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Acta Biochimica et Biophysica Sinica 2004年第12期36卷 811-816页

作者： zhi-yong liao1,2.and shang-quan zhu2. 1college of life sciences,{2., Nanchang 33002., china 2.ey Laboratory of Proteomics Biochemistry and Cell Biology, shanghai Institutes for Biological sciences, Chinese Academy of sciences, Graduate School of the Chinese Academy of sciences, shanghai 2.0031, china college of life {2. Jiangxi Normal UniversityNanchang 330027 China Key Laboratory of Proteomics Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China

Chinese sturgeon, a kind of cartilage ganoid, has a history of over one billion years and it is called the living fossil of aquatic biology since it keeps some evolutionary trace. Here, we characterized the growth hormone receptor (GHR) and serum growth hormone binding protein (GHBP) of Chinese sturgeon. It was shown that GHR was expressed in various tissues, mainly in hepatic, kidney and intestine tissues. GHR on the hepatic membrane has high and specific affinity for bream GH (brGH) and Scatchard analysis of the binding data showed a single class of high affinity binding site with an association constant Ka of 3.1×109 M–1. A specific band around 94 kD was detected by SDS-PAGE in cross-linking studies of membrane receptors. After incubation of Chinese sturgeon serum with 12.I-brGH, a 12.I-brGH-GHBP complex was identified by Sephadex G-75, indicating that in the serum exists GHBP specially binding to brGH.

关键词： Chinese sturgeon growth hormone receptor growth hormone binding protein ligand binding

Enhancing Deep Learning Semantics:The Diffusion Sampling and Label-Driven Co-Attention Approach

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Computers, Materials & Continua 2024年第5期79卷 1939-1956页

作者： ChunhuaWang Wenqian shang Tong Yi Haibin zhu State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China School of Computer and Cyber sciences Communication University of ChinaBeijing100024China School of Computer Science and Engineering Guangxi Normal UniversityGuilin541004China Department of Computer Science Nipissing UniversityNorth BayON P1B 8L7Canada

The advent of self-attention mechanisms within Transformer models has significantly propelled the advancement of deep learning algorithms,yielding outstanding achievements across diverse ***,self-attention mechanisms falter when applied to datasets with intricate semantic content and extensive dependency *** response,this paper introduces a Diffusion Sampling and Label-Driven Co-attention Neural Network(DSLD),which adopts a diffusion sampling method to capture more comprehensive semantic information of the ***,themodel leverages the joint correlation information of labels and data to introduce the computation of text representation,correcting semantic representationbiases in thedata,andincreasing the accuracyof semantic ***,the model computes the corresponding classification results by synthesizing these rich data semantic *** on seven benchmark datasets show that our proposed model achieves competitive results compared to state-of-the-art methods.

关键词： Semantic representation sampling attention label-driven co-attention attention mechanisms

Thermally modulated photoelectronic synaptic behavior in HfS_(2./VO_(2. heterostructure

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Rare Metals 2024年第8期43卷 3798-3809页

作者： Le Wang Lin Wang Xiao-Yun Ye Xiong-Hu Xu Li-Yan shang Ya-Wei Li Jin-Zhong Zhang Liang-Qing zhu {2.-Gao Hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Neuromorphic computing is known for its efficient computational speed,low latency,and reduced power consumption,which is considered a pivotal technology to overcome the von Neumann *** synapses are an indispensable component of neuromorphic computational artificial neural *** guarantee effective and precise processing of optical signals,it must have a high responsivity,detectivity,and the ability to adapt to various ***,a synaptic transistor based on the HfS_(2./VO_(2. heterojunction with a responsivity of8.6×10^(3) A·W^(-1)and a detectivity of 1.2.×10^(14)Jones at405 nm laser was ***,the typical synaptic behavior was successfully simulated,including postsynaptic currents(PSCs),the transition from shortterm plasticity(STP)to long-term plasticity(LTP).When VO_(2. converts from the semiconductor state to the metal state,the HfS_(2./VO_(2. heterojunction transforms into a Schottky heterojunction from a TypeⅡheterojunction with ***'s important,the heterojunction still exhibits excellent responsivity and detectivity,as well as stability of synaptic *** addition,the classical Pavlovian conditioning experiment is simulated under different laser intensity to study the brain's associative learning *** results demonstrate that the HfS_(2./VO_(2. heterojunction synapse exhibits significant responsivity and detectivity and is adaptable to high-temperature environments,showing great potential for neuromorphic computational applic ations.

