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Chinese Chemical Letters 2024年第12期35卷 466-469页

作者： Zheng-Biao Zou Tai-Zong wu Chun-Lan Xie Yuan Wang Yan Li Gang Zhang Rong Chao Lian-Zhong Luo Li-sheng Li Xian-Wen Yang School of Pharmacy Hainan Medical UniversityHaikou 571199China Key Laboratory of Marine Genetic Resources Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China The School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350122China Fujian Province Universities and Colleges Engineering Research Center for Marine Biopharmaceutical Resource Utilization Xiamen Medica CollegeXiamen 361023China

The chemical investigation into the EtOAc extract of the deep-sea-derived fungus Penicillium citrinum W22 yielded three unprecedented citrinin dimers,neo-Dicitrinols A–C(1–3)and a known one,penicitrinone A(4).Their structures were elucidated by extensive analysis of spectroscopic data,electronic circular dichroism(ECD)calculation,X-ray diffraction,and biogenetic ***-Dicitrinols A–C(1–3),bearing a tetramic acid unit,represent the first example of citrinin analogues as hybrid polyketide synthase-nonribosomal peptide synthase(PKS-NRPS)***-Dicitrinol C(3)significantly inhibited renin-angiotensin system-selective lethal 3(RSL3)-induced ferroptosis with a half maximal effective concentration(EC50)value of 21.6μmol/L.

关键词： Deep-sea Fungus Citrinin dimers PKS-NRPS hybrid Ferroptosis

A Research into the Evaluation Target System and Comprehensive Evaluation Method About the Science and Technology Development of Provinces

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Journal of Systems Science and Systems Engineering 2001年第3期13卷 343-349页

作者： wu Ci-sheng,\ WANG Min,\ LI Xing-guo School of Management, Hefei University of Technology, Hefei 230009, China School of Management He fei University of Technology He fei 230009 China

Based on the systematic theory and the system analytic method, this thesis expounds manifestly the evaluation target system and comprehensive evaluation method about the science and technology development of provinces (cities and districts). By putting it into practice of provinces (cities and districts) science and technology development, this set of target system and method may fully reflect the impact on the social development. The acceleration of transferring the extensive economy to the intensive one in province (cities and districts) and the relation of coordinated growth of science and technology, economy, society are of momentous current significance.

关键词： science and technology development target system effect coefficient linear weighted method

Apoptosis and its pathway in X gene-transfected HepG_2 cells

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World Journal of Gastroenterology 2005年第28期11卷 4326-4331页

作者： Na Lin Hong-Ying Chen Dan Li sheng-Jun Zhang zhi-Xin Cheng Xiao-Zhong Wang Department of Gastroenterology Affiliated Union Hospital Fujian Medical University Fuzhou 350001 Fujian Province China

AIM： To investigate the effect of hepatitis B virus （HBV） X gene on apoptosis and expressions of apoptosis factors in X gene-transfected HepG2 cells.METHODS： The HBV X gene eukaryon expression vector pcDNA3-X was transiently transfected into HepG2 cells by lipid-media transfection. Untransfected HepG2 and HepG2 transfected with pcDNA3 were used as controls. Expression of HBx in HepG2 was identified by RT-PCR. MTT and TUNEL were employed to measure proliferation and apoptosis of cells *** groups. Semi-quantified RT-PCR was used to evaluate the expression levels of Fas/FasL, Bax/Bcl-xL, and c-myc in each group.RESULTS： HBV X gene was transfected into HepG2 cells successfully. RT-PCR showed that HBx was only expressed in HepG2/pcDNA3-X cells, but not expressed in HepG2 and HepG2/pcDNA3 cells. Analyzed by MTT, cell proliferationcapacity was obviously lower in HepG2/pcDNA3-X cells （0.08910±0.003164） than in HepG2 （0.14410±0.004927） and HepG2/pcDNA3 cells （0.12150±0.007159）（P〈0.05 and P〈0.01）. Analyzed by TUNEL, cell apoptosis was much more in HepG2/pcDNA3-X cells （980/2 000） than HepG2 （420/2 000）, HepG2/pcDNA3 cells （520/2 000）（P〈0.05 and P〈0.01）. Evaluated by semi-quantified RT-PCR, the expression level of Fas/FasL was significantly higher in HepG2 cells transfected with HBx than in HepG2 and HepG2/pcDNA3 cells （P〈0.05 and P〈0.01）. Bax/Bcl-xL expression level was also elevated in HepG2/pcDNA3-X cells （P〈0.05 and P〈0.01）. Expression of c-myc was markedly higher in HepG2/pcDNA3-X cells than in HepG2 and HepG2/pcDNA3 cells （P〈0.05 and P〈0.01）.CONCLUSION： HBV X gene can impair cell proliferation capacity, improve cell apoptosis, and upregulate expression of apoptosis factors. The intervention of HBV X gene on the expression of apoptosis factors may be a possible mechanism responsible for the change in cell apoptosis and proliferation.

