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Molecular Mobility in the Amorphous Phase Determines the Critical Strain of Fibrillation in the Tensile Stretching of Polyethylene

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Chinese Journal of Polymer Science 2020年第7期38卷 740-747,I0006页

作者： Rui Li Guo-Xing Yang Ya-Nan Qin Li Liu zhi-yong jiang School of Chemistry and Chemical Engineering State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of TechnologyHarbin 150001China Daqing Petrochemical Research Center Petrochemical Research InstituteChina National Petroleum CorporationDaqing 163714China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The microstructural development of bimodal high density polyethylene subjected to tensile deformation was investigated as a function of strain after annealing at different temperatures by means of a scanning synchrotron small angle X-ray scattering(SAXS)*** different deformation mechanisms were activated in sequence upon tensile deformation:intralamellar slipping of crystalline blocks dominates the deformation behavior at small deformations whereas a stress-induced crystalline block fragmentation and recrystallization process occurs at a critical strain yielding new crystallites with the molecular chains preferentially oriented along the drawing *** critical strain associated with the lamellar-to-fibrillar transition was found to be ca.0.9 in bimodal sample,which is significantly larger than that observed for unimodal high-density polyethylene(0.4).This observation is primarily due to the fact that the bimodal sample possesses a greater mobility of the amorphous phase and thereby a reduced modulus of the entangled amorphous *** conclusion of the mobility of the amorphous phase as a determining factor for the critical strain was further proven by the 1H-NMR T2 relaxation *** these findings contribute to our understanding of the excellent slow crack growth resistance of bimodal polyethylene for pipe application.

关键词： SAXS Bimodal high density polyethylene Molecular mobility

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An Efficient and Chemoselective Deprotection of tert-Butyldimethyl-silyl Protected Alcohols Using SnCl_2·2H_2O as Catalyst

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Chinese Chemical Letters 2004年第12期15卷 1430-1432页

作者： Jun HUA zhi yong jiang Yan Guang WANG Department of Chemistry, Zhejiang University, Hangzhou 310027 Department of Chemistry Zhejiang University Hangzhou 310027 China

An efficient and selective method for the deprotection of primary alcoholic tert-butyl-dimethylsilyl (TBS) ethers using SnCl_2·2H_2O as catalyst is described. The reaction conditionsallow primary alcoholic TBS ethers to be desilylated chemoselectively in the presence of phenolicTBS ethers, secondary and tertiary alcolholic TBS ethers, and the extensively used TBDPS-,acetyl-, benzyloxycarbonyl-, p-toluenesulfonyl- and benzyl protective groups.

关键词： tert-Butyldimethylsilyl (TBS) ethers deprotection tin dichloride

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Role and mechanism of circ-PRKCI in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第16期25卷 1964-1974页

作者： Su-Xia Qi Hui Sun Hui Liu Jing Yu zhi-yong jiang Ping Yan Emergency Department Qingdao Municipal Hospital (Group) Department of Clinical Laboratory Qingdao Municipal Hospital (Group) Department of Clinical Laboratory Qingdao Women's and Children's Hospital Department of Clinical Laboratory Qingdao Haici Medical Group

BACKGROUND The circular RNA circ-PRKCI is an endogenous non-coding RNA that forms a covalently closed ring after reverse splicing, which plays a key role in the occurrence and development of multiple digestive system *** To investigate the role and mechanism of circ-PRKCI in the occurrence and development of hepatocellular carcinoma(HCC).METHODS This study used real-time polymerase chain reaction to detect the expression of circ-PRKCI in tumor tissues, tumor adjacent tissues, and blood in patients with HCC and other digestive system tumor cells. A series of functional tests were performed to explore whether circ-PRKCI affects the growth of HCC cells and what is its mechanism in HCC. Meanwhile, fluorescence in situ hybridization was used to detect the subcellular localization of circ-PRKCI. Survival analysis was performed to predict the correlation between circ-PRKCI and the prognosis of HCC. Chi-square test and t-test were performed for statistical *** The level of circ-PRKCI was significantly higher in HCC tissues than in tumor adjacent tissues, and in HCC cell lines than in cells lines of esophageal, liver,stomach, and colon cancers. A series of functional tests showed that circ-PRKCI substantially inhibited cell apoptosis and promoted cell invasion. It was foundthat circ-PRKCI can act as the sponge of miRNA-545 to reduce the expression of AKT3 protein. Moreover, the result of survival analysis showed that circ-PRKCI target gene E2 F7 can reduce liver cancer patients' survival rate. And clinical data suggested that the distribution of circ-PRKCI rose with the depth of invasion,lymph node metastasis, distant metastasis, and TNM stage, indicating that circPRKCI may affect the survival and prognosis of patients with HCC by regulating E2 *** This study explores the role and mechanism of circ-PRKCI in HCC, which provides a new research direction and theoretical basis for the treatment of HCC.

