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Role of interventional endovascular therapy for delayed hemorrhage after pancreaticoduodenectomy

Chinese Medical Journal 2010年第21期123卷 3110-3117页

作者： WANG zhi-jun WANG Mao-qiang LIU Feng-yong DUAN Feng SONG Peng FAN Qing-sheng Department of Interventional Radiology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Delayed massive hemorrhage （DMH） after pancreaticoduodenectomy （PD） is a sedous complication and one of the most common causes of mortality after PD. Its ideal management remains unclear. This paper is to present our experience in the endovascular treatment of patients with DMH after PD using different techniques and *** During a seven years period, 19 patients （fifteen men, four women） with DMH arter PD were treated with endovascular procedures, including transcatheter arterial embolization （TAE） with coils embolization in eight cases, with coils plus N-butyl-2-cyanoacrylate （NBCA）-Lipiodol mixture in six cases, and stent-graft placement in five cases. The mean age of the patients was 58.2 years. Follow-up, including clinical condition, liver function tests, and Doppler ultrasound examinations, was *** The immediate technical success rate was 84.2% （16/19）. There were no significant procedure-related complications. Hemostasis was not achieved with interventional procedures in three patients： one died of uncontrolled bleeding four days after the second TAE, and two patients required emergency laparotomy without re-angiography because of worsening clinical status. Among the 16 patients with successfully stopped bleeding who became hemodynamically stable after the procedure without evidence of further bleeding, two patients died during the peri-interventional procedure period because of multiple organ failure, and fourteen patients survived to hospital discharge. The mean length of follow-up was 14.6 months. Recurrent bleeding after discharge did not occur in any of these cases. Clinical and laboratory follow-up findings were unremarkable. Doppler ultrasound examinatation verified patency of the hepatic artery in the four patients with stent-graft placement during the follow-up period （5 months-29 months; mean, 15.3 months）.Conclusions Interventional endovascular procedure is a safe and technically feasible solution to control D

关键词： pancreaticoduodenectomy delayed massive hemorrhage hepatic artery pseudoaneurysm interventional radiology

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Research gaps for three main tropical diseases in the People’s Republic of China

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Infectious Diseases of Poverty 2013年第1期2卷 112-125页

作者： Qi Zheng Samantha Vanderslott Bin Jiang Li-Li Xu Cong-Shan Liu Le-Le Huo Li-Ping Duan Ning-Bo wu Shi-Zhu Li zhi-Gui Xia Wei-Ping wu Wei Hu Hao-Bing Zhang National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionWHO Collaborating Centre on MalariaSchisostomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of Health207 Rui Jin Er RdShanghai 200025People’s Republic of China The Department of Science and Technology Studies University College LondonLondon WC1E 6BTUK

This scoping review analyzes the research gaps of three diseases:schistosomiasis japonica,malaria and *** on available data in the ***,we highlight the gaps between control capacity and prevalence levels,and between diagnostic/drug development and population need for treatment at different stages of the national control *** reviewing the literature from 848 original studies and consultations with experts in the field,the gaps were identified as ***,the malaria research gaps include(i)deficiency of active testing in the public community and no appropriate technique to evaluate elimination,(ii)lack of sensitive diagnostic tools for asymptomatic patients,(iii)lack of safe drugs for mass ***,gaps in research of schistosomiasis include(i)incongruent policy in the implementation of integrated control strategy for schistosomiasis,(ii)lack of effective tools for Oncomelania *** control,(iii)lack of a more sensitive and cheaper diagnostic test for large population samples,(iv)lack of new drugs in addition to ***,gaps in research of echinococcosis include(i)low capacity in field epidemiology studies,(ii)lack of sanitation improvement studies in epidemic areas,(iii)lack of a sensitivity test for early diagnosis,(iv)lack of more effective drugs for short-term *** believe these three diseases can eventually be eliminated in China's Mainland if all the research gaps are abridged in a short period of time.

