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Distribution of ApoE Gene Polymorphism and Significance of Auxiliary Diagnosis and Treatment of Cerebrovascular Diseases(Intracerebral Hemorrhage and Cerebral Thrombosis) in the Longyan Area

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Chinese Journal of Biomedical Engineering(English Edition) 2021年第4期30卷 172-177页

作者： ZHANG Hong-bin HE Xiang-sheng YOU Yu-dong FAN zhi-quan ZHANG Man’e LU zhi-hua The Second Hospital of Longyan Longyan Fujian Province 364000China

Objective:To make statistics on the distribution of ApoE gene polymorphism in the Longyan area,provide data for the statistics of regional cerebrovascular diseases,explore the significance of ApoE gene polymorphism distribution for clinical guidance,diagnosis and treatment,and provide more suggestions for clinical diagnosis and treatment of cerebrovascular ***:800 patients with cerebrovascular disease in the Longyan area from July 2018 to April 2021 were selected as the research object,and 800 normal healthy patients were selected as the control *** data were further analyzed according to the collected patient information,and the patients were distinguished according to age and other basic information,the type of cerebrovascular disease,ApoE gene polymorphism and blood lipid test *** distribution of ApoE gene polymorphism in the cerebrovascular disease population in the Longyan area was given to determine the correlation between the incidence of cerebrovascular disease and the distribution of ApoE gene ***:In the study group,E2/E3 genotyping was the most common 400(50.00%),and E4/E4 genotyping 6(0.75%)was the least common;In the control group,E2/E4 genotyping was the most common 480(60.00%),and E2/E3 genotyping accounted for the second 290(36.25%).In the study group,E3 allele was the most common 383(47.88%),E4 allele 121(15.12%);in the control group,E2 allele was the most common391(48.88%),and E3 allele 142(17.75%).Conclusion:According to the statistics of ApoE gene polymorphism distribution in the Longyan area and the analysis of the correlation of other cerebrovascular diseases,it is found that E2/E3 genotype may be related to cerebrovascular diseases,and E3 allele may be a susceptibility *** the above analysis,the occurrence of diseases can be predicted and prevented.

关键词： ApoE gene treatment polymorphism distribution Longyan area cerebral vascular disease

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Determination of Periplocymarin in Human Blood and Urine by High-Performance Liquid Chromatography-Mass Spectrometry

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Journal of Forensic Science and Medicine 2017年第4期3卷 191-196页

作者： Chen Jian Xia Wei Qing Tao Chen Fan wu Hao Fu Ying Qing wu zhi Gui Dai Xin Hua Ye Yi Yan You Yi Liao Lin Chuan Department of Forensic Toxicological Analysis West China School of Basic Medical Sciences and Forensic MedicineSichuan UniversityChengduSichuan 610041China

A simple,rapid and sensitive liquid chromatography with tandem mass spectrometry method for the determination of periplocymarin in human blood and urine was *** digoxin‑d3 was used as an internal *** and digoxin‑d3(IS)were processed with ethyl acetate by liquid–liquid *** chromatographic separation was performed on a Shim‑pack XR‑ODSIII C18 column with a 7 min gradient elution using methanol‑ammonium formate(5 mmol/L)as mobile phase at a flow rate of 0.3 mL/min(65:35,v/v).The detection was performed on a triple quadrupole tandem mass spectrometer using positive‑ion mode electrospray ionization in selected reaction monitoring *** periplocymarin was well separated from the internal *** calibration curves were linear within the concentration range 0.01–1µg/*** limit of detection and quantification of blood and urine samples were both estimated at 0.005 and 0.01µg/*** interday and intraday precisions,accuracy,and recovery were assessed to verify this *** results showed that the method was suitable for the determination of periplocymarin in forensic toxicological analysis and clinical diagnosis.

