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Melatonin restores normal Bax and Bcl-2 protein expression in the subgranular zone of the dentate gyrus in pinealectomized rats

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Neural Regeneration Research 2011年第27期6卷 2129-2133页

作者： Shengchang Zhang Shuang Zhao Lu Bai Mingming Guan Jielin mo Ling Lan Department of Human Anatomy Basic Medical College Guangxi Medical University Nanning 530021 Guangxi Zhuang AutonomousRegion China Department of Pathophysiology Youjiang Medical College for Nationalities Baise 533000 Guangxi Zhuang Autonomous Region China

In this study, we sought to elucidate the effects of melatonin on learning and memory as well as apoptosis and expression of the Bax or Bcl-2 proteins in the subgranular zone of the dentate gyrus in pinealectomized rats. Using the morris water maze and the olfactory memory tests, we found that the average escape latency in pinealectomized rats was clearly increased compared with sham-operated rats. moreover, the average escape latency in the melatonin-treated and pinealectomized rats was longer than that in the sham-operated rats and shorter than that in the pinealectomized and untreated rats. Immunohistochemistry and terminal-deoxynucleoitidyl transferase mediated nick end labeling （TUNEL） showed that there were fewer Bax immunoreactive cells and TUNEL-positive （apoptotic） cells but more Bcl-2 immunoreactive cells in the melatonin-treated rats compared with the pinealectomized rats. The sham-operated rats showed numbers of these cells similar to the melatonin-treated rats. These experimental findings demonstrate that melatonin treatment may reduce abnormal apoptosis by promoting gene expression of Bax and suppressing gene expression of Bcl-2 in the subgranular zone of the dentate gyrus in pinealectomized rats. These effects appear to result in the inhibition of cellular apoptosis and the improvement of spatial learning and memory in pinealectomized rats.

关键词： melatonin subgranular zone Bax Bcl-2 apoptosis learning and memory neural regeneration

轻度创伤性颅脑损伤患者谵妄发生情况及其影响因素分析

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创伤外科杂志 2024年第7期26卷 512-516页

作者：李佳雨刘素云莫景书李海娟许光远周小舟张莹莹沈印广西壮族自治区人民医院急诊科南宁530021 广西壮族自治区人民医院国际医疗部南宁530021

目的探讨轻度创伤性颅脑损伤患者(mTBI)谵妄的发生率及危险因素。方法前瞻性纳入2021年1月—2023年12月在广西壮族自治区人民医院急诊科住院的107例根据《颅脑创伤临床救治指南》标准诊断为mTBI的患者,患者入院后72 h内每24h采用意识... 详细信息

目的探讨轻度创伤性颅脑损伤患者(mTBI)谵妄的发生率及危险因素。方法前瞻性纳入2021年1月—2023年12月在广西壮族自治区人民医院急诊科住院的107例根据《颅脑创伤临床救治指南》标准诊断为mTBI的患者,患者入院后72 h内每24h采用意识模糊评估法中文修正版(CAM-CR)进行谵妄评估,同时收集患者年龄、性别、合并疾病、入院血清钾、血清钠、血肌酐、血清白蛋白、入院24 h匹兹堡睡眠质量指数(PSQI)等临床指标。根据患者有无谵妄发生分为谵妄组和正常组,比较两组患者的相关临床指标,采用单因素分析和多因素Logistic回归分析筛选患者发生谵妄的危险因素。结果 107例mTBI患者中有41例在住院期间发生谵妄,发生率为38.32%(95%CI:22%~47.7%),谵妄组患者年龄、合并冠心病、高血压病的比例和入院24 h PSQI指数、WBC、CRP数值高于正常组,血清钠、血清钾、血清白蛋白数值低于正常组,两组比较差异有统计学意义(P均<0.05)。Logistic多因素回归分析提示年龄(OR=1.208,95%CI:1.089~1.341)、血清钠(OR=0.758,95%CI:0.624~0.920)、血清白蛋白(OR=0.755,95%CI:0.586~0.971)、入院24 h PSQI指数(OR=2.725,95%CI:1.237~6.002)是mTBI患者住院期间发生谵妄的独立影响因素(P均<0.05)。结论年龄增加及PSQI指数增加与mTBI患者住院期间发生谵妄风险增加显著相关,血清钠浓度和血清白蛋白水平增加与mTBI患者住院期间发生谵妄风险降低显著相关。

关键词：创伤性颅脑损伤谵妄危险因素

The Counting Problem of an Order N-group of Set

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Chinese Quarterly Journal of Mathematics 2003年第3期18卷 283-285页