关键词： Schistosomiasis Malaria Echinococcosis Epidemiology Diagnosis Chemotherapy Research capacity building

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Inhomogeneity of density and mechanical properties of A357 aluminum alloy backward extruded in semi-solid state

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Transactions of Nonferrous Metals Society of China 2011年第10期21卷 2285-2293页

作者：杜之明陈刚程远胜谢水生哈尔滨工业大学材料科学与工程学院哈尔滨150001 北京有色金属研究总院有色金属制造与加工国家重点实验室北京100088

The inhomogeneity of density and mechanical properties of A357 aluminum alloy in the semi-solid state were *** simulation and backward extrusion were adopted to study the preparation of cup *** results show that the relative density of the wall is the lowest in samples,and that of the base is the *** increasing the billet height,more time is needed for relative density of the corner to reach the maximum value,and the relative densities in every region improve evidently with increasing the *** tensile stress was simulated to be the largest at the corner,and the hot tearings were forecasted to mainly appear at the corner *** employing proper billet height and pressure,the extruded samples consisted of fine and uniform microstructures,and can obtain excellent mechanical properties and Brinell hardness.

关键词： A357 aluminum alloy inhomogeneity semi-solid state backward extrusion numerical simulation

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越南高栏民歌与壮族文化的传承认同

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河池学院学报 2007年第1期27卷 89-94页

作者：吴盛枝广西民族大学文学院广西南宁530006

《高栏民歌》是越南高栏民族的韵文体口述文本,是高栏族群文化和历史记忆的一个部分。通过这些零散的片段记忆,让我们看到一个民族的非物质文化遗产对族群成员所起到的不断强化族群中人的认同感和归属意识,是不可估量的。《高栏民歌》... 详细信息

《高栏民歌》是越南高栏民族的韵文体口述文本,是高栏族群文化和历史记忆的一个部分。通过这些零散的片段记忆,让我们看到一个民族的非物质文化遗产对族群成员所起到的不断强化族群中人的认同感和归属意识,是不可估量的。《高栏民歌》所涉及的壮族民俗文化,以及它所展示的壮族文化风采,无一不与壮族有着血肉般的联系。

关键词：高栏民族壮族口述记忆传承认同越南《高栏民歌》

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四肢变截面钢管混凝土格构柱恢复力模型计算方法

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交通运输工程学报 2018年第5期18卷 77-89页

作者：欧智菁陈盛富吴庆雄袁辉辉福建工程学院土木工程学院福建福州350118 福州大学土木工程学院福建福州350108

提出了四肢变截面钢管混凝土格构柱抗震性能有限元分析方法,应用OpenSEES通用程序对试件进行建模,计算了格构柱荷载-位移滞回曲线与水平峰值荷载;以柱肢坡度、轴压比、长细比、支主管面积比、柱肢钢材强度、混凝土强度、缀管布置形式等... 详细信息

提出了四肢变截面钢管混凝土格构柱抗震性能有限元分析方法,应用OpenSEES通用程序对试件进行建模,计算了格构柱荷载-位移滞回曲线与水平峰值荷载;以柱肢坡度、轴压比、长细比、支主管面积比、柱肢钢材强度、混凝土强度、缀管布置形式等为拓展参数,研究了各参数对变截面平缀管式和斜缀管式钢管混凝土格构柱荷载-位移骨架曲线的影响规律;借鉴等截面钢管混凝土格构柱骨架曲线统一算法的计算框架,采用等效长度法,拟合得到四肢变截面钢管混凝土格构柱骨架曲线各特征值(弹性刚度、水平峰值荷载、峰值荷载位移与下降段刚度)的计算公式;结合骨架曲线计算模型,推导了恢复力模型的计算公式,并进行了实例验证。研究结果表明:轴压比、长细比、柱肢坡度、支主管面积比和材料参数是影响变截面格构柱抗震性能的关键参数,且与等截面格构柱影响规律具有共性,数值相差不超过20%;各试件特征值计算结果与有限元分析结果均吻合良好,两者之比为0.990～1.029,均方差为0.105～0.153,误差基本控制在15%内;四肢变截面钢管混凝土格构柱恢复力模型计算误差小于12%,计算结果可靠。

