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Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 195-204页

作者： Ji-Chuan Quan Xu Guan Chen-Xi Ma Zheng Liu Ming Yang zhi-xun zhao Peng Sun Meng Zhuang Song Wang Zheng Jiang Xi-Shan Wang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Colorectal Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150000Heilongjiang ProvinceChina

BACKGROUND Brain metastasis(BM)from colorectal cancer(CRC)is rarely encountered clinically,and its prognosis has not been fully *** To construct a scoring system and accurately predict the survival of patients with synchronous BM at diagnosis of *** A retrospective study of 371 patients with synchronous BM from CRC was performed,using the data from 2010 to 2014 from the Surveillance,Epidemiology,and End Results *** time and prognostic factors were statistically analyzed by the Kaplan-Meier method and Cox proportional hazards models,respectively.A scoring system was developed using the independent prognostic factors,and was used to measure the survival difference among different *** For the 371 patients,the median overall survival was 5 mo,survival rates were 27%at 1 year and 11.2%at 2 *** analysis showed that age,carcinoembryonic antigen level and extracranial metastasis to the liver,lung or bone were independent prognostic factors.A scoring system based on these three prognostic factors classified the patients into three prognostic subgroups(scores of 0-1,2-3,and 4).The median survival of patients with scores of 0-1,2-3 and 4 was 14,5 and 2 mo,respectively(P<0.001).Subgroup analysis showed that there were significant differences in prognosis among the *** 2-3 vs 0-1:hazard ratio(HR)=2.050,95%CI:1.363-3.083;P=0.001;score 4 vs 0-1:HR=3.721,95%CI:2.225-6.225;P<0.001;score 2-3 vs 4:HR=0.551,95%CI:0.374-0.812;P=*** The scoring system effectively distinguishes long-term and short-term survivors with synchronous BM from *** results are helpful in providing a reference for guiding therapy.

关键词： Colorectal cancer Brain metastasis Survival Prognosis factors Scoring system Synchronous

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Classification and genetic counselling for a novel splicing mutation of the MLH1 intron associated with Lynch syndrome in colorectal cancer

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Gastroenterology Report 2021年第6期9卷 552-559页

作者： Ling-Ling Wang Shuang-Mei Zou Lin Dong Ming Yang Dan Qi zhao Lu Jia-Nan Chen Shi-Wen Mei zhi-xun zhao Xu Guan Zheng Jiang Qian Liu Zheng Liu Xi-Shan Wang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China

Background:Lynch-syndrome-associated cancer is caused by germline pathogenic mutations in mismatch repair *** major challenge to Lynch-syndrome screening is the interpretation of variants found by diagnostic *** study aimed to classify the MLH1 c.1989t5G>A mutation,which was previously reported as a variant of uncertain significance,to describe its clinical phenotypes and characteristics,to enable detailed genetic ***:We reviewed the database of patients with Lynch-syndrome gene detection in our hospital.A novel variant of MLH1 c.1989t5G>A identified by next-generation sequencing was further investigated in this *** staining was carried out to assess the expression of MLH1 and PMS2 protein in tumour *** silico analysis by Alamut software was used to predict the MLH1 c.1989t5G>A variant *** transcription-polymerase chain reaction and sequencing of RNA fromwhole bloodwere used to analyse the functional significance of this ***:Among affected family members in the suspected Lynch-syndrome pedigree,the patient suffered from late-stage colorectal cancer but had a good *** found the MLH1 c.1989t5G>A variant,which led to aberrant splicing and loss of MLH1 and PMS2 protein in the nuclei of tumour *** aberrant transcript was detectable and skipping of MLH1 exon 17 in carriers of MLH1 c.1989t5G>A was ***:MLH1 c.1989t5G>A was detected in a cancer family pedigree and identified as a pathological variant in patients with Lynch *** spectrumof Lynch syndrome was enriched through enhanced genetic testing and close surveillancemight help future patients who are suspected of having Lynch syndrome to obtain a definitive early diagnosis.