作者： WANGJing-zhou ZHANGHai-mo CollegeofMathematicsandInformationScience HenanUniversityKaifeng475001China ZhongyuanVocationalandTechnicalCollege Zhumadian463000 China

In this paper, we discuss the counting prob lem of an order n-group of set (A 1,A 2,…,A n) which satisfies ∪ni=1A i=｛a 1,a 2,…,a m｝ and one of the following: (1) ∩ni=1A i=Φ; (2) ∩ni=1A i=｛b 1,b 2,…,b k｝;(3)... 详细信息

关键词：计数问题 n有序集组元素分析法约束条件

发泡法与自体表皮细胞移植治疗面颈部白癜风美学效果的比较研究

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中华医学美学美容杂志 2024年第3期30卷 208-212页

作者：陶勇刘志飞张明子胡晓函俞楠泽龙飞夏泽楠莫斓王晓军南京华厦白癜风医院南京210028 中国医学科学院北京协和医院整形外科北京100140 河北医科大学19级基础医学院临床医学系石家庄050011

目的探讨发泡法移植技术与非培养自体表皮细胞移植再生技术在面颈部稳定期白癜风外科治疗的差异与美学意义。方法2016年5月至2020年5月,北京协和医院整形美容外科与南京华厦白癜风医院治疗面颈部稳定期白癜风患者64例,男25例、女39例;年... 详细信息

目的探讨发泡法移植技术与非培养自体表皮细胞移植再生技术在面颈部稳定期白癜风外科治疗的差异与美学意义。方法2016年5月至2020年5月,北京协和医院整形美容外科与南京华厦白癜风医院治疗面颈部稳定期白癜风患者64例,男25例、女39例;年龄10~46岁,平均25岁。随机数字表法分为发泡法移植组和自体表皮移植组,每组32例;分别于术后3个月和6个月计算两组患者的治疗有效率、色素沉着、拼缝畸形出现情况。结果发泡法移植组:治疗后3个月有效22例(68.75%),6个月有效29例(90.63%);自体表皮移植组:治疗后3个月有效19例(59.37%),6个月有效28例(87.50%);两组比较差异无统计学意义(P>0.05)。自体表皮移植组在术后3个月及6个月未出现色素沉着及拼缝畸形患者,效果优于发泡法移植组。结论非培养自体表皮细胞移植再生技术治疗白癜风更符合患者的美学需求。

关键词：白癜风发泡法移植技术非培养自体表皮细胞移植再生技术美学有效率

Targeting MET in cancer therapy

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Chronic Diseases and Translational Medicine 2017年第3期3卷 148-153页

作者： Hong-Nan mo Peng Liu Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

MET encodes a receptor tyrosine kinase c-MET for hepatocyte growth factor (HGF). The specific combination of c-MET and HGF activates downstream signaling pathways to trigger cell migration, proliferation, and angiogenesis. MET exon 14 alterations and MET gene amplification play a critical role in the origin of cancer. Several monoclonal antibodies and small-molecule inhibitors of c-MET have been evaluated in clinical trials. In patients with advanced non-small cell lung cancer, cabozantinib and crizotinib showed clear efficacy with a generally tolerable adverse events profile. In gastrointestinal cancers, most phase III trials of MET inhibitors showed negative results. In hepatocellular carcinoma, based on the encouraging results of some phase II studies, a series of phase III trials are currently recruiting patients to access the efficacy and safety of MET inhibitors.

关键词： Proto-oncogene protein c-MET Antineoplastic agents Protein kinase inhibitors molecular targeted therapy

Development prospects of metal-based two-dimensional nanomaterials in lithium-sulfur batteries

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Chinese Chemical Letters 2023年第1期34卷 102-113页

作者： Yuxue mo Liling Liao Dongyang Li Rongwu Pan Yanhong Deng Yanliang Tan Haiqing Zhou College of Physics and Electronic Engineering Hengyang Normal UniversityHengyang 421002China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key Laboratory for Matter Microstructure and Function of Hunan ProvinceDepartment of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal UniversityChangsha 410081China Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Changsha 410082China Hunan Shengli High-tech Energy Technology Co. Ltd.Yongzhou 425000China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang 421002China

A lithium-sulfur(Li-S)system is an important candidate for future lithium-ion system due to its low cost and high specific theoretical capacity(1675 m Ah/g,2600 Wh/kg),which is greatly hindered by the poor conductivity of sulfur,large volume change and dissolution of lithium ***-dimensional(2D)materials with monolayers or few-layers usually have peculiar structures and physical/chemical properties,which can resolve the critical issues in Li-S ***,the metal-based 2D nanomaterials,including ferrum,cobalt or other metal-based composites with various anions,can provide high conductivity,large surface area and abundant reaction sites for restraining the diffusion for lithium *** this mini-review,we will present an overview of recent developments on metal-based 2D nanomaterials with various anions as the electrode materials for Li-S *** the main bottleneck for the Li-S system is the shuttle of polysulfides,emphasis is placed on the structure and components,physical/chemical interaction and interaction mechanisms of the 2D ***,the challenges and prospects of metal-based 2D nanomaterials for Li-S batteries are discussed and proposed.