关键词： Blood forensic toxicological analysis liquid chromatography‑tandem mass spectrometry periplocymarin urine

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测量平差的基准方程与相对形变及其精度分析

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煤炭学报 2007年第8期32卷 808-812页

作者：武继军胡圣武河南理工大学测绘学院河南焦作454000

以基准方程表示基准数据,利用基准方程进行最小二乘平差的求解方法是一种具有普遍意义的求解方法,既适用于在一般基准下求解,也适用于重心基准或拟稳基准下求解,而且便于对有关问题进行分析;通过这种求解方法导出了不同基准下解的转换... 详细信息

以基准方程表示基准数据,利用基准方程进行最小二乘平差的求解方法是一种具有普遍意义的求解方法,既适用于在一般基准下求解,也适用于重心基准或拟稳基准下求解,而且便于对有关问题进行分析;通过这种求解方法导出了不同基准下解的转换关系式.论述了相对于一定基准的相对解、相对形变和相对点位精度是广义的,以及意义更完善的相对解、相对形变和相对点位精度,并通过算例对此作了进一步说明.从该算例可以看到,各点的相对点位中误差随基准点至该点距离的增大而增大,根据在各种基准下得到的相对形变值有利于进行形变分析.

关键词：测量平差基准方程相对形变相对点位误差

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混合直流输电系统功率同步控制研究

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电机与控制学报 2017年第7期21卷 1-10页

作者：吴杰王志新上海交通大学电子信息与电气工程学院上海200240 上海师范大学信息与机电工程学院上海200000

针对一端采用传统电网换相换流阀(line commutated converter,LCC)另一端为电压源换流阀(voltage sourced converter,VSC)的混合直流输电系统因其直流侧电抗较大,造成传统双闭环矢量控制策略中电流内环的快速性与稳定性相互矛盾、暂态... 详细信息

针对一端采用传统电网换相换流阀(line commutated converter,LCC)另一端为电压源换流阀(voltage sourced converter,VSC)的混合直流输电系统因其直流侧电抗较大,造成传统双闭环矢量控制策略中电流内环的快速性与稳定性相互矛盾、暂态扰动易造成系统功率振荡等问题,提出VSC侧换流站采用功率同步控制的方法,同时,通过增加桥臂电容储能控制环,保持三相桥臂电容电压之和基本不变,抑制系统功率和直流电压波动,减小了有功功率控制环存在欠阻尼特性的影响。最后,结合模块化多电平变流器(modular multi-level converter,MMC)应用,利用仿真软件搭建双端混合直流输电系统模型,通过仿真验证了所采用方法的正确性、有效性。

关键词：功率同步控制混合直流输电模块化多电平稳态模型欠阻尼特性

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激光焊接5083/6016异种铝合金光谱信号与焊件质量的关系

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湖南大学学报（自然科学版） 2014年第8期41卷 30-35页

作者：周惦武李升张红湖南大学汽车车身先进设计制造国家重点实验室湖南长沙410082

采用光纤激光器对1.0mm厚5083和1.2mm厚6016异种铝合金平板试件进行激光搭接焊试验,利用光谱测量系统、扫描电镜、维氏显微硬度仪和微机控制的电子万能试验机等手段,检测激光焊接过程等离子体产生时辐射出的时域MgI光谱信号,分析焊缝形... 详细信息

采用光纤激光器对1.0mm厚5083和1.2mm厚6016异种铝合金平板试件进行激光搭接焊试验,利用光谱测量系统、扫描电镜、维氏显微硬度仪和微机控制的电子万能试验机等手段,检测激光焊接过程等离子体产生时辐射出的时域MgI光谱信号,分析焊缝形貌、显微硬度和力学性能,研究等离子体中MgI光谱信号相对强度与焊件质量之间关系.结果表明,随着扫描速度增加,MgI光谱信号强度降低,离焦量对MgI光谱信号作用明显,而激光功率对MgI信号整体幅度改变较小;MgI光谱强度较小或较大,试件出现焊不透或焊穿现象;MgI等离子体信号波动较大处,出现咬边、凹陷、气孔等缺陷,力学性能低;而MgI等离子体信号平稳时,焊缝平整,缺陷少,力学性能好.基于MgI光谱信号与焊件质量之间的对应关系,运用Hugh hart的统计过程控制(SPC)理论,建立了焊接过程单值-移动极差控制(X-Rs)图.

