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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing liu li-Fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-lin Jiang Hui-Na liu Yu-Fan Yang zhi-Cheng Zhang Qi Dai Xiao-Yan Bao lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Vaccination against AGE-LDL attenuates atherosclerosis in diabetic apoE mice

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Vaccination against AGE-LDL attenuates atherosclerosis in di...

农业类上市公司经营绩效评价——基于因子分析与改进熵值法的实证研究

第十三次全国心血管病学术会议

作者： ZHU lin,liANG Chun,HE zhi-qing,li Mei,DING Ru,ZHEN Yi, FAN Ming,WU Zong-gui Department of Cardiology,Second Affiliated Hospital of Second Military Medical University,Shanghai 200003,China

Objective To investigate the immunoprotective effects of vaccination against AGE-LDL in atherosclerotic lesions and underlying immunoregulatory *** Male apoE deficient mice were maintained on a standard diet for 2 weeks then changed to high fat diet during the rest of the *** model was induced by intraperitoneal injection of streptozotocin at a dose of 40 mg/kg in citrate buffer for 5 days in such mice,and identified by randomly measured fast blood glucose. LDL was obtained by ultracentrifugation from healthy human volunteers’ serum and then incubated in glucose for gly-

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江西农业学报 2017年第5期29卷 133-138页

作者：马成志李青吕晓焕河海大学商学院江苏南京210000

选取了78家A股农业类上市公司作为研究对象,运用因子分析法与改进熵值法,对78家农业类上市公司的经营绩效进行了实证分析与评价。研究结果发现农业类上市公司经营绩效水平差异较大,呈现"倒U型"分布,不同企业性质、不同行业的经营绩效水... 详细信息

选取了78家A股农业类上市公司作为研究对象,运用因子分析法与改进熵值法,对78家农业类上市公司的经营绩效进行了实证分析与评价。研究结果发现农业类上市公司经营绩效水平差异较大,呈现"倒U型"分布,不同企业性质、不同行业的经营绩效水平差异较为显著,并且在规模实力、盈利能力、运营能力、偿债能力、发展能力5个方面发展不均衡,并据此分析结果提出了相应的对策建议。

关键词：农业类上市公司经营绩效因子分析法改进熵值法

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橡子粉酶法制备低聚异麦芽糖的工艺研究

食品工业科技 2017年第21期38卷 151-156,161页

作者：张智李晴化洪苓尹文哲李杰马建章东北林业大学黑龙江哈尔滨150040 哈尔滨医科大学附属第二医院黑龙江哈尔滨150086 东北农业大学黑龙江哈尔滨150030

对橡子粉酶法制备低聚异麦芽糖的工艺过程进行优化,以期提高低聚异麦芽糖中异麦芽糖、潘糖和异麦芽三糖的含量。采用Box-Benhnken响应面法,优化以耐高温α-淀粉酶液化橡子粉的工艺条件。最佳的液化工艺条件为:以DE值13%为最佳液化指标,... 详细信息

对橡子粉酶法制备低聚异麦芽糖的工艺过程进行优化,以期提高低聚异麦芽糖中异麦芽糖、潘糖和异麦芽三糖的含量。采用Box-Benhnken响应面法,优化以耐高温α-淀粉酶液化橡子粉的工艺条件。最佳的液化工艺条件为:以DE值13%为最佳液化指标,液化时间31 min、液化温度95℃、液化p H6.6、酶添加量13 U/g,结合生产实际最佳条件下的DE值为12.91%;继而采用正交实验,优化以普鲁兰酶、β-淀粉酶糖化橡子粉液化液的工艺条件,得到最佳的糖化工艺条件为:普鲁兰酶添加量25 U/g、β-淀粉酶添加量130 U/g、温度60℃、时间10 h,在此最佳工艺条件下糖化转苷后的(IG2+P+IG3)含量为36.11%±0.17%;转苷工艺过程的α-葡萄糖转苷酶最佳添加量为1.5 U/g,最佳条件下异麦芽糖、潘糖、异麦芽三糖含量之和为36.27%±0.18%。

关键词：低聚异麦芽糖橡子粉液化糖化转苷工艺

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变电站电能质量监测系统研制

铁道学报 2001年第1期23卷 43-47页

作者：贺建闽黄治清李群湛高师湃余俊祥西南交通大学电气工程学院四川成都610031

BDC- 5型变电站电能质量监测系统为基于计算机技术和现代测试技术的虚拟仪器 ,适用于单、三相电力负荷特性测试及变电站三相电能质量测试。本文主要介绍该系统的基本构成、硬件和软件设计以及在工程中的应用。

关键词：变电站虚拟仪器电气化铁道电能质量监测系统构成设计应用

轨道交通行业业务外包供应商业绩评价管理研究

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经济研究导刊 2017年第5期 26-29,149页

作者：卓先智张立清中车长春轨道客车股份有限公司长春130062

为了加强业务外包供应商业绩评价管理工作,促进各个具有业务外包供应商业绩评价权限的职能单位进行有效评价和填报业务外包供应商供货业绩以及评价信息,确保业务外包供应商业绩评价工作得以规范、全面完成,设计了业务外包供应商业绩评... 详细信息

为了加强业务外包供应商业绩评价管理工作,促进各个具有业务外包供应商业绩评价权限的职能单位进行有效评价和填报业务外包供应商供货业绩以及评价信息,确保业务外包供应商业绩评价工作得以规范、全面完成,设计了业务外包供应商业绩评价体系。

关键词：业务外包绩效评价轨道交通行业

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling liao Xiao-li Pu zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

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矿业废弃地的植被恢复与重建

水土保持学报 2003年第4期17卷 172-175页

作者：卫智军李青丰贾鲜艳杨静内蒙古农业大学生态环境学院呼和浩特010019

未经治理的矿业废弃地是造成环境污染、水土流失和土地荒漠化的重大隐患,所带来的后果对经济发展和人类生存构成严重威胁。矿业废弃地植被自然恢复是极其缓慢的,科学合理的人工植被建植大大地加速了这一过程,特别是人工生态体系模式的建... 详细信息

未经治理的矿业废弃地是造成环境污染、水土流失和土地荒漠化的重大隐患,所带来的后果对经济发展和人类生存构成严重威胁。矿业废弃地植被自然恢复是极其缓慢的,科学合理的人工植被建植大大地加速了这一过程,特别是人工生态体系模式的建立,可在矿业废弃地植被恢复与重建过程中带来生态效益的同时,亦产生巨大的经济效益。

关键词：矿业废弃地植被恢复植被重建人工生态体系模式生态效益经济效益