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A digital pulsar backend based on FPGA

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Research in Astronomy and Astrophysics 2017年第1期17卷 97-102页

作者： Jin-Tao Luo Lan Chen Jin-lin Han Ali Esamdin Ya-Jun Wu zhi-xuan li Long-Fei Hao Xiu-Zhong Zhang National Time Service CenterChinese Academy of SciencesXi'an 710600China Key Laboratory of Time and Frequency Primary Standards Chinese Academy of SciencesXi'an 710600China National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Institute of Technology Shanghai 200235China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

A digital pulsar backend based on a Field Programmable Gate Array （FPGA） is developed. It is designed for incoherent de-dispersion of pulsar observations and has a maximum bandwidth of 512MHz. The channel bandwidth is fixed to 1 MHz, and the highest time resolution is 10 p.s. Testing observations were carried out using the Urumqi 25-m telescope administered by Xinjiang Astronomical Observatory and the Kunming 40-m telescope administered by Yunnan Observatories, targeting PSR J0332＋5434 in the L band and PSR J0437-4715 in the S band, respectively. The successful observation of PSR J0437-4715 demonstrates its ability to observe millisecond pulsars.

关键词： instrumentation miscellaneous - methods data analysis - pulsars general

METTL14 downregulation drives S100A4^(+)monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2176-2192页

作者： Yue-fan Wang Wen-li Zhang zhi-xuan li Yue liu Jian Tan Hao-zan Yin zhi-chao Zhang Xian-jie Piao Min-hao Ruan zhi-hui Dai Si-jie Wang Chen-yang Mu Ji-hang Yuan Shu-han Sun Hui liu Fu Yang The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University200438 ShanghaiChina The Department of Medical Genetics Naval Medical University200433 ShanghaiChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital100048 BeijingChina The Department of Pharmaceutical Analysis School of PharmacyNaval Medical University200433 ShanghaiChina Key Laboratory of Biosafety Defense Ministry of Education200433 ShanghaiChina Shanghai Key Laboratory of Medical Biodefense 200433 ShanghaiChina

Without intervention,a considerable proportion of patients with metabolism‐associated fatty liver disease(MAFLD)will progress from simple steatosis to metabolism‐associated steatohepatitis(MASH),liver fibrosis,and even hepatocellular ***,the molecular mechanisms that control progressive MAFLD have yet to be fully ***,we unraveled that the expression of the N6-methyladenosine(m6A)methyltransferase METTL14 is remarkably downregulated in the livers of both patients and several murine models of MAFLD,whereas hepatocyte-specific depletion of this methyltransferase aggravated lipid accumulation,liver injury,and ***,hepatic Mettl14 overexpression alleviated the above pathophysiological changes in mice fed on a high-fat diet(HFD).Notably,in vivo and in vitro mechanistic studies indicated that METTL14 downregulation decreased the level of GLS2 by affecting the translation efficiency mediated by YTHDF1 in an m6A-depedent manner,which might help to form an oxidative stress microenvironment and accordingly recruit Cx3cr1^(+)Ccr2^(+)monocyte-derived macrophages(Mo-macs).In detail,Cx3cr1^(+)Ccr2^(+)Mo-macs can be categorized into M1-like macrophages and S100A4-positive macrophages and then further activate hepatic stellate cells(HSCs)to promote liver *** experiments revealed that CX3CR1 can activate the transcription of S100A4 via CX3CR1/MyD88/NF-κB signaling pathway in Cx3cr1^(+)Ccr2^(+)*** of METTL14 or GLS2,or interfering with this signal transduction pathway such as inhibiting MyD88 could ameliorate liver injuries and *** together,these findings indicate potential therapies for the treatment of MAFLD progression.

关键词： S100A4 MyD88 metabolism

Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients

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Engineering 2021年第10期7卷 1381-1392页

作者： Tong Wu Ying-Cheng Yang Bo Zheng Xue-Bing Shi Wei li Wen-Cong Ma Shan Wang zhi-xuan li Yan-Jing Zhu Jian-Min Wu Kai-Ting Wang Yan Zhao Rui Wu Cheng-Jun Sui Si-Yun Shen xuan Wu Lei Chen Zhen-Gang Yuan Hong-Yang Wang International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of liver Cancer Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor BiologyEastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China National Center for liver Cancer Shanghai 201805China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Fudan University Shanghai Cancer Center Shanghai 200032China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200433China Department of Laboratory Medicine The Tenth People’s Hospital of ShanghaiTongji UniversityShanghai 200072China Key Laboratory of Signaling Regulation and Targeting Therapy of liver Cancer Ministry of EducationShanghai 200438China Department of Oncology Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

Intrahepatic cholangiocarcinoma(ICC)is the second most common liver *** remains the main therapeutic strategy for advanced ICC patients,but chemosensitivity varies ***,we applied cytometry by time-of-flight(CyTOF)to establish the immune profile of peripheral blood mononuclear cells(PBMCs)on the single-cell level at indicated time points before,during,and after *** immunofluorescence staining was applied to examine the spatial distribution of certain immune *** microarrays(TMAs)were used for prognostic evaluation.A total of 20 ICC patients treated with gemcitabine(GEM)were enrolled in our study,including eight cases with good response(R)and 12 cases with non-response(NR).Tremendous changes in PBMC composition,including an increased level of CD4/CD8 double-positive T cells(DPT),were observed after *** with higher level of CD4^(+)CD45RO^(+)CXCR3^(+)T cells before treatment had a favorable response to *** study identified a positive correlation between the percentage of T cell subpopulations and clinical response after chemotherapy,which suggests that it is practical to predict the potential response before treatment by evaluating the proportions of the cell population in PBMCs.