关键词：激光焊接异种铝合金等离子体信号焊件质量

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基于运动控制和频域分析的移动机器人能耗最优轨迹规划

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自动化学报 2020年第5期46卷 934-945页

作者：高志伟代学武郑志达东北大学流程工业综合自动化国家重点实验室沈阳110819

本文针对两轮自平衡可移动机器人,提出了一种新的能耗最优运动轨迹规划方法.本文将轨迹规划与由轨迹跟踪控制器和机器人动力学方程组成的运动控制模型相结合,基于期望轨迹与实际电机输入电压间的传递函数和能量在时域和频域上的对应关系... 详细信息

本文针对两轮自平衡可移动机器人,提出了一种新的能耗最优运动轨迹规划方法.本文将轨迹规划与由轨迹跟踪控制器和机器人动力学方程组成的运动控制模型相结合,基于期望轨迹与实际电机输入电压间的传递函数和能量在时域和频域上的对应关系,通过频域分析的方法得到了具有明确机理表达的线性能耗模型,并采用最小二乘线性回归法对模型参数进行辨识.对于能耗最优轨迹,由全局路径规划得到的路径点作为局部轨迹规划的局部目标点,通过一定的数学转换和参数求导,可直接得到相邻两个局部目标点间的能耗最优运行轨迹和对应的运行时间.通过仿真实验证明了本文所提能耗模型的准确性和所得轨迹的能耗最优性.

关键词：轨迹规划能耗最低移动机器人频域分析

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立式蒸发式冷凝器传热传质的CFD模拟

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高校化学工程学报 2009年第4期23卷 566-571页

作者：蒋翔朱冬生吴治将李元希汪南华南理工大学化学与化工学院传热强化与过程节能教育部重点实验室广东广州510640

基于VOF算法,建立了立式蒸发式冷凝器气-液两相顺流传热传质的计算模型。根据CFD模型,计算了在不同气、液相进口条件下,管壁温度的分布、气-液相界面处潜热和显热换热量的关系,模拟得到的管壁温度分布与实验数据吻合很好。计算结果表明... 详细信息

基于VOF算法,建立了立式蒸发式冷凝器气-液两相顺流传热传质的计算模型。根据CFD模型,计算了在不同气、液相进口条件下,管壁温度的分布、气-液相界面处潜热和显热换热量的关系,模拟得到的管壁温度分布与实验数据吻合很好。计算结果表明,降低进口空气的相对湿度、增大气相流速或者液相流量,都可增强气-液相间热质交换的剧烈程度;气-液相界面处的换热主要形式是由于水蒸发引起的潜热换热,占80%以上,它远远大于由于温度梯度而引起的显热换热量;气-液相界面处的蒸发潜热主要受空气的相对湿度影响,其次是气相流速和液相流量。

关键词：竖管蒸发式冷凝器传热传质计算流体力学(CFD)

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Plasmon-driven reaction controlled by the number of graphene layers and localized surface plasmon distribution during optical excitation

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Light(Science & Applications) 2015年第1期4卷 137-143页

作者： zhi-gao Dai Xiang-heng Xiao Wei wu Yu-peng Zhang Lei Liao Shi-shang Guo Jian-jian Ying Chong-xin Shan Meng-tao Sun Chang-zhong Jiang Department of Physics and Key Laboratory of Artificial Micro-and Nano-structures of the Ministry of Education Hubei Nuclear Solid Physics Key LaboratoryWuhan UniversityWuhan 430072China Laboratory of Functional Nanomaterials and Printed Electronics School of Printing and PackagingWuhan UniversityWuhan 430072China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China School of Physical Engineering Zhengzhou UniversityZhengzhou 450052China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Graphene-plasmonic hybrid platforms have attracted an enormous amount of interest in surface-enhanced Raman scattering(SERS);however,the mechanism of employing graphene is still ambiguous,so clarification about the complex interaction among molecules,graphene,and plasmon processes is urgently *** report that the number of graphene layers controlled the plasmon-driven,surface-catalyzed reaction that converts para-aminothiophenol(PATP)-to-p,p'-dimercaptoazobenzene(DMAB)on chemically inert,graphene-coated,silver bowtie nanoantenna *** catalytic reaction was monitored by SERS,which revealed that the catalytic reaction occurred on the chemical inertness monolayer graphene(1G)-coated silver *** introduction of 1G enhances the plasmon-driven surface-catalyzed reaction of the conversion of PATP-to-p,p'-*** chemical reaction is suppressed by bilayer *** the process of the catalytic reaction,the electron transfer from the PATP molecule to 1G-coated silver ***,the transferred electrons on the graphene recombine with the hot-hole produced by the localized surface plasmon resonance of silver ***,a couple of PATP molecules lost electrons are catalyzed into the p,p'-DMAB molecule on the graphene *** experimental results were further supported by the finite-difference time-domain method and quantum chemical calculations.

