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Chinese Journal of Polymer Science 2022年第1期40卷 21-28页

作者： Dong Liu Fan Wu zhi-Hao shen Xing-He Fan Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Liquid electrolytes used in lithium-ion batteries suffer from leakage,flammability,and lithium dendrites,making polymer electrolyte a potential ***,a series of ABA triblock copolymers(ABA-x)containing a mesogen-jacketed liquid crystalline polymer(MJLCP)with a polynorbornene backbone as segment A and a second polynorbornene-based polymer having poly(ethylene oxide)(PEO)side chains as segment B were synthesized through tandem ring-opening metathesis *** block copolymers can self-assemble into ordered morphologies at 200℃.After doping of lithium salts and ionic liquid(IL),ABA-x self-assembles into cylindrical *** MJLCP segments with a high glass transition temperature and a stable liquid crystalline phase serve as physical crosslinking points,which significantly improve the mechanical performance of the polymer *** ionic conductivity of ABA-x/lithium salt/IL is as high as 10-3 S·cm-1 at ambient temperature owing to the high IL uptake and the continuous phase of conducting PEO *** relationship between ionic conductivity and temperature fits the Vogel-Tamman-Fulcher(VTF)*** addition,the electrolyte films are flame retardant owing to the addition of *** polymer electrolytes with good safety and high ambient-temperature ionic conductivity developed in this work are potentially useful in solid lithium-ion batteries.

关键词： ABA triblock copolymer Polymer electrolyte Ionic conductivity Inflammability Cylindrical structure

Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor

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World Journal of Gastroenterology 2010年第37期16卷 4716-4724页

作者： Yun Zhang Hui Cao Ming Wang Wen-Yi Zhao zhi-Yong shen Dan-Ping shen Xing-zhi Ni zhi-Yong Wu Yan-Ying shen Yan-Yan Song Department of General Surgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Pathology China Section of Statistics Teaching and Research Shanghai Jiao Tong University School of MedicineShanghai 200025China

AIM: To investigate loss of heterozygosity (LOH) of chromosome 9p21 and the prognostic relevance of p16 expression in gastrointestinal stromal tumor (GIST). METHODS: Fifty-one GIST patients (30 men and 21 women; median age 59 years; range 29-80 years) treated surgically within a 10-year period were grouped by aggressive behavior risk (17 with very low and low, 14 intermediate, and 20 high risk). GISTs were characterized immunohistochemically and evaluated for LOH of 9p21 by microsatellite analysis at D9S1751, D9S1846, D9S942, and D9S1748. LOH of 9p21 and immunohistochemicalexpression of p16 protein encoded at 9p21 were correlated with clinicopathological parameters, and the prognostic significance of p16 alterations was evaluated. RESULTS: Thirty-one (63.3%) cases showed LOH with at least one microsatellite marker. LOH frequency was 37.0% at D9S1751, 37.5% at D9S1846, 42.1% at D9S942, and 24.2% at D9S1748. There was a higher LOH frequency of D9S942 in high-risk than in non-highrisk tumors (P < 0.05, χ 2 = 4.47). Gender, age, tumor size and site were not correlated with allelic loss. Ninety percent (18/20) of the GIST patients in the high risk group showed LOH with at least one of the 9p21 markers, while 57.1% (8/14) in the intermediate risk group and 33.3% (5/15) in the very low and low risk groups, respectively (P < 0.05, χ 2 = 12.16). Eight (28.5%) of 31 patients with LOH and 1 (5.6%) of 18 patients without LOH died of the disease during the follow-up period. Loss of p16 protein expression occurred in 41.2%, but in 60% of the high risk group and 23.5% of the very low and low risk groups (P < 0.05, χ 2 = 4.98). p16 loss was associated with poor prognosis (P < 0.05, χ 2 = 4.18): the 3and 5-year overall survival rates were 84.8% and 70.8% for p16-negative and 100% and 92.0% for p16-positive patients, respectively. CONCLUSION: LOH at 9p21 appears to play an important role in GIST progression; decreased p16 expression in GIST is highly predictive of poor outcome.