关键词： Lithium-sulfur battery Two-dimensional materials Cathode materials Anode materials Anode protection

轴承用8Cr4mo4V钢稳定热处理期间相转变分析

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航空发动机 2023年第3期49卷 170-174页

作者：夏云志于兴福杨文武刘璐魏英华苏勇中国航发哈尔滨轴承有限公司哈尔滨150500 沈阳工业大学机械工程学院沈阳110870 沈阳化工大学机械与动力工程学院沈阳110142

为了研究稳定热处理期间8Cr4mo4V钢的组织转变及尺寸变化规律,采用热膨胀仪和差热分析仪测定经淬火和回火处理后的8Cr4mo4V钢升温期间相变引起的尺寸及热流变化特征,分析了稳定热处理期间钢的相变特征,并采用扫描电镜观察了稳定处理后... 详细信息

为了研究稳定热处理期间8Cr4mo4V钢的组织转变及尺寸变化规律,采用热膨胀仪和差热分析仪测定经淬火和回火处理后的8Cr4mo4V钢升温期间相变引起的尺寸及热流变化特征,分析了稳定热处理期间钢的相变特征,并采用扫描电镜观察了稳定处理后的微观组织。结果表明:在8Cr4mo4V钢淬火后的回火升温期间,马氏体回火相变温度为132~243℃,残余奥氏体转变温度为215~303℃,马氏体分解为铁素体+碳化物的温度为278~420℃。随着稳定处理次数的增加,8Cr4mo4V钢中的马氏体发生回火转变的温度及马氏体分解为铁素体+碳化物的温度逐渐升高,钢中亚稳相的稳定性增加。当进行3次稳定处理后,未检测到钢中发生马氏体回火相变,而马氏体分解为铁素体+碳化物的相变仍然存在。微观组织观察表明,随着稳定次数的增加,钢中析出的碳化物数量增多。

关键词：航空轴承钢 8Cr4mo4V 尺寸稳定性差热分析热膨胀航空发动机

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深度链接行为的法律评价问题研究

山西大学学报(哲学社会科学版) 2018年第3期41卷 114-118页

作者：莫洪宪刘芷含武汉大学法学院

将深度链接纳入法律规制的范围,具有一定的难度。在民事领域内,按照"服务器标准",深度链接行为只能是信息网络传播行为的帮助行为,属于间接侵权。而对于深度链接的犯罪化,无论是以侵犯著作权罪的正犯入罪,还是作为侵犯著作权罪的帮助犯... 详细信息

将深度链接纳入法律规制的范围,具有一定的难度。在民事领域内,按照"服务器标准",深度链接行为只能是信息网络传播行为的帮助行为,属于间接侵权。而对于深度链接的犯罪化,无论是以侵犯著作权罪的正犯入罪,还是作为侵犯著作权罪的帮助犯处理,或是采取共犯正犯化的模式均存在诸多障碍。从刑法的谦抑性和利益平衡的角度,刑法的介入和干预必须谨慎适度。

关键词：深度链接行为著作权信息网络传播行为侵犯著作权罪共犯正犯化

Effects of Nitrogen Fertilizer Treatments on Caryopsis Filling and Respiratory Rate of Rice

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Rice science 2006年第3期13卷 199-204页

作者： CHEN Juan WANG Zhong CHEN Gang mo Yi-wei Agronomy Department Agricultural College Yangzhou University Yangzhou 225009 China

An experiment was conducted to study the effects of nitrogen （N） rate and application time on grain filling and respiratory trait of caryopsis in two rice varieties, IR36 and Dali. The treatments were consisted of no N application topdressing at both tillering and booting stages （CK）, 6 g/pot of N topdressing at the tillering stage and 2 g/pot of N topdressing at the booting stage, 2 g/pot of N topdressing at the tillering stage and 6 g/pot of N topdressing at the booting stage. The results showed that the proper utilization of N fertilizer can be helpful to maintain the higher water content, higher respiratory rate and higher dehydrogenase activity of rice caryopsis in late filling phase, and prolong the course for filling and maintaining higher respiratory rate and dehydrogenase activity of rice caryopsis. more N application at booting was more effective compared to more N application at tillering.

关键词： nitrogen fertilizer water content filling duration respiratory rate dehydrogenase activity rice caryopsis