关键词： graphene graphene-mediated SERS plasmon-driven reaction SERS

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Recent Progress in Dual-Polarization Radar Research and Applications in China

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Advances in Atmospheric Sciences 2019年第9期36卷 961-974页

作者： Kun ZHAO Hao HUANG Mingjun WANG Wen-Chau LEE Gang CHEN Long WEN Jing WEN Guifu ZHANG Ming XUE Zhengwei YANG Liping LIU Chong wu zhiqun HU sheng CHEN Key Laboratory of Mesoscale Severe Weather of Ministry of Education and School of Atmospheric Sciences Nanjing University163 Xianlin RoadNanjing 210023China State Key Laboratory of Severe Weather and Joint Center for Atmospheric Radar Research of China Meteorological Administration and Nanjing University Chinese Academy of Meteorological SciencesBeijing 100081China National Center for Atmospheric Research BoulderColorado 80301USA School of Meteorology and Advanced Radar Research Center University of OklahomaNormanOklahoma 73019USA School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSun Yat-sen UniversityGuangzhou 510006China

Dual-polarization(dual-pol)radar can measure additional parameters that provide more microphysical information of precipitation systems than those provided by conventional Doppler *** dual-pol parameters have been successfully utilized to investigate precipitation microphysics and improve radar quantitative precipitation estimation(QPE).The recent progress in dual-pol radar research and applications in China is summarized in four ***,the characteristics of several representative dual-pol radars are *** approaches have been developed for radar data quality control,including calibration,attenuation correction,calculation of specific differential phase shift,and identification and removal of non-meteorological *** dual-pol radar measurements,the microphysical characteristics derived from raindrop size distribution retrieval,hydrometeor classification,and QPE is better understood in *** limited number of studies in China that have sought to use dual-pol radar data to validate the microphysical parameterization and initialization of numerical models and assimilate dual-pol data into numerical models are *** challenges of applying dual-pol data in numerical models and emerging technologies that may make significant impacts on the field of radar meteorology are discussed.

关键词： dual-polarization radar quantitative precipitation estimation precipitation microphysics drop size distribution numerical model

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Fluorogenic detection of mercury ion in aqueous environment using hydrogel-based AIE sensing films

Aggregate

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Aggregate 2023年第3期4卷 94-101页

作者： Shujun wu Yujiao Yang Yao Cheng Shuodong Wang zhibiao Zhou Pei Zhang Xinqi Zhu Baodui Wang Hua Zhang sheng Xie Zebing Zeng Ben Zhong Tang Shenzhen Research Institute of Hunan University Nanshan DistrictShenzhenState Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaChina Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province Lanzhou UniversityGansuChina State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyangChina AIE Institute Guangzhou Development DistrictHuangpuChina School of Science and Engineering Shenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhenChina

A“turn-on”fluorescent sensing strategy was developed for ultrasensitive detection of heavy metal mercury ion(Hg2+)directly in *** utilized an aqueous soluble aggregation-induced emission(AIE)-active probe,named 1,1,2,2-tetrakis(4-(1Htetrazol-5-yl)phenyl)ethene(TPE-4TA),composing of a luminescent tetraphenylene core and multiple anionic tetrazolate *** probe retained dark when molecularly dissolved in ***,mercury ions can ligate with multiple tetrazolate groups to form infinite coordination polymer particles spontaneously,thus inducing a fluorogenic AIE response for in situ ***,by embedding this AIE sensing molecules in a hydrophilic polyvinyl alcohol substrate,the resulting hydrogel film allowed in situ detection of Hg^(2+)on a laser-induced fluorescence analysis setup in aqueous *** strategy worked effectively in common aqueous environments with pH from 4 to 7.5 and showed high sensitivity(limit of detection down to 0.38 ppb/1.9 nM),good selectivity and a wide linearity range for *** work may lead to a reliable and promising platform for on-site environmental water analysis.

关键词： aggregation-induced emission heavy metal detection hydrogel

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