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腹板开孔标准轻钢龙骨力学性能比较研究

大连理工大学学报 2009年第6期49卷 876-883页

作者：左宏亮武胜东北林业大学土木工程学院黑龙江哈尔滨150040

腹板开孔轻钢龙骨作为一种有效的节能构件而被广泛应用于寒冷地区的轻钢龙骨复合住宅体系中.采用ANSYS非线性有限元方法系统分析了在轴压、弯矩、压弯基本荷载作用下,腹板开孔对标准轻钢龙骨的屈曲模式、变形、截面应力、承载力等方面... 详细信息

腹板开孔轻钢龙骨作为一种有效的节能构件而被广泛应用于寒冷地区的轻钢龙骨复合住宅体系中.采用ANSYS非线性有限元方法系统分析了在轴压、弯矩、压弯基本荷载作用下,腹板开孔对标准轻钢龙骨的屈曲模式、变形、截面应力、承载力等方面力学性能的影响规律,给出龙骨腹板孔洞的合理取值范围.结果表明,常用孔洞参数范围内腹板开孔对龙骨承载力的降低幅度可以控制在10%以内;腹板开孔后龙骨整体变形能力降低,峰值应变相应减小,使龙骨的初始刚度略微增大.腹板孔洞长度是影响龙骨力学性能的重要参数,随孔洞长度增加,龙骨承载力下降,延性变差.

关键词：腹板开孔标准轻钢龙骨力学性能有限元分析

Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2021

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Chinese Chemical Letters 2023年第5期34卷 174-186页

作者： Quan Wen Qiuquan Cai Ping Fu Dan Chang Xiaoyi Xu Tian-Jiao Wen Guang-Peng wu Weipu Zhu Ling-Shu Wan Chengjian Zhang Xing-Hong Zhang Qiao Jin Zi-Liang wu Chao Gao Haoke Zhang Ning Huang Chang-zhi Li Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2021,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang University had achieved several important ***,a series of versatile organoboron catalysts were synthesized for ring-opening(co)***,a catalyst-free polycondensation mechanism was proposed for the production of polyesters with high molecular ***,a co-assembly method that can fabricate films and coatings with controllable structures and properties on various substrates was demonstrated,providing a platform for the construction of novel surface ***,facile methods for producing high-productivity poly(propylene carbonate)and semicrystalline polyester have been *** linear non-conjugated polyesters exhibiting yellow-green clusteroluminescence were developed for the first ***,a supramolecular prodrug nano-assembly strategy has been developed for reactive nitrogen species potentiated ***,a series of tough and stiff supramolecular hydrogels with shape memory properties have been used for information ***,reversible fusion and fission of wet-spun graphene oxide fibers has been successfully ***,three non-conjugated polypeptides were synthesized and the mechanism of clusteroluminescence was ***,a series of conducting covalent organic frameworks with high electrical conductivity and carrier mobility have been used as high-performance chemiresistor,electrocatalyst,and organic field-effect ***,the exploration of non-fused electron acceptors,and their photostable mechanism are exemplified for developing high-performance,low-cost and eco-friendly polymer solar ***,gel-grown long-range ordering bulk-heterojunctions has achieved improved X-ray detector performance.

关键词： Polymer Catalyst Surface coating Drug delivery Gel Graphene Organic optoelectronics

The Synergistic Effect of HT and Complement Regulatory Proteins in Resisting the Immunological Rejection of Heterogenic Transplantation

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Chinese Journal of Biomedical Engineering(English Edition) 2007年第4期16卷 139-147页

作者： LI sheng-zhi LIU Bing-qian WANG Guang,you ZHANG Yue MA zhi-fang MA Teng-xiang Tianjin Institute of Urologic Surgery Tianjin 300211 China

Objective：To establish the polytransgenic mice expressing the human HT and complement regulatory proteins （CRPs） and discuss their ability to resist the hyperacute rejection （HAR） and delayed xenograft rejection （DXR） of heterogenic transplantation. Methods ：Transgenic mice were produced by microinjection to construct gene for human HT, delay acceleration factor （DAF） and/or CD59 into the male pronucleus of zygote. PCR and Southern blot were used to screen the positive trarisgenic mice. Flow cytometry （FCM） was used to detect the expression of HT, ct-Gal and DAF or CD59 on the PBMCs of transgenic mice. The survival time and function of the heart of transgenic mice were determined by a modified Langendorff cardiac perfusion apparatus： The change of proteinosis on IgM,IgG, C3c and C9 from different cardiac vascular iendothelial cells of transgenic mice were detected by immunohistochemistry. Results：HT, DAF or CD59 were highly expressed on the positive transgenic mice by FCM. The deposition of IgM,IgG,C3c or C9 in the cardiac vascular endothelial cells of the positive transgenic mice were de- creased. The survival time and function of the heart of the co-transgenic mice with AB serum perfusion were significantly longer and higher than that of the single HT positive transgenic mice（P 〈0.05）. Conclusion ：The mice co-expressing HT/DAF or HT/CD59 could resist the HAR,which was better than those expressing HT alone. It is feasible to use HT and CRPs co-transgenic methods to resist the HAR and DXR.