关键词： Circ-PRKCI Hepatocellular carcinoma Cell invasion Protein kinase B signaling pathway Progression

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Massive hemorrhagic ascites: A rare presentation of eosinophilic gastroenteritis

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World Journal of Clinical Cases 2018年第7期6卷 156-160页

作者： Lei Shi Qiu-Hong Jia Fu-Jian Liu Hang Guan zhi-yong jiang Department of Gastroenterology the Eighth Affiliated Hospital of Guangxi Medical University

According to Klein's classification system, the symp-tomatology of eosinophilic gastroenteritis(EG), a rare disease, differs based on the affected tissue layer. Pati-ents with subserosal EG often have peritoneal effusion. Hemorrhagic ascites due to EG is extremely rare and has not been reported in the literature. Here, we report a 57-year-old woman with EG and massive hemorrhagic ascites. Laboratory investigations showed elevated per-ipheral eosinophils with significant eosinophilia(65.6%). Ultrasonography showed massive abdominal ascites. Ab-dominal paracentesis revealed hemorrhagic peritoneal fluid and microscopy showed predominant eosinophils. Upper gastrointestinal endoscopy revealed erosions, ex-udates, and mucosal rings in the duodenal mucosa; hist-ological examination indicated eosinophilic infiltration. EG presenting with hemorrhagic ascites was diagnosed by histologic examination of eosinophilic infiltration. She was empirically treated with ketotifen 1 mg bid po with rapid resolution of ascites and a remarkable decline in peripheral eosinophil counts. Clinicians should consider the different-ial diagnosis of unexplained hemorrhagic ascites.

关键词： Hemorrhagic ascites Eosinophilic infiltration Eosinophilic gastroenteritis

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Simultaneous determination of flavonoids and anthraquinones in chrysanthemum by capillary electrophoresis with amperometry detection

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Chinese Chemical Letters 2010年第10期21卷 1231-1234页

作者： Yin Yan Zhang Zi Cheng Li Jin Kun Zhu zhi yong Yang Qing jiang Wang Pin Gang He Yu zhi Fang Department of Chemistry East China Normal University Shanghai 200062 China

A high-performance capillary electrophoresis with amperometry detection method （CE-AD） has been developed for the analysis of flavonoids and anthraquinones （emodin, kaempferol, apigenin, luteolin and rhein） in chrysanthemum. Under optimum conditions, these five analytes were base-line separated within 17 min using a borate-phosphate running buffer （1.5 ×10^-2 mol/L borate-3× 10^-2 mol/L phosphate running buffer, pH 9.0） at a working potential of ＋0.90 V （vs. SCE） and a separation voltage of 19 kV. The linear relationship between concentration and current response was obtained with detection limits （S/N = 3） ranging from 1.0 × 10^-7 to 2.1 × 10^-7 g/mL for all analytes. This proposed method was successfully used in the analysis of four kinds of chrysanthemum with relatively simple extraction procedures, the assay results were satisfactory.