关键词： HBx Transfect HepG2 Apoptosis Fas FasL Bax Bcl-xL c-mvc

Cosmic-ray helium nuclei measurement with the calorimeter of the Alpha Magnetic Spectrometer

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Radiation Detection Technology and Methods 2022年第3期6卷 427-432页

作者： Feng-ze Zhang zhi-Cheng Tang Zu-Hao Li Cheng Zhang Ze-Tong Sun Jia-Yu Hu Shang-Lin Li Guo-Ming Chen He-sheng Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose The distributions of energy responses of helium measured by the electromagnetic calorimeter(ECAL)of Alpha Magnetic Spectrometer(AMS-02)in Monte-Carlo do not agree with those in real data,thus using energy response matrix obtained from Monte-Carlo to measure the cosmic ray helium spectrum is not ***,the spectrum measured with ECAL based on raw Monte-Carlo would be different from the real *** purpose is to correct the response matrix to measure helium spectrum with *** The energy measured by ECAL of AMS-02 provides in-ﬂight correction for the energy response matrix in *** The spectrum based on corrected response matrix is consistent with the AMS collaboration published *** It is feasible to measure helium spectrum with ECAL with corrected energy response matrix.

关键词： Cosmic rays Helium spectrum Electromagnetic calorimeter Monte Carlo simulation Fig.1 a The structure of ECAL b The indication of PMTs in one superlayer

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二维单站纯方位运动目标跟踪的可观测性

兵工学报 2007年第5期28卷 617-620页

作者：许志刚盛安冬南京理工大学自动化学院

利用量测目标方位序列求解目标运动参数的纯方位跟踪(BOT)系统会发生解的不惟一的问题,即不可观测性。针对二维空间单目标和单平台(观测器)情形,利用向量变换以及线性矩阵方程解的性质,对BOT的可观测性问题进行了讨论;给出了当目标匀加... 详细信息

利用量测目标方位序列求解目标运动参数的纯方位跟踪(BOT)系统会发生解的不惟一的问题,即不可观测性。针对二维空间单目标和单平台(观测器)情形,利用向量变换以及线性矩阵方程解的性质,对BOT的可观测性问题进行了讨论;给出了当目标匀加速直线运动下,观测器保持匀加速直线运动时BOT系统不存在惟一解的命题;同时给出当量测方位序列和采样时间满足一定的条件,系统可以求出目标某些运动参数比值的算法。进一步将结论推广到观测器和目标都作任意阶次时间序列机动的一般场合,推导出当观测器机动阶次不超过目标机动阶次下,系统不可观测的重要结论;向量法以及得出的结论为进一步分析观测器的机动策略具有重要的指导意义。

关键词：信息处理技术纯方位系统二维空间可观测性匀加速运动机动阶次

Effects of splenectomy in patients with cirrhosis undergoing hepatic resection for hepatoceUular carcinoma

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World Journal of Gastroenterology 2003年第11期9卷 2460-2463页

作者： zhi-Xin Cao Xiao-Ping Chen Zai-De wu, Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, wuhan 430030, Hubei Province, China Hepatic Surgery Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China.

