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RIS-4D生物雷达多人体定位与生命体征监测

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信号处理 2024年第2期40卷 225-235页

作者：金添李志戴永鹏宋勇平国防科技大学电子科学学院陆军工程大学通信士官学校

非接触式生命体征监测是一种可以被广泛用于健康医疗、辅助生活、汽车交通、搜索救援和公共安全的新兴技术。在本文工作中，我们开发了RIS-4D生物雷达用于非接触式生命体征监测，提出了同时定位多个人体目标以及监测对应的呼吸和心跳微... 详细信息

非接触式生命体征监测是一种可以被广泛用于健康医疗、辅助生活、汽车交通、搜索救援和公共安全的新兴技术。在本文工作中，我们开发了RIS-4D生物雷达用于非接触式生命体征监测，提出了同时定位多个人体目标以及监测对应的呼吸和心跳微动信号的方法，具有低成本、低能耗、可编程、易部署的优势。该系统利用可重构智能表面（Reconfigurable Intelligent Surface,RIS）天线动态操纵电磁波进行波束形成和三维雷达成像，从而实现对多个人体目标的三维空间定位，然后从时间维度上的连续回波中提取呼吸和心跳信号。“三维空间”+“一维时间”形成的四维时空高分辨率信息使得该RIS-4D生物雷达能够多维度感知目标和环境。空间波束形成使得电磁波能量聚焦在人体胸腔位置，有助于减少杂波（四肢以及环境多径等杂波）造成的干扰和失真，从而提高生物雷达的探测性能。在真实室内办公环境中的实测数据对该系统和所提出方法进行了验证，实验结果表明，利用该系统可以准确地定位并监测多个受试者的呼吸和心跳微动信号，对瞬时心率和心变异率的监测结果进一步验证了该系统的有效性。所提出的RIS-4D生物雷达为非接触生理信号采集提供了一种多目标、多功能、高精度的实现方式。

关键词：生命体征生物雷达四维可重构智能表面定位

甲磺酸伏美替尼一线治疗1例EGFR 20号外显子插入突变肺腺癌患者

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中国肺癌杂志 2024年第3期27卷 241-244页

作者：李正国魏婷曾多赵丽张建婷陈来秀甘肃省武威肿瘤医院呼吸内科武威733000

随着基因组学、蛋白组学和分子生物检测技术的不断创新,晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗模式逐渐多样化,已经从传统的化疗逐渐过渡到免疫治疗及靶向治疗。其中,以靶向酪氨酸激酶通路为靶点的分子肿瘤标志物... 详细信息

随着基因组学、蛋白组学和分子生物检测技术的不断创新,晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗模式逐渐多样化,已经从传统的化疗逐渐过渡到免疫治疗及靶向治疗。其中,以靶向酪氨酸激酶通路为靶点的分子肿瘤标志物在临床中发挥着越来越重要的作用。针对NSCLC患者表皮生长因子受体(epidermal growth factor receptor,EGFR)突变阳性,现阶段市面上已经有众多一线治疗药物上市,且均有较为明显的治疗效果。在中国患者中EGFR常见的变异位点位于19、20和21号外显子上,其中19和21号外显子突变是较为常见的突变类型,除此以外,EGFR突变还有一种亚型,被称为EGFR 20号外显子插入(EGFR exon 20 insertion,EGFR20ins)突变。我们针对1例EGFR20ins突变肺腺癌患者接受甲磺酸伏美替尼治疗进行总结,以期为临床诊疗提供有效借鉴。

关键词：肺肿瘤甲磺酸伏美替尼表皮生长因子受体 20号外显子插入突变

Rearranged 19-nor-7,8-seco-labdane diterpenoids and Diels-Alder cycloadducts from the Chinese liverwort Pallavicinia ambigua:Structural elucidation,photoinduced rearrangement,and cytotoxic activity

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Chinese Chemical Letters 2024年第3期35卷 415-418页

作者： Chunyang Zhang Yuelan li Zhaojun Chu Shuangzhi Yuan Yanan Qiao Jiaozhen Zhang lin li Yueqing Zhang Ruifeng Tian Yajie Tang Hongxiang Lou Department of Natural Products Chemistry Key Lab of Chemical Biology(MOE)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Two distinctive rearranged 19-nor-7,8-seco-labdane diterpenoids(1 and 2)with a novel tetracyclo[5.***.1.0^(2,5.)0^(4,10)]decane skeleton,a derivative of the open tetrahydrofuran ring(7),three dimeric compounds(8-10),and four revised homologs(3-6)were obtained from Chinese liverwort Pallavicinia ambigua.Their structures were identified via combined analysis of their spectroscopic data,single-crystal X-ray diffraction patterns,and ECD calculations.The light-driven conversion of compound 5 to compounds 1-4 demonstrated that photochemically induced postmodification involved in biosynthesis is an important way to diversify natural structures.A preliminary cytotoxicity assay revealed that compound 5 showed significant inhibition in the human prostate cancer(PC-3)cell line via an apoptotic pathway.