关键词： Capillary electrophoresis Amperometry detection Chrysanthemu Flavonoids Anthraquinones

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Diagnostic ability of multi-detector spiral computed tomography for pathological lymph node metastasis of advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 435-446页

作者： zhi-yong jiang Shinichi Kinami Naohiko Nakamura Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka Department of Surgical Oncology Kanazawa Medical University1-1 DaigakuUchinada-machiKahoku-gunIshikawa 920-0293Japan

BACKGROUND The reliability of preoperative nodal diagnosis of advanced gastric cancer by multi-detector spiral computed tomography(MDCT)is still *** To examine the diagnostic ability of MDCT more precisely by using data on intranodal pathological metastatic *** A total of 108 patients with advanced gastric cancer who underwent MDCT and curative gastrectomy at Kanazawa Medical University Hospital were enrolled in this *** nodal sizes measured on computed tomography(CT)images were compared with the pathology results.A receiver-operating characteristic curve was constructed,from which the critical value(CV)was calculated by using the data of the first 69 patients *** using the CV,sensitivity and specificity were calculated with prospectively collected data from 39 consecutive *** enabled a more precise one-to-one correspondence of lymph nodes between CT and pathological examination by using the size data of lymph node *** intranodal pathological metastatic patterns were classified into the following four types:Small nodular,peripheral,large nodular,and *** Although all the cases were clinically suspected as having metastasis,81 had lymph node metastasis and 27 had no *** number of dissected,detected on CT,and metastatic nodes were,4241,897,and 801,*** CV obtained from the receiver-operating characteristic was 7.6 mm for the long *** sensitivity was 91.4%and the specificity was 47.3%in the prospective *** large nodular and diffuse metastases were easy to diagnose becausemetastatic nodes with a large axis often exhibit these *** The ability of MDCT to contribute to a nodal diagnosis of advanced gastric cancer was examined prospectively with precise size data from node mapping,using a CV of 7.6 mm for the long axis that was calculated from the retrospectively collected *** sensitivity was as high as 91%,and would be improved when referring to the en

关键词： Advanced gastric cancer Lymph node metastasis Multi-detector spiral computed tomography Pathological diagnosis

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Efficacy of the fat-dissociation method for nodal harvesting in gastric cancer

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World Journal of Gastrointestinal Surgery 2020年第6期12卷 277-286页

作者： Shinichi Kinami Toshio Ohnishi Naohiko Nakamura zhi yong jiang Takashi Miyata Hideto Fujita Hiroyuki Takamura Nobuhiko Ueda Takeo Kosaka Department of Surgical Oncology Kanazawa Medical UniversityKahoku-gunIshikawa920-0293Japan

BACKGROUND There is an increased need for accurate staging for gastric cancer ***, it is necessary to carefully examine all dissected lymph nodes for precise staging. Recently, the fat-dissociation method has been developed as a quick and accurate method for harvesting dissected lymph nodes of colorectal cancer *** To investigate the usefulness of the fat-dissociation method for harvesting dissected lymph nodes of gastric cancer *** Fifty-six resected specimens from gastric cancer patients who underwent standard curative gastrectomy and lymph node dissection at our hospital were used. Group 2 lymph nodes were separated from each specimen, and the remaining adipose tissue containing the group 1 lymph nodes was used. Some resected specimens were subjected to the fat-dissociation method. One vial of Imofully~? was dissolved in 50 m L of saline and injected into the tissue. The tissue was incubated for 1 h and the dissolved fat was removed. Subsequently, the nodes were identified, picked up with scissors, and mapped. The number of nodes in each lymphatic compartment and duration of lymph node harvest and mapping were *** The fat-dissociation method was used for 24 samples, while the conventional dissection method was used for 32 samples. The total number of harvested lymph nodes was 45.9 in the fat dissociation group and 44.3 in the control group, and there was no significant difference between the two groups. There were also no significant differences in the number of lymph nodes between the two groups based on a comparison of the lymphatic compartments. However, the total median duration of the fat-dissociation method was 38.2 min, reflecting a reduced duration of approximately 60 min compared to the control *** Based on our results, the fat-dissociation method is effective in shortening the duration of lymph node harvest in gastric cancer surgery.