AIM: To study the effects of splenectomy in patients with cirrhosis undergoing hepatic resection for hepatocellular ***: Twenty-six patients with HCC associated with cirrhosis were divided into hepatectomy with splenectomy group (splenectomy group, n=11) and hepatectomy without splenectomy group (non-splenectomy group, n=15). T lymphocyte subsets such as CD4, CD8, CD4/CD8, helper T (Th) lymphocyte cytokines such as interferon γ(IFN-γ),interleukin 2(IL-2), interleukin 10(IL-10) and white blood cell (WBC), platelet (PLT), total bilirubin (T-Bil) were measured and used as parameters to evaluate the effects of ***: There was no significant difference in CD4, CD8,CD4/CD8, IL2, IFN-γ, IL10, WBC, PLT, T-Bil levels between two groups before surgery. Two months after operation,the levels of CD4 (41.2 %±4.2 % vs 34.7 %±3.8 %), CD4/CD8 (1.7±0.2 vs 1.0±0.2), IFN-γ (102.3±15.9 pg/ml vs 86.5±14.8 pg/ml), IL-2(97.2±15.6 pg/ml vS77.6±14.5 pg/ml) were increased and those of CD8 (25.6±3.9 vs32.8 %±4.1%),IL-10 (56.9±10.4 pg/ml vs 72.6±15.3 pg/ml) were decreased in splenectomy groups as compared with those in nonsplenectomy group (P<0.05). WBC and PLT counts in the splenectomy group were 8.9±1.6×109 and 310±32×109,respectively, which were significantly higher than those in non-splenectomy group (3.7±1.4×109 and 104±41×109) respectively on the 14th post-operative day. T-Bil concentration in the splenectomy group (24±7 μmol/L) was significantly lower than that in the non-splenectomy group (37±13 μmol/L) on the 7th post-operative day (P<0.05).CONCLUSION: Splenectomy combined with hepatectomy for HCC associated with cirrhosis is helpful for the recovery of T-lymphocyte subsets and the maintenance of Th:L/Th2 cytokine balance.

关键词：肝细胞癌肝切除术肝硬化脾切除术临床研究

The effects of anisodamine and dobutamine on gut mucosal blood flow during gut ischemia/reperfusion

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World Journal of Gastroenterology 2002年第3期8卷 555-557页

作者： Sen Hu zhi-Yong sheng,Burns Institute,304th Hospital of PLA,Beijing 100037,China Burns Institute 304th Hospital of PLA 51 Fu Cheng Road Beijing 100037 China.

AIM: To determine if anisodamine is able to augment mucosal perfusion during gut I/R ischemia-reperfusion. METHODS: A jejunal sac was formed in Sprague Dawley rat. A Laser Doppler probe and a tonometer were inserted into the sac which was filled with saline. The superior mesenteric artery was occluded (SMAO)for 60 minutes followed by 90 minutes of reperfusion. At the end of 60 minutes of SMAO, either 0.2 mg/kg of anisodmine or dobutamine was injected into the jejunal sac. Laser Doppler mucosal blood flow and regional PCO2 (PrCO2)measurements were made. RESULTS: Mucosal blood flow was significantly increased at 30,60 and 90 minutes of reperfusion (R30, R60, R90) when intraluminal anisodamine or dobutamine was present compared to intraluminal saline only(44+/-3.3% or 48+/-4.1% vs 37+/-2.6% at R30, 57+/-5.0% or 56+/-4.7% vs 45+/-2.7% at R60, 64+/-3.3% or 56+/-4.2% vs 48+/-3.4% at R90,respectively P<0.05). Blood flow changes were also reflected by lowering of jejunal PrCO2 measurements after intraluminal anisodamine or dobutamine compared with that of the saline controls (41+/-3.1 mmHg or 44+/-3.0 mmHg vs 49+/-3.7 mmHg at R30,38+/-3.7 mmHg or 40+/-2.1 mmHg vs 47+/-3.8 mmHg at R60,34+/-2.1 mmHg or 39+/-3.0 mmHg vs 46+/-3.4 mmHg at R90, respectively, P<0.05). Most interesting finding was that there were significantly higher mucosal blood flow and lower jejunal PrCO2 in anisodamine group than those in dobutamine group at 90 minutes of reperfusion(64+/-3.3% vs 56+/-4.2% for blood flow or 34+/-2.1 mmHg vs 39+/-3.0 mmHg for PrCO2, respectively, P<0.05), suggesting that anisodamine had a more lasting effect on mucosal perfusion than dobutamine. CONCLUSION: Intraluminal anisodamine and dobutamine can augment mucosal blood flow during gut I/R and alleviate mucosal acidosis. The results provided beneficial effects on the treatment of splanchnic hypoperfusion following traumatic or burn shock.

关键词： Animals Carbon Dioxide Dobutamine Intestinal Mucosa Ischemia Jejunum Male Rats Rats, Sprague-Dawley Regional Blood Flow Reperfusion Injury Research Support, Non-U.S. Gov't Solanaceous Alkaloids

A Modification to Vertical Distribution of Tidal Flow Reynolds Stress in Shallow Sea

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China Ocean Engineering 2012年第3期26卷 431-442页

作者：倪志辉宋志尧张绪进吴立春易静 Key Laboratory of Hydraulic and Waterway Engineering of the Ministry of Education and National Engineering Research Center for Inland Waterway RegulationChongqing Jiaotong University Southwestern Research Institute of Water Transportation Engineering Chongqing Jiaotong University Key Lab of Virtual Geographic Environment under Ministry of Education and Jiangsu Key Lab for Numerical Simulation of Large-Scale Complex SystemNanjing Normal University Chongqing University of Education

