检索结果-南通市图书馆

Effect of Occupational Extremely Low-Frequency Electromagnetic Field Exposure on the Thyroid Gland of Workers:A Prospective Study

引用

Current Medical Science 2022年第4期42卷 817-823页

作者： Yuan-yuan FANG Qian TU Yu-ting ZHANG Jian LIU Hui-guo LIU zhi-hua ZHAO Hua wu Tie-jun yiN Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of Geriatric Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Naval University of Engineering Wuhan 430030China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:The aim of this study was to investigate the biological effects of occupational extremely low-frequency electromagnetic field(ELF-EMF)exposure on the thyroid ***:We conducted a prospective analysis of 85 workers(exposure group)exposed to an ELF-EMF(100μT,10-100 Hz)produced by the electromagnetic aircraft launch system and followed up on thyroid function indices,immunological indices,and color Doppler images for 3 ***,116 healthy volunteers were randomly selected as controls(control group),the thyroid function of whom was compared to the exposure ***:No significant difference was observed in thyroid function between the exposure and control *** the follow-up of the exposure group,the serum free triiodothyronine(FT3)level was found to slowly decrease and free thyroxine(FT4)level slowly increase with increasing exposure ***,no significant difference was found in thyroid-stimulating hormone(TSH)over the three years,and no significant difference was observed in the FT3,FT4 and TSH levels between different exposure ***,no significant changes were observed in thyroid autoantibody levels and ultrasound images between subgroups or over ***:Long-term exposure to ELF-EMF may promote thyroid secretion of T4 and inhibit deiodination of T4 to ***-EMF has no significant effect on thyroid immune function and morphology.

关键词： extremely low-frequency electromagnetic field thyroid function thyroid autoantibody thyroid ultrasound thyroid nodule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional numerical study of flow characteristics and membrane fouling evolution in an enzymatic membrane reactor

引用

Journal of Hydrodynamics 2018年第5期30卷 851-858页

作者： Xu-qu Hu Pai-qing wu Xing-yi Wang Hai-cheng Zhang Jian-quan Luo State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

In order to enhance the understanding of the membrane fouling mechanism, the hydrodynamics of the granular flow in a stirred enzymatic membrane reactor is numerically investigated in the present paper. A three-dimensional Euler-Euler model, coupled with the k-ε mixture turbulence model and the drag function proposed by Syamlal and O＇Brien（1989） for the interphase momentum exchange, is built to simulate the two-phase（fluid-solid） turbulent flow. Numerical simulations of single-or two-phase turbulent flows at various stirring speeds are carried out. The numerical results agree very well with the published experimental data. Results include the distributions of the velocity, the shear stress and the turbulent kinetic energy. It is shown that the increase of the stirring speed not only enlarges the circulation loops in the reactor, but also increases the shear stress on the membrane surface and accelerates the mixing process for the granular materials. The time evolution of the volumetric function of the granular materials on the membrane surface can qualitatively explain the evolution of the membrane fouling.

关键词： Turbulent flow multiphase flow membrane fouling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inherent thermal-responsive strategies for safe lithium batteries

引用

Journal of Energy Chemistry 2024年第2期89卷 519-534,I0012页

作者： Jia-Xin Guo Chang Gao He Liu Feng Jiang Zaichun Liu Tao Wang Yuan Ma yiren Zhong Jiarui He zhi Zhu Yuping wu Xin-Bing Cheng School of Energy and Environment Southeast UniversityNanjing 211189JiangsuChina School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjing 210044JiangsuChina

Safe batteries are the basis for next-generation application scenarios such as portable energy storage devices and electric vehicles,which are crucial to achieving carbon ***,separators,and electrodes as main components of lithium batteries strongly affect the occurrence of safety *** materials,which can respond to external stimuli or environmental change,have triggered extensive attentions recently,holding great promise in facilitating safe and smart *** review thoroughly discusses recent advances regarding the construction of high-safety lithium batteries based on internal thermal-responsive strategies,together with the corresponding changes in electrochemical performance under external ***,the existing challenges and outlook for the design of safe batteries are presented,creating valuable insights and proposing directions for the practical implementation of safe lithium batteries.