关键词： HfS_(2. VO_(2. Phase transition Photoelectric synapse Heterojunction

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG yong-quan LIU Jia-lin CHEN Geng-xin SHEN Dan-ting {2. Wang CHEN Xin-lin LIU Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2.weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(Pnormal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

Monotropein Induced Apoptosis and Suppressed Cell Cycle Progression in Colorectal Cancer Cells

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Chinese Journal of Integrative Medicine 2024年第1期30卷 25-33页

作者： GAO quan LI Lin ZHANG Qi-man SHENG Qin-song ZHANG Ji-liang JIN Li-jun shang Rui-yan School of Pharmacy and Department of Medical Oncology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Department of Colorectal Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Beijing Tong Ren Tang Chinese Medicine Co. Ltd.Beijing(100000)China Department of Traditional Chinese Medicine Hangzhou Shangcheng District People's HospitalHangzhou(310006)China Department of Gynecology Hangzhou Women's HospitalHangzhou(310008)China

Objective: To determine whether monotropein has an anticancer effect and explore its potential mechanisms against colorectal cancer(CRC) through network pharmacology and molecular docking combined with experimental verification. Methods: Network pharmacology and molecular docking were used to predict potential targets of monotropein against CRC. Cell counting kit assay, plate monoclonal assay and microscopic observation were used to investigate the antiproliferative effects of monotropein on CRC cells HCT116, HT2. and LoVo. Flow cytometry and scratch assay were used to analyze apoptosis and cell cycle, as well as cell migration, respectively in HCT116, HT2., and LoVo cells. Western blotting was used to detect the expression of proteins related to apoptosis, cell cycle, and cell migration, and the expression of proteins key to the Akt pathway. Results: The Gene Ontology and Reactome enrichment analyses indicated that the anticancer potential of monotropein against CRC might be involved in multiple cancer-related signaling pathways. Among these pathways, RAC-beta serine/threonine-protein kinase(Akt1, Akt2., cyclin-dependent kinase 6(CDK6), matrix metalloproteinase-9(MMP9), epidermal growth factor receptor(EGFR), cell division control protein 42.homolog(CDC42. were shown as the potential anticancer targets of monotropein against CRC. Molecular docking suggested that monotropein may interact with the 6 targets(Akt1, Akt2. CDK6, MMP9, EGFR, CDC42.. Subsequently, cell activity of HCT116, HT2. and LoVo cell lines were significantly suppressed by monotropein(P2.and increasing Bax, induced G_1–S cycle arrest in colorectal cancer by decreasing the expressions of CyclinD1, CDK4 and CDK6, inhibited cell migration by suppressing the expressions of CDC42.and MMP9(P<0.05), and might play an anticancer role through Akt signaling pathway. Conclusions: Monotropein exerts its antitumor

关键词： monotropein Chinese medicine anticancer activity colorectal cancer cells network pharmacology

Rydberg-Atom Terahertz Heterodyne Receiver with Ultrahigh Spectral Resolution

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Chinese Physics Letters 2024年第8期41卷 17-21页

作者： Zhenyue She Xiaojie zhu Yayi Lin Xianzhe Li Xiaolin Yang Yanfei shang Yuqin Teng Haitao Tu Kaiyu {2. Caixia Zhang Xiaohong Liu Jiehua Chen Wei Huang Key Laboratory of Atomic and Subatomic Structure and quantum Control(Ministry of Education) School of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of quantum Engineering and quantum Materials South China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of quantum Matter Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China GPETR Center for quantum Precision Measurement South China Normal UniversityGuangzhou 510006China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China university of Chinese Academy of sciences Beijing 100049China Key Laboratory of Atomic Frequency Standards Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Wuhan Institute of quantum Technology Wuhan 430206China