Tidal flow is a periodic movement of unsteady and non-uniform, which has acceleration and deceleration process obviously, especially in coastal shallow waters. Many researches show that vertical distribution of tidal flow Reynolds stress deviated from linear distribution. The parabolic distribution of the tidal flow Reynolds stress was proposed by Song et al. （2009）. Although the model fills better with field observations and indoor experimental data, it has the lower truncated series expansion of tidal flow Reynolds stress, and the description of the distribution is not very comprehensive By introducing the motion equation of tidal flow and improving the parabolic distribution established by Song et al. （2009）, the cubic distribution of the tidal flow Reynolds stress is proposed. The cubic distribution is verified well by field data （Bowden and Fairbairn, 1952; Bowden et al., 1959; Rippeth et al., 2002） and experimental data （Anwar and Atkins, 1980）, is consistent with the numerical model results of Kuo et al. （1996）, and is compared with the parabolic distribution of the tidal flow Reynolds stress. It is shown that this cubic distribution is not only better than the parabolic distribution, but also can better reflect the basic features of Reynolds stress deviating from linear distribution downward with the tidal flow acceleration and upward with the tidal flow deceleration, for the foundation of further study on the velocity profile of tidal flow.

关键词： tidal flow Reynolds stress linear distribution parabolic distribution cubic distribution

Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson's disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第10期15卷 923-927页

作者： Dan ZHU Gui-you LIU Zheng LV Shi-rong WEN sheng BI Wei-zhi WANG Department of Neurology the Second Affiliated Hospital Harbin Medical University Genome Analysis Laboratory Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Department of Rehabilitation the First Affiliated Hospital Harbin Medical University Department of Neurology the First Affiliated Hospital Harbin Medical University

Early studies had suggested that vitamin D intake was inversely associated with neurodegenerative diseases, such as Alzheimer＇s disease and multiple sclerosis. However, the associations of vitamin D intake and outdoor activities with Parkinson＇s disease（PD） are still unclear, so this study is to evaluate these relationships from a case-control study in elderly Chinese. The study population involved 209 cases with new onsets of PD and 210 controls without neurodegenerative diseases. The data on dietary vitamin D and outdoor activities were collected using a food-frequency questionnaire and self-report questionnaire. Multivariable logistic regressions were used to examine the associations between dietary outdoor activities, vitamin D intake and PD. Adjustment was made for sex, age, smoking, alcohol use, education, and body mass index（BMI）. Adjusted odds ratios（ORs） for PD in quartiles for outdoor physical activity were 1（reference）, 0.739（0.413, 1.321）, 0.501（0.282, 0.891）, and 0.437（0.241, 0.795）, respectively（P=0.002 for trend）. Adjusted ORs for PD in quartiles for total vitamin D intake were 1（reference）, 0.647（0.357, 1.170）, 0.571（0.318, 1.022）, and 0.538（0.301, 0.960）, respectively（P=0.011 for trend）. Our study suggested that outdoor activity and total vitamin D intake were inversely associated with PD, and outdoor activity seems to be more significantly associated with decreased risk for PD.

关键词： Outdoor activity Vitamin D intake Parkinson's disease

一种新的正规自适应边缘保护的超分辨率算法(英文)

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红外与毫米波学报 2014年第1期33卷 98-105页

作者：余徽陈福胜张智杰王晨晟华中科技大学光学与电子信息学院湖北武汉430074 华中光电技术研究所-武汉光电国家实验室湖北武汉430074

主要提出了一个新的正规自适应超分辨率算法.正规项只惩罚图像中可能包含有大量噪声的低频部分,同时保护图像中可能包含有锐利边缘的高频部分,其中,惩罚阈值自动地被一个线性函数决定.对于正规参数的选择,这里不采用固定的正规参数而是... 详细信息

主要提出了一个新的正规自适应超分辨率算法.正规项只惩罚图像中可能包含有大量噪声的低频部分,同时保护图像中可能包含有锐利边缘的高频部分,其中,惩罚阈值自动地被一个线性函数决定.对于正规参数的选择,这里不采用固定的正规参数而是提出一个对数函数在每次迭代时自适应地选择正规参数.该算法经过仿真实验和真实的红外图像测试,实验结果显示该算法鲁棒性好,可以有效复原图像细节.

关键词：超分辨率正规项正规参数惩罚阈值