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DCFNet:An Effective Dual-Branch Cross-Attention Fusion Network for Medical Image Segmentation

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1103-1128页

作者： Chengzhang Zhu Renmao Zhang Yalong Xiao Beiji Zou Xian Chai Zhangzheng yang Rong Hu Xuanchu Duan School of Computer Science and Engineering Central South UniversityChangsha410083China School of Humanities Central South UniversityChangsha410083China Xiangya Hospital Central South University Changsha410008China Changsha Aier Eye Hospital Changsha410015China

Automatic segmentation of medical images provides a reliable scientific basis for disease diagnosis and ***,most existing methods that combine the strengths of convolutional neural networks(CNNs)and Transformers have made significant ***,there are some limitations in the current integration of CNN and Transformer technology in two key ***,most methods either overlook or fail to fully incorporate the complementary nature between local and global ***,the significance of integrating the multiscale encoder features from the dual-branch network to enhance the decoding features is often disregarded in methods that combine CNN and *** address this issue,we present a groundbreaking dual-branch cross-attention fusion network(DCFNet),which efficiently combines the power of Swin Transformer and CNN to generate complementary global and local *** then designed the Feature Cross-Fusion(FCF)module to efficiently fuse local and global *** the FCF,the utilization of the Channel-wise Cross-fusion Transformer(CCT)serves the purpose of aggregatingmulti-scale features,and the Feature FusionModule(FFM)is employed to effectively aggregate dual-branch prominent feature regions from the spatial ***,within the decoding phase of the dual-branch network,our proposed Channel Attention Block(CAB)aims to emphasize the significance of the channel features between the up-sampled features and the features generated by the FCFmodule to enhance the details of the *** results demonstrate that DCFNet exhibits enhanced accuracy in segmentation *** to other state-of-the-art(SOTA)methods,our segmentation framework exhibits a superior level of ***’s accurate segmentation of medical images can greatly assist medical professionals in making crucial diagnoses of lesion areas in advance.

关键词： Convolutional neural networks Swin Transformer dual branch medical image segmentation feature cross fusion

MPZL1 as an HGF/MET signaling amplifier promotes cell migration and invasion in glioblastoma

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Genes & Diseases 2024年第5期11卷 70-73页

作者： Haimin Song Bowen Ni Xuetao Peng Weijuan Xu Shaochun yang Runwei yang Ziyu Wang Kaishu Li Rui Lin Yunxiao Zhang Jinglin Guo Kezhi Wu Guangwei Shi Jichao Sun Chunming He Yawei Liu Department of Neurosurgery The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi 341000China Department of Neurosurgery&Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Medical Research Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Bidding and Procurement Office Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)FoshanGuangdong 528300China Department of Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Neurosurgery The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuanGuangdong 511518China Department of Neurosurgery The First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China Department of Geriatrics Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China

The extremely poor prognosis of patients is largely due to hepatocyte growth factor(HGF)/MET signaling,which promotes migration and invasion of glioblastoma(IDH wildtype;GBM;WHO grade 4).1,2 Clinical trials targeting MET,the only receptor of HGF,have yielded unimpressive results in GBM.3,4 Here we found that HGF induced strong chemotaxis on GBM cells,but MET expression was extremely ***,therefore,used single-cell RNA sequencing(scRNA-seq)coupled with label-free proteome profiling to identify membrane proteins associated with HGF/MET signaling amplification in GBM and to provide a novel modulator,MPZL1,for HGF/MET-targeted therapy.

关键词： invasion prognosis Clinical

Confidence Estimation Transformer for Long-Term Renewable Energy Forecasting in Reinforcement Learning-based Power Grid Dispatching

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1502-1513页

作者： Xinhang Li Nan yang Zihao Li Yupeng Huang Zheng Yuan Xuri Song Lei Li Lin Zhang Beijing University of Posts and Telecommunications Beijing 100876China Beijing Key Laboratory of Research and System Evaluation of Power Dispatching Automation Technology