关键词： Lithium battery Thermal safety Thermal runaway Thermal-responsive

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of interface within the composite barrier on the tunneling electroresistance of ferroelectric tunnel junctions with symmetric electrodes

引用

Chinese Physics B 2015年第2期24卷 372-375页

作者：王品之朱素华潘涛吴银忠 Physics Department Soochow University Physics Department Changshu Institute of Technology School of Mathematics and Physics Suzhou University of Science and Technology

The interface with a pinned dipole within the composite barrier in a ferroelectric tunnel junction（FTJ） with symmetric electrodes is *** from the detrimental effect of the interface between the electrode and barrier in previous studies,the existence of an interface between the dielectric SrTiO_3 slab and ferroelectric BaTiO_3 slab in FTJs will enhance the tunneling electroresistance（TER） ***,the interface with a lower dielectric constant and larger polarization pointing to the ferroelectric slab favors the increase of TER ***,interface control of high performance FTJ can be achieved.

关键词： ferroelectric tunnel junction interface effect tunneling electroresistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MOF-derived nitrogen-doped iron–nickel oxide carbon nanotubes as efficient oxygen electrocatalyst for long-life rechargeable zinc–air batteries

引用

Rare Metals 2023年第10期42卷 3326-3336页

作者： Tao Zhao Yu-Hang wu zhi-Rong Song Xue Wang Rui-Lian yin Hui Xu Hui Cui Xie-Hong Cao Jun-Kuo Gao School of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou310018China College of Materials Science and Engineering Pinghu Institute of Advanced MaterialsZhejiang University of TechnologyHangzhou310014China Institute of Optoelectronic Materials and Devices China Jiliang UniversityHangzhou310018China Physics Division Argonne National LaboratoryLemontIL60439USA Department of Chemistry and International Institute for Nanotechnology(IIN) Northwestern UniversityEvanstonIL60208USA

Electrocatalysts with high activities are crucial for highenergy-density Zn-air ***,the sluggish kinetics of oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)on the electrocatalysts hindered the development of Zn-air ***,a new class of MOF-derived nitrogen-doped carbon nanotubes encapsulated with bimetallic oxide(FeNiO@NCNT)through facile pyrolysis strategy is *** FeNiO@NCNT exhibits high catalytic activities for both OER and ORR.

关键词： nickel catalyst carbon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

易黄汤调节cGAS/STING信号通路对宫颈癌小鼠移植瘤HPV及免疫功能的影响

引用

广西中医药大学学报 2025年第1期28卷 58-63页

作者：吴荣莉吴冬梅林兰福建中医药大学附属第二人民医院福建福州350003

[目的]探讨易黄汤降低高危型人乳头状瘤病毒(HR-HPV)病毒载量的分子机制,为易黄汤治疗HR-HPV持续感染提供理论依据。[方法]选取50只小鼠,其中40只采用腋下接种CaSKi细胞法建立脾虚湿热证人乳头状瘤病毒(HPV)16阳性宫颈癌皮下移植瘤小鼠... 详细信息

[目的]探讨易黄汤降低高危型人乳头状瘤病毒(HR-HPV)病毒载量的分子机制,为易黄汤治疗HR-HPV持续感染提供理论依据。[方法]选取50只小鼠,其中40只采用腋下接种CaSKi细胞法建立脾虚湿热证人乳头状瘤病毒(HPV)16阳性宫颈癌皮下移植瘤小鼠模型,造模成功后随机分为模型组和易黄汤低、中、高剂量组,每组10只。未造模的10只小鼠予以正常喂养,设为正常对照组。易黄汤低、中、高剂量组隔天灌胃给予中药1次,给药剂量分别为10 g/kg、20 g/kg、40 g/kg,连续给药4周。正常对照组和模型组灌胃给予等容积生理盐水。采用实时荧光定量PCR法检测各组移植瘤组织中HPV病毒载量,免疫组化法检测移植瘤组织中Ki67蛋白的表达,流式细胞法检测各组小鼠血清CD4/CD8值,Western blot测定各组小鼠移植瘤组织中腺苷酸合成酶(cGAS)、干扰素基因刺激因子(STING)蛋白的表达。[结果]与正常对照组比较,模型组小鼠移植瘤中HPV病毒载量、Ki67蛋白表达明显升高(P<0.05),CD4/CD8值明显下降(P<0.05);与模型组比较,易黄汤可呈浓度依赖性降低HPV病毒载量和Ki67蛋白表达(P<0.05),提高CD4/CD8值及cGAS、STING的蛋白水平(P<0.05)。[结论]易黄汤可降低脾虚湿热证宫颈癌小鼠移植瘤HPV病毒载量,其作用机制可能是通过调节cGAS/STING通路,从而增强免疫功能,维持免疫系统平衡。