关键词： Gastrointestinal stromal tumor Loss of heterozygosity p16 Prognosis Tumor suppressor gene

Genetic spectrum and clinical features in a cohort of Chinese patients with autosomal recessive cerebellar ataxias

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Translational Neurodegeneration 2021年第4期10卷 536-550页

作者： Hao-Ling Cheng Ya-ru Shao Yi Dong Hai-Lin Dong Lu Yang Yin Ma Ying shen zhi-Ying Wu Department of Neurology and Research Center of Neurology in Second Affiliated Hospital and Key Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310000China Department of Neurology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200000China Institute of Neuroscience Zhejiang University School of MedicineHangzhou 310000China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200000China

Background:Although many causative genes have been uncovered in recent years,genetic diagnosis is still missing for approximately 50%of autosomal recessive cerebellar ataxia(ARCA)*** studies have been performed to determine the genetic spectrum and clinical profile of ARCA patients in the Chinese ***:Fifty-four Chinese index patients with unexplained autosomal recessive or sporadic ataxia were investigated by whole-exome sequencing(WES)and copy number variation(CNV)calling with *** causal CNV predictions were validated by ***:Thirty-eight mutations including 29 novel ones were identified in 25 out of the 54 patients,providing a 46.3%positive molecular diagnostic *** different genes were involved,of which four most common genes were SACS,SYNE1,ADCK3 and SETX,which accounted for 76.0%(19/25)of the positive *** de novo microdeletion in SACS was reported for the first time in China and the uniparental disomy of ADCK3 was reported for the first time *** features of the patients carrying SACS,SYNE1 and ADCK3 mutations were ***:Our results expand the genetic spectrum and clinical profiles of ARCA patients,demonstrate the high efficiency and reliability of WES combined with CNV analysis in the diagnosis of suspected ARCA,and emphasize the importance of complete bioinformatics analysis of WES data for accurate diagnosis.

关键词： Autosomal recessive cerebellar ataxias Chinese Genetic spectrum Structural variation Clinical features

Facile synthesis of phthalan derivatives via a Pd-catalyzed tandem hydroalkynylation,isomerization,Diels-Alder cycloaddition and aromatization reaction

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Chinese Chemical Letters 2015年第1期26卷 73-76页

作者： ru-Wei shen Jian-Jun Yang Li-Xiong Zhang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical EngineeringNanjing Tech University

A novel Pd-catalyzed tandem reaction involving hydroallojnylation, isomerization, Diels-Alder cycloaddition and aromatization reaction to produce phthalan derivatives in moderate yields is reported. The reaction is at... 详细信息

关键词： Tandem reaction Palladium catalysis Alkyne Phthalan Diels-Alder cycloaddition

Neuropeptide Y and melanocortin receptors in fish:regulators of energy homeostasis

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Marine Life Science & Technology 2022年第1期4卷 42-51页

作者： zhi-Shuai Hou Hai-shen Wen Key Laboratory of Mariculture(Ocean University of China) Ministry of Education(KLMME)Fisheries CollegeOcean University of ChinaQingdao266003China

Energy homeostasis,which refers to the physiological processes that the energy intake is exquisitely coordinated with energy expenditure,is critical for ***,multiple and complex mechanisms have been involved in the regulation of energy *** central melanocortin system plays an important role in modulating energy *** system includes the orexigenic neurons,expressing neuropeptide Y/Agouti-related protein(NPY/AgRP),and the anorexigenic neurons expressing proopiomelanocortin(POMC).The downstream receptors of NPY,AgRP and post-translational products of POMC are G protein-coupled receptors(GPCRs).This review summarizes the compelling evidence demonstrating that NPY and melanocortin receptors are involved in energy ***,the comparative studies on physiology and pharmacology of NPY and melanocortin receptors in humans,rodents and teleosts are ***,we provide a strategy demonstrating the potential application of the new ligands and/or specific variants of melanocortin system in aquaculture.

关键词： Energy homeostasis Neuropeptide Y receptors Melanocortin receptors GPCRs Fish(Teleost)

Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

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Neuroscience Bulletin 2017年第5期33卷 576-584页

作者： Hong Jin Jin-ru Zhang Yun shen Chun-Feng Liu Department of Neurology and Sleep Center The Second Affiliated Hospital of Soochow University Institute of Neuroscience Soochow University

Rapid eye movement sleep behavior disorder （RBD） is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson＇s disease （PD） with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.