关键词： Lynch syndrome MLH1 genetic testing colorectal cancer genetic counselling

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Joint effect of pre-operative anemia and perioperative blood transfusion on outcomes of colon-cancer patients undergoing colectomy

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Gastroenterology Report 2020年第2期8卷 151-157,I0003页

作者： Zheng Liu Jia-Jun Luo Kevin Y.Pei Sajid A.Khan Xiao-Xu Wang zhi-xun zhao Ming Yang Caroline H.Johnson Xi-Shan Wang Yawei Zhang Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Surgery Yale School of MedicineNew HavenCTUSA Department of Surgery School of MedicineTexas Tech University Health Sciences CenterLubbockTXUSA Department of Environmental Health Sciences Yale School of Public HealthNew HavenCTUSA

Background:Both pre-operative anemia and perioperative(intra-and/or post-operative)blood transfusion have been reported to increase post-operative complications in patients with colon cancer undergoing ***,their joint effect has not been *** purpose of this study was to evaluate the joint effect of pre-operative anemia and perioperative blood transfusion on the post-operative outcome of colon-cancer patients after ***:We identified patients from the American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database 2006–2016 who underwent colectomy for colon *** logistic regression analysis was employed to assess the independent and joint effects of anemia and blood transfusion on patient ***:A total of 35,863 patients—18,936(52.8%)with left-side colon cancer(LCC)and 16,927(47.2%)with right-side colon cancer(RCC)—were *** patients were more likely to have mild anemia(62.7%)and severe anemia(2.9%)than LCC patients(40.2%mild anemia and 1.4%severe anemia).A total of 2,661(7.4%)of all patients(1,079[5.7%]with LCC and 1,582[9.3%]with RCC)received a perioperative blood ***,the occurrence rates of complications were comparable between LCC and RCC patients(odds ratio[OR]=1.01;95%confidence interval[CI]=0.95–1.07;P=0.750).There were significant joint effects of anemia and transfusion on complications and the 30-day death rate(P for interaction:0.010).Patients without anemia who received a transfusion had a higher risk of any complications(LCC,OR=3.51;95%CI=2.55–4.85;P<0.001;RCC,OR=3.74;95%CI=2.50–5.59;P<0.001),minor complications(LCC,OR=2.54;95%CI=1.63–3.97;P<0.001;RCC,OR=2.27;95%CI=1.24–4.15;P=0.008),and major complications(LCC,OR=5.31;95%CI=3.68–7.64;P<0.001;RCC,OR=5.64;95%CI=3.61–8.79;P<0.001),and had an increased 30-day death rate(LCC,OR=6.97;95%CI=3.07–15.80;P<0.001;RCC,OR=4.91;95%CI=1.88–12.85;P=0.001)than patients without anemia who did not receive a

关键词： colon cancer colectomy anemia blood transfusion

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Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO2 Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences (CAS) University of Chinese Academy of Sciences

The supercritical carbon dioxide（sCO2） Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO2Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve（TBV） and the main regulating valve（MGV） to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： buffer tank dynamic characteristic dynamic model sCO2 Brayton cycle startup strategy

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Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu xun Cao Kang Huang Siyu Zhu Bowei Zhang Yu Liang Chunwang zhao Junsheng Wu Yizhong Huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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LiDAR-Visual SLAM with Integrated Semantic and Texture Information for Enhanced Ecological Monitoring Vehicle Localization

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Computers, Materials & Continua 2025年第1期82卷 1401-1416页

作者： Yiqing Lu Liutao zhao Qiankun zhao Foreign Environmental Cooperation Center Ministry of Ecology and Environment of PRCBeijing100035China Beijing Computing Center Co. Ltd.Beijing Academy of Science and TechnologyBeijing100083China Beijing Guyu Interactive Artificial Intelligence Application Co. Ltd.Beijing100024China

