检索结果-南通市图书馆

SAPT:a synchrotron-based proton therapy facility in Shanghai

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-Ming Li Li-Ren Shen Hai-Rong Zhang zhi-Ling Chen Han-Wen Du Ming Gu Rui Li De-Kang Liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang Jiang zhi-Qiang Jiang Lin Jin Wen-Jing Li Xiu-Fang Li Ye Lin Ming Liu Yong-Hao Liu Ya-Juan Liu Ming Lv Qing-Ru Mi Lian-Hua Ouyang Wei-Guo Shi Hang Shu Qi-sheng Tang Kun Wang zhi-Shan Wang Jun wu Xiao-Bing wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang Miao Zhang Wen-zhi Zhang Li-Ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Shale Gas Formation and Occurrence in China： An Overview of the Current Status and Future Potential

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2016年第4期90卷 1249-1283页

作者： ZOU Caineng YANG zhi PAN Songqi CHEN Yanyan LIN Senhu HUANG Jinliang wu Songtao DONG Dazhong WANG Shufang LIANG Feng SUN Shasha HUANG Yong WENG Dingwei Research Institute of Petroleum Exploration and Development PetroChina Beijing 100083 China Langfang Branch of Research Institute of Petroleum Exploration and Development PetroChina Langfang 065007 Hebei China Geosciences and Technology Institute of Southwest Petroleum University Chengdu 610500 Sichuan China

Shale gas is one of the most promising unconventional resources both in China and abroad. It is known as a form of self-contained source-reservoir system with large and continuous dimensions. Through years of considerable exploration efforts, China has identified three large shale gas fields in the ruling, Changning and Weiyuan areas of the Sichuan Basin, and has announced more than 540 billion m3 of proven shale gas reserves in marine shale systems. The geological theories for shale gas development have progressed rapidly in China as well. For example, the new depositional patterns have been introduced for deciphering the paleogeography and sedimentary systems of the wufeng shale and Longmaxi shale in the Sichuan Basin. The shale gas storage mechanism has been widely accepted as differing from conventional natural gas in that it is adsorbed on organic matter or a mineral surface or occurs as free gas trapped in pores and fractures of the shale. Significant advances in the techniques of microstructural characterization have provided new insights on how gas molecules are stored in micro- and nano-scale porous shales. Furthermore, newly-developed concepts and practices in the petroleum industry, such as hydraulic fracturing, microseismic monitoring and multiwell horizontal drilling, have made the production of this unevenly distributed but promising unconventional natural gas a reality. China has 10-36 trillion m3 of promising shale gas among the world＇s whole predicted technically recoverable reserves of 206.6 trillion m3. China is on the way to achieving its goal of an annual yield of 30-50 billion m3 by launching more trials within shale gas projects.

关键词： shale gas organic-rich shale unconventional system fine-grained sediments micro-nano pores core area

Probabilistic Neural Networks based network security management

在线全文

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2008年第2期5卷 19-24页

作者： LIU wu wu zhi-you DUAN Hai-xin LI Xing wu Jian-ping Network Research Center of Tsinghua University Beijing 100084 China Research Center of Information Technology ＆ Intelligent Optimization Chongqing Normal University Chongqing 40004Z China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自适应的彩色图像光照补偿新方法

光电工程 2006年第2期33卷 94-97页

作者：梁晓辉游志胜四川大学图形图像研究所四川成都610064

环境光照变化、光照分布不均匀会影响彩色图像中人脸的正确检测。在融合了不同的基于空域的解决方案的基础上,提出了一种自适应的彩色图像光照补偿新方法。分别对光照过亮、过暗以及中间灰度区域进行自适应的处理。对亮度值最小、最大... 详细信息

环境光照变化、光照分布不均匀会影响彩色图像中人脸的正确检测。在融合了不同的基于空域的解决方案的基础上,提出了一种自适应的彩色图像光照补偿新方法。分别对光照过亮、过暗以及中间灰度区域进行自适应的处理。对亮度值最小、最大的5%的像素,如果这些像素的数目足够多(本文大于100),在变换后分别压缩为0和255;用对数函数做非线性变换函数来修正中间灰度区域。在人脸PIE数据库上对光照不均的彩色图像进行了实验,验证了该方法能对人脸检测中的光照进行有效的补偿。

关键词：光照补偿非线性变换图像增强人脸检测

General Exact Penalty Functions in Integer Programming

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai University(English Edition) 2004年第1期8卷 19-23页

作者：白富生张连生吴至友 Department of Mathematics College of Sciences Shanghai University Shanghai 200436P.R. China Department of Mathematics College of Sciences Shanghai University Shanghai 200436P.R. China Department of Mathematics and Computer Science Chongqing Normal University Chongqing 400047 P.R.China

In this paper, the general exact penalty functions in integer programming were studied. The conditions which ensure the exact penalty property for the general penalty function with one penalty parameter were given and... 详细信息

关键词： integer programming exact penalty function penalty parameter.