关键词： Gastric cancer Lymph node dissection Staging Lymph node mapping Fatdissociationmethod Efficacy

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Expression of RUNX2 and MDM21 in rats with periodontitis under chronic intermittent hypoxia

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 759-763页

作者： Kun Li Su-Ge Dong Hua-Xiang Zhang Shu Zhou Li Ma Qiong-Qiong Yu zhi-yong jiang Qiang-Fu Hu Dan Zhou Department of Stomatology the Fifth Affiliated Hospital of Zhengzhou University Department of Periodontics Wuhan University Stomatological Hospital Department of Anesthesiology the Fifth Affiliated Hospital of Zhengzhou University Department of Cardiac Surgery the Fifth Affiliated Hospital of Zhengzhou University

Objective: To discuss the expression of RUNX2 and MDM21 in rats with periodontitis under the chronic intermittent hypoxia. Methods: A total of 32 SD healthy rats were randomly divided into four groups, with 8 rats in each group. The molecular biological techniques of immunohistochemistry, RT-PCR and Western blotting were employed to detect the effect of different hypoxia time(0, 6, 12, 24 and 48 h) and different concentrations of hypoxia(0.000, 0.001, 0.010, 0.060 and 0.100 ppm) on the expression of RUNX2 and MDM21 in rats of four groups. Results: The expression of RUNX2 and MDM21 in each group was significantly higher than the one at other concentrations when the concentration was 0.010 ppm, with the statistical difference(P periodontitis group> chronic intermittent hypoxia group > compound group under the action with the concentration of 0.010 ppm for 12 h, but there was no significant difference for the comparison among groups(P>0.05). Conclusions: The condition of chronic intermittent hypoxia can reduce the expression of RUNX2 and MDM21 in rats with periodontitis and aggravate the damage of periodontal bone.

关键词： Chronic intermittent hypoxia RUNX2 MDM21 Periodontitis

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基于同步辐射超小角X射线散射的高密度聚乙烯空洞化行为研究

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高分子学报 2021年第2期52卷 204-213,I0005页

作者：付莲莲卢影姜志勇门永锋华侨大学材料科学与工程学院厦门361021 中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022

以一系列高温结晶后自然冷却的高密度聚乙烯(HDPE)为研究对象,利用同步辐射超小角X射线散射(USAXS)和示差扫描量热技术(DSC)对样品的微观结构进行了分析,并在线研究了单轴拉伸过程中的空洞化行为.结果表明,结晶温度高于110℃后自然冷却... 详细信息

以一系列高温结晶后自然冷却的高密度聚乙烯(HDPE)为研究对象,利用同步辐射超小角X射线散射(USAXS)和示差扫描量热技术(DSC)对样品的微观结构进行了分析,并在线研究了单轴拉伸过程中的空洞化行为.结果表明,结晶温度高于110℃后自然冷却到室温的样品中存在热稳定性不同的两组片晶,等温过程形成结构完善的厚片晶,而在冷却过程会形成有缺陷的薄片晶,两组片晶的熔点分别在133和110℃附近.在30℃拉伸时,所有样品都可观察到空洞化并伴随发白现象.并且,等温结晶中形成片晶厚度越大的样品,相应的空洞化现象越明显.在拉伸过程中,空洞出现在屈服点附近,其法向方向平行于拉伸方向,后随应变的增加发生转向,法向方向与拉伸方向垂直.样品中空穴的长度为900~1200 nm.另一方面,随着冷却过程生成薄片晶比例的增加,空洞化趋势下降.此外,提高拉伸温度,样品更倾向发生塑性形变,空洞化程度减弱.

关键词： X射线散射聚乙烯空洞化拉伸温度

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Effect of Sb-doping on the morphology and dielectric properties of chrysanthemum-like ZnO nanowire clusters

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Chinese Physics B 2012年第9期21卷 520-524页

作者：闫军锋游天桂张志勇田江晓江妮赵武 School of Information Science and Technology Northwest University

Chrysanthemum-like ZnO nanowire clusters with different Sb-doping concentrations were prepared using a hy- drothermal process. The microstructures, morphologies, and dielectric properties of the as-prepared products were characterized by X-ray diffraction （XRD）, high-resolution transmission electron microscopy （HRTEM）, field emission environment scanning electron microscope （FEESEM）, and microwave vector network analyzer respectively. The results indicate that the as-prepared products are Sb-doped ZnO single crystallines with a hexagonal wurtzite structure, the flower bud saturation degree Fd is obviously different from that of the pure ZnO nanowire clusters, the good dielectric loss property is found in Sb-doped ZnO products with low density, and the dielectric loss tangent tanSe increases with the increase of the Sb-doping concentration in a certain concentration range.

关键词： chrysanthemum-like ZnO nanowire clusters dielectric properties hydrothermal method Sb doping

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