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Clinical Effect of Tripterygium Glycosides Combined with Glucocorticoids in the Treatment of Refractory Nephrotic Syndrome Patients: A Systematic Review and Meta-Analysis

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World Journal of Traditional Chinese Medicine 2020年第3期6卷 249-259页

作者： Ya-Qing Cheng Jing Li Hai-Shun Qu xian-zhi zhang Hai-Li zhang Jing zhang Bo Peng Department of Nephroendocrine Dongzhimen Hospital of Beijing University of Chinese MedicineBeijingChina Department of State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

The objective of this study is to evaluate the effectiveness and safety of Tripterygium glycosides combined with glucocorticoids for the treatment of refractory nephrotic syndrome(NS).Computer search of Chinese and English databases,including CNKI,VIP,Wan Fang Database,PubMed,Cochrane Library,Embase,and Sinomed,for randomized controlled trials(RCTs)of Tripterygium glycosides combined with glucocorticoids for refractory NS(RNS)was ***-analysis was performed using *** RCTs comprising 994 patients were included in the *** glycosides combined with glucocorticoids had a statistical significance on the effective rate(odds ratio[OR]=4.69,95%confidence interval[CI]3.29,6.67,P<0.00001),24-h urine protein(Weighted mean difference(MD)=-0.57,95%CI[-0.62,-0.51],P<0.00001),serum albumin(MD=4.77,95%CI[4.30,5.24],P<0.00001),total serum protein(MD=9.45,95%CI[8.73,10.17],P<0.00001),urea nitrogen(MD=-0.53,95%CI[-0.90,-0.17],P=0.005),and serum creatinine(MD=-8.45,95%CI[-15.32,-1.57],P=0.02).There was no statistical significance on adverse reactions(OR=0.68,95%CI[0.41,1.12],P=0.13).Tripterygium glycosides combined with glucocorticoids could improve clinical effective rate,reduce 24-h urine protein,improve serum albumin and total serum protein,and reduce urea nitrogen and serum creatinine levels in patients with ***,the quality of the included literature is poor,and conclusion still needs further verification using larger samples and high-quality randomized,double-blind controlled trials.

关键词： Glucocorticoids meta-analysis refractory nephrotic syndrome Tripterygium glycosides

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Effect and safety of sorafenib in patients with intermediate hepatocellular carcinoma who received transarterial chemoembolization: A retrospective comparative study

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World Journal of Clinical Cases 2018年第5期6卷 74-83页

作者： Xue-Fen Lei Yang Ke Tian-Hao Bao Hao-Ran Tang Xue-Song Wu zhi-Tian Shi Jie Lin zhi-xian zhang Hou Gu Lin Wang Department of Medical Oncology The Second Affiliated Hospital of Kunming Medical University Department of Hepatobiliary Surgery The Second Affiliated Hospital of Kunming Medical University The Mental Health Center of Kunming Medical University Department of Hepatobiliary Surgery The Second Affiliated Hospital of Kunming Medical University Department of Gastro- enterological Surgery The Second Affiliated Hospital of Kunming Medical University

AIM To evaluate the safety and efficacy of sorafenib plus transarterial chemoembolization(TACE) treatment for intermediate hepatocellular carcinoma(HCC).METHODS Sixty-seven patients with intermediate-stage [Barcelona Clinic liver cancer stage B(BCLC-B)] HCC who were treated with sorafenib plus TACE or TACE alone between 2009 and 2011 were included in the study. Follow-up was until 2014 or patient death. Two groups were defined in the experiment: The experimental group, treated with sorafenib plus TACE, and the control group, treated with standard TACE *** The Kaplan-Meier survival analysis showed that the median overall survival(m OS) of the experimental group was 35.2 mo, while that of the control group was 22.0 mo(P < 0.05). Sorafenib plus TACE showed higher incidence rates of rash, hand-foot syndrome(HFS), and hypertension(P < 0.05) than TACE treatment *** Sorafenib plus TACE treatment for BCLC-B HCC significantly prolonged the m OS of patients compared to TACE treatment alone. The most common toxicities with sorafenib were rash(31.6%), HFS(39.5%) and hypertension(31.6%), but there were no intolerable adverse events. The Cox multivariate analysis showed that the survival of patients with BCLC-B HCC depended on the Child-Pugh classification, tumor diameter, and treatment with sorafenib plus TACE compared to TACE alone.