关键词： xenotransplantation [ alpha ] 1,2-fucosyltransferase complement regulatory proteins hyperacute rejection

Mutation Analysis of Gap Junction Protein Beta 1 and Genotype-Phenotype Correlation in X-linked Charcot-Marie- Tooth Disease in Chinese Patients

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Chinese Medical Journal 2016年第9期129卷 1011-1016页

作者： Bo Sun Zhao-HuiChen Li Ling Yi-Fan Li Li-zhi Liu Fei Yang Xu-sheng Huang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Among patients with Charcot-Marie-Tooth disease （CMT）, the X-linked variant （CMTX） caused by gap junction protein beta 1 （GJB1） gene mutation is the second most frequent type, accounting for approximately 90% of all CMTX. More than 400 mutations have been identified in the GJB1 gene that encodes connexin 32 （CX32）. CX32 is thought to form gap junctions that promote the diffusion pathway between cells. GJB1 mutations interfere with the formation of the functional channel and impair the maintenance of peripheral myelin, and novel mutations are continually discovered. Methods： We included 79 unrelated patients clinically diagnosed with CMT at the Department of Neurology of the Chinese People＇s Liberation Army General Hospital from December 20, 2012, to December 31, 2015. Clinical examination, nerve conduction studies, and molecular and bioinformatics analyses were performed to identify patients with CMTX 1. Results： Nine GJBI mutations （c.283G〉A, c.77C〉T, c.643C〉T, c.515C〉T, c.191G〉A, c.610C〉T, c.490C〉T, c.491G〉A, and c.44G〉A） were discovered in nine patients. Median motor nerve conduction velocities of all nine patients were 〈 38 m/s, resembling CMT Type 1. Three novel mutations, c.643C〉T, c.191G〉A, and c.610C〉T, were revealed and bioinformatics analyses indicated high pathogenicity. Conclusions： The three novel missense mutations within the GJB1 gene broaden the mutational diversity ofCMT1X. Molecular analysis of family members and bioinformatics analyses of the afflicted patients confirmed the pathogenicity of these mutations.

关键词： Connexin 32 Electrophysiology Gap Junction Protein Beta 1 Genetic Mutation X-linked Charcot-Marie-Tooth Disease

Optimal Energy Management for a Complex Hybrid Electric Vehicle:Tolerating Power-loss of Motor

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Journal of Shanghai Jiaotong university(Science) 2009年第4期14卷 476-481页

作者：张培智殷承良张勇吴志伟 School of Mechanical Engineering Shanghai Jiaotong University

The energy management may perform well under normal conditions, but may lead to poor behavior under abnormal situations. To tackle this problem, an optimal control strategy called rule-based equivalent fuel consumption minimization strategy （RECMS） is developed for a new complex hybrid electric vehicle （CHEV）. It optimizes the energy efficiency and drive performance to cater for normal and power-loss operations of the tractive motor. Firstly, the strategy formulates a novel objective function based on the equivalent fuel concept. By accounting for the actual fuel cost, the equivalent fuel cost for the electric machines and virtual fuel cost for the drivability, the cost function is obtained. Furthermore, some penalty factors are presented to optimize the performance target. Finally, experiments for a practical CHEV are performed to validate a simulation model. Then simulations are carried out for both rule-based and RECMS. The results show that the optimal energy management is working well.

关键词： optimal energy management hybrid electric vehicle control strategy equivalent fuel consumption Dower-loss

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风速脉动对跃移运动的影响

兰州大学学报（自然科学版） 2013年第5期49卷 611-615页

作者：崔军强武生智兰州大学西部灾害与环境力学教育部重点实验室土木工程与力学学院兰州730000

对风沙流中随机风场模型进行了描述,然后基于高斯概率分布,利用随机Fourier级数生成脉动风场,进而对混合粒径颗粒在湍流随机风场中的运动进行数值计算,给出了颗粒的垂直质量通量和水平质量通量以及沙粒粒径分布的变化情况.实例分析表明... 详细信息

对风沙流中随机风场模型进行了描述,然后基于高斯概率分布,利用随机Fourier级数生成脉动风场,进而对混合粒径颗粒在湍流随机风场中的运动进行数值计算,给出了颗粒的垂直质量通量和水平质量通量以及沙粒粒径分布的变化情况.实例分析表明,所提出的算法在给定条件下,数值模拟结果与实际观测结果符合良好.