Epigenetic regulation in metabolic diseases:mechanisms and advances in clinical study

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第4期8卷 1434-1460页

作者： Yan-Lin wu Zheng-Jun Lin Chang-Chun Li Xiao Lin Su-Kang Shan Bei Guo Ming-Hui Zheng Fuxingzi Li Ling-Qing Yuan zhi-hong Li National Clinical Research Center for Metabolic Disease Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Orthopaedics The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases,such as diabetes,obesity,non-alcoholic fatty liver disease(NAFLD),osteoporosis,gout,hyperthyroidism,hypothyroidism and *** term‘epigenetics’was firstly proposed in 1942 and with the development of technologies,the exploration of epigenetics has made great *** are four main epigenetic mechanisms,including DNA methylation,histone modification,chromatin remodelling,and noncoding RNA(ncRNA),which exert different effects on metabolic *** and non-genetic factors,including ageing,diet,and exercise,interact with epigenetics and jointly affect the formation of a *** epigenetics could be applied to diagnosing and treating metabolic diseases in the clinic,including epigenetic biomarkers,epigenetic drugs,and epigenetic *** this review,we introduce the brief history of epigenetics as well as the milestone events since the proposal of the term‘epigenetics’.Moreover,we summarise the research methods of epigenetics and introduce four main general mechanisms of epigenetic ***,we summarise epigenetic mechanisms in metabolic diseases and introduce the interaction between epigenetics and genetic or non-genetic ***,we introduce the clinical trials and applications of epigenetics in metabolic diseases.

关键词： diseases clinical mechanisms

Percutaneous cryosurgery for the treatment of hepatic colorectal metastases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第9期14卷 1430-1436页

作者： Ke-Cheng Xu Li-zhi Niu Wei-Bing He Yi-Zi Hu Jian-sheng Zuo Cryosurgery Center for Cancer Fuda Cancer Hospital Guangzhou Guangzhou 510300 Guangdong Province China

AIM:To determine the safety and efficacy of efficacy of percutaneous cryosurgery for treatment of patients with hepatic colorectal metastases. METHODS: Three hundred and twenty-six patients with non-resectable hepatic colorectal metastases underwent percutaneous cryosurgery under the guidance of ultrasound or CT. Follow-up was 1 mo after cryosurgery and then every 4 mo thereafter by assessment of tumor markers, liver ultrasonography, and abdominal CT. For lesions suspicious of recurrence, a liver biopsy was performed and subsequent repeat cryosurgery was given if histology was positive for cancer. RESULTS: All patients underwent a total of 526 procedures of cryosurgery. There were 151 patients who underwent repeat procedures of cryosurgery for recurrent tumors in the liver and extrahepatic places. At 3 mo after cryosurgery, carcinoembryonic antigen (CEA) levels in 197 (77.5%) patients who had elevated markers before cryosurgery decreased to normal range. Among 280 patients who received CT following-up, cryotreated lesions showed complete response (CR) in 41 patients (14.6%), partial response (PR) in 115 patients (41.1%), stable disease (SD) in 68 patients (24.3%) and progressive disease (PD) in 56 patients (20%). The recurrence rate was 47.2% during a median follow-up of 32 mo (range, 7-61). Sixty one percent of the recurrences were seen in liver only and 13.9% in liver and extrahepatic areas. The recurrence rate at cryotreated site was only 6.4% for all cases. During a median follow-up of 36 mo (7-62 mo), the median survival of all patient was 29 mo (range 3-62 mo). Overall survival was 78%, 62%, 41%, 34% and 23% at 1, 2, 3, 4 and 5 years, respectively, after the treatment. Patients with tumor size less than 3 cm, tumor in right lobe of liver, lower CEA levels (< 100 ng/dL) and post- cryosurgery TACE had higher survival rate. There wasno significant difference in terms of survival based on the number of tumors, pre-cryosurgery chemotherapy and the timing of the dev

关键词： Hepatic colorectal metastases Hepatic cryosurgery Percutaneous cryosurgery Colorectal cancer

Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang Heng-Chang Yao Liang-Xin Peng Bao-Jia Yao zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

考虑回填层的护盾式TBM隧道结构设计方法研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

岩土工程学报 2018年第5期40卷 857-863页

作者：吴圣智姜志毅王明年刘大刚董宇苍西南交通大学土木工程学院四川成都610031 西南交通大学交通隧道工程教育部重点实验室四川成都610031

回填层作为管片与围岩之间的传力层对管片受力有着重要的影响,而现行护盾式TBM隧道设计方法均忽略了回填层的影响,与工程实际存在一定的差异。研究考虑了护盾式TBM隧道中回填层的实际分布,推导了回填层-围岩等效抗力系数计算公式,并以... 详细信息

回填层作为管片与围岩之间的传力层对管片受力有着重要的影响,而现行护盾式TBM隧道设计方法均忽略了回填层的影响,与工程实际存在一定的差异。研究考虑了护盾式TBM隧道中回填层的实际分布,推导了回填层-围岩等效抗力系数计算公式,并以此建立了TBM隧道管片结构设计模型。研究得出：由于回填层的存在,围岩-回填层的等效抗力系数与围岩抗力系数存在一定的差别,围岩抗力系数的改变程度与围岩、回填层力学参数比有关;回填层在管片背后分布呈＂上厚下薄＂状,使得管片背后围岩-回填层弹性抗力系数分布不同,Ⅱ级围岩回填层-围岩弹性抗力系数呈＂上小下大＂的鸭蛋状,Ⅲ,Ⅳ级围岩近乎圆状,Ⅴ级围岩呈＂上大下小＂的倒鸭蛋状;基于回填层-围岩等效抗力系数的结构设计模型计算出的管片受力结果与现场试验值更加接近,验证了回填层-围岩等效抗力系数计算方法和设计模型的准确性。

关键词：管片围岩回填层抗力系数结构设计模型