关键词： Intrahepatic cholangiocarcinoma Gemcitabine Chemosensitivity Peripheral blood mononuclear cells

Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le Chen Qiang-Qiang li Armido Studer Jun xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

Single-cell transcriptome profiling of sepsis identifies HLA-DR^(low)S100A^(high)monocytes with immunosuppressive function

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Military Medical Research 2023年第6期10卷 778-797页

作者： Ren-Qi Yao Peng-Yue Zhao zhi-xuan li Yu-Yang liu li-Yu Zheng Yu Duan Lu Wang Rong-li Yang Hong-Jun Kang Ji-Wei Hao Jing-Yan li Ning Dong Yao Wu Xiao-Hui Du Feng Zhu Chao Ren Guo-Sheng Wu Zhao-Fan Xia Yong-Ming Yao Translational Medicine Research Center Medical Innovation Research Division and the Fourth Medical Center of Chinese PLA General HospitalBei‑jing 100853China Department of Burn Surgery the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury Chinese Academy of Medical SciencesBeijing 100730China Department of General Surgery the First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurosurgery the First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Critical Care Medicine the First Medical Center of Chinese PLA General HospitalBeijing 100853China Intensive Care Unit Dalian Municipal Central Hospital Affiliated Dalian University of TechnologyDalian 116033LiaoningChina Department of Emergency the Second Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Pulmonary and Criti‑cal Care Medicine Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China.

Background Sustained yet intractable immunosuppression is commonly observed in septic patients,resulting in aggravated clinical ***,due to the substantial heterogeneity within septic patients,precise indicators in deciphering clinical trajectories and immunological alterations for septic patients remain largely *** We adopted cross-species,single-cell RNA sequencing(scRNA-seq)analysis based on two published datasets containing circulating immune cell profile of septic patients as well as immune cell atlas of murine model of *** cytometry,laser scanning confocal microscopy(LSCM)imaging and Western blotting were applied to identify the presence of S100A9^(+)monocytes at protein *** interrogate the immunosuppressive function of this subset,splenic monocytes isolated from septic wild-type or S100a9^(–/–)mice were co-cultured with naive CD4^(+)T cells,followed by proliferative *** inhibition of S100A9 was implemented using Paquinimod via oral *** scRNA-seq analysis of human sepsis revealed substantial heterogeneity in monocyte compartments following the onset of sepsis,for which distinct monocyte subsets were enriched in disparate subclusters of septic *** identified a unique monocyte subset characterized by high expression of S100A family genes and low expression of human leukocyte antigen DR(HLA-DR),which were prominently enriched in septic patients and might exert immunosuppressive *** combining single-cell transcriptomics of murine model of sepsis with in vivo experiments,we uncovered a similar subtype of monocyte significantly associated with late sepsis and immunocompromised status of septic mice,corresponding to HLA-DR^(low)S100A^(high)monocytes in human ***,we found that S100A9^(+)monocytes exhibited profound immunosuppressive function on CD4^(+)T cell immune response and blockade of S100A9 using Paquinimod could partially reverse sepsis-induced ***

关键词： Single-cell analysis Sepsis Immunosuppression S100A Human leukocyte antigen DR(HLA-DR) Monocytes Myeloid-derived suppressor cells(MDSCs) Paquinimod

Development and validation of a web-based calculator to predict individualized conditional risk of site-specific recurrence in nasopharyngeal carcinoma: Analysis of 10,058 endemic cases

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Cancer Communications 2021年第1期41卷 37-50页

作者： Chen-Fei Wu Jia-Wei Lv li lin Yan-Ping Mao Bin Deng Wei-Hong Zheng Dan-Wan Wen Yue Chen Jia Kou Fo-Ping Chen Xing-li Yang Zi-Qi Zheng zhi-xuan li Si-Si Xu Jun Ma Ying Sun Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Wuzhou Red Cross HospitalWuzhouGuangxi 543002P.R.China

