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Prognostic Factors of Liver Transplantation for Hepatocellular Carcinoma: A Surveillance, Epidemiology, and End Results (SEER) Database Analysis

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Current Medical Science 2023年第2期43卷 329-335页

作者： Jun-bo LI Yuan-yuan ZHAO chen DAI Dong chen Lai WEI Bo YANG zhi-shui chen Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Organ Transplantation Key Laboratory of the National Health Commissionthe Ministry of Education and Chinese Academy of Medical SciencesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective We aimed to identify new,more accurate risk factors of liver transplantation for liver cancer through using the Surveillance,Epidemiology,and End Results(SEER)*** Using the SEER database,we identified patients that had undergone surgical resection for non-metastatic hepatocellular carcinoma(HCC)and subsequent liver transplantation between 2010 and *** survival(OS)was estimated using Kaplan-Meier *** proportional hazards regression modelling was used to identify factors independently associated with recurrent disease[presented as adjusted hazard ratios(HR)with 95%CIs].Results Totally,1530 eligible patients were included in the *** were significant differences in ethnicity(P=0.04),cancer stage(P<0.001),vascular invasion(P<0.001)and gall bladder involvement(P<0.001)between the groups that survived,died due to cancer,or died due to other *** the Cox regression model,there were no significant differences in OS at 5 years with different operative strategies(autotransplantation versus allotransplantation),nor at survival at 1 year with neoadjuvant ***,neoadjuvant radiotherapy did appear to improve survival at both 3 years(HR:0.540,95%CI:0.326–0.896,P=0.017)and 5 years(HR:0.338,95%CI:0.153–0.747,P=0.007)from *** This study demonstrated differences in patient characteristics between prognostic groups after liver resection and transplantation for *** criteria can be used to inform patient selection and consent in this *** radiotherapy may improve long-term survival post-transplantation.

关键词： database analysis cohort study liver transplantation organ transplantation hepatocellular carcinoma SEER database

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Role of selected criteria and preventive chemotherapy in tumor recurrence after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 378-383页

作者： Mei-Xi Wang Dong chen Yuan-Yuan Zhao Bo Yang Ji-Pin Jiang Fan-Jun Zeng Lai Wei zhi-shui chen Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationWuhan 430030China NHC Key Laboratory of Organ Transplantation Wuhan 430030China Key Laboratory of Organ Transplantation Chinese Academy of Medical SciencesWuhan 430030China

Background:Long-term survival after liver transplantation(LT)for hepatocellular carcinoma(HCC)patients remains poor because of tumor *** improve the prognosis of HCC patients after LT,we aimed to identify different transplantation criteria and risk factors related to tumor recurrence and evaluate the effect of preventive chemotherapy in a single ***:In total,data on 20 variables and the survival of 199 patients with primary HCC who underwent LT between 2005 and 2015 were included for *** patients were divided into the following three groups:Group 1,within the Milan and Hangzhou criteria(n=51);Group 2,beyond the Milan but within the Hangzhou criteria(n=36);and Group 3,beyond the Milan and Hangzhou criteria(n=112).Survival probabilities for the three groups were calculated using multivariate Cox regression *** association between preventive therapy and HCC-recurrence after LT was analyzed by multiple logistic regression ***:Child-Pugh stage C and hepatitis B virus(HBV)infection were independent risk factors for patients with tumor recurrence who did not meet the Milan *** overall survival rates of the 199 patients showed statistically significant differences among the three groups(P0.05).Multivariate logistic regression analysis showed that postoperative prophylactic chemotherapy reduced the risk of tumor recurrence in patients who did not meet the Hangzhou and Milan criteria(OR=0.478;95%CI:0.308–0.741;P=0.001).Conclusions:Child-Pugh classification and HBV infection were the independent risk factors of tumor recurrence in HCC patients with *** Hangzhou criteria were effective and analogous compared with the Milan *** chemotherapy significantly reduced the risk of recurrence and prolonged the survival time for HCC patients beyond the Milan and Hangzhou criteria after LT.

关键词： Hepatocellular carcinoma Liver transplantation Preventive chemotherapy Hangzhou criteria

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Early steroid withdrawal after liver transplantation for hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第39期13卷 5273-5276页