关键词：桥梁工程变截面钢管混凝土格构柱骨架曲线恢复力模型

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潼关高程下降对渭河下游防洪的影响

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水利学报 2005年第2期36卷 147-154页

作者：李昌志王兆印吴保生王费新清华大学水利系河流海洋研究所北京100084

潼关高程抬升引起渭河下游大量泥沙淤积,给防洪带来一系列问题。本文针对这一问题,通过对渭河下游河道40多年的大断面地形资料进行分析和计算,探讨了潼关高程与渭河下游泥沙冲淤的关系,并分析了典型断面的水位变化。结果表明,潼关高程... 详细信息

潼关高程抬升引起渭河下游大量泥沙淤积,给防洪带来一系列问题。本文针对这一问题,通过对渭河下游河道40多年的大断面地形资料进行分析和计算,探讨了潼关高程与渭河下游泥沙冲淤的关系,并分析了典型断面的水位变化。结果表明,潼关高程与渭河下游泥沙冲淤密切相关,潼关高程下降后,渭河会产生溯源冲刷。在大水少沙情况下,近槽滩地也会受到冲刷,但是洪水漫滩后滩地会发生淤积,由于主槽面积增加,过洪能力增强,中小洪水防洪压力减小;但如果发生高含沙漫滩洪水,滩地淤积,漫滩洪水水位反而有所抬高,大洪水威胁依然存在。

关键词：潼关高程渭河下游防洪形势

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Functional analysis of a miRNA‐like small RNA derived from Bombyx mori cytoplasmic polyhedrosis virus

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Insect Science 2020年第3期27卷 449-462页

作者： Jian-Yong Guo Yong-sheng Wang Tian Chen Xiao-Xu Jiang Ping wu Tao Geng Zhong-Hua Pan Meng-Ke Shang Cheng-Xiang Hou Kun Gao Xi-Jie Guo School of Biotechnology Jiangsu University of Science and TechnologyZhenjiangChina Sericultural Research Institute Chinese Academy of Agricultural SciencesZhenjiangChina Environment and Plant Protection Institute Chinese Academy of Tropical Agricultural SciencesHaikoouChina School of Biology&Basic Medical Science Soochow UniversitySuzhouChina

Bombyx mori cytoplasmic polyhedrosis virus(BmCPV)is a major pathogen of the economic insect silkworm,Bombyx ***‐encoded microRNAs(miRNAs)have been proven to play important roles in host–pathogen *** this study we identified a BmCPV‐derived miRNA‐like 21 nt small RNA,BmCPV‐miR‐1,from the small RNA deep sequencing of BmCPV‐infected silkworm larvae by stem‐loop quantitative real‐time PCR(qPCR)and investigated its functions with qPCR and lentiviral expression *** mori inhibitor of apoptosis protein(BmIAP)gene was predicted by both target prediction software miRanda and Targetscan to be one of its target genes with a binding site for BmCPV‐miR‐1 at the 5′untranslated *** was found that the expression of BmCPV‐miR‐1 and its target gene BmIAP were both up‐regulated in BmCPV‐infected *** the same time,it was confirmed that BmCPV‐miR‐1 could up‐regulate the expression of BmIAP gene in HEK293T cells with lentiviral expression systems and in BmN cells by transfecting ***,BmCPV‐miR‐1 mimics could up‐regulate the expression level of BmIAP gene in midgut and fat body in the *** the midgut of BmCPV‐infected larvae,BmCPV‐miR‐1 mimics could be further up‐regulated and inhibitors could lower the virus‐mediated expression of BmIAP *** the viral genomic RNA segments S1 and S10 as indicators,BmCPV‐miR‐1 mimics could up‐regulate and inhibitors down‐regulate their replication in the infected *** results implied that BmCPV‐miR‐1 could inhibit cell apoptosis in the infected silkworm through up‐regulating BmIAP expression,providing the virus with a better cell circumstance for its replication.

