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World Journal of Gastroenterology 2020年第21期26卷 2691-2701页

作者： Fei Teng Ke-Yan Sun zhi-ren fu Department of Liver Surgery and Organ Transplantation Changzheng HospitalNavy Medical UniversityShanghai 200003China

Portal vein thrombosis(PVT)is currently not considered a contraindication for liver transplantation(LT),but diffuse or complicated PVT remains a major surgical ***,we review the prevalence,natural course and current grading systems of PVT and propose a tailored classification of PVT in the setting of *** in liver transplant recipients is classified into three types,corresponding to three portal reconstruction strategies:Anatomical,physiological and *** I PVT can be removed via low dissection of the portal vein(PV)or thrombectomy;porto-portal anastomosis is then performed with or without an interposed vascular *** reconstruction used for type II PVT includes vascular interposition between mesenteric veins and PV,collateral-PV and splenic vein-PV ***-physiological reconstruction used for type III PVT includes cavoportal hemitransposition,renoportal anastomosis,portal vein arterialization and multivisceral *** portal reconstruction techniques were *** tailored classification system stratifies PVT patients by surgical complexity,risk of postoperative complications and long-term *** advocate using the tailored classification for PVT grading before LT,which will urge transplant surgeons to make a better preoperative planning and pay more attention to all potential strategies for portal *** verification in a large-sample cohort study is needed.

关键词： Portal vein thrombosis Liver transplantation Portal reconstruction Grading Anatomical Physiological Non-physiological

Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-zhi Chen Chang-Zhen ren Ke-Yan Sun Hao Liu Shao-Hua Song zhi-ren fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation

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World Journal of Gastroenterology 2014年第31期20卷 10900-10907页

作者： Fei Teng Gui-Hua Wang Yi-Feng Tao Wen-Yuan Guo Zheng-Xin Wang Guo-Shan Ding Xiao-Min Shi zhi-ren fu Organ Transplantation Institute of Changzheng Hospital Second Military Medical University

AIM: To establish a model to predict long-term survival of hepatocellular carcinoma (HCC) patients after liver transplantation (MHCAT).

关键词： Criteria Hepatocellular carcinoma Liver transplantation MHCAT Survival model

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对我国建设工程索赔机制运行有关问题的探讨

中国港湾建设 2006年第5期26卷 70-73页

作者：任志福广州航海高等专科学校广东广州510330

索赔机制及其运行是实现索赔的重要保证。文章通过对索赔机制的定义及构成分析,阐释了索赔机制的本质及运行影响因素。据此,对我国索赔机制运行中的困境及原因做了剖析,提出了完善我国索赔机制、改善索赔环境的具体措施和建议。

关键词：索赔机制定义索赔困境原因分析措施

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真空预压法加固软土地基机理相关问题的探讨

建筑科学 2008年第3期24卷 43-47页

作者：任志福广州航海高等专科学校广州510330

分析了真空度传递特性和影响因素,对涉及真空预压软土地基加固机理的相关热点问题进行了深入探讨,包括真空预压加固过程土体强度变化特征,加固区地下水位变化及有效加固深度,加固区边界的土体变形特征、边界水位变化及边界影响范围等,... 详细信息

分析了真空度传递特性和影响因素,对涉及真空预压软土地基加固机理的相关热点问题进行了深入探讨,包括真空预压加固过程土体强度变化特征,加固区地下水位变化及有效加固深度,加固区边界的土体变形特征、边界水位变化及边界影响范围等,以助于更好地理解真空预压软土地基加固的机理问题。

关键词：真空预压法软土地基加固加固机理探讨

Reconstruction of the middle hepatic vein tributary in adult right lobe living donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 581-586页

作者： Xiao-Min Shi, Yi-Feng Tao, zhi-ren fu, Guo-Shan Ding, Zheng-Xin Wang and Liang Xiao Division of Liver Transplantation, Department of Organ Transplantation, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Division of Liver Transplantation Department of Organ Transplantation Shanghai Changzheng Hospital Second Military Medical University Shanghai 200003 China