作者： zhi-shui chen Fan He Fan-Jun Zeng Ji-Pin Jiang Dun-Feng Du Bin Liu Institution of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM: To evaluate the impact of early steroid withdrawal on the incidence of rejection, tumor recurrence and complications after liver transplantation for advanced- stage hepatocellular carcinoma. METHODS: Fifty-four patients underwent liver transplantation for advanced-stage hepatocellular carcinoma from April 2003 to June 2005. These cases were divided into a steroid-withdrawal group (group A, n = 28) and a steroid-maintenance group (group B, n = 26). In group A, steroid was withdrawn 3 mo after transplantation. In group B, steroid was continuously used postoperatively. The incidence of rejection, 6-mo and 1-year recurrence rate of carcinoma, 1-year survival rate, mean serum tacrolimus trough level, and liver and kidney function were compared between the two groups. RESULTS: In the two groups, no statistical difference was observed in the incidence of rejection (14.3 vs 11.5%, P > 0.05), mean serum tacrolimus trough levels (6.9 ± 1.4 vs 7.1 ± 1.1 μg/L, P > 0.05), liver and kidney function after 6 mo [alanine aminotransferase (ALT): 533 ± 183 vs 617 ± 217 nka/L, P > 0.05; creatinine: 66 ± 18 vs 71 ± 19 μmol/L, P > 0.05], 6-mo recurrence rate of carcinoma (25.0 vs 42.3%, P > 0.05), and 1-year survival rate (64.2 vs 46.1%, P > 0.05). The 1-year tumor recurrence rate (39.2 vs 69.2%, P < 0.05), serum cholesterol level (3.9 ± 1.8 vs 5.9 ± 2.6 mmol/L, P < 0.01) and fasting blood sugar (5.1 ± 2.1 vs 8.9 ± 3.6 mmol/L, P < 0.01) were signifi cantly different. These were lower in the steroid-withdrawal group than in the steroid- maintenance group. CONCLUSION: Early steroid withdrawal was safe after liver transplantation in patients with advanced-stage hepatocellular carcinoma. When steroids were withdrawn 3 mo post-operation, the incidence of rejection didnot increase, and there was no demand to maintain tacrolimus at a high level. In contrast, the tumor recurrence rate and the potential of adverse effects decreased signifi cantly. This may have led to an increase in long-ter

关键词： Hepatocellular carcinoma Liver transplantation Steroids Tumor recurrence

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Infective Artery Rupture of Renal Allografts:A Single-Center Retrospective Study in China

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Current Medical Science 2022年第4期42卷 847-855页

作者： Yu-liang GUO Xia LU Lan ZHU Dun-feng DU Bin LIU Zhong-hua Klaus chen Song chen Wei-jie ZHANG zhi-shui chen Sheng CHANG Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyKey Laboratory of Organ TransplantationMinistry of EducationNHC Key Laboratory of Organ TransplantationKey Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China

Objective:This study investigated the composition of pathogenic microorganisms,clinical features,and therapeutic strategies of infective artery rupture of renal allografts in recipients receiving deceased donor(DD)***:We retrospectively studied the clinical data of the DD kidney transplant recipients with donor-associated infection at Tongji Hospital,Wuhan,China from January 1,2015 to December 31,2018,related recipients and corresponding *** collected the entire results of pathogenic microorganisms cultured from these related ruptured kidneys and then analyzed their distribution and ***:A total of 1440 kidney transplants from DD were performed in our *** total incidence of infective artery rupture in kidney transplants was about 0.76%(11/1440),and the annual incidence ranged from 0.25%to 1.03%.The microbial culture results revealed that 11 recipients suffered from infective artery rupture and 3 recipients who accepted the kidney from same donor had the donor-associated pathogens,including 9 fungal strains(28.1%)and 23 bacterial strains(71.9%).There were 4 recipients infected with multi-drug-resistant Staphylococcus and Klebsiella pneumoniae from the above 11 recipients,of which,10 recipients underwent graft loss,and one died of septic *** microbial cultures of the remaining 3 recipients who received appropriate anti-infective regimens turned negative eventually,and the patients were discharged successfully without significant ***:Renal recipients with infections derived from DDs were at high risk of artery rupture,graft loss,or even *** anti-infective treatment is essential to reduce the incidence of artery rupture and mortality.

关键词： kidney transplantation deceased donor renal artery rupture infection

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Updated Genetic Testing of Primary Hyperoxaluria Type 1 in a Chinese Population:Results from a Single Center Study and a Systematic Review

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Current Medical Science 2018年第5期38卷 749-757页