Ecological monitoring vehicles are equipped with a range of sensors and monitoring devices designed to gather data on ecological and environmental *** vehicles are crucial in various fields,including environmental science research,ecological and environmental monitoring projects,disaster response,and emergency management.A key method employed in these vehicles for achieving high-precision positioning is LiDAR(lightlaser detection and ranging)-Visual Simultaneous Localization and Mapping(SLAM).However,maintaining highprecision localization in complex scenarios,such as degraded environments or when dynamic objects are present,remains a significant *** address this issue,we integrate both semantic and texture information from LiDAR and cameras to enhance the robustness and efficiency of data ***,semantic information simplifies the modeling of scene elements,reducing the reliance on dense point clouds,which can be less ***,visual texture information complements LiDAR-Visual localization by providing additional contextual *** incorporating semantic and texture details frompaired images and point clouds,we significantly improve the quality of data association,thereby increasing the success rate of *** approach not only enhances the operational capabilities of ecological monitoring vehicles in complex environments but also contributes to improving the overall efficiency and effectiveness of ecological monitoring and environmental protection efforts.

关键词： LiDAR-Visual simultaneous localization and mapping integrated semantic texture information

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小区雨水回收利用系统的经济效益分析

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工程管理学报 2017年第3期31卷 92-96页

作者：孙轲荀志远赵琛琛青岛理工大学管理学院山东青岛266520

雨水回收利用系统具有很好的环境效益,是缓解城市水资源短缺和浪费问题的重要措施。为分析雨水回收利用系统的经济效益,运用给排水和工程经济的相关理论,研究了其节水效益和全生命周期成本,通过动态投资回收期的方法建立了雨水回收利用... 详细信息

雨水回收利用系统具有很好的环境效益,是缓解城市水资源短缺和浪费问题的重要措施。为分析雨水回收利用系统的经济效益,运用给排水和工程经济的相关理论,研究了其节水效益和全生命周期成本,通过动态投资回收期的方法建立了雨水回收利用系统的成本效益模型。结合广州某小区工程实例,利用时间序列法对水价进行了预测,计算得到雨水回收利用系统的成本效益,求出动态投资回收期,证明了雨水回收利用系统具有较好的经济效益。模型也为类似工程的雨水回收利用系统的经济性研究提供了参考方法。

关键词：雨水回收利用节水效益成本效益模型投资回收期

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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Gradient maturation experiment on hairs implies taphonomic changes in fossil hairs

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Science China Earth Sciences 2025年第1期68卷 62-73页

作者： Xin LI Yibo ZHOU Tao zhao Xingjian HE Yanhong PAN State Key Laboratory for Mineral Deposits Research Center for Critical Earth Material Cycling Centre for Research and Education on Biological Evolution and Environment and Frontiers Science School of Earth Sciences and Engineering Nanjing University Institute of Palaeontology Yunnan Key Laboratory of Earth System Science Yunnan Key Laboratory for PalaeobiologyYunnan University

Mammalian hair, as a key feature related to endothermy, physical protection, and camouflage, has a long geohistorical record that dates back even to the Mesozoic. However, the limited information on the taphonomy of hair hinders the understanding of its evolutionary significance in deep time. To address this, we conducted taphonomic experiments to simulate the transformation process of black hair. The changes in the morphological structure, microscopic characteristics, and chemical composition of hair during the simulated fossilization process were documented by scanning electron microscopy, Fourier transform infrared(FTIR) spectroscopy, and Raman spectroscopy. Our results revealed that damage to the morphology of hair began at a mild temperature(150–175°C), and hair transformed into a fluid-like mass at a relatively high temperature(200°C). In addition, the morphological structure of melanosomes had relatively greater preservation potential than keratins did, and the microscopic features of melanosomes were persistently stable. The Raman and FTIR spectra indicated that the characteristic melanin and keratin peaks changed as the temperature increased. Although the chemical signals were not lost completely, the variations in the characteristic amide bands in the FTIR spectra indicate that the keratins severely degraded at high temperatures(>200°C), whereas the characteristic melanin bands in the Raman spectra suggested that melanin signals were still recognizable, even at high temperatures(>200°C). These results were confirmed by principal component analysis(PCA) and principal component analysis linear discriminant analysis(PCA–LDA). In addition, the Raman signals of all the samples in the simulated experiments were distinguished from the signals of common geological carbonaceous materials(humic acid), which suggested that Raman spectroscopy can be used to detect melanin in fossils.

关键词： Mammalian hair Melanin Keratin Fossilization Experimental taphonomy

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