关键词： Sorafenib Hepatocellular carcinoma Transarterial chemoembolization Overall survival Adverse reaction

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Meta-Analysis of Niaoduqing Granules Combined With RAAS System Blocker in the Treatment of Diabetic Nephropathy

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World Journal of Traditional Chinese Medicine 2019年第4期5卷 193-201页

作者： Jing zhang Jing Li Hai-Li zhang Hai-Shun Qu xian-zhi zhang Ya-Qing Cheng Zheng-Mei zhang Jia-Qin Huang Department of Nephroendocrine Dongzhimen Hospital Beijing University of Chinese Medicine

To systematically evaluate the efficacy of urinary granules combined with RAAS system blockers in the treatment of diabetic nephropathy(DN).A meta-analysis of the data required in the literature in accordance with this study was performed using Rev Man 5.3 *** randomized controlled trials were analyzed in the present study to evaluate the clinical effect of Niaoduqing-angiotensin converting enzyme inhibitors/angiotensin receptor blocker(ACEI/ARB)in DN patients.A total of 1063 patients were involved,including 538 patients receiving the combination treatment and 525 patients in the control *** results showed that the clinical efficacy of Niaoduqing granule combined with ACEI/ARB was significantly better than of the control group(odds ratio=2.92,95%confidence interval[CI]1.76–4.86).The treatment combined with Niaoduqing granule decreased the 24-h urinary protein quantitation(mean difference[MD]0.71,95%CI 0.28–1.14)and urine albumin excretion rate(UAER)(MD 41.13,95%CI 26.66–55.59)***,the combination group had no treatment advantage on reducing serumurea nitrogen(MD 0.86,95%CI 0.05–1.68,P=0.02)and fasting blood glucose(MD-0.03,95%CI-0.15–0.09,P=0.61).And there was no significance in adverse events between two groups(risk ratio=2.34,95%CI 0.69–7.95,P=0.17).Niaoduqing granule-ACEI/ARB combination group maybe as safe as ACEI/ARB alone,and the combination played an advantage in improvement in total effective rate,reduction of 24-h urinary protein quantitation and UAER.

关键词： Diabetic nephropathy meta-analysis niaoduqing granules RAAS system blocker

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抗泄漏的身份基聚合签密方案

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北京邮电大学学报 2016年第5期39卷 20-25页

作者：王志伟张献一南京邮电大学计算机学院南京210023

为了解决聚合签密方案中存在的密钥泄漏问题,在无限制身份基聚合签密方案的基础上,设计出一个抗身份密钥泄漏所需的身份基哈希证明系统,证明了其解封正确性、合法/非法密文不可区分性、平滑性和普遍性.基于该身份基哈希证明系统,结合随... 详细信息

为了解决聚合签密方案中存在的密钥泄漏问题,在无限制身份基聚合签密方案的基础上,设计出一个抗身份密钥泄漏所需的身份基哈希证明系统,证明了其解封正确性、合法/非法密文不可区分性、平滑性和普遍性.基于该身份基哈希证明系统,结合随机数提取器,构造了一个抗泄漏的身份基签密方案,并给出了方案的安全证明,结果表明,其身份密钥的泄漏比值可达1-o(1).