Background:Conditional survival(CS)provides dynamic prognostic estimates by considering the patients existing survival *** CS for endemic nasopharyngeal carcinoma(NPC)is lacking,we aimed to assess the CS of endemic NPC and establish a web-based calculator to predict individualized,conditional sitespecific recurrence ***:Using an NPC-specific database with a big-data intelligence platform,10,058 endemic patients with non-metastatic stage I–IVA NPC receiving intensity-modulated radiotherapy with or without chemotherapy between April 2009 and December 2015 were *** CS estimates of conditional overall survival(COS),conditional disease-free survival(CDFS),conditional locoregional relapse-free survival(CLRRFS),conditional distant metastasis-free survival(CDMFS),and conditional NPC-specific survival(CNPC-SS)were ***-adjusted CS estimates were generated using inverse probability weighting.A prediction model was established using competing risk models and was externally validated with an independent,non-metastatic stage I–IVA NPC cohort undergoing intensity-modulated radiotherapy with or without chemotherapy(n=601)at another ***:The median follow-up of the primary cohort was 67.2 *** 5-year COS,CDFS,CLRRFS,CDMFS,and CNPC-SS increased from 86.2%,78.1%,89.8%,87.3%,and 87.6%at diagnosis to 87.3%,87.7%,94.4%,96.0%,and 90.1%,respectively,for an existing survival time of 3 years since *** in CS estimates between prognostic factor subgroups of each endpoint were noticeable at diagnosis but diminished with time,whereas an ever-increasing disparity in CS between different age subgroups was observed over ***,the prognoses of patients that were poor at diagnosis improved greatly as patients survived *** individualized CS predictions,we developed a web-based model to estimate the conditional risk of local(C-index,0.656),regional(0.667),bone(0.742),lung(0.681),and liver(0.711)recurren

关键词： endemic nasopharyngeal carcinoma conditional survival big data web-based individualized prediction model overall survival disease-free survival locoregional relapse-free survival distant metastasis-free survival NPC-specific survival

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Wafer‑Scale Vertical 1D GaN Nanorods/2D MoS_(2)/PEDOT:PSS for Piezophototronic Effect‑Enhanced Self‑Powered Flexible Photodetectors

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Nano-Micro Letters 2025年第3期17卷 102-116页

作者： Xin Tang Hongsheng Jiang Zhengliang lin xuan Wang Wenliang Wang Guoqiang li State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Department of Electronic Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640People’s Republic of China

van der Waals(vdW)heterostructures constructed by lowdimensional(0D,1D,and 2D)materials are emerging as one of the most appealing systems in next-generation flexible ***,hand-stacked vdW-type photodetectors are not compatible with large-areaarray fabrication and show unimpressive performance in self-powered ***,vertical 1D GaN nanorods arrays(NRAs)/2D MoS_(2)/PEDOT:PSS in wafer scale have been proposed for self-powered flexible photodetectors arrays *** as-integrated device without external bias under weak UV illumination exhibits a competitive responsivity of 1.47 A W^(−1)and a high detectivity of 1.2×10^(11)Jones,as well as a fast response speed of 54/71μs,thanks to the strong light absorption of GaN NRAs and the efficient photogenerated carrier separation in type-II ***,the strain-tunable photodetection performances of device have been ***,the device at−0.78%strain and zero bias reveals a significantly enhanced photoresponse with a responsivity of 2.47 A W^(−1),a detectivity of 2.6×10^(11)Jones,and response times of 40/45μs,which are superior to the state-of-the-art self-powered flexible *** work presents a valuable avenue to prepare tunable vdWs heterostructures for self-powered flexible photodetection,which performs well in flexible sensors.

关键词： Vertical nanorod arrays van der Waals heterostructure Piezophototronic effect Self-powered photodetection Flexible sensors

Discovering broader antiviral strategies:Role of interferon-induced transmembrane proteins in virus infection

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hlife 2024年第8期2卷 377-379页

作者： Zi-Ying Jiang Chu Xie Pei-Huang Wu zhi-xuan li Mu-Sheng Zeng Cong Sun State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-Sen University Cancer CenterGuangdongChina Division of Infectious Diseases Department of MedicineBrigham and Women’s HospitalMassachusettsUSA Broad Institute of Harvard and MIT MassachusettsUSA

Host antiviral strategies have been studied for a long time,and the antibody response and T-cell response represent the classic host antiviral *** entry of enveloped viruses into host cells is a complex process that could involve interactions ofmultiple viral glycoproteins and host-cell *** this process is the key to preventing *** general,antigenspecific neutralizing antibodies are thought to effectively bind to viral glycoproteins to block virus ***,there are other unknown host factors that inhibit or enhance the virus entry into the host ***,Yang et *** that interferon-induced transmembrane protein-1(IFITM1)inhibited Epstein–Barr virus(EBV)infection in epithelial cells(ECs)by competing with viral glycoproteins to bind to Ephrin receptor A2(EphA2),thereby blocking this key entry receptor[1](Figure 1).Together with previous research,this finding hints at the importance of discovering broader host protective *** are known to be critical sites for EBV infection and ***2 has been reported as one of the most crucial EBV entry receptors on the EC surface,which binds to viral glycoprotein H/L(gH/gL)and glycoprotein B(gB)[2]to drive the internalization and fusion of EBV[3].However,ECs with low susceptibility to EBV can still express a high level of EphA2[4],raising questions about additional factors that influence host susceptibility.

关键词： EphA2 protective inhibited