,especially for improving sleep quality and sleep duration.

关键词： Sleep initiation and maintenance disorders Shyness Heart Qi deficiency Zhenjingdingzhi decoction Randomized controlled trial Double-blind method

传统转化与东西融合——关于动画电影《天降大任》的创作对话

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当代动画 2024年第1期 37-41,F0004页

作者：宇宙之铁张卫孙平不详中国电影评论学会北京电影学院动画学院

向世界讲述中国故事张卫(以下简称张):这部电影继承了中国经典IP的传统,又对传统进行了现代化的创新,创新使它更容易走向世界,被外国观众所接受。宇宙之铁(以下简称宇):是的,我们希望这部动画不但中国观众爱看,也能让各种文化背景下的... 详细信息

向世界讲述中国故事张卫(以下简称张):这部电影继承了中国经典IP的传统,又对传统进行了现代化的创新,创新使它更容易走向世界,被外国观众所接受。宇宙之铁(以下简称宇):是的,我们希望这部动画不但中国观众爱看,也能让各种文化背景下的外国人爱看。张:的确,向外国人讲述中国故事的时候,要考虑到他们是带着自己的文化视野、价值观念、审美趣味组成的先在结构来看中国故事的。

关键词：天降大任走向世界先在结构动画电影外国观众审美趣味现代化东西融合

Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis

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Genes & Diseases 2023年第3期10卷 1029-1039页

作者： yuan yuan Guoqiang Qiao Jiajiao zhou Yilu zhou Yali Li Xia Li Zhenglin Jiang Yihua Wang Department of Neurophysiology and Neuropharmacology Institute of Special Environmental Medicine and Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu 226019China Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthamptonSO171BJUnited Kingdom Institute for Life Sciences University of SouthamptonSouthamptonSO171BJUnited Kingdom

Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.

关键词： Epithelial-mesenchymal transition Hyperbaricoxygen Hypoxia Pulmonary fibrosis Systematic analysis

Generating a nanoscale blade-like optical field in a coupled nanofiber pair

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Photonics Research 2024年第1期12卷 154-162页

作者： YUXIN YANG JIAXIN GAO HAO WU ZHANKE zhou LIU YANG XIN GUO PAN WANG LIMIN TONG Interdisciplinary Center for Quantum Information New Cornerstone Science LaboratoryState Key Laboratory of Extreme Photonics and InstrumentationCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Jiaxing Key Laboratory of Photonic Sensing&Intelligent Imaging Intelligent Optics&Photonics Research CenterJiaxing Research Institute Zhejiang UniversityJiaxing 314000China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

An optical field with sub-nm confinement is essential for exploring atomic-or molecular-level light-matter *** such fields demonstrated so far have typically point-like cross-sections,an optical field having a higher-dimensional cross-section may offer higher flexibility and/or efficiency in ***,we propose generating a nanoscale blade-like optical field in a coupled nanofiber pair(CNP)with a 1-nm-width central *** on a strong mode coupling-enabled slit waveguide mode,a sub-nm-thickness blade-like optical field can be generated with a cross-section down to~0.28 nm×38 nm at 1550 nm wavelength(i.e.,a thickness of~λ_(0)∕5000)and a peak-to-background intensity ratio(PBR)higher than 20 d *** slit waveguide mode of the CNP can be launched from one of the two nanofibers that are connected to a standard optical fiber via an adiabatical fiber taper,in which a fundamental waveguide mode of the fiber can be converted into a high-purity slit mode with high efficiency(>98%)within a CNP length of less than 10μm at 1550 nm *** wavelengthdependent behaviors and group velocity dispersion in mode converting processes are also investigated,showing that such a CNP-based design is also suitable for broadband and ultrafast pulsed *** results may open up new opportunities for studying light-matter interaction down to the sub-nm scale,as well as for exploring ultra-high-resolution optical technology ranging from super-resolution nanoscopy to chemical bond manipulation.

关键词： fiber waveguide optical

日本滑雪产业助力乡村振兴的经验与启示——基于共生理论的考察

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唐山师范学院学报 2024年第3期46卷 83-88页

作者：周启星赵志明闽南理工学院体育学院福建泉州362000

为促进乡村振兴,日本积极发展滑雪产业,构建了多元主体共生的产业治理模式。研究发现,多元主体协同治理、“六次产业化”、广域DMO合作框架是日本滑雪产业发展的主要实践内容。运用共生理论分析日本滑雪产业共生框架:政府-非政府组织-... 详细信息

为促进乡村振兴,日本积极发展滑雪产业,构建了多元主体共生的产业治理模式。研究发现,多元主体协同治理、“六次产业化”、广域DMO合作框架是日本滑雪产业发展的主要实践内容。运用共生理论分析日本滑雪产业共生框架:政府-非政府组织-企业构成了基本共生单元,政策-区域-市场构成了日本滑雪产业赖以生存的共生环境,关系-价值-治理共同维护了日本滑雪产业共生模式。由此提出我国乡村滑雪产业发展的建议。

关键词：滑雪产业乡村振兴体育产业日本共生理论

“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu Shi-Lei Chen Shuai zhou Hui-Chun Liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： Juan zhou Yiran Xu Luyao Wang Yu Cong Ke Huang Xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei Xu Xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child Health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

基于数据关联感知的无监督深度融合指针网络模型

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控制与决策 2024年第2期39卷 499-508页

作者：张长勇周虎中国民航大学电子信息与自动化学院天津300300

为了提高组合优化问题可行解集合的收敛性和泛化性,根据不同无监督学习策略的特点,提出一种基于数据关联感知的深度融合指针网络模型(DMAG-PN),模型通过指针网络框架将Mogrifier LSTM、多头注意力机制与图卷积神经网络三者融合.首先,编... 详细信息

为了提高组合优化问题可行解集合的收敛性和泛化性,根据不同无监督学习策略的特点,提出一种基于数据关联感知的深度融合指针网络模型(DMAG-PN),模型通过指针网络框架将Mogrifier LSTM、多头注意力机制与图卷积神经网络三者融合.首先,编码器模块中的嵌入层对输入序列进行编码,引入多头注意力机制获取编码矩阵中的特征信息;然后构建数据关联模型探索序列节点间的关联性,采用图卷积神经网络获取其多维度关联特征信息并融合互补,旨在生成多个嵌入有效捕捉序列深层的节点特征和边缘特征;最后,基于多头注意力机制的解码器模块以节点嵌入数据和融合图嵌入数据作为输入,生成选择下一个未访问节点的全局概率分布.采用对称旅行商问题作为测试问题,与当前先进算法进行对比,实验结果表明,所提出DMAG-PN模型在泛化性和求解精确性方面获得较大的改进与提高,预训练好的DMAG-PN模型能够直接对大规模实例进行端到端的求解,避免传统算法迭代搜索的过程,具有较高的求解效率.

关键词：指针网络 Mogrifier LSTM 多头注意力机制图卷积神经网络旅行商问题数据关联