关键词：易黄汤 HPV 移植瘤 cGAS/STING信号通路免疫功能实验研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

教师课程标准意义建构的本质、影响因素与进路

引用

教学与管理 2025年第3期 12-18页

作者：毋翠玲和小军玉林师范学院教育科学学院广西玉林537000

从课程标准到课程实施不可避免地要经历教师自身对课程标准的意义建构。理解教师对课程标准的意义建构过程,把握影响教师对课程标准意义建构的因素,有利于从教育实践的角度推动课程改革入心做实。基于此,研究从意义建构的概念出发,提出... 详细信息

从课程标准到课程实施不可避免地要经历教师自身对课程标准的意义建构。理解教师对课程标准的意义建构过程,把握影响教师对课程标准意义建构的因素,有利于从教育实践的角度推动课程改革入心做实。基于此,研究从意义建构的概念出发,提出教师对课程标准意义建构是一个个性化、社会化的持续往复循环过程,并受到课程标准的影响力、个体自我解释框架、社会组织环境等多重因素影响。在分析各要素动态循环综合作用的基础上,从课程标准的作用及行为性,教师自身解释框架,社会组织环境三个方面提出提升教师对课程标准意义建构的路径。

关键词：课程标准课程实施课程意义建构课程标准解读

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expression and role of autophagy related protein p62 and LC3 in the retina in a rat model of acute ocular hypertension

引用

International Journal of Ophthalmology(English edition) 2020年第1期13卷 21-28页

作者： Yu-Yu wu Bing-Ru Zheng Wan-Zhu Chen Mao-Sheng Guo yi-Hong Huang Yan Zhang Department of Ophthalmology the Second Affiliated Hospital of Fujian Medical University

AIM: To investigate the expression and possible role of the autophagy related protein p62 and LC3 in the retina based on a rat model of acute ocular ***: Fifty rats were randomized into five groups: control group A, B, C, and D. Groups A to D all received normal saline perfusion into the anterior chamber with pressure of 80 mm Hg for one hour, and retina tissue was obtained at 6, 12, 24 and 48 h after perfusion respectively, to investigate the activation of autophagy following ischemiareperfusion. The distribution and semi-quantification of autophagy related protein p62 and LC3 in the retina were detected using immunohistochemistry technique. The expression level of these two proteins was evaluated using Western ***: The number of retinal ganglion cells(RGCs) decreased with increasing reperfusion time, and significant reduction in the retinal thickness was observed 48 h after perfusion. In normal adult rats, LC3 protein was mainly expressed in the ganglion cell layer(GCL), and p62 protein was expressed in the nerve fiber layer(NFL), GCL, inner plexiform layer(IPL), inner nuclear layer(INL) and outer plexiform layer(OPL). In comparison to the control group, the expression level of LC3-II was higher in all the experimental groups(P<0.05), with the peak expression at 12 h after reperfusion. Additionally, the expression level of p62 was higher in all the experimental groups than the control(P<0.05, except for group A), with the peak level occurred 24 h after reperfusion. CONCLUSION: Both p62 and LC3 show low level and uneven expression in the retina of normal adult rats. Acute ocular hypertension can lead to upregulation of LC3-II and p62 expression in the retina. Autophagy flux is damaged 12 h after reperfusion, potentially resulting in further loss of RGCs.

关键词： glaucoma acute ocular hypertension LC3 p62 autophagy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel alternative for pyrogen detection based on a transgenic cell line

引用

Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： Qing He Chuan-Fei Yu Gang wu Kai-Qin Wang Yong-Bo Ni Xiao Guo zhi-Hao Fu Lan Wang De-Jiang Tan Hua Gao Can Wang Gang Chen Xu-Hong Chen Bo Chen Jun-zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats

引用

Biomedical and Environmental Sciences 2019年第1期32卷 1-10页

作者： CHEN zhi Jian CHEN Jia Xing wu Li Kang LI Bi Yun TIAN Ya Feng XIAN Min HUANG Zi Pei YU Ri An School of Public Health Guangdong Pharmaceutical University Bao'an Center for Disease Control and Prevention of Shenzhen

Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity.

关键词： Cadmium Endoplasmic reticulum stress PERK Nrf2 Kidney Rat

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：