作者： Dun-feng DU Qian-qian LI chen chen Shu-mei SHI Yuan-yuan ZHAO Ji-pin JIANG Dao-wen WANG Hui GUO Wei-jie ZHANG zhi-shui chen Institute of Organ Transplantation Departments of Internal Medicine and Genetic Diagnosis CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of Health/EducationWuhan 430030China Key Laboratory of Molecular Biophysics of the Ministry of Education Cardio-X CenterCollege of Life Science and Technology and Center for Human Genome ResearchHuazhong University of Science and TechnologyWuhan 430030China Institute of Hypertension Departments of Internal Medicine and Genetic Diagnosis CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Primary hyperoxaluria type 1(PH1)is a rare but devastating autosomal recessive inherited disease caused by mutations in gene *** mutations of AGXT were mostly reported in Caucasian but infrequently in Asian,especially in *** update the genotypes of PH1 in the Chinese population,we collected and identified 7 Chinese probands with PH1 from 2013 to 2017 in our center,five of whom had delayed diagnosis and failed in kidney *** of peripheral blood DNA from the 7 patients and their family members were collected and sequencing analysis was performed to test the mutations of gene *** blotting and enzyme activity analysis were conducted to evaluate the function of the ***,a systematic review from 1998 to 2017 was performed to observe the genetic characteristics between Chinese and Caucasian. The results showed that a total of 12 mutations were identified in the 7 *** the best of ourknowledge,2 novel variants of A GXT,***41 Trp and ***33Met,were first *** and functional analysis showed that only 7 mutations led to a reduced expression of alanine-glyoxylate amino transferase (AGT)at a protein *** systematic review revealed significant population heterogeneity in *** conclusion,new genetic subtypes and genetic characteristics of PH1 are updated in the Chinese population. Furthermore,a genotype-phenotype correlation is found in PH1.

关键词： primary hyperoxaluria type 1 gene sequencing AGXT Chinese population

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Combined en bloc liver/pancreas transplantation in two different patients

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World Journal of Gastroenterology 2009年第20期15卷 2552-2555页

作者： zhi-shui chen Fan-Ying Meng Xiao-Ping chen Dun-Gui Liu Lai Wei Ji-Pin Jiang Dun-Feng Du Wei-Jie Zhang Chang-Sheng Ming Nian-Qiao Gong Institute of Organ Transplantation Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubci Province China

Combined en bloc liver/pancreas transplantation （CLPT） was used primarily in the treal^nent of otherwise non- resectable upper abdominal malignancy. In fact, a more appropriate indication is in patients with liver disease and insulin-dependent diabetes mellitus （IDDM）. Here, we report on two successful cases of CLPT at our hospital. One was a patient with non-resectable advanced liver cancer. The recipient survived for 23 mo and finally died of recurrent tumor. The other was a patient with severe biliary complication after orthotopic liver transplantation and preoperative IDDM. We performed CLPT with a modified surgical technique of preserving the native pancreas. He is currently liver-disease- and insulin-free more than 27 mo post-transplant. Based on our experience in two cases of abdominal cluster transplantation, we describe the technical details of CLPT and a modification of the surgical procedure.

关键词： Transplantation Liver Pancreas Diabetes mellitus Liver cancer

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Fluid-structure interaction simulation for multi-body flexible morphing structures

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Chinese Journal of Aeronautics 2024年第2期37卷 137-147页

作者： Wenzhi GUO Yongtao shui Lu NIE Gang chen State Key Laboratory of Strength and Vibration for Mechanic Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China China Academy of Launch Vehicle Technology Beijing 100076China China Academy of Aerospace Science and Innovation Beijing 100086China Shannxi Key Laboratory of Service Environment and Control for Flight Vehicles Xi’an Jiaotong UniversityXi’an 710049China

The multi-body flexible morphing airfoil can improve the aerodynamic characteristics based on different flight missions *** researches have focused on the unsteady aerodynamic characteristics of flexible wings under passive ***,the unsteady aerodynamic characteristics with the fluid-structure interaction effects in the multi-body active actuation process of morphing airfoil deserve further *** this paper,a fluid-structure coupled simulation method for multi-body flexible morphing airfoil with active actuation subsystem was investigated,and the aerodynamic characteristics during deformation were compared with different skin flexibility,flow field environment,actuation mode and actuation *** numerical results show that for the steady aerodynamic,the skin flexibility can improve the stability *** the unsteady process,the change trend of the transient lift coefficient and pitching moment are consistent with those of the active drive characteristics,while the instantaneous lift-drag ratio coefficient is greatly affected by the driving mode and can be improved by increasing the driving duration.

关键词： Fluid-structure interaction Multi-body dynamics modeling Flexible structures Aerodynamics Morphing wings

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Estrogen restores disordered lipid metabolism in visceral fat of prediabetic mice

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World Journal of Diabetes 2024年第5期15卷 988-1000页