BACKGROUND: In adult-to-adult living donor liver transplantation (LDLT), the use of a right lobe graft without the middle hepatic vein (MHV) can cause hepatic congestion and disturbance of venous drainage. To solve this problem, we successfully used cadaveric venous allografts preserved in 4 ℃ University of Wisconsin (UW) solution within 10 days as interposition veins for drainage of the paramedian portion of the right lobe in adult LDLT. METHODS: From June 2007 to January 2008, 11 adult LDLT patients received modified right liver grafts. The major MHV tributaries (greater than 5 mm in diameter) of 9 cases were preserved and reconstructed using cadaveric interposition vein allografts that had been stored for 1 to 10 days in 4 ℃ UW solution. The regeneration of the paramedian sector of the grafts and the patency of the interposition vein allografts were examined by Doppler ultrasonography after the operation. RESULTS: MHV tributaries were reconstructed in 9 recipients. Only 1 recipient died of renal failure and severe pulmonary infection on day 9 after transplantation without any hemiliver venous outflow obstruction. The other 8 recipients achieved long-term survival with a median follow-up of 30 months. The cumulative patency rates of the 8 recipients were 63.63% (7/11), 45.45% (5/11), 45.45% (5/11) and 36.36% (4/11) at 3, 6, 12 and 24 months, respectively. Regeneration of the paramedian sectors was ***: The cadaveric venous allograft preserved in 4 ℃ UW solution within 10 days serves as a useful alternative for interposition veins in facilitating implantation of a right lobe graft and guarantees outflow of the MHV.

关键词： adult-to-adult living donor liver transplantation middle hepatic vein venous allograft reconstruction

Prevention of hepatitis B virus reinfection after orthotopic liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 345-348页

作者： Zheng-Xin Wang, Guo-Shan Ding, Hong fu, Jian-Jun Zhang, Xiao-Song Chen,Wen-Yuan Guo, Xiao-Min Shi and zhi-ren fu Liver Transplantation Group of Transplantation Cen-ter , Changzheng Hospital, Second Military University, Shanghai 200003,China Liver Transplantation Group of Transplantation Center Changzheng Hospital Second Military University Shanghai 200003 China.

BACKGROUND: Hepatitis B virus reinfection is an impor-tant problem after liver transplantation. The aim of thisstudy was to discuss the prevention of hepatitis B virus rein-fection following orthotopic liver ***: Sixty-eight cases of chronic fulminant hepatitisB, end-stage liver cirrhosis, and liver carcinoma complicat-ed with HBV cirrhosis were given anti-viral drugs beforeand after transplantation to prevent hepatitis B virus rein-fection. Lamivudine was administered in 2 patients, lami-vudine + hepatitis B immunoglobulin ( HBIG ) in 63, andadefovir + HBIG in 3. The measurement of serum HBV,HBV DNA, liver biopsy immunohistochemistry and clini-cal study were ***: In 1 of the 2 patients who developed reinfectionafter lamivudine administration, serum HBsAg, HBeAb,HBcAb, HBV DNA were positive and liver biopsy immu-nohistochemistry showed HBsAg phenotype. In 2 of 63 pa-tients who developed reinfection after use of lamivudine +HBIG, serum HBsAg, HBeAb, HBcAb were positive andliver biopsy immunohistochemistry showed HBsAg pheno-type. Serum HBV DNA was positive in one of *** patients developed no reinfection with HBV after useof ***: Orthotopic liver transplantation is effectivein the treatment of HBV-infected diseases. Lamivudine +HBIG or adefovir + HBIG could effectively prevent hepatitisB virus reinfection.