Expansion of renewable energy could help realize the goals of peaking carbon dioxide emissions and carbon *** existing grid dispatching methods integrating short-term renewable energy prediction and reinforcement learning(RL)have been proven to alleviate the adverse impact of energy fluctuations ***,these methods omit long-term output prediction,which leads to stability and security problems on optimal power *** paper proposes a confidence estimation Transformer for long-term renewable energy forecasting in reinforcement learning-based power grid dispatching(Conformer-RLpatching).Conformer-RLpatching predicts long-term active output of each renewable energy generator with an enhanced Transformer to ensure stable operation of the hybrid energy grid and improve the utilization rate of renewable energy,thus boosting dispatching ***,a confidence estimation method is proposed to reduce the prediction error of renewable ***,a dispatching necessity evaluation mechanism is put forward to decide whether the active output of a generator needs to be *** carried out on the SG-126 power grid simulator show that Conformer-RLpatching achieves great improvement over the second best algorithm DDPG in security score by 25.8%and achieves a better total reward compared with the golden medal team in the power grid dispatching competition sponsored by State Grid Corporation of China under the same simulation *** are outsourced in https://***/BUPT-ANTlab/Conformer-RLpatching.

关键词： Conformer-RLpatching optimal power flow reinforcement learning renewable energy prediction

Morphology effect on catalytic performance of ebullated-bed residue hydrotreating over Ni-Mo/Al_(2)O_(3)catalyst:a kinetic modeling study

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Green Chemical Engineering 2024年第1期5卷 60-67页

作者： Zhe Liu Juncong Yuan Zongzhuang Sun Xiang Feng Yibin Liu Huihong Zhu Chong Peng Chaohe yang State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao266580China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116045China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024China

Upgrading of vacuum residue is of prime industrial significance due to the increasing demand for light *** the effect of catalyst morphology on vacuum residue hydrotreating performance by kinetic modeling is therefore of great ***,kinetic analysis of hydrodemetallization(HDM)and hydrodeconradsoncarbon-residue(HDCCR)performances on industrial Ni-Mo/Al_(2)O_(3)catalysts with spherical and cylindrical morphologies in ebullated-bed were evaluated for more than 1600 *** was found that the percentage of light impurities easier to be removed on spherical catalysts were 78.20%and 39.43%in HDM and HDCCR reactions,respectively,higher than 65.20%and 17.50%on cylindrical *** suggests that catalyst morphology affects the impurity removal ability and the impurity properties,resulting in better hydrotreating performance of spherical *** work not only combines catalyst morphology with impurity removal capability through kinetic modeling,but also provides new insights into the design of efficient hydrotreating catalysts.

关键词： Morphology effect Kinetic analysis Vacuum residue Hydrotreating

Selective oxygen electroreduction to hydrogen peroxide in acidic media:The superiority of single-atom catalysts

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Nano Research 2024年第6期17卷 4668-4681页

作者： Ergui Luo Tongtong yang Jingyi Liang Yuhong Chang Junming Zhang Tianjun Hu Junjie Ge Jianfeng Jia Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Electroanalytic Chemistry Jilin Province Key Laboratory of Low Carbon Chemistry PowerChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Two-electron oxygen reduction reaction(2e-ORR)provides an environmentally friendly direction for the on-site production of hydrogen peroxide(H_(2)O_(2)).Central to this technology is the exploitation of efficient,economical,and safe 2e-ORR *** overview starts with the fundamental chemistry of ORR to highlight the decisive role of adsorbing intermediates on the reaction pathway and activity,followed by a comprehensive survey of the tuning strategies to favor 2e-ORR on traditional precious *** latest achievements in designing efficient and selective precious-metal-based single-atom catalysts(SACs)and metal-nitrogen-carbon(M-Nx/C)catalysts,from the aspects of material synthesis,theoretical calculations,and mass transport promotion,are systematically *** introductions on the evaluation metrics for 2e-ORR catalysts and the primary reactor designs for cathodic H_(2)O_(2)synthesis are also *** conclude this review with an outlook on the challenges and direction of efforts to advance electrocatalytic 2e-ORR into realistic H_(2)O_(2)production.

关键词： oxygen reduction reaction H_(2)O_(2)production single-atom catalysts selectivity

Flurbiprofen microneedle patches for the management of acute postoperative pain

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Nano Research 2024年第8期17卷 7493-7503页

作者： Huaqing Chu Yanyan Zhang Yuan yang Jiangtao Xue Cong Li Wei Zhang Zhou Li Hui Zheng National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases School of Integrated Chinese and Western MedicineHunan University of Chinese MedicineChangsha 410208China School of Life Science Institute of Engineering MedicineBeijing Institute of TechnologyBeijing 100081China Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China