关键词： liverwort Pallavicinia ambigua 19-nor-7 8-seco-Labdan diterpenoid Photoinduced rearrangement Cytotoxic activity

Nanoconfinement-induced water molecules and hydrogen molecules transport behaviors in ball-in-ball structure photocatalysts to improve hydrogen evolution

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Nano Research 2024年第5期17卷 3752-3760页

作者： Ben Chong Baorong Xu He li Honghui Ou Guidong Yang XJTU-Oxford Joint International Research Laboratory of Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China

The diffusion,adsorption/desorption behaviors of water molecules and hydrogen molecules are of great importance in heterogeneous photocatalytic hydrogen production.In the study of structure-property-performance relationships,nanoconfined space provides an ideal platform to promote mass diffusion and transfer due to their extraordinary properties that are different from the bulk systems.Herein,we designed and prepared a nanoconfined CdS@SiO_(2)-NH_(2) nanoreactor,whose shell is composed of amino-functionalized silica nanochannels,and encapsulates spherical CdS as a photocatalyst inside.Experimental and simulated results reveal that the amino-functionalized nanochannels promote water molecules’and hydrogen molecules’directional diffusion and transport.Water molecules are enriched in the nanocavity between the core and the shell,and promote the interfacial photocatalytic reaction.As a result,the maximized water enrichment and minimized hydrogen-occupied active sites enable photocatalyst with optimized mass transfer kinetics and localization electron distribution on the CdS surface,leading to superior hydrogen production performance with activity as high as 37.1 mmol·g^(-1)·h^(-1).

关键词： nanochannels photocatalytic hydrogen evolution mass transfer amino-functionalized CdS

Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 703-715页

作者： li Xu Yu-Hong Fan Xiao-Jing Zhang Lan Bai State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Gannan Innovation and Translational Medicine Research InstituteGannan Medical UniversityGanzhou 341000China School of Basic Medical Sciences Wuhan UniversityWuhan 430060China

Non-alcoholic fatty liver disease(NAFLD)poses a significant health challenge in modern societies due to shifts in lifestyle and dietary habits.Its complexity stems from genetic predisposition,environmental influences,and metabolic factors.Epigenetic processes govern various cellular functions such as transcription,chromatin structure,and cell division.In NAFLD,these epigenetic tendencies,especially the process of histone methylation,are intricately intertwined with fat accumulation in the liver.Histone methylation is regulated by different enzymes like methyltransferases and demethylases and influences the expression of genes related to adipogenesis.While early-stage NAFLD is reversible,its progression to severe stages becomes almost irreversible.Therefore,early detection and intervention in NAFLD are crucial,and understanding the precise role of histone methylation in the early stages of NAFLD could be vital in halting or potentially reversing the progression of this disease.

关键词： Non-alcoholic fatty liver disease Mechanism Histone methylation Methyltransferases Demethytrasferases Epigenetic modification Adipogenesis

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2023年度中国新药盘点

中国新药与临床杂志 2024年第1期43卷 4-11页

作者：李秋戈乾玮邵黎明复旦大学药学院上海201203 上海市药物研发协同创新中心上海201203

为了解我国新药创新现状,本文盘点了2023年度国家药品监督管理局(NMPA)批准的新药上市申请信息,通过对药品类型、治疗领域、靶点分布和优先审评审批等内容的梳理,为生物医药创新相关领域的研究者提供参考。截至2023年12月31日,NMPA共批... 详细信息

为了解我国新药创新现状,本文盘点了2023年度国家药品监督管理局(NMPA)批准的新药上市申请信息,通过对药品类型、治疗领域、靶点分布和优先审评审批等内容的梳理,为生物医药创新相关领域的研究者提供参考。截至2023年12月31日,NMPA共批准190个新药上市申请,化学药品、治疗用生物制品和中药分别为117、64和9个。1类新药37个,改良型新药117个。抗肿瘤药物仍占主导(34.2%)。儿童用药和罕见疾病用药批准数量大幅提升。

关键词：药物批准 1类新药改良型新药生物制品治疗应用靶点

Compound events of heatwave and dust storm in the Taklamakan Desert

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Science China Earth Sciences 2024年第7期67卷 2073-2083页

作者： Yuzhi liU Jianping HUANG Ziyuan TAN Chenglong ZHOU Dan li Yongkun XIE Key Laboratory for Semi-Arid Climate Change of the Ministry of Education Lanzhou UniversityLanzhou 730000China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China Taklamakan National Station of Observation and Research for Desert Meteorology in Xinjiang Urumqi 830002China