关键词：风沙运动跃移随机风场

Long term outcomes of saphaneous vein graft intervention in elderly patients with prior coronary artery bypass graft

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Journal of Geriatric Cardiology 2014年第1期11卷 26-31页

作者： Ji-Hong WANG Wei LIU Xin DU Chang-sheng MA Xue-Si wu Department of Cardiology Beijing An-Zhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Beijing Ji-Shui-Tan Hospital the 4th Clinical College of Peking University Health Science Center Beo'ing 100035 China

Objectives To investigate the procedure characteristics and long term follow-up ofpercutaneous coronary intervention （PCI） for sa phaneous vein graft （SVG） lesions in the elderly patients. Methods From December 2005 to December 201 l, 84 graft lesions were treated percumneously. Seventeen were located at proximal anastomosis, 48 were located at SVG body, 19 were located at distal anastomosis. Pri mary endpoint was defined as major adverse cardiovascular events （MACE, composite of cardiac death, target vessel revascularization, acute myocardial infarction）. Results The graft age was 6.7 i 4.0 years. Most anastomosis lesions （80.0%） presented within one year post coro-nary artery bypass grafting （CABG）. Proximal anastomosis lesion had the lowest successful rate for PCI compared with graft body and distal anastomosis lesions （70.6% vs. 91.7%, 79.0%, P 〈 0.05）. The distal embolic protection device was used in 19.1% of patients, most frequently used in body graft PCI （29.2%, P 〈 0.01）. The diameter of the stent was smallest in distal anastomosis group （2.9 ±0.4 mm, P 〈 0.05）. The highest post dilatation pressure was required in the proximal anastomosis （17.8 ± 2.7 atm, P 〈 0.05）. The patients were followed up for 24.3 ±16.9 months. MACE occurred in 18.57% of patients. Incidence of MACE was highest among proximal anastomosis PCI （47.1% vs. body graft PCI 16.7%, distal anastomosis PCI 21.1%; P 〈 0.05）. Old myocardial infarction was the predictive factor for the poor clinical outcomes （P〈 0.04）. Conclusions PCI of SVG lesions is feasible with lower success rate. PCI of ostial graft anastomosis lesions had the lowest procedure success rate and highest MACE rate compared with graft body and distal anastomosis lesions. Old myocardial infarction was a predictive factor of poor outcomes.

关键词： Graft Anastomosis Percutaneous coronary intervention Coronary artery bypass grafting

末端有未知扰动的分布参数柔性机械臂的鲁棒边界控制

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控制理论与应用 2011年第4期28卷 511-518页

作者：吴忻生邓军华南理工大学精密电子制造装备教育部工程研究中心广东广州510640 华南理工大学自动化科学与工程学院广东广州510640

本文研究在柔性机械臂的末端具有未知扰动的边界控制,以降低机械臂的振动.柔性机械臂的动态特性由偏微分方程表示的分布参数模型描述.在机械臂的末端边界基于Lyapunov直接法进行控制,以调节机械臂的振动.应用本文所提出的边界控制方法,... 详细信息

本文研究在柔性机械臂的末端具有未知扰动的边界控制,以降低机械臂的振动.柔性机械臂的动态特性由偏微分方程表示的分布参数模型描述.在机械臂的末端边界基于Lyapunov直接法进行控制,以调节机械臂的振动.应用本文所提出的边界控制方法,可达到外界干扰下的指数稳定性.所提出的控制方法与系统参数无关,可确保在参数变化下系统具有鲁棒性.最后对所提控制方法的有效性进行了数值模拟.

关键词：边界控制偏微分方程分布参数模型 Lyapunov直接法指数稳定性

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微生物发酵法生产L-色氨酸的代谢工程研究

中国生物工程杂志 2011年第6期31卷 135-141页

作者：赵志军陈晟吴丹吴敬陈坚江南大学食品科学与技术国家重点实验室无锡214122 江南大学生物工程学院工业生物技术教育部重点实验室无锡214122

L-色氨酸作为人体内的一种必需氨基酸,广泛应用于医药、食品与饲料等行业。工业上采用的色氨酸生产方法有化学合成法、转化法及微生物发酵法。近年来,随着代谢工程在色氨酸菌种选育中的成功运用,微生物发酵法逐渐成为主要的色氨酸生产... 详细信息

L-色氨酸作为人体内的一种必需氨基酸,广泛应用于医药、食品与饲料等行业。工业上采用的色氨酸生产方法有化学合成法、转化法及微生物发酵法。近年来,随着代谢工程在色氨酸菌种选育中的成功运用,微生物发酵法逐渐成为主要的色氨酸生产方法。系统综述了微生物发酵法生产色氨酸所涉及的代谢工程策略,包括生物合成色氨酸的代谢调控机制以及途径改造的措施和效果,此外,还探讨了L-色氨酸未来的发展前景。

关键词： L-色氨酸代谢工程微生物发酵法