Acute postoperative pain is commonly treated with flurbiprofen(FBP),but conventional delivery methods are *** study prepared a new non-burst release microneedles(MNs)using genipin cross-linked gelatin(cGel).By adding varying amounts of genipin to modulate the crosslinking degree of cGel,the drug release behavior of the drug-loaded MNs in the skin can be *** crosslinking parameters that meet therapeutic requirements are selected,thus providing rapid and longlasting analgesic *** solutions were successfully cross-linked,altering matrix material microstructure,confirmed by scanning electron microscope imaging and fourier transform infrared *** demonstrated increasing mechanical strength with higher *** release rates were rapid initially,then slowed,exhibiting a characteristic of decreased release rates with increasing degrees of *** vivo,FBP/cGel MNs significantly reduced allodynia and hyperalgesia post-surgery,with the greatest effect observed at 2–3 h post-surgery,and can maintain analgesia for up to 6 *** tests confirmed good ***/cGel MNs effectively penetrate the stratum corneum,safely delivering drugs with significant analgesic effects,excellent mechanical properties,and good biocompatibility,representing a promising strategy for managing acute postoperative pain.

关键词： microneedle postoperative pain flurbiprofen non-steroid anti-inflammatory drug cross-linked gelatin

土地资源错配对城市碳排放效率的影响及作用机制研究

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城市问题 2024年第1期 27-34,55页

作者：安勇山西财经大学金融学院

基于中国政治治理制度和土地制度,从理论上系统剖析土地资源错配对碳排放效率的内在影响逻辑,在此基础上借助Super-SBM模型对中国273个城市的碳排放效率进行测算,综合运用面板Tobit模型和固定效应模型实证分析土地资源错配对城市碳排放... 详细信息

基于中国政治治理制度和土地制度,从理论上系统剖析土地资源错配对碳排放效率的内在影响逻辑,在此基础上借助Super-SBM模型对中国273个城市的碳排放效率进行测算,综合运用面板Tobit模型和固定效应模型实证分析土地资源错配对城市碳排放效率的影响及其作用机制。结果表明:土地资源错配抑制了城市碳排放效率提升,且这种负向作用在中西部城市、中小城市和资源型城市表现得更为突出。机制检验发现,抑制产业结构高级化转型、扭曲财政支出结构、阻碍企业履行社会责任、抑制企业绿色创新是四条重要的传导渠道。进一步分析表明,地方政府经济增长目标设定和财政压力会强化土地资源错配对城市碳排放效率的抑制作用,而绿色绩效考核机制则弱化了土地资源错配的负向影响。

关键词：土地资源错配碳排放效率面板Tobit模型作用机制

The secretory function of adipose tissues in metabolic regulation

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Life Metabolism 2024年第2期3卷 9-23页

作者： yang Liu Shu-Wen Qian Yan Tang Qi-Qun Tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan HospitalFudan UniversityShanghai 200032China

In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic *** secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose *** processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise *** this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic ***,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关键词： adipokines autocrine paracrine endocrine metabolic regulation

Pancreatic β-cell failure,clinical implications,and therapeutic strategies in type 2 diabetes

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Chinese Medical Journal 2024年第7期137卷 791-805页

作者： Daxin Cui Xingrong Feng Siman Lei Hongmei Zhang Wanxin Hu Shanshan yang Xiaoqian Yu zhiguang Su Molecular Medicine Research Center and Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuan 610041China Clinical Translational Innovation Center West China HospitalSichuan UniversityChengduSichuan 610041China

Pancreaticβ-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes(T2D).Reserving insulin-producingβ-cells and hence restoring insulin production are gaining attention in translational diabetes research,andβ-cell replenishment has been the main focus for diabetes *** findings inβ-cell proliferation,transdifferentiation,pluripotent stem cell differentiation,and associated small molecules have served as promising strategies to regenerateβ-*** this review,we summarize current knowledge on the mechanisms implicated inβ-cell dynamic processes under physiological and diabetic conditions,in which genetic factors,age-related alterations,metabolic stresses,and compromised identity are critical factors contributing toβ-cell failure in *** article also focuses on recent advances in therapeutic strategies for diabetes treatment by promotingβ-cell proliferation,inducing non-β-cell transdifferentiation,and reprograming stem cell *** a significant challenge remains for each of these strategies,the recognition of the mechanisms responsible forβ-cell development and mature endocrine cell plasticity and remarkable advances in the generation of exogenousβ-cells from stem cells and single-cell studies pave the way for developing potential approaches to cure diabetes.

关键词： Pancreaticβ-cell regeneration Diabetes Insulin Dedifferentiation Transdifferentiation Stem cell