关键词： Parkinson's disease · Rapid eye movement sleep behavior disorder · Risk factors ·Parkinsonism

A new era of mass data storage in artificial chromosome

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Science China(Life Sciences) 2022年第7期65卷 1477-1478页

作者： zhi Ping Huanming Yang Yue shen BGI-shenzhen Shenzhen 518083China Guangdong Provincial Key Laboratory of Genome Read and Write BGI-ShenzhenShenzhen 518120China George Church Institute of Regenesis BGI-ShenzhenShenzhen 518120China shenzhen Institute of Synthetic Biology Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Traditional silicon-based storage media will soon be unable to meet the exponentially increasing data archiving demands,and efforts must be made to find *** an ancient and efficient information carrier in living organisms,DNA has been believed to have great potential as a novel storage *** holds numerous advantages,such as remarkably high storage density,extremely long durability,and the costefficiency of information replication.

关键词： artificial durability holds

Effect of near PT-symmetric potentials on nonlinear modes for higher-order generalized Ginzburg–Landau model

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Communications in Theoretical Physics 2022年第12期74卷 1-8页

作者： Da Lin Kai-ru Dong Jia-rui Zhang Yu-Jia shen College of Science China Agricultural UniversityBeijing 100083China

In this paper,we study the higher-order generalized Ginzburg–Landau model which contributes to describing the propagation of optical solitons in *** means of the Hirota bilinear method,the analytical solutions are obtained and the effect of relevant parameters is *** by the near parity-time-symmetric potentials,the nonlinear modes with 5%initial random noise are numerically simulated to possess stable ***,the evolution of nonlinear modes is displayed through the adiabatical change of some *** investigation of the present work is intended as a contribution to the work for the higher-order generalized Ginzburg–Landau model.

关键词： generalized Ginzburg–Landau model parity-time symmetry stability of soliton solutions

Converting Thiophene in Simulated Coking Crude Benzene to N,N-Dimethyl-2-thiophenecarboxamide by Dimethylcarbamyl Chloride Under Mild Conditions

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Chemical Research in Chinese Universities 2019年第4期35卷 674-679页

作者： shen Xizhou SONG Hao FANG Liuya DENG Hang GAN Feng shen zhi School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Wuhan 430205 P. R. China Key Laboratory for Green Chemical Process Ministry of Education Wuhan Institute of Technology Wuhan 430073 P. R. China

Since the content of thiophene in coking crude benzene is high, it is necessary to remove it from coking crude benzene for efficient utilization. In this study, an important intermediate, N,N-dimethyl-2-thiophenecarboxamide, was synthesized from thiophene and dimethylcarbamyl chloride. The influences of the dosages of dimethylcarbamyl chloride and ZnCl2 catalyst, reaction temperature and time on the removal rate were further explored based on the reaction *** structure of the target product was characterized by means of MS,NMR and 13C *** removal rate of thiophene was 98.14% after the reaction for 2 h and thiophene was almost removed after the reaction for 3 h under the optimal reaction conditions [a molar ratio of n(thiophene):n(dimethylcarbamyl chioride):w(ZnCl2)=1:12:10,300 r/min, 318 K and 101.325 kPa].The acylation of thiophene with dimethylcarbamyl chloride was approximately in accord with the first order kinetic equation at *** activation energy was 53.9850 kJ/mol and the pre-exponential factor was 1.4521×10^9 h^-1.

关键词： Coking crude benzene F-C acylation Acyl chloride Thiophene Thiophene derivative

Development of Transgenic Glyphosate-Resistant Rice with G6 Gene Encoding 5-Enolpyruvylshikimate-3-Phosphate Synthase

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Agricultural Sciences in China 2011年第9期10卷 1307-1312页

作者： ZHAO Te LIN Chao-yang shen zhi-cheng State Key Laboratory of Rice Biology and Institute of Insect Sciences Zhejiang University Hangzhou 310028 P.R. China

Glyphosate-resistant crops have been a huge economic success for genetic engineering. The creating of new glypbosateresistant plants would increase the available choices for planting and lower the price of genetically modified crop seeds. A novel G6 gene from Pseudomonas putida that encoded 5-enolpyruvylshikimate-3-phosphate synthase （EPSPS） was previously isolated. The G6 gene was transfected into rice via Agrobacterium-mediated transformation. The transgenic rice obtained was confirmed by PCR, Southern, and Western blots. The lab experiment and field trials further confirmed that the transgenic rice can survive glyphosate spraying at a dose of 8 g L^-1. In contrast, conventional rice was killed at a weed control glyphosate spray dose of 1 g L^-1. Altogether, the present study showed that the G6 gene works well in rice in vivo for glyphosate-resistance.

关键词： transgenic rice glyphosate-resistance EPSPS