Terahertz heterodyne receivers with high sensitivity and spectral resolution are crucial for various ***,we present a room-temperature atomic terahertz heterodyne receiver that achieves ultrahigh sensitivity and frequency *** a signal frequency of 338.7 GHz,we obtain a sensitivity of 2.88±0.09V·cm^(−1)·Hz^(−1/2. for electric field *** calibrated linear dynamical range spans approximately 89 dB,ranging from−110 dBV/cm to−2. dBV/*** demodulate a 400 symbol stream encoded in 4-state phase-shift keying,demonstrating excellent phase detection *** scanning the frequency of the local oscillator,we realize a terahertz spectrometer with Hz level frequency *** resolution is more than two orders of magnitude higher than that of existing terahertz *** demonstrated terahertz heterodyne receiver holds promising potential for working across the entire terahertz spectrum,significantly advancing its practical applications.

关键词： magnitude holds resolution

High pressure phase boundaries of AgNbO_(3)

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Journal of Materiomics 2024年第2期10卷 431-439页

作者： Kai Dai Anyang Cui Yafang Li Zhen Liu Yuting Yan Kai Jiang Jinzhong Zhang Liyan shang Liangqing zhu Yawei Li Genshui Wang {2.gao Hu Technical Center for Multifunctional Magneto-Optical Spectroscopy(shanghai) Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education)Department of PhysicsSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai200241China Key Laboratory of Optoelectronic Material and Device Department of PhysicsShanghai Normal UniversityShanghai200234China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing401120China Key Laboratory of Inorganic Functional Materials and Devices Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi030006China

The external pressure is one of the essential parameters for regulating the structure and energy con-version properties of antiferroelectric AgNbO_(3).For pure AgNbO_(3),however,there has been still a blank of its real lattice structure under the stress ***,high-pressure lattice structures and phase transitions of AgNbO_(3)have been explored by spectroscopic experiments and theoretical models.A successive phase transition process from Pbcm to C2.2.(1) to P2.(1) has been observed at the pressure range of 0-30 GPa,associated with displacive-type characterized by soft-mode *** that the paraelectric phase cannot be achieved under high-pressure at room ***,the competition of long-range Coulomb force,short-range interatomic interaction,and covalent interaction in AgNbO_(3)lattice were demonstrated under the stress *** present work can provide fundamental guidelines to reveal the high-pressure phase transitions of AgNbO_(3),which will open up possibilities for the designing device with functional properties at extremes.

关键词： temperature. field. phase

Rad9 Plays an Important Role in DNA Mismatch Repair through Physical Interaction with MLH1

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Rad9 Plays an Important Role in DNA Mismatch Repair through ...

2.08年全国生物化学与分子生物学学术大会

作者： Wei He~(1,2. Yun Zhao~(1,2. Chun-bo Zhang~(1,5) Li-li An~(1,2. zhi-shang Hu~(1,2. Yu-heng Liu~(1,2. Lu Han~(1,2. Li-jun Bi~3 Zhen-sheng Xie~4 Peng Xue~4 Fu-{2. Yang~4 Hai-ying Hang~(1,2. 1 National Laboratory of Biomacromolecules 2.Center for Infection and Immunity 3 Center for Systems Biology 4 proteomics Platform,Institute of Biophysics.Chinese Academy of {2..Beijing 100101,china 5 college of life Science.Capital normal university,Beijing 100037,china

Rad9 is conserved from yeast to human and plays roles in DNA repair (homologous recombination repair, nucleotide excision repair and base pair excision repair) and cell cycle checkpoint *** has not been reported wheth...