Taklamakan Desert(TD)has been characterized by numerous heatwaves and dust storms,leading to negative effects on societies and ecosystems at regional and global scales.However,the association between heatwaves and dust storms is poorly known.In this study,we describe the association between heatwaves and dust events and propose a mechanism for such compound events in the TD.The results show that,from 1993 to 2022,the frequency and intensity of heatwaves in the TD have increased at a rate of 0.21 days year^(-1)and 0.02℃ year^(-1),respectively.More than 40% of heatwaves existed with dust events,which significantly lagged behind heatwaves.Mechanically,the higher the air temperature,the hotter and drier the soil,leading to more dust emissions in the TD.In high-occurrence heatwave years,a large-scale wave train of“cyclone-anticyclone-cyclone”in the northwest-southeast direction was found,with the anticyclone of which hovered over the TD region.The anomalous anticyclones favored the formation and maintenance of heatwaves,and subsequent anomalous cyclones in the wave train triggered strong dust events followed by heatwaves.With climate warming,the compound events of heatwave and dust storm are becoming bigger hazards threatening the socioeconomic and ecological security in the TD,the profound study of which is critical to understanding regional extreme responses.

关键词： Heatwave Dust storm Compound events Taklamakan Desert

Improving strength-ductility synchronously of Electron beam welded Ti600/Ti2AlNb joint through isothermal forging

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Progress in Natural Science:Materials International 2024年第3期34卷 532-539页

作者： Yongqiang Zhang Xiangyi Xue Guoming Zheng Jingli Zhang Huiming li Shewei Xin State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi'an Qin Ti Intelligent Manufacturing Technologies Co.Ltd. Northwest Institute for Nonferrous Metal Research Xi'an University of Science and Technology Avic Xi'an Aircraft Industry Group Company Ltd.

Different alloys can be flexibly combined to meet the performance needs of different parts of the compressor disc by welding process. However, achieving a good combination of dissimilar alloys with different mechanical properties has always been a research difficulty. In this work, a Ti600/Ti2AlNb joint was fabricated through electron beam welding and an isothermal forging was used to optimized its microstructure and mechanical performance. The isothermal forging process increases the ultimate tensile strength（UST） and yield strength（YS）of the Ti600/Ti2AlNb joint by ～18 %, while ～2.5 times the ductility. It is indicated that before forging, the Ti600/Ti2AlNb joint exhibits a much lower strength than that of Ti600 matrix, whereas the opposite is true after isothermal forging. The isothermal forging broken the coarse columnar grains of Ti600/Ti2AlNb joint and render to an equiaxed B2 structure in which the acicular α2and O phase are precipitated, resulting a synchronous enhancement of strength and ductility. This work may pave an effective routine for improving the comprehensive mechanical properties of dissimilar metal welding joint.

关键词： Electron beam welding Isothermal forging Mechanical performance Ti600/Ti2AlNb joint

Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury

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Neural Regeneration Research 2023年第6期18卷 1325-1331页

作者： zhi-Lai Zhou Huan Xie Xiao-Bo Tian Hua-li Xu wei li Shun Yao Hui Zhang The Spine Surgery Department Guangdong Second Provincial General HospitalGuangzhouGuangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Anesthesiology ZhuJiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Astrocytes and microglia play an orchestrated role following spinal cord injury;however,the molecular mechanisms through which microglia regulate astrocytes after spinal cord injury are not yet fully understood.Herein,microglia were pharmacologically depleted and the effects on the astrocytic response were examined.We further explored the potential mechanisms involving the signal transducers and activators of transcription 3(STAT3)pathway.For in vivo experiments,we constructed a contusion spinal cord injury model in C57BL/6 mice.To deplete microglia,all mice were treated with colony-stimulating factor 1 receptor inhibitor PLX3397,starting 2 weeks prior to surgery until they were sacrificed.Cell proliferation was examined by 5-ethynyl-2-deoxyuridine(EdU)and three pivotal inflammatory cytokines were detected by a specific Bio-Plex Pro^(TM) Reagent Kit.Locomotor function,neuroinflammation,astrocyte activation and phosphorylated STAT3(pSTAT3,a maker of activation of STAT3 signaling)levels were determined.For in vitro experiments,a microglia and astrocyte coculture system was established,and the small molecule STA21,which blocks STAT3 activation,was applied to investigate whether STAT3 signaling is involved in mediating astrocyte proliferation induced by microglia.PLX3397 administration disrupted glial scar formation,increased inflammatory spillover,induced diffuse tissue damage and impaired functional recovery after spinal cord injury.Microglial depletion markedly reduced EdU+proliferating cells,especially proliferating astrocytes at 7 days after spinal cord injury.RNA sequencing analysis showed that the JAK/STAT3 pathway was downregulated in mice treated with PLX3397.Double immunofluorescence staining confirmed that PLX3397 significantly decreased STAT3 expression in astrocytes.Importantly,in vitro coculture of astrocytes and microglia showed that microglia-induced astrocyte proliferation was abolished by STA21 administration.These findings suggest that microglial depletion impaired astrocyte proliferation and astro

关键词： astrocytes coculture colony-stimulating factor 1 receptor inhibitor EdU glia scar inflammatory response microglia phosphorylation proliferation spinal cord injury STAT3