关键词：聚合签密抗泄露哈希证明系统随机数提取器

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苯并-15-冠-5和二苯并-18-冠-6萃取分离铟(III)的研究

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化学学报 1988年第5期46卷 496-499页

作者：周稚仙张宪新郑州大学化学系郑州

苯并-15-冠-5(B-15-C-5)和二苯并-18-冠-6(DB-18-C-6)应用于金属离子的萃取分离已有许多报道,但In3+电荷数高、离子半径小、水合能较大,因此很难用B-15-C-5和DB-18-C-6萃取,有关这方面的工作迄今未见报道.本文用斜率法、饱和法以及通过... 详细信息

苯并-15-冠-5(B-15-C-5)和二苯并-18-冠-6(DB-18-C-6)应用于金属离子的萃取分离已有许多报道,但In3+电荷数高、离子半径小、水合能较大,因此很难用B-15-C-5和DB-18-C-6萃取,有关这方面的工作迄今未见报道.本文用斜率法、饱和法以及通过与萃合物相对应的冠醚配合物品体的制备及其性质研究,探讨了In3+的萃取机理,测定并计算了表观萃取平衡常数K′ex.将此萃取体系应用于In3+和某些金属离子的萃取分离,亦获得较好的结果.

关键词：配合物饱和法萃取机理 III 金属离子分配比萃合物萃取分离二苯并

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Regulation of rectangular descriptor systems with constrained states and controls

Regulation of rectangular descriptor systems with constraine...

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2010 Chinese Control and Decision Conference

作者： Xin-Rong Yang,Rui-zhi zhang,xian zhang School of Mathematical Science,Heilongjiang University,Harbin 150080,China

＜正＞The constrained regulation problem for a class of rectangular descriptor systems with constrained states and controls is considered in this paper.A dynamic compensator is designed to guarantee that resultant closed-loop singular systems are admissible,and have a prescribed positively invariant *** design approach first translates the regulation problem into that for square descriptor systems,and then the constrained regulation problem is solved by using the generalized inverse and a result（some modifications are done） obtained in[*** Sci.,38,689-698].A numerical example shows the applicability of proposed approach.

关键词： Regulation Positively Invariant Set Rectangular Descriptor System Dynamic Compensator

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苯并-15-冠-5四溴合铟(Ⅲ)酸钾配合物的晶体结构

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化学学报 1986年第9期44卷 870-874页

作者：周稚仙张宪新黄锦顺郑州大学化学系中国科学院福建物质结构研究所郑州郑州福州

苯并-15-冠-5四溴合铟（III）酸钾,KInBr4(C14H20O5)2,晶体属单斜晶系,空间群为C2h5-P21/n,晶胞参数α=14.402（3）,b=15.082（3）,c=17.262（5）A,β=93.42（2）°,Z=4.非氢原子的位置由Patterson函数及Fourier合成法找出,经全矩阵最小二乘法修正R=0.057.结构分析表明K+和两个苯并-15-冠-5（B-15-C-5）分子直接配位,对阴离子为InBr4-,具有四面体构型.InBr4-与配阳离子K（B-15-C-5）2+依靠静电引力结合为离子对.由此说明,In（III）在过量KBr存在下可以被B-15-C-5定量地萃取至有机相中.

关键词：晶体结构四面体构型苯并单斜晶系氢原子静电引力冠醚有机相 Patterson 单晶衍射

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A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo zhang Yinfan Liu xian Jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

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Synthesis and biological evaluation of coumarin derivatives as amyloid-beta oligomer aggregation inhibitors

Synthesis and biological evaluation of coumarin derivatives ...

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2011年全国药物化学学术会议——药物的源头创新

作者： Hai-Qiang Wu~(a,*),Liao zhang~a,Jie-Yu Zeng~a,zhi-Yi Yang~a,Yi-zhi Zheng~a,xian-zhang Bu~b a,College of Life Sciences,Shenzhen University,Shenzhen 518060 China b,School of Pharmaceutical Science,Sun Yat-sen University,Guangzhou 510006,China

＜正＞Objective Protein misfolding and aggregation are common hallmarks in Alzheimer’s disease （AD）.Many studies suggested that the toxicity and neurodegeneration in AD may be attributed to solube amyloid-βoligome...

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-xian Li Wei-Qi zhang Yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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