关键词： Bombyx mori cytoplasmic polyhedrosis virus inhibitor of apoptosis protein miRNA-like small RNA

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双层球面网壳的风振特性与等效静风荷载

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哈尔滨工业大学学报 2010年第10期42卷 1543-1547页

作者：吴迪武岳张建胜哈尔滨工业大学土木工程学院哈尔滨150090 浙江工业大学建筑工程学院杭州310014

对于网壳结构的抗风性能研究以往大多针对单层网壳,而实际工程中应用较多的则是双层网壳,因此,有必要研究双层网壳的风振性能和抗风设计方法.以实际工程为例,对双层球壳结构的风致动力响应特性进行系统研究,结果表明,对于刚度较大的双... 详细信息

对于网壳结构的抗风性能研究以往大多针对单层网壳,而实际工程中应用较多的则是双层网壳,因此,有必要研究双层网壳的风振性能和抗风设计方法.以实际工程为例,对双层球壳结构的风致动力响应特性进行系统研究,结果表明,对于刚度较大的双层球壳,脉动风响应以背景分量为主,结构对风荷载的动力放大作用可以忽略不计.在此基础上以脉动风荷载均方差作为基向量,提出一种不同于现行规范的等效静风荷载表达方法.

关键词：双层球壳风洞试验风致响应等效静风荷载

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Focal nodular hyperplasia of the liver in 86 patients

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 52-57页

作者： Shen, Ying-Hao Fan, Jia wu, zhi-Quan Ma, Zeng-Chen Zhou, Xin-Da Zhou, Jian Qiu, Shuang-Jian Qin, Lun-Xiu Ye, Qin-Hai Sun, Hui-Chuan Huang, Xiao-wu Tang, Zhao-You Fudan Univ Zhongshan Hosp Dept Liver Surg Shanghai 200032 Peoples R China

BACKGROUND: Focal nodular hyperplasia (FNH), the second most common benign hepatic tumor after hemangioma, is characterized by a stellate central scar and hyperplastic nodules. Although some large FNH may be associated with significant symptoms, more frequently they are discovered incidentally on physical examination or the work-up of unrelated symptoms. Since its nature and pathogenesis are still controversial, accurate diagnosis of FNH based on clinical presentation and radiographic studies is difficult. The purpose of this study was to explore the diagnosis and treatment of FNH. METHODS: Eighty-six FNH patients confirmed pathologically were treated at the Liver Cancer Institute in our hospital from 1996 to 2006. Their clinical manifestions, imaging presentation, pathological findings, and surgical results were analyzed retrospectively. RESULTS: Of the 86 patients with 99 foci, 54 were male and 32 female, with a mean age of 37 years. Eighty patients had a single solitary focus and 6 had multiple foci. Tumor diameter was less than 5 cm in 69 patients, 5-10 cm in 15, and more than 10 cm in 2. The overall rate of correct preoperative diagnosis was 59.3% (51/86) including 32.9% (26/79) by color Doppler flow imaging (CDFI), 60.3% (35/58) by CT, and 77.4% (24/31) by MRI. All the 86 patients underwent resection with good curative effect. CONCLUSIONS: CT and MRI are important diagnostic methods for FNH but it is difficult to make a definite preoperative diagnosis for partial classical and all non-classical FNH patients. We suggest that patients with clinical symptoms or with indefinite diagnosis should accept surgical removal.

关键词： liver focal nodular hyperplasia diagnosis treatment

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机器人多指手抓取爆炸物能力研究

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华南理工大学学报（自然科学版） 2015年第7期43卷 124-129页

作者：莫海军林志生华南理工大学机械与汽车工程学院广东广州510640

应用力螺旋理论建立了多指手抓取矩阵与外力螺旋之间的关系,对多指手抓取爆炸物能力进行研究.首先建立多指手抓取爆炸物的力学模型,确定影响抓取的参数;然后以最大抓取重量为目标函数,建立满足力封闭约束条件下的抓取数学模型,并采用神... 详细信息

应用力螺旋理论建立了多指手抓取矩阵与外力螺旋之间的关系,对多指手抓取爆炸物能力进行研究.首先建立多指手抓取爆炸物的力学模型,确定影响抓取的参数;然后以最大抓取重量为目标函数,建立满足力封闭约束条件下的抓取数学模型,并采用神经网络和优化方法对多指手抓取爆炸物进行了仿真,研究多指手不同抓取位置与爆炸物重量之间的对应关系,获得了多指手抓取爆炸物时最有利的抓取位置.

关键词：机器人多指手抓取能力神经网络爆炸物

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