关键词： hepatitis B hepatitis B immunoglobulin prophylaxis liver transplantation lamivudine reinfection

Effects of tacrolimus on proliferation, apoptosis, and fluorouracil sensitivity of liver cancer cell line of SMMC-7721

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 269-273页

作者： Xiao-Wei Cao, zhi-ren fu and Guo-Shan Ding Shanghai, China Organ Transplantation Institute of PLA, Liver Trans- plantation Group of Transplantation Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Liver Transplantation Group of Transplantation Center Changzheng Hospital Second Military Medical University Shanghai 200003 China. zhirenf@***

BACKGROUND: The effect of tacrolimus (FK506) and 5- fluorouracil (5-fu) on hepatocellular carcinoma remains elusive. The aim of this study was to assess the effect of ta- crolimus on the proliferation, and apoptosis in liver cancer cell line of SMMC-7721 and its sensitivity to fluorouracil (5- fu). METHODS: The liver cancer cell line of SMMC-7721 was cultured in vitro, and the MTT assay was used to examine the antiproliferative effect of FK506. Flow cytometry (FCM) was used to examine the effect of 5-fu alone or in combination with FK506 on the apoptosis and cell cycle of SMMC-7721 cells. RESULTS: FK506 produced concentration-dependent anti- proliferative effect on SMMC-7721 cells at all experimental concentrations(P fu induced apoptosis in a concentration-depen- dent manner, whereas the percentage of G0/G1-phase cells and proliferation index (PI) were increased with the in- creased concentration of 5-fu. Pretreatment with FK506 for 2 hours enhanced the effect of 5-fu on the induction of apoptosis. CONCLUSIONS: FK506 inhibits the growth of SMMC-7721 cells and enhances their sensitivity to 5-fu. This may be as- sociated with the synergic effect of FK506 and 5-fu in in- ducing apoptosis and G0/G1-phase stasis.

关键词： fluorouracil tacrolimus hepatocellular carcimona apoptosis chemotherapy proliferation

Postreperfusion syndrome during orthotopic liver transplantation:a single-center experience

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Hepatobiliary & Pancreatic Diseases International 2012年第1期11卷 34-39页

作者： Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, zhi-ren fu and Xue-Yin Shi Department of Anesthesiology, Huashan Hospital, fudan University, Shanghai 200040, China Department of Anesthesiology Organ Transplantation Center , Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Department of Anesthesiology Huashan Hospital Fudan University Shanghai 200040 Shanghai China Department of Anesthesiology Changzheng Hospital Second Military Medical University Shanghai 200003 Shanghai China Organ Transplantation Center Changzheng Hospital Second Military Medical University Shanghai 200003 Shanghai China

BACKGROUND: Marked hemodynamic alteration, commonly referred to as postreperfusion syndrome (PRS), often occurs after revascularization of the donor organ during orthotopic liver transplantation (OLT) and is associated with poor outcomes. This study aimed to investigate the incidence, predictive factors and clinical outcomes of PRS in Chinese patients following OLT at a liver transplantation center in China. METHODS: Over a 5-year period, 330 consecutive patients who had undergone OLT for hepatocellular carcinoma or cirrhosis were included in this retrospective study. PRS was defined as a >30% decrease in the mean arterial pressure compared with that before revascularization for more than 1 minute during the first 5 minutes of graft reperfusion. The patients were divided into 2 groups according to the development of PRS: group 1 (patients with PRS, n=56) and group 2 (patients without PRS, n=274). The demographic characteristics, operative and postoperative courses, and outcomes of the patients were analyzed using SPSS version 18.0. RESULTS: Multivariate regression analysis showed that left ventricular diastolic dysfunction determined by echocardiography and prolonged cold ischemia time were the independent risk factors for PRS. More patients in group 1 showed postoperative renal dysfunction than those in group 2 (19.23% vs 8.4%). Moreover, patients in group 1 also had higher intraoperative (7.14% vs 0%) and postoperative mortalities (26.92% vs 12.04%).CONCLUSION: Left ventricular diastolic dysfunction and prolonged cold ischemia time contribute to a high incidence of PRS, which is associated with adverse outcomes in Chinese patients following OLT.

关键词： liver transplantation complications risk factors outcome

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如何抓好工程项目管理中责任索赔

建筑管理现代化 2006年第1期20卷 33-36页

作者：任志福广州航海高等专科学校

施工责任索赔是工程项目管理工作中必定要碰到的一项工作。文章对责任索赔进行界定并分析其起因。在工程项目管理工作中应重视责任索赔管理,理清索赔思路,做好责任索赔工作。

关键词：工程项目合同管理责任索赔界定起因索赔思路