作者： Su-Huan Liu Zhao-shui Shangguan Paiziliya Maitiaximu zhi-Peng Li Xin-Xin chen Can-Dong Li Research Base of Chinese Medicine Syndrome Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Research Center for Translational Medicine The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 ***[17β-estradiol(E2)]is known to offer protection against obesity via diverse me-chanisms,while its specific effects on visceral adipose tissue(VAT)remain to be fully *** To investigate the impact of E2 on the gene expression profile within VAT of a mouse model of *** Metabolic parameters were collected,encompassing body weight,weights of visceral and subcutaneous adipose tissues(VAT and SAT),random blood glucose levels,glucose tolerance,insulin tolerance,and overall body *** gene expression profiles of VAT were quantified utilizing the Whole Mouse Genome Oligo Microarray and subsequently analyzed through Agilent Feature Extraction *** and pathway analyses were conducted employing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses,*** Feeding a high-fat diet(HFD)moderately increased the weights of both VAT and SAT,but this increase was mitigated by the protective effect of endogenous ***,ovariectomy(OVX)led to a significant increase in VAT weight and the VAT/SAT weight ratio,and this increase was also reversed with E2 ***,OVX diminished the expression of genes involved in lipid metabolism compared to HFD feeding alone,signaling a widespread reduction in lipid metabolic activity,which was completely counteracted by E2 *** study provides a comprehensive insight into E2's local and direct protective effects against visceral adiposity in VAT at the gene *** In conclusion,the present study demonstrated that the HFD-induced over-nutritional challenge disrupted the gene expression profile of visceral fat,leading to a universally decreased lipid metabolic status in E2 deficient mice.E2 treatment effectively reversed this condition,shedding light on the mechanistic role and thera

关键词： Estrogen Obesity,Visceral adiposity Energy metabolism Type 2 diabetes

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Separation of halogens and recovery of heavy metals from secondary copper smelting dust

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2686-2701页

作者： zhi-lou LIU zhi-kang chen Fu-ze SUN zhi-heng ZHANG Kang YAN shui-ping ZHONG Hui LIU Rui-xiang WANG Jia-yuan LI zhi-feng XU School of Metallurgy Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Chemistry and Environmental Science Xiangnan UniversityChenzhou 423000China Ganzhou Engineering Technology Research Centre of Green Metallurgy and Process Intensification Ganzhou 341000China Key Laboratory of Ionic Rare Earth Resources and Environment Ministry of Natural ResourcesGanzhou 341000China

The separation of halogens and recovery of heavy metals from secondary copper smelting(SCS)dust using a sulfating roasting−water leaching process were *** thermodynamic analysis results confirm the feasibility of the phase transformation to metal sulfates and to gaseous HF and *** the sulfating roasting conditions of the roasting temperature of 250°C and the sulfuric acid excess coefficient of 1.8,over 74 wt.%of F and 98 wt.%of Cl were volatilized into flue *** 98.6 wt.%of Zn and 96.5 wt.%of Cu in the roasting product were dissolved into the leaching solution after the water leaching process,while the leaching efficiencies of Pb and Sn were only 0.12%and 0.22%,*** mechanism studies indicate the pivotal effect of roasting temperature on the sulphation reactions from various metal species to metal sulfates and the salting out reactions from various metal halides to gaseous hydrogen halides.

关键词： secondary copper smelting dust sulfating roasting water leaching halogen volatilization heavy metal separation

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Dynamic simulation of GEH-IES with distributed parameter characteristics for hydrogen-blending transportation

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Frontiers in Energy 2024年第4期18卷 506-524页

作者： Dengji ZHOU Jiarui HAO Wang XIAO chen WANG Chongyuan shui Xingyun JIA Siyun YAN Key Laboratory of Power Machinery and Engineering of the Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Sichuan Research Institute Shanghai Jiao Tong UniversityChengdu 610042China West Pipeline Company National Petroleum and Natural Gas Pipe Network Group Co.Ltd.Urumqi 830012China Institute of Intelligent Manufacturing Modern Industry Xinjiang UniversityUrumqi 830046China

For the purpose of environment protecting and energy saving,renewable energy has been distributed into the power grid in a considerable ***,the consuming capacity of the power grid for renewable energy is relatively *** an effective way to absorb the excessive renewable energy,the power to gas(P2G)technology is able to convert excessive renewable energy into ***-blending natural gas pipeline is an efficient approach for hydrogen ***,hydrogen-blending natural gas complicates the whole integrated energy system(IES),making it more problematic to cope with the equipment failure,demand response and dynamic ***,dynamic simulation of distribution parameters of gas-electricity-hydrogen(GEH)energy system,especially for hydrogen concentration,still remains a *** dynamics of hydrogen-blending IES is *** tackle the issue,an iterative solving framework of the GEH-IES and a cell segment-based method for hydrogen mixing ratio distribution are proposed in this *** typical numerical cases studying the conditions under which renewables fluctuate and generators fail are conducted on a real-word *** results show that hydrogen blending timely and spatially influences the flow parameters,of which the hydrogen mixing ratio and gas pressure loss along the gas pipeline are negatively correlated and the response to hydrogen mixing ratio is ***,the hydrogen-blending amount and position also have a significant impact on the performance of the compressor.

关键词： gas-electricity IES dynamic simulation hydrogen blending power to gas(P2G) renewable energy

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