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饲料钙磷水平对宝石鲈生长和体成分的影响

水产学报 2009年第3期33卷 488-495页

作者：宋理平冒树泉王爱英朱永安韩勃山东师范大学生命科学学院山东省淡水水产研究所上海海洋大学水产与生命学院

以酪蛋白和明胶作为蛋白源,乳酸钙（Ca-lactate）和磷酸二氢钠（NaH2.O4.2.2.）为钙源和磷源,配制成D1（0.0%钙,0.0%磷）、D2.0.5%钙,0.0%磷）、D3（0.0%钙,0.6%磷）、D4（0.5%钙,0.6%磷）、D5（1.0%钙,0.6%磷）和D6（1.5%钙,0.6%磷）六种等氮等能纯化试验饲料。每组饲料饲喂3个重复,每重复饲养2.尾宝石鲈幼鱼,经过室内网箱60 d生长试验,探讨在饲料中添加钙磷对宝石鲈幼鱼[初始体重（13.42.0.68）g]生长性能、全鱼和肌肉营养成分以及脊椎骨钙磷含量的影响。试验结果表明:饲料中未添加磷组（D1和D2.试验鱼的终末体重、特定生长率和脊椎骨钙磷含量显著低于添加组（P0.05）。当饲料中添加0.6%磷时,钙的添加量（01.5%）对宝石鲈的终末体重、特定生长率、饲料系数、全鱼组成、肌肉组成（水分、粗蛋白和灰分）和脊椎骨组成（粗灰分、磷和钙磷比）没有显著影响（P>0.05）。饲料中钙添加量过大（1.5%）组脊椎骨钙含量显著减少（P1.781.82.围内,组间差异不显著（P>0.05）。通过宝石鲈幼鱼生长性能和脊椎骨矿化作用分析表明,当饲料中添加0.6%磷时,钙的适宜添加量为0.5%。

关键词：宝石鲈生长体成分钙磷

Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2.Balance in DNCB-Induced BALB/c Mice

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Chinese Journal of Integrative Medicine 2022年第7期28卷 612-619页

作者： ZENG zhi-wen HUANG Jin-quan CHEN {2. YU Xiao zhu Wei ZHANG Dong-shu School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Traditional Chinese Medicine Affiliated Dongguan People's HospitalSouthern Medical UniversityDongguanGuangdong Province 523058China Department of Rheumatology and Immunology Shenzhen People's HospitalThe Second Clinical Medical College of Jinan UniversityShenzhenGuangdong Province 518020China School of Basic Medical sciences Southern Medical UniversityGuangzhou 510515China Guangzhou Center for Disease Control and Prevention Guangzhou 510515China

Objective: To evaluate the therapeutic effects of acupoint autohemotherapy(A-AHT) on 1-chloro-2.4-dinitrobenzene(DNCB)-induced atopic dermatitis(AD) in mice focusing on regulating T helper 1/T helper 2.Th1/Th2. immune responses. Methods: Thirty BALB/c mice were divided into 5 groups by a random number table, including normal control(NC), AD model(AD), A-AHT, sham A-AHT(sA-AHT), and acupoint injection of normal saline(A-NS) groups, 6 mice per group. Mice were challenged by DNCB for the establishment of experimental AD model. On the 8th day, except for the NC and AD groups, the mice in the other groups received management once every other day for a total of 2. days. For the A-AHT and sA-AHT groups, 0.05 mL of autologous whole blood(AWB) was injected into bilateral Zusanli(ST 36) and Quchi(LI 11) and sham-acupoints(5 mm lateral to ST 36 and LI 11), respectively. The A-NS group was administrated with 0.05 m L of normal saline by acupoint injection into ST 36 and LI 11. Dermatitis severity for dorsal skin of mice was determined using the Severity Scoring of Atopic Dermatitis(SCORAD) every week. The total immunoglobulin E(IgE), interleukin-4(IL-4), and interferon-gamma(IFN-γ) cytokine levels in serum were examined by enzyme-linked immunosorbent assay(ELISA). Spleen Th1/Th2.expression were analyzed via flow cytometry and immunohistochemical assay was used to detect T-box expressed in T cell(T-bet) and GATA-binding protein 3(GATA3) expressions in skin lesions of mice. Results: Compared with the AD group, both A-AHT and sA-AHT reduced the SCORAD index and serum IgE level(P1);A-AHT, sA-AHT and A-NS down-regulated serum IL-4 level and upregulated IFN-γ/IL-4 ratio(P1);A-AHT regulated the Th1/Th2.shift specifically and increased the related transcription factors such as T-bet expression and T-bet/GATA3 ratio(P1/Th2.immune responses.

关键词： acupoint autohemotherapy atopic dermatitis Th1/Th2 immunoglobulin E