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World Journal of Clinical Cases 2022年第12期10卷 3966-3968页

作者： Long Ma zhi-wen luo Ya-Ying Sun Department of Orthopedics The First People's Hospital of Pindingshan CityPingdingshan 467000Henan ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently we read the article entitled“Outcomes of different minimally invasive surgical treatments for vertebral compression fractures:An observational study”.This was an observational study that reviewed the safety and efficacy of different cement augmentation modalities for vertebral compression fractures under osteoporotic ***,this is a valuable study that can provide a reference for clinical *** the other hand,we also noticed some points in the article and are willing to share our *** studies with a higher level of evidence can add more knowledge regarding relevant concerns.

关键词： Vertebral compression fractures Osteoporosis Study design Observational study Randomize

Physical energy-based ultrasound shifts M1 macrophage differentiation towards M2 state

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World Journal of Stem Cells 2022年第2期14卷 214-218页

作者： Hao-Cheng Qin zhi-wen luo Yu-Lian Zhu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently,we read with interest the article entitled“Unveiling the Morphogenetic Code:A New Path at the Intersection of Physical Energies and Chemical Signaling”.In this paper,the investigation into the systematic and comprehensive bio-effects of physical energies prompted us to reflect on our *** believe that ultrasound,which possesses a special physical energy,also has a certain positive regulatory effect on macrophages,and we have already obtained some preliminary research results that support our hypothesis.

关键词： Ultrasound Macrophages Stem cells Physical energies Inflammation

The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu Cheng zhi-Hui Wang Mou Peng zhi-Chao Huang Lu Yi Yi-Jian Li Lei Yi wen-zhi luo Jia-wen Chen Yin-Huai Wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

Parity and carotid atherosclerosis in elderly Chinese women

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Journal of Geriatric Cardiology 2020年第12期17卷 759-765页

作者： Xiao-Yan WANG Fei YE Li-Xiong ZENG Shan TU wen-zhi luo Xu DENG zhi-Hui ZHANG Department of Cardiology the Third Xiangya HospitalCentral South UniversityChangshaChina

Background The relationship between parity and atherosclerosis has been reported in some ethnic ***,results regarding Chinese women are still *** study aimed to investigate the association of parity and carotid atherosclerosis,which has a predictive value of subsequent atherosclerotic events in elderly Chinese *** A total of 2,052 participants from the medical examination center of the Third Xiangya Hospital were enrolled in the study.A standardized,structured questionnaire was administered to collect information on subjects’demographic characteristics,socioeconomic status,and cardiovascular risk ***-resolution ultrasound was used to examine carotid plaques and carotid intima-media thickness(IMT).Results The mean age of participants was 66.1±5.5 *** with more birth appeared to have a higher risk of carotid artery plaques.A multivariate-adjusted model yielded an odds ratio of 1.38(95%CI:12%-70%,P=0.003)per birth.A positive association was observed between parity and common carotid IMT(β±SE:0.029±0.006,P<0.001),and internal carotid IMT(β±SE:0.011±0.005,P=0.03)in a univariate model;however,these associations became non-significant in multivariate-adjusted *** common carotid IMT was classified into an IMT≥1 mm group and an IMT<1 mm group,higher parity was associated with more obvious thickening both in the unadjusted model(OR=1.61,95%CI:1.29-2.00,P<0.001)and in the fully adjusted model(OR=1.43,95%CI:1.09-1.88,P=0.01).Conclusions There is a positive association between parity and risk of carotid plaques,as well as between parity and risk of obvious thickening for common carotid IMT in elderly Chinese women,indicating multiparous women might experience more atherosclerotic challenges.

关键词： Atherosclerosis Elderly women Parity

Comparison of three administration modes for establishing a zebrafish seizure model induced by N-Methyl-D-aspartic acid

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World Journal of Psychiatry 2020年第7期10卷 150-161页

作者： Xin-Yi Long Shuang Wang zhi-wen luo Xu Zhang Hong Xu Queen Mary School of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200433China Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Institute of Life Science Nanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Epilepsy is a complex neurological disorder characterized by recurrent,unprovoked seizures resulting from the sudden abnormal discharge of brain *** leads to transient brain dysfunction,manifested by abnormal physical movements and *** can occur at any age,affecting approximately 65 million worldwide,one third of which are still estimated to suffer from refractory *** is an urgent need for further establishment of seizure models in animals,which provides an approach to model epilepsy and could be used to identify novel anti-epileptic therapeutics in the *** To compare three administration modes for establishing a seizure model caused by N-Methyl-D-aspartic acid(NMDA)in *** Three administration routes of NMDA,including immersion,intravitreal injection and intraperitoneal injection,were compared with regard to their effects on inducing seizure-like behaviors in adult *** evaluated neurotoxicity by observing behavioral changes in zebrafish and graded those behaviors with a seizure *** addition,the protective effects of MK-801(Dizocilpine)and natural active constituent resveratrol against NMDA-induced alterations were *** The three NMDA-administration methods triggered different patterns of the epileptic process in adult *** scores were increased after increasing NMDA concentration regardless of the mode of ***,the curve of immersion continuously rose to a high plateau(after 50 min),while the curves of intravitreal injection and intraperitoneal injection showed a spike in the early stage(10-20 min)followed by a steady decrease in seizure ***,pretreatment with resveratrol and MK-801 significantly delayed seizure onset time and lowered seizure *** By comparing the three methods of administration,intravitreal injection of NMDA was the most suitable for establishing an acute epileptic model in ***,intraperitoneal i

关键词： Seizure Zebrafish N-Methyl-D-aspartic acid Administration modes

New-onset depression after hip fracture surgery among older patients:Effects on associated clinical outcomes and what can we do?

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World Journal of Psychiatry 2021年第11期11卷 1129-1146页

作者： Hao-Cheng Qin zhi-wen luo Heng-Yi Chou Yu-Lian Zhu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Orthopedics Huashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Hip fracture in the elderly is a worldwide medical ***-onset depression after hip fracture has also received attention because of its increasing incidence and negative impact on *** To provide a synthesis of the literature addressing two very important questions arising from postoperative hip fracture depression(PHFD)research:the risk factors and associated clinical outcomes of PHFD,and the optimal options for intervention in *** We searched the PubMed,Web of Science,EMBASE,and PsycINFO databases for English papers published from 2000 to *** Our results showed that PHFD may result in poor clinical outcomes,such as poor physical function and more medical *** addition,the risk factors for PHFD were summarized,which made it possible to assess patients ***,our work preliminarily suggested that comprehensive care may be the optimal treatment option for PHFDs,while interdisciplinary intervention can also be clinically *** We suggest that clinicians should assess risk factors for PHFDs preoperatively,and future research should further validate current treatment methods in more countries and regions and explore more advanced solutions.

关键词： Depression Hip fracture New onset Risk factors Treatments Clinical outcomes

Geographic variation in photoperiodic diapause induction and diapause intensity in Sericinus montelus （Lepidoptera Papilionidae）

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Insect Science 2012年第3期19卷 295-302页

作者： Xiao-Ping Wang Qiu-Sheng Yang Peter Dalin Xing-Miao Zhou zhi-wen luo Chao-Liang Lei Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhanChina Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden College of Life Science Jiamusi UniversityJiamusiHelongjiang ProvinceChina

Due to the risk of extinction and ornamental value of the swallowtail butterfly, Sericinus montelus Gray （Lepidoptera： Papilionidae） in China, knowledge about local adaptations is important for the conservation and economical utilization of the species. In the present study, photoperiodie diapause induction and diapause intensity of S. montelus populations from Jiamusi （46°37＇N）, Beijing （40° 15＇N）, Zibo （36°48＇N）, Fangxian （32°36＇N）, Wuhan （30°33＇N） and Huaihua （27°33＇N） were characterized at 25℃. Logistic regression analysis revealed a significant population x hours of light interaction, confirming that photoperiodic responses varied among populations. The critical photoperiod was positively correlated with latitude and increased toward the north at a rate of about 1 h for each 6.67 degrees of latitude. Survival analyses indicated that survival time of diapausing pupae before adult eclosion differed significantly among populations at 25℃ and 16 ： 8 L ＂D h. The mean duration of pupal diapause was also positively correlated with latitude. Our study reveals geographic variation in the critical photoperiod for diapause induction and in diapause intensity of S. montelus. These results provide useful information for our general understanding about seasonal adaptation in insects and may also be used to predict how geographic populations respond to climate warming.

关键词： critical photoperiod duration of diapause geographic population pupal diapause Sericinus montelus

Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation

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World Journal of Stem Cells 2021年第11期13卷 1762-1782页

作者： zhi-wen luo Ya-Ying Sun Jin-Rong Lin Bei-Jie Qi Ji-Wu Chen Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

BACKGROUND Acute muscle injuries are one of the most common injuries in *** injured muscles are prone to re-injury due to fibrotic scar formation caused by prolonged *** to regulate inflammation and suppress fibrosis is the focus of promoting muscle *** studies have found that myoblasts and macrophages play important roles in the inflammatory phase following muscle injury;however,the crosstalk between these two types of cells in the inflammatory environment,particularly the exosome-related mechanisms,had not been well *** To evaluate the effects of exosomes from inflammatory C2C12 myoblasts(IFC2C12-Exos)on macrophage polarization and myoblast proliferation/*** A model of inflammation was established in vitro by lipopolysaccharide stimulation of myoblasts.C2C12-Exos were isolated and purified from the supernatant of myoblasts by gradient *** methods were used to identify the *** concentrations of IF-C2C12-Exos were added to normal macrophages and ***67 fluorescence tracing was used to identify the interaction between exosomes and *** morphology,Giemsa stain,and immunofluorescence were carried out for histological ***,ELISA assays,flow cytometry,and western blot were conducted to analyze molecular ***,myogenic proliferation was assessed by the BrdU test,scratch assay,and CCK-8 *** We found that the PKH-67-marked C2C12-Exos can be endocytosed by both macrophages and ***-C2C12-Exos induced M1 macrophage polarization and suppressed the M2 phenotype in *** addition,these exosomes also stimulated the inflammatory reactions of ***-more,we demonstrated that IF-C2C12-Exos disrupted the balance of myoblast proliferation/differentiation,leading to enhanced proliferation and suppressed fibrogenic/myogenic *** IF-C2C12-Exos can induce M1 polarization,resulting in a su

关键词： C2C12 myoblast Exosomes Macrophage polarization Inflammation Differentiation Proliferation

Management of hip fracture in COVID-19 infected patients

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World Journal of Orthopedics 2022年第6期13卷 544-554页

作者： Hao-Cheng Qin Zhong He zhi-wen luo Yu-Lian Zhu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Given that the global population of elderly individuals is expanding and the difficulty of recovery,hip fractures will be a huge challenge and a critical health issue for all of *** people have spent more time at home during the coronavirus disease 2019(COVID-19)pandemic,hip fractures show no sign of *** studies have shown that patients with hip fracture and COVID-19 have a multifold increase in mortality compared to those uninfected and a more complex clinical *** present,no detailed research has systematically analyzed the relationship between these two conditions and proposed a comprehensive *** article aims to systematically review the impact of COVID-19 on hip fracture and provide practical *** found that hip fracture patients with COVID-19 have higher mortality rates and more complicated clinical ***,COVID-19 prevents hip fracture patients from receiving regular medical *** regard to the problems we encounter,we provide clinical recommendations based on existing research evidence and a clinical flowchart for the management of hip fracture patients who are COVID-19 *** study will help clinicians adequately prepare in advance when dealing with such patients and optimize treatment decisions.

关键词： Hip fracture COVID-19 Management Adverse impact Comorbidity Treatment

Bone marrow mesenchymal stem cell-derived exosomal microRNAs target PI3K/Akt signaling pathway to promote the activation of fibroblasts

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World Journal of Stem Cells 2023年第4期15卷 248-267页

作者： Fang-Qi Li wen-Bo Chen zhi-wen luo Yi-Sheng Chen Ya-Ying Sun Xiao-Ping Su Jun-Ming Sun Shi-Yi Chen Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Laboratory Animal Center Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Fibroblast plays a major role in tendon-bone *** derived from bone marrow mesenchymal stem cells(BMSCs)can activate fibroblasts and promote tendon-bone healing via the contained microRNAs(miRNAs).However,the underlying mechanism is not comprehensively ***,this study aimed to identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets,and to verify their effects as well as mechanisms on *** To identify overlapped BMSC-derived exosomal miRNAs in three GSE datasets and verify their effects as well as mechanisms on *** BMSC-derived exosomal miRNAs data(GSE71241,GSE153752,and GSE85341)were downloaded from the Gene Expression Omnibus(GEO)*** candidate miRNAs were obtained by the intersection of three data *** was used to predict potential target genes for the candidate *** and pathway analyses were conducted using the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)databases,respectively,by processing data with the *** interconnected genes in the protein-protein interaction(PPI)network were analyzed using Cytoscape ***,wound healing assay,collagen contraction assay and the expression of COL I andα-smooth muscle actin positive were applied to investigate the cell proliferation,migration and collagen *** real-time reverse transcription polymerase chain reaction was applied to determine the cell fibroblastic,tenogenic,and chondrogenic *** Bioinformatics analyses found two BMSC-derived exosomal miRNAs,has-miR-144-3p and hasmiR-23b-3p,were overlapped in three GSE *** network analysis and functional enrichment analyses in the GO and KEGG databases indicated that both miRNAs regulated the PI3K/Akt signaling pathway by targeting phosphatase and tensin homolog(PTEN).In vitro experiments confirmed that miR-144-3p and miR-23b-3p stimulated proliferation,migration and collagen sy

关键词： Exosome MicroRNA Fibroblast Mesenchymal